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Bioss
ZNT8 Polyclonal Antibody
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FIGURE: 1 / 2
ZNT8 Antibody (BS-15382R) in IHC (P)
Paraformaldehyde-fixed, paraffin embedded mouse pancreas; Antigen retrieval by boiling in sodium citrate buffer (pH6) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (normal goat serum) at 37°C for 20min; Antibody incubation with ZNT8 Polyclonal Antibody (bs-15382R) at 1:400 overnight at 4°C, followed by a conjugated secondary and DAB staining.
Product Details
BS-15382R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human ZNT8, amino acids 101-200.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Slc30A8 is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles and is expressed at a high level in the pancreas, particularly in islets of Langerhans, and co-localizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of Slc30A8 have been identified as major genetic risk factors for the development of Type 2 diabetes, but no genetic association has been found with Type 1 diabetes. Slc30A8 expression in b-cells was found to be influenced by cytokine expression, particularly IFN-gamma and IL-1 beta.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Proton-coupled zinc antiporter SLC30A8; solute carrier family 30 (zinc transporter), member 8; Solute carrier family 30 member 8; Zinc transporter 8; zinc transporter ZnT-8; ZnT-8
Gene Aliases: C820002P14Rik; SLC30A8; ZnT-8; ZNT8
UniProt ID: (Human) Q8IWU4, (Rat) P0CE46, (Mouse) Q8BGG0
Entrez Gene ID: (Human) 169026, (Rat) 299903, (Mouse) 239436
zinc II ion transport
cellular zinc ion homeostasis
response to glucose
insulin secretion
positive regulation of insulin secretion
sequestering of zinc ion
response to interferon-gamma
glucose homeostasis
regulation of vesicle-mediated transport
regulation of sequestering of zinc ion
response to interleukin-1
zinc II ion transmembrane transport
response to zinc ion
transport
ion transport
cation transport
transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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