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Proteintech
ZNF746 Polyclonal Antibody
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Product Details
24543-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ZNF746 Fusion Protein Ag21566 (186-531 aa encoded by BC068505)
Conjugate
Form
Liquid
Concentration
0.31 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
The calculated molecular weight of ZNF746 is 69 kDa, but phosphorylated ZNF746 is about 80-85 kDa.
Immunogen sequence: MQIKQEGEL QLQEQQALGV EAWAAGQPDI GEEPWGLSQL DSGAGDISTD ATSGVHSNFS TTIPPTSWQT DLPPHHPSSA CSDGTLKLNT AASTEDVKIV IKTEVQEEEV VATPVHPTDL EAHGTLFGPG QATRFFPSPA QEGAWESQGS SFPSQDPVLG LREPARPERD MGELSPAVAQ EETPPGDWLF GGVRWGWNFR CKPPVGLNPR TGPEGLPYSS PDNGEAILDP SQAPRPFNEP CKYPGRTKGF GHKPGLKKHP AAPPGGRPFT CATCGKSFQL QVSLSAHQRS CGAPDGSGPG TGGGGSGSGG GGGGSGGGSA RDGSALRCGE CGRCFTRPAH LIRHRML (186-531 aa encoded by BC068505 )
Target Information
ZNF746 is a transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and represses transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: PARIS; parkin interacting substrate; Parkin-interacting substrate; parkin-interacting sustrate; Zinc finger protein 746
Gene Aliases: 2810407L07Rik; AI317225; PARIS; RGD1306209; Zfp746; ZNF746
UniProt ID: (Human) Q6NUN9, (Mouse) Q3U133
Entrez Gene ID: (Human) 155061, (Mouse) 69228, (Rat) 312303
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
protein binding
ubiquitin protein ligase binding
transcription regulatory region DNA binding
metal ion binding
nucleic acid binding
DNA binding
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of neuron death
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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