Product References
Electroacupuncture Ameliorates Neuronal Injury by NLRP3/ASC/Caspase-1 Mediated Pyroptosis in Cerebral Ischemia-Reperfusion.
Molecular neurobiology
Tang B,Li Y,Xu X,Du G,Wang H
61-7300 was used in Western Blot to find that EA improved cerebral infarct size and neuronal damage, including ultrastructural injury, and ameliorated nitro/oxidative stress in cerebral I/R. Additionally, EA treatment significantly decreased ASC, Caspase-1, GSDMD, and IL-1β expression and VX-765 treatment significantly decreased NLRP3, Caspase-1, and IL-1β expression.
Mon Apr 01 00:00:00 UTC 2024
A rodent thyroid-liver chip to capture thyroid toxicity on organ function level.
ALTEX
Karwelat D,Kühnlenz J,Steger-Hartmann T,Bars R,Tinwell H,Marx U,Bauer S,Born O,Raschke M
61-7300 was used in Immunohistochemistry to introduce a rat thyroid-liver chip that enables simultaneous identification of direct and indirect (liver-mediated) thyroid perturbation on organ-level functions in vitro.
Thu Jan 19 00:00:00 UTC 2023
Effects of sevoflurane on lung epithelial permeability in experimental models of acute respiratory distress syndrome.
Journal of translational medicine
Zhai R,Lenga Ma Bonda W,Leclaire C,Saint-Béat C,Theilliere C,Belville C,Coupet R,Blondonnet R,Bouvier D,Blanchon L,Sapin V,Jabaudon M
61-7300 was used in Immunocytochemistry to suggest that sevoflurane may decrease lung epithelial permeability through the RhoA/pMLC/F-actin pathway.
Sun Jun 18 00:00:00 UTC 2023
Effects of sevoflurane on lung epithelial permeability in experimental models of acute respiratory distress syndrome.
Journal of translational medicine
Zhai R,Lenga Ma Bonda W,Leclaire C,Saint-Béat C,Theilliere C,Belville C,Coupet R,Blondonnet R,Bouvier D,Blanchon L,Sapin V,Jabaudon M
61-7300 was used in Immunocytochemistry to suggest that sevoflurane may decrease lung epithelial permeability through the RhoA/pMLC/F-actin pathway.
Sun Jun 18 00:00:00 UTC 2023
Effects of sevoflurane on lung epithelial permeability in experimental models of acute respiratory distress syndrome.
Journal of translational medicine
Zhai R,Lenga Ma Bonda W,Leclaire C,Saint-Béat C,Theilliere C,Belville C,Coupet R,Blondonnet R,Bouvier D,Blanchon L,Sapin V,Jabaudon M
61-7300 was used in Immunocytochemistry to suggest that sevoflurane may decrease lung epithelial permeability through the RhoA/pMLC/F-actin pathway.
Sun Jun 18 00:00:00 UTC 2023
β1 integrin is essential for blood-brain barrier integrity under stable and vascular remodelling conditions; effects differ with age.
Fluids and barriers of the CNS
Halder SK,Delorme-Walker VD,Milner R
61-7300 was used in Immunocytochemistry-immunofluorescence to demonstrate that β1 integrin plays an essential role in maintaining BBB integrity, both under stable normoxic conditions and during hypoxia-induced vascular remodeling.
Mon Jul 03 00:00:00 UTC 2023
An effective method for culturing functional human corneal endothelial cells using a xenogeneic free culture medium.
Scientific reports
Alonso-Alonso S,Vázquez N,Chacón M,Caballero-Sánchez N,Del Olmo-Aguado S,Suárez C,Alfonso-Bartolozzi B,Fernández-Vega-Cueto L,Nagy L,Merayo-Lloves J,Meana A
61-7300 was used in Immunocytochemistry to demonstrate that CECs cultured in the xenogeneic-free medium exhibit comparable gene expression, morphology, and functionality to those cultured in the xenogeneic medium.
Thu Nov 09 00:00:00 UTC 2023
Micromolded honeycomb scaffold design to support the generation of a bilayered RPE and photoreceptor cell construct.
Bioactive materials
Lee IK,Xie R,Luz-Madrigal A,Min S,Zhu J,Jin J,Edwards KL,Phillips MJ,Ludwig AL,Gamm DM,Gong S,Ma Z
61-7300 was used in Immunocytochemistry-immunofluorescence to develop microfabricated, honeycomb-patterned, biodegradable poly(glycerol sebacate) (PGS) scaffolds to deliver organized, adjacent layers of RPE and PRs to the subretinal space.
Fri Dec 01 00:00:00 UTC 2023
Tocilizumab promotes repair of spinal cord injury by facilitating the restoration of tight junctions between vascular endothelial cells.
Fluids and barriers of the CNS
Luo Y,Yao F,Shi Y,Zhu Z,Xiao Z,You X,Liu Y,Yu S,Tian D,Cheng L,Zheng M,Jing J
61-7300 was used in Immunohistochemistry to demonstrate that at 14 and 28 dpi, the expression of claudin-5 (CLDN5) and zonula occludens-1 (ZO-1) between vascular endothelial cells was significantly increased and the leakage of BSCB was significantly reduced in the injured core after daily intrathecal injection of Tocilizumab.
Mon Jan 09 00:00:00 UTC 2023
Hyperreflective Foci in Diabetic Macular Edema with Subretinal Fluid: Association with Visual Outcomes after Anti-VEGF Treatment.
Ophthalmic research
Tang L,Luo D,Qiu Q,Xu GT,Zhang J
61-7300 was used in Immunocytochemistry-immunofluorescence to conclude that the number of HRF in outer retina was negatively associated with the microstructural restoration of ELM and EZ, as well as the visual outcome in DME patients with SRF after anti-VEGF treatment.
Wed Jan 10 00:00:00 UTC 2024
Interaction between mitochondrial homeostasis and barrier function in lipopolysaccharide-induced endothelial cell injury.
International journal of experimental pathology
Zhu W,Liu X,Luo L,Huang X,Wang X
61-7300 was used in Western Blot to investigate the effects of mitochondrial homeostasis on lipopolysaccharide (LPS)-induced endothelial cell barrier function and the mechanisms that underlie these effects.
Fri Dec 01 00:00:00 UTC 2023
Differential impact of yeast cell wall products in recovery of porcine intestinal epithelial cell barrier function following Lipopolysaccharide challenge.
Porcine health management
Browne N,Daly D,Horgan K
61-7300 was used in Western Blot to compare Mannan rich fraction (MRF) and three YCW products by examining their impact on intestinal barrier function using a Jejunal model of intestine in response to a bacterial challenge using Salmonella LPS.
Mon Apr 17 00:00:00 UTC 2023
miR-4780 Derived from N2-Like Neutrophil Exosome Aggravates Epithelial-Mesenchymal Transition and Angiogenesis in Colorectal Cancer.
Stem cells international
Wang L,Shan Y,Zheng S,Li J,Cui P
61-7300 was used in Immunohistochemistry-immunofluorescence to reveal an important mechanism by which mR-4780 from N2-like neutrophil exosomes exacerbates tumor metastasis and progression via EMT and angiogenesis.
Thu Dec 28 00:00:00 UTC 2023
Commensal bacteria weaken the intestinal barrier by suppressing epithelial neuropilin-1 and Hedgehog signaling.
Nature metabolism
Pontarollo G,Kollar B,Mann A,Khuu MP,Kiouptsi K,Bayer F,Brandão I,Zinina VV,Hahlbrock J,Malinarich F,Mimmler M,Bhushan S,Marini F,Ruf W,Belheouane M,Baines JF,Endres K,Reba SM,Raker VK,Deppermann C,Welsch C,Bosmann M,Soshnikova N,Chassaing B,Bergentall M,Sommer F,Bäckhed F,Reinhardt C
61-7300 was used in Western Blotting to reveal a role for the commensal microbiota and epithelial NRP1 signaling in the regulation of intestinal barrier function through postnatal control of Hh signaling.
Sat Jul 01 00:00:00 UTC 2023
Sucrose-induced hyperglycemia dysregulates intestinal zinc metabolism and integrity: risk factors for chronic diseases.
Frontiers in nutrition
Mitchell SB,Hung YH,Thorn TL,Zou J,Baser F,Gulec S,Cheung C,Aydemir TB
61-7300 was used in Western Blotting to investigate how dietary sources of intestinal permeability, such as high sucrose consumption, impact transporter-mediated zinc homeostasis and subsequent zinc-dependent physiology contributing to disease development.
Mon Sep 23 00:00:00 UTC 2024
Bioprinted 3D outer retina barrier uncovers RPE-dependent choroidal phenotype in advanced macular degeneration.
Nature methods
Song MJ,Quinn R,Nguyen E,Hampton C,Sharma R,Park TS,Koster C,Voss T,Tristan C,Weber C,Singh A,Dejene R,Bose D,Chen YC,Derr P,Derr K,Michael S,Barone F,Chen G,Boehm M,Maminishkis A,Singec I,Ferrer M,Bharti K
61-7300 was used in Immunohistochemistry to engineer a native-like three-dimensional (3D) oBRB tissue (3D-oBRB) by bioprinting endothelial cells, pericytes, and fibroblasts on the basal side of a biodegradable scaffold and establishing an RPE monolayer on top.
Sun Jan 01 00:00:00 UTC 2023
Dysfunctional Extracellular Matrix Remodeling Supports Perianal Fistulizing Crohn's Disease by a Mechanoregulated Activation of the Epithelial-to-Mesenchymal Transition.
Cellular and molecular gastroenterology and hepatology
Rizzo G,Rubbino F,Elangovan S,Sammarco G,Lovisa S,Restelli S,Pineda Chavez SE,Massimino L,Lamparelli L,Paulis M,Maroli A,Roda G,Shalaby M,Carvello M,Foppa C,Drummond SP,Spaggiari P,Ungaro F,Spinelli A,Malesci A,Repici A,Day AJ,Armuzzi A,Danese S,Vetrano S
61-7300 was used in Immunohistochemistry-immunofluorescence to dissect the tissue changes in the fistula area and address whether a dysregulation of extracellular matrix (ECM) homeostasis can support fistula formation.
Thu Feb 23 00:00:00 UTC 2023
Vitamin A deficiency compromises the barrier function of the retinal pigment epithelium.
PNAS nexus
Moon J,Zhou G,Jankowsky E,von Lintig J
61-7300 was used in Immunohistochemistry-immunofluorescence to perform RNA-seq analyses and complemented the data with tests of visual physiology, ocular morphology, and retinoid biochemistry to compare eyes with different vitamin A status.
Thu Jun 01 00:00:00 UTC 2023
In Vitro Characteristics of Canine Primary Tracheal Epithelial Cells Maintained at an Air-Liquid Interface Compared to In Vivo Morphology.
International journal of molecular sciences
Runft S,Färber I,Krüger J,Schöne K,Lehmbecker A,Baumgärtner W
61-7300 was used in Immunohistochemistry-immunofluorescence to culture canine primary tracheal epithelial cells at an air-liquid interface (ALI) for four weeks, aiming to create an in vitro model of the respiratory tract epithelium in dogs.
Sun Mar 05 00:00:00 UTC 2023
Simvastatin as a topical anti-inflammatory: Effect on airway epithelial cell homeostasis.
International forum of allergy & rhinology
Farrell NF,Pan J,Huang T,Piccirillo JF,Goldstein BJ,Brody SL
61-7300 was used in Immunocytochemistry to indicate a positive impact of this intervention on asthma control.
Fri Sep 01 00:00:00 UTC 2023
Cilia-associated wound repair mediated by IFT88 in retinal pigment epithelium.
Scientific reports
Ning K,Bhuckory MB,Lo CH,Sendayen BE,Kowal TJ,Chen M,Bansal R,Chang KC,Vollrath D,Berbari NF,Mahajan VB,Hu Y,Sun Y
61-7300 was used in Immunohistochemistry to suggest that retinal pigment epithelium (RPE) cilia contribute to both retinal development and repair and provide insights into potential therapeutic targets for more common RPE degenerative diseases.
Sun May 21 00:00:00 UTC 2023
DR3 Regulates Intestinal Epithelial Homeostasis and Regeneration After Intestinal Barrier Injury.
Cellular and molecular gastroenterology and hepatology
Shimodaira Y,More SK,Hamade H,Blackwood AY,Abraham JP,Thomas LS,Miller JH,Stamps DT,Castanon SL,Jacob N,Ha CWY,Devkota S,Shih DQ,Targan SR,Michelsen KS
61-7300 was used in Immunocytochemistry to establish a novel function of DR3 in IEC homeostasis and postinjury regeneration independent of its established role in innate lymphoid cells and T-helper cells.
Tue Jun 20 00:00:00 UTC 2023
DR3 Regulates Intestinal Epithelial Homeostasis and Regeneration After Intestinal Barrier Injury.
Cellular and molecular gastroenterology and hepatology
Shimodaira Y,More SK,Hamade H,Blackwood AY,Abraham JP,Thomas LS,Miller JH,Stamps DT,Castanon SL,Jacob N,Ha CWY,Devkota S,Shih DQ,Targan SR,Michelsen KS
61-7300 was used in Immunocytochemistry to establish a novel function of DR3 in IEC homeostasis and postinjury regeneration independent of its established role in innate lymphoid cells and T-helper cells.
Tue Jun 20 00:00:00 UTC 2023
Fucose ameliorates the proinflammatory property of Fusobacterium nucleatum in colitis via altering its metabolism.
Frontiers in cellular and infection microbiology
Duan C,Hou L,Deng X,Wu J,Qian W,Han C,Hou X
61-7300 was used in Western Blotting to explore whether fucose could ameliorate the proinflammatory property of Fn in colitis and the underlying mechanisms.
Fri May 19 00:00:00 UTC 2023
Evaluation of arsenic metabolism and tight junction injury after exposure to arsenite and monomethylarsonous acid using a rat in vitro blood-Brain barrier model.
PloS one
Yamauchi H,Hitomi T,Takata A
61-7300 was used in Western Blot to show that a small percentage (~15%) of iAsIII was oxidized or methylated within the BBB, suggesting the persistence of toxicity as iAsIII.
Mon Dec 04 00:00:00 UTC 2023
Cannabinoid receptor type 1 in the aging gut regulates the mucosal permeability via miR-191-5p.
Frontiers in endocrinology
Lee Y,Kim Y,Park S,Heo G,Chung HY,Im E
61-7300 was used in Immunocytochemistry to suggest that CB1 signaling may be a useful strategy to reduce intestinal permeability in aging-related and other inflammatory conditions in the gut.
Tue Sep 12 00:00:00 UTC 2023
Protective Effects of Human Pericyte-like Adipose-Derived Mesenchymal Stem Cells on Human Retinal Endothelial Cells in an In Vitro Model of Diabetic Retinopathy: Evidence for Autologous Cell Therapy.
International journal of molecular sciences
Lupo G,Agafonova A,Cosentino A,Giurdanella G,Mannino G,Lo Furno D,Romano IR,Giuffrida R,D'Angeli F,Anfuso CD
61-7300 was used in Immunocytochemistry to assess possible beneficial effects exerted by adipose mesenchymal stem cells (ASCs) and their pericyte-like differentiated phenotype (P-ASCs) on human retinal endothelial cells (HRECs) in high glucose conditions (25 mM glucose, HG).
Wed Jan 04 00:00:00 UTC 2023
Comparative study of extracellular vesicles derived from mesenchymal stem cells and brain endothelial cells attenuating blood-brain barrier permeability via regulating Caveolin-1-dependent ZO-1 and Claudin-5 endocytosis in acute ischemic stroke.
Journal of nanobiotechnology
Li Y,Liu B,Zhao T,Quan X,Han Y,Cheng Y,Chen Y,Shen X,Zheng Y,Zhao Y
61-7300 was used in Western Blotting to demonstrate that Cav-1 aggravated BBB permeability in acute ischemic stroke, and BMSC-EVs exerted similar antagonistic efficacy to BEC-EVs on Cav-1-dependent ZO-1 and Claudin-5 endocytosis.
Tue Feb 28 00:00:00 UTC 2023
Loss of Hepatic Leucine-Rich Repeat-Containing G-Protein Coupled Receptors 4 and 5 Promotes Nonalcoholic Fatty Liver Disease.
The American journal of pathology
Saponara E,Penno C,Orsini V,Wang ZY,Fischer A,Aebi A,Matadamas-Guzman ML,Brun V,Fischer B,Brousseau M,O'Donnell P,Turner J,Graff Meyer A,Bollepalli L,d'Ario G,Roma G,Carbone W,Annunziato S,Obrecht M,Beckmann N,Saravanan C,Osmont A,Tropberger P,Richards SM,Genoud C,Ley S,Ksiazek I,Nigsch F,Terracciano LM,Schadt HS,Bouwmeester T,Tchorz JS,Ruffner H
61-7300 was used in Immunohistochemistry to study whether hepatic epithelial cell-specific loss of the Wnt/β-catenin modulator Lgr4/5 promoted NAFLD.
Wed Feb 01 00:00:00 UTC 2023
A ROCK inhibitor suppresses the transforming growth factor-beta-2-induced endothelial-mesenchymal transition in Schlemm's canal endothelial cells.
Scientific reports
Fujimoto T,Inoue-Mochita M,Inoue T
61-7300 was used in Immunocytochemistry to indicate that a ROCK inhibitor inhibited the TGF-β2-induced EndMT in SC cells, implying the involvement of p38 MAPK and BMP4 signaling.
Wed Jun 14 00:00:00 UTC 2023
Colonic Epithelial Circadian Disruption Worsens Dextran Sulfate Sodium-Induced Colitis.
Inflammatory bowel diseases
Jochum SB,Engen PA,Shaikh M,Naqib A,Wilber S,Raeisi S,Zhang L,Song S,Sanzo G,Chouhan V,Ko F,Post Z,Tran L,Ramirez V,Green SJ,Khazaie K,Hayden DM,Brown MJ,Voigt RM,Forsyth CB,Keshavarzian A,Swanson GR
61-7300 was used in Western Blot to explore the effects of isolated peripheral colonic circadian disruption on the colonic barrier in a mouse model of colitis and explore the mechanisms, including intestinal microbiota community structure and function.
Wed Mar 01 00:00:00 UTC 2023
Macrophage lineage cells-derived migrasomes activate complement-dependent blood-brain barrier damage in cerebral amyloid angiopathy mouse model.
Nature communications
Hu M,Li T,Ma X,Liu S,Li C,Huang Z,Lin Y,Wu R,Wang S,Lu D,Lu T,Men X,Shen S,Huang H,Liu Y,Song K,Jian B,Jiang Y,Qiu W,Liu Q,Lu Z,Cai W
61-7300 was used in Western Blotting to propose that macrophage-derived migrasomes and the consequent complement activation are potential biomarkers and therapeutic targets in cerebral amyloid angiopathy (CAA).
Tue Jul 04 00:00:00 UTC 2023
ERdj5 protects goblet cells from endoplasmic reticulum stress-mediated apoptosis under inflammatory conditions.
Experimental & molecular medicine
Jeong H,Hong EH,Ahn JH,Cho J,Jeong JH,Kim CW,Yoon BI,Koo JH,Park YY,Yang YM,Iwawaki T,Vallance BA,Chang SY,Ko HJ
61-7300 was used in Immunocytochemistry-immunofluorescence to highlight the important role of ERdj5 in preserving goblet cell viability and function by resolving endoplasmic reticulum stress.
Wed Feb 01 00:00:00 UTC 2023
Integration of human stem cell-derived in vitro systems and mouse preclinical models identifies complex pathophysiologic mechanisms in retinal dystrophy.
Frontiers in cell and developmental biology
Jones MK,Orozco LD,Qin H,Truong T,Caplazi P,Elstrott J,Modrusan Z,Chaney SY,Jeanne M
61-7300 was used in Immunohistochemistry to find that DRAM2 loss in human pluripotent stem cell (hPSC)-derived retinal organoids caused the presence of additional mesenchymal cells.
Wed Sep 13 00:00:00 UTC 2023
Siponimod As a Novel Inhibitor of Retinal Angiogenesis: In Vitro and In Vivo Evidence of Therapeutic Efficacy.
The Journal of pharmacology and experimental therapeutics
Alshaikh RA,Zaki RGE,El Din RAS,Ryan KB,Waeber C
61-7300 was used in Immunocytochemistry to investigate the potential of siponimod for the inhibition of ocular angiogenesis in vitro and in vivo.
Tue Aug 01 00:00:00 UTC 2023
EpCAM proteolysis and release of complexed claudin-7 repair and maintain the tight junction barrier.
The Journal of cell biology
Higashi T,Saito AC,Fukazawa Y,Furuse M,Higashi AY,Ono M,Chiba H
61-7300 was used in Immunocytochemistry-immunofluorescence to reveal a novel mechanism of TJ maintenance through the localized proteolysis of EpCAM at TJ leaks, and provide a better understanding of the dynamic regulation of epithelial permeability.
Mon Jan 02 00:00:00 UTC 2023
Hypoxia-Driven Changes in a Human Intestinal Organoid Model and the Protective Effects of Hydrolyzed Whey.
Nutrients
de Lange IH,van Gorp C,Massy KRI,Kessels L,Kloosterboer N,Bjørnshave A,Stampe Ostenfeld M,Damoiseaux JGMC,Derikx JPM,van Gemert WG,Wolfs TGAM
61-7300 was used in Immunocytochemistry to investigate the effects of whey protein fractions with different degrees of enzymatic hydrolysis on the intestinal epithelium in health and disease with a novel 2D human intestinal organoid (HIO) monolayer model.
Thu Jan 12 00:00:00 UTC 2023
Klotho prevents transforming growth factor-β2-induced senescent-like morphological changes in the retinal pigment epithelium.
Cell death & disease
Jang HY,Kim SJ,Park KS,Kim JH
61-7300 was used in Immunocytochemistry-immunofluorescence to investigate the protective effects of soluble α-klotho on TGF-β2-induced RPE degeneration.
Sat May 20 00:00:00 UTC 2023
Validation and characterization of a novel blood-brain barrier platform for investigating traumatic brain injury.
Scientific reports
Bolden CT,Skibber MA,Olson SD,Zamorano Rojas M,Milewicz S,Gill BS,Cox CS
61-7300 was used in Immunocytochemistry to develop and validate a novel in vitro platform that closely mimics the physiologic parameters of the blood-brain barrier (BBB), including fluidic shear stress and hemodynamic conditions, enabling the characterization of BBB functional properties and its response to ischemic, inflammatory, and metabolic cues.
Tue Sep 26 00:00:00 UTC 2023
Validation and characterization of a novel blood-brain barrier platform for investigating traumatic brain injury.
Scientific reports
Bolden CT,Skibber MA,Olson SD,Zamorano Rojas M,Milewicz S,Gill BS,Cox CS
61-7300 was used in Immunocytochemistry to develop and validate a novel in vitro platform that closely mimics the physiologic parameters of the blood-brain barrier (BBB), including fluidic shear stress and hemodynamic conditions, enabling the characterization of BBB functional properties and its response to ischemic, inflammatory, and metabolic cues.
Tue Sep 26 00:00:00 UTC 2023
The gut microbiota is important for the maintenance of blood-cerebrospinal fluid barrier integrity.
The European journal of neuroscience
Knox EG,Lynch CMK,Lee YS,O'Driscoll CM,Clarke G,Cryan JF,Aburto MR
61-7300 was used in Immunohistochemistry-immunofluorescence to indicate that the blood-cerebrospinal fluid barrier is another barrier along the gut microbiota-brain axis.
Sun Jan 01 00:00:00 UTC 2023
The Bcl-2/Bcl-xL Inhibitor ABT-263 Attenuates Retinal Degeneration by Selectively Inducing Apoptosis in Senescent Retinal Pigment Epithelial Cells.
Molecules and cells
Ryu W,Park CW,Kim J,Lee H,Chung H
61-7300 was used in Immunocytochemistry-immunofluorescence to suggest that ABT-263, which removes senescent RPE cells through its senolytic effect, has the potential to be the first orally administered senolytic drug for the treatment of AMD.
Mon Jul 31 00:00:00 UTC 2023
Centrosome amplification promotes cell invasion via cell-cell contact disruption and Rap-1 activation.
Journal of cell science
Prakash A,Paunikar S,Webber M,McDermott E,Vellanki SH,Thompson K,Dockery P,Jahns H,Brown JAL,Hopkins AM,Bourke E
61-7300 was used in Immunocytochemistry to demonstrate a key role of small GTPase Rap-1 signalling through inhibition using GGTI-298, which blocked various CA-induced effects.
Wed Nov 01 00:00:00 UTC 2023
Efficacy of Hydroponically Cultivated Saffron in the Preservation of Retinal Pigment Epithelium.
Molecules (Basel, Switzerland)
Di Paolo M,Corsi F,Maggi M,Nardi L,Bisti S,Piano I,Gargini C
61-7300 was used in Immunocytochemistry-immunofluorescence to conclude that hydroponic culturing is a suitable strategy to produce high-quality saffron to reduce costs and increase the accessibility of this promising treatment for retinal degeneration.
Fri Feb 10 00:00:00 UTC 2023
Knockout of Sirt2 alleviates traumatic brain injury in mice.
Neural regeneration research
Wang W,Gong QY,Cai L,Jing Y,Yang DX,Yuan F,Chen H,Tian HL
61-7300 was used in Immunocytochemistry-immunofluorescence to find that knockout of Sirt2 in a mouse model of TBI reduced brain edema, attenuated disruption of the blood-brain barrier, decreased expression of the nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome, reduced the activity of the effector caspase-1, reduced neuroinflammation and neuronal pyroptosis, and improved neurological function.
Wed Feb 01 00:00:00 UTC 2023
Modelling BK Polyomavirus dissemination and cytopathology using polarized human renal tubule epithelial cells.
PLoS pathogens
Lorentzen EM,Henriksen S,Rinaldo CH
61-7300 was used in Immunocytochemistry-immunofluorescence to propose that during in vivo low-level BKPyV replication, BKPyV disseminates inside the tubular system, thereby causing minimal damage and delaying immune detection.
Tue Aug 01 00:00:00 UTC 2023
rTMS treatment for abrogating intracerebral hemorrhage-induced brain parenchymal metabolite clearance dysfunction in male mice by regulating intracranial lymphatic drainage.
Brain and behavior
Liu Y,Liu X,Sun P,Li J,Nie M,Gong J,He A,Zhao M,Yang C,Wang Z
61-7300 was used in Western Blotting to indicate that rTMS can abrogate ICH-induced brain parenchymal metabolite clearance dysfunction by regulating intracranial lymphatic drainage.
Sat Jul 01 00:00:00 UTC 2023
A ratchet-like apical constriction drives cell ingression during the mouse gastrulation EMT.
eLife
Francou A,Anderson KV,Hadjantonakis AK
61-7300 was used in Immunocytochemistry-immunofluorescence to show that loss of function analyses demonstrated a requirement for Crumbs2 in myosin II localization and activity at apical junctions, and as a candidate regulator of actomyosin anisotropy.
Wed May 10 00:00:00 UTC 2023
Efficacy of the Radical Scavenger, Tempol, to Reduce Inflammation and Oxidative Stress in a Murine Model of Atopic Dermatitis.
Antioxidants (Basel, Switzerland)
Ardizzone A,Repici A,Capra AP,De Gaetano F,Bova V,Casili G,Campolo M,Esposito E
61-7300 was used in Immunohistochemistry to demonstrate the numerous advantages provided by the topical administration of a tempol-based cream formulation, in reducing inflammation and oxidative stress through modulation of the NF-κB/Nrf2 signaling pathways.
Thu Jun 15 00:00:00 UTC 2023
An altered extracellular matrix-integrin interface contributes to Huntington's disease-associated CNS dysfunction in glial and vascular cells.
Human molecular genetics
Hernandez SJ,Lim RG,Onur T,Dane MA,Smith R,Wang K,Jean GE,Reyes-Ortiz A,Devlin K,Miramontes R,Wu J,Casale M,Kilburn D,Heiser LM,Korkola JE,Van Vactor D,Botas J,Thompson-Peer KL,Thompson LM
61-7300 was used in Immunocytochemistry to study the extracellular matrix-integrin interface in astrocytes and brain microvascular endothelial cells.
Thu Apr 20 00:00:00 UTC 2023
Human Colonoid-Myofibroblast Coculture for Study of Apical Na+/H+ Exchangers of the Lower Cryptal Neck Region.
International journal of molecular sciences
Salari A,Zhou K,Nikolovska K,Seidler U,Amiri M
61-7300 was used in Immunohistochemistry-immunofluorescence to establish an in vitro model of the colonic lower crypt compartment, which expresses the transit amplifying/progenitor (TA/PE) cells, with accessibility of the apical membrane for functional study of lower crypt-expressed Na+/H+ exchangers (NHEs).
Tue Feb 21 00:00:00 UTC 2023
Receptor-interacting protein kinase 2 (RIPK2) profoundly contributes to post-stroke neuroinflammation and behavioral deficits with microglia as unique perpetrators.
Journal of neuroinflammation
Larochelle J,Tishko RJ,Yang C,Ge Y,Phan LT,Gunraj RE,Stansbury SM,Liu L,Mohamadzadeh M,Khoshbouei H,Candelario-Jalil E
61-7300 was used in Western Blot to identify RIPK2 as a potent propagator of neuroinflammatory signaling, highlighting its potential as a therapeutic target for post-stroke intervention.
Sat Sep 30 00:00:00 UTC 2023
Long-Term Evaluation of Retinal Morphology and Function in Rosa26-Cas9 Knock-In Mice.
International journal of molecular sciences
Mohan K,Dubey SK,Jung K,Dubey R,Wang QJ,Prajapati S,Roney J,Abney J,Kleinman ME
61-7300 was used in Immunohistochemistry-immunofluorescence to show that both the retina and RPE maintain their phenotypic and functional features in Cas9 knock-in mice, establishing this as an ideal animal model for developing therapeutics for retinal diseases.
Wed Mar 08 00:00:00 UTC 2023
Circular RNA expression and the competitive endogenous RNA network in pathological, age-related macular degeneration events: A cross-platform normalization study.
Journal of biomedical research
Sun R,Zhu H,Wang Y,Wang J,Jiang C,Cao Q,Zhang Y,Zhang Y,Yuan S,Liu Q
61-7300 was used in Western Blot to provide insights into the pathological processes of atrophic AMD.
Fri Apr 28 00:00:00 UTC 2023
DUSP3 regulates phosphorylation-mediated degradation of occludin and is required for maintaining epithelial tight junction.
Journal of biomedical science
Chou HC,Cheng CM,Yang CH,Lin TY,Liu YW,Tan TH,Chen YR
61-7300 was used in Western Blotting to reveal that DUSP3 is an important TJ regulatory protein and its decrease may be involved in progression of epithelial cancers.
Wed Jun 15 00:00:00 UTC 2022
CU06-1004 enhances vascular integrity and improves cardiac remodeling by suppressing edema and inflammation in myocardial ischemia-reperfusion injury.
Experimental & molecular medicine
Zhang H,Kim H,Park BW,Noh M,Kim Y,Park J,Park JH,Kim JJ,Sim WS,Ban K,Park HJ,Kwon YG
61-7300 was used in Immunohistochemistry to investigate the role of CU06-1004 in improving cardiac function by influencing cardiac microvascular endothelial cells in ischeamia-repurfusion injury.
Sat Jan 01 00:00:00 UTC 2022
Blocking C3d+/GFAP+ A1 Astrocyte Conversion with Semaglutide Attenuates Blood-Brain Barrier Disruption in Mice after Ischemic Stroke.
Aging and disease
Zhang Q,Liu C,Shi R,Zhou S,Shan H,Deng L,Chen T,Guo Y,Zhang Z,Yang GY,Wang Y,Tang Y
61-7300 was used in Immunohistochemistry-immunofluorescence to conclude that astrocytes undergo a phenotypic shift over time after ischemic stroke.
Wed Jun 01 00:00:00 UTC 2022
Dl-3-n-butylphthalide attenuates brain injury caused by cortical infarction accompanied by cranial venous drainage disturbance.
Stroke and vascular neurology
Song K,Zeng X,Xie X,Zhu R,Liang J,Chen G,Huang L
61-7300 was used in Immunohistochemistry to explore the potential mechanism of the adverse effects of cerebrovenous disorders in cerebral infarction and explore the protective effect of Dl-3-n-butylphthalide on cerebral infarction accompanied through cerebral venous disturbance.
Wed Jun 01 00:00:00 UTC 2022
Rhinovirus C replication is associated with the endoplasmic reticulum and triggers cytopathic effects in an in vitro model of human airway epithelium.
PLoS pathogens
Gagliardi TB,Goldstein ME,Song D,Gray KM,Jung JW,Ignacio MA,Stroka KM,Duncan GA,Scull MA
61-7300 was used in Western Blot to identify both shared and unique features of rhinovirus C (RV-C) replication compared to related rhinoviruses and define the impact of RV-C on both epithelial cell organization and tissue functionality-aspects of infection that may contribute to pathogenesis in vivo.
Sat Jan 01 00:00:00 UTC 2022
Vascular Sema3E-Plexin-D1 Signaling Reactivation Promotes Post-stroke Recovery through VEGF Downregulation in Mice.
Translational stroke research
Yu R,Kim NS,Li Y,Jeong JY,Park SJ,Zhou B,Oh WJ
61-7300 was used in Immunohistochemistry to investigate whether Sema3E-Plexin-D1 signaling was involved in cerebrovascular remodeling after ischemic injury.
Tue Feb 01 00:00:00 UTC 2022
ACKR1 favors transcellular over paracellular T-cell diapedesis across the blood-brain barrier in neuroinflammation in vitro.
European journal of immunology
Marchetti L,Francisco D,Soldati S,Haghayegh Jahromi N,Barcos S,Gruber I,Pareja JR,Thiriot A,von Andrian U,Deutsch U,Lyck R,Bruggmann R,Engelhardt B
61-7300 was used in Immunocytochemistry to support that ACKR1 mediated chemokine shuttling enhances transcellular T-cell diapedesis across the BBB during autoimmune neuroinflammation.
Sat Jan 01 00:00:00 UTC 2022
Collagen triple helix repeat containing-1 promotes functional recovery of sweat glands by inducing adjacent microvascular network reconstruction in vivo.
Burns & trauma
Yuan X,Duan X,Li Z,Yao B,Song W,Kong Y,Wang Y,Zhang F,Liang L,Zhu S,Zhang M,Zhang C,Huang S,Fu X
61-7300 was used in Immunocytochemistry-immunoflourescence to conclude that CTHRC1 promotes the development, morphogenesis and function execution of SGs and their neighboring vasculature and provides a novel target for the restoration or regeneration of SG function in vivo.
Tue Aug 09 00:00:00 UTC 2022
Rifaximin enhances the L‑carnitine‑mediated preventive effects on skeletal muscle atrophy in cirrhotic rats by modulating the gut‑liver‑muscle axis.
International journal of molecular medicine
Murata K,Kaji K,Nishimura N,Enomoto M,Fujimoto Y,Takeda S,Tsuji Y,Fujinaga Y,Takaya H,Kawaratani H,Namisaki T,Akahane T,Yoshiji H
61-7300 was used in Immunohistochemistry to demonstrate that the combination of rifaximin with L‚carnitine may provide a clinical benefit for liver cirrhosis‚related sarcopenia.
Mon Aug 01 00:00:00 UTC 2022
A Novel In Vitro Membrane Permeability Methodology Using Three-dimensional Caco-2 Tubules in a Microphysiological System Which Better Mimics In Vivo Physiological Conditions.
Journal of pharmaceutical sciences
Hagiwara Y,Kumagai H,Ouwerkerk N,Gijzen L,Annida R,Bokkers M,van Vught R,Yoshinari K,Katakawa Y,Motonaga K,Tajiri T
61-7300 was used in Immunohistochemistry to develop an in vitro drug permeability methodology which mimics the gastrointestinal environment more accurately than conventional 2D methodologies through 3D Caco-2 tubules using a microphysiological system.
Sat Jan 01 00:00:00 UTC 2022
SARS-CoV-2 spike S1 subunit protein-mediated increase of beta-secretase 1 (BACE1) impairs human brain vessel cells.
Biochemical and biophysical research communications
Choi JY,Park JH,Jo C,Kim KC,Koh YH
61-7300 was used in Western Blotting to demonstrate that BACE1-mediated endothelial cell damage and senescence may be linked to CVD after COVID-19 infection.
Thu Oct 20 00:00:00 UTC 2022
Effect of Propionic Acid on Diabetes-Induced Impairment of Unfolded Protein Response Signaling and Astrocyte/Microglia Crosstalk in Rat Ventromedial Nucleus of the Hypothalamus.
Neural plasticity
Natrus LV,Osadchuk YS,Lisakovska OO,Labudzinskyi DO,Klys YG,Chaikovsky YB
61-7300 was used in Western Blotting to investigate the influence of propionic acid (PA) on the endoplasmic reticulum (ER), unfolded protein response (UPR) state, and astrocyte/microglia markers in rat ventromedial hypothalamus (VMH) after type 2 diabetes mellitus (T2DM).
Tue Mar 29 00:00:00 UTC 2022
Claudin5 protects the peripheral endothelial barrier in an organ and vessel-type-specific manner.
eLife
Richards M,Nwadozi E,Pal S,Martinsson P,Kaakinen M,Gloger M,Sjöberg E,Koltowska K,Betsholtz C,Eklund L,Nordling S,Claesson-Welsh L
61-7300 was used in Immunohistochemistry-immunofluorescence to identify structural and functional in vivo characteristics of the endothelial cell barrier.
Thu Jul 21 00:00:00 UTC 2022
A mixture of organic acids and thymol protects primary chicken intestinal epithelial cells from Clostridium perfringens infection in vitro.
Poultry science
Ghiselli F,Giovagnoni G,Felici M,Tugnoli B,Piva A,Grilli E
61-7300 was used in Immunocytochemistry to show that the usage of thymol combined with 2 organic acids can protect primary chicken intestinal epithelial cells from CP-induced damages creating a valid candidate to substitute or adjuvate the antibiotic treatment against necrotic enteritis.
Sat Oct 01 00:00:00 UTC 2022
Hypoxia-induced carbonic anhydrase mediated dorsal horn neuron activation and induction of neuropathic pain.
Pain
Da Vitoria Lobo ME,Weir N,Hardowar L,Al Ojaimi Y,Madden R,Gibson A,Bestall SM,Hirashima M,Schaffer CB,Donaldson LF,Bates DO,Hulse RP
61-7300 was used in Western Blotting to show that spinal cord vasculopathy results in nociceptive behavioural hypersensitivity.
Tue Nov 01 00:00:00 UTC 2022
Prolonged culturing of iPSC-derived brain endothelial-like cells is associated with quiescence, downregulation of glycolysis, and resistance to disruption by an Alzheimer's brain milieu.
Fluids and barriers of the CNS
Williams LM,Fujimoto T,Weaver RR,Logsdon AF,Evitts KM,Young JE,Banks WA,Erickson MA
61-7300 was used in Western Blot to study responses to disease-relevant stimuli in proliferating vs. more quiescent endothelial cell states.
Sat Feb 05 00:00:00 UTC 2022
Regulating microglial miR-155 transcriptional phenotype alleviates Alzheimer's-induced retinal vasculopathy by limiting Clec7a/Galectin-3+ neurodegenerative microglia.
Acta neuropathologica communications
Shi H,Yin Z,Koronyo Y,Fuchs DT,Sheyn J,Davis MR,Wilson JW,Margeta MA,Pitts KM,Herron S,Ikezu S,Ikezu T,Graham SL,Gupta VK,Black KL,Mirzaei M,Butovsky O,Koronyo-Hamaoui M
61-7300 was used in Immunohistochemistry-immunofluorescence to identify MGnD microglia in APPSWE/PS1L166P mouse retina.
Thu Sep 08 00:00:00 UTC 2022
Disruption of the crypt niche promotes outgrowth of mutated colorectal tumor stem cells.
JCI insight
Klingler S,Hsu KS,Hua G,Martin ML,Adileh M,Baslan T,Zhang Z,Paty PB,Fuks Z,Brown AM,Kolesnick R
61-7300 was used in Immunohistochemistry to study the direct impact of dextran sulfate sodium on colonic epithelial stem cells and their progeny.
Tue Mar 08 00:00:00 UTC 2022
CRISPR interference interrogation of COPD GWAS genes reveals the functional significance of desmoplakin in iPSC-derived alveolar epithelial cells.
Science advances
Werder RB,Liu T,Abo KM,Lindstrom-Vautrin J,Villacorta-Martin C,Huang J,Hinds A,Boyer N,Bullitt E,Liesa M,Silverman EK,Kotton DN,Cho MH,Zhou X,Wilson AA
61-7300 was used in Immunohistochemistry-immunofluorescence to apply CRISPR interference to interrogate the function of nine genes implicated in COPD by GWAS in induced pluripotent stem cell-derived type 2 alveolar epithelial cells.
Fri Jul 15 00:00:00 UTC 2022
Long Non-Coding RNA H19 Prevents Lens Fibrosis through Maintaining Lens Epithelial Cell Phenotypes.
Cells
Xiong L,Sun Y,Huang J,Ma P,Wang X,Wang J,Chen B,Chen J,Huang M,Huang S,Liu Y
61-7300 was used in Western Blotting to identify that lncRNA H19 was highly expressed in LECs, but downregulated by exposure to TGF-β2.
Wed Aug 17 00:00:00 UTC 2022
Long Non-Coding RNA H19 Prevents Lens Fibrosis through Maintaining Lens Epithelial Cell Phenotypes.
Cells
Xiong L,Sun Y,Huang J,Ma P,Wang X,Wang J,Chen B,Chen J,Huang M,Huang S,Liu Y
61-7300 was used in Western Blotting to identify that lncRNA H19 was highly expressed in LECs, but downregulated by exposure to TGF-β2.
Wed Aug 17 00:00:00 UTC 2022
p115RhoGEF activates RhoA to support tight junction maintenance and remodeling.
Molecular biology of the cell
Chumki SA,van den Goor LM,Hall BN,Miller AL
61-7300 was used in Immunohistochemistry (PFA fixed) to demonstrate a central role for p115RhoGEF in activating junctional RhoA to preserve barrier function and direct local TJ remodeling.
Thu Dec 01 00:00:00 UTC 2022
Robotic search for optimal cell culture in regenerative medicine.
eLife
Kanda GN,Tsuzuki T,Terada M,Sakai N,Motozawa N,Masuda T,Nishida M,Watanabe CT,Higashi T,Horiguchi SA,Kudo T,Kamei M,Sunagawa GA,Matsukuma K,Sakurada T,Ozawa Y,Takahashi M,Takahashi K,Natsume T
61-7300 was used in Immunohistochemistry to demonstrate that the use of autonomous robotic AI systems drastically accelerates systematic and unbiased exploration of experimental search space, suggesting immense use in medicine and research.
Tue Jun 28 00:00:00 UTC 2022
PCP Protein Inversin Regulates Testis Function Through Changes in Cytoskeletal Organization of Actin and Microtubules.
Endocrinology
Li L,Gao S,Wang L,Bu T,Chu J,Lv L,Tahir A,Mao B,Li H,Li X,Wang Y,Wu X,Ge R,Cheng CY
61-7300 was used in Western Blot to examine the role of inversin (Invs) in Sertoli cell (SC) and testis function by corresponding studies in vitro and in vivo.
Fri Apr 01 00:00:00 UTC 2022
Effect of Helicobacter pylori infection and its eradication on the expression of tight junction proteins in the gastric epithelium in relation to gastric carcinogenesis.
Helicobacter
Choi S,Kim N,Park JH,Nam RH,Song CH,Lee HS
61-7300 was used in Immunohistochemistry to evaluate the expression of TJPs in relation to Hp infection and eradication in gastric carcinogenesis.
Thu Dec 01 00:00:00 UTC 2022
Effect of Helicobacter pylori infection and its eradication on the expression of tight junction proteins in the gastric epithelium in relation to gastric carcinogenesis.
Helicobacter
Choi S,Kim N,Park JH,Nam RH,Song CH,Lee HS
61-7300 was used in Immunohistochemistry to evaluate the expression of TJPs in relation to Hp infection and eradication in gastric carcinogenesis.
Thu Dec 01 00:00:00 UTC 2022
Mucin O-glycan-microbiota axis orchestrates gut homeostasis in a diarrheal pig model.
Microbiome
Xia B,Zhong R,Wu W,Luo C,Meng Q,Gao Q,Zhao Y,Chen L,Zhang S,Zhao X,Zhang H
61-7300 was used in Western Blotting to suggest that facilitating O-glycan elongation, modifying the microbiota, and developing specific inhibitors to some key inflammasomes could be the options for therapy of diarrhea including human infants.
Wed Aug 31 00:00:00 UTC 2022
NLRP3 Inhibition Reduces rt-PA Induced Endothelial Dysfunction under Ischemic Conditions.
Biomedicines
Bellut M,Raimondi AT,Haarmann A,Zimmermann L,Stoll G,Schuhmann MK
61-7300 was used in Immunohistochemistry-immunofluorescence to investigate the protective effect of NLRP3 inflammasome inhibition using the NLRP3-specific inhibitor MCC950 on brain-derived endothelial cells under ischemic conditions when exposed to recombinant tissue plasminogen activator (rt-PA).
Thu Mar 24 00:00:00 UTC 2022
Astrocytic p75NTR expression provoked by ischemic stroke exacerbates the blood-brain barrier disruption.
Glia
Qin X,Wang J,Chen S,Liu G,Wu C,Lv Q,He X,Bai X,Huang W,Liao H
61-7300 was used in Western Blotting to provide novel insight into the role of astrocytic p75NTR in BBB disruption after acute cerebral ischemia.
Sun May 01 00:00:00 UTC 2022
Astrocytic p75NTR expression provoked by ischemic stroke exacerbates the blood-brain barrier disruption.
Glia
Qin X,Wang J,Chen S,Liu G,Wu C,Lv Q,He X,Bai X,Huang W,Liao H
61-7300 was used in Western Blotting to provide novel insight into the role of astrocytic p75NTR in BBB disruption after acute cerebral ischemia.
Sun May 01 00:00:00 UTC 2022
Spermine protects intestinal barrier integrity through ras-related C3 botulinum toxin substrate 1/phospholipase C-γ1 signaling pathway in piglets.
Animal nutrition (Zhongguo xu mu shou yi xue hui)
Liu G,Xu X,Wu C,Jia G,Zhao H,Chen X,Tian G,Cai J,Wang J
61-7300 was used in Western Blot to show that spermine protects intestinal barrier integrity through ras-related C3 botulinum toxin substrate 1 (Rac1)/ phospholipase C-γ1PLC-γ1 signaling pathway in piglets.
Tue Mar 01 00:00:00 UTC 2022
Ultrastructural characteristics of finger-like membrane protrusions in cell competition.
Microscopy (Oxford, England)
Kamasaki T,Uehara R,Fujita Y
61-7300 was used in Immunocytochemistry to suggest that the dynamic reorganization of intercellular adhesions via finger-like protrusions may positively control cell competition between normal and RasV12-transformed cells.
Mon Aug 01 00:00:00 UTC 2022
T-Cell-Specific CerS4 Depletion Prolonged Inflammation and Enhanced Tumor Burden in the AOM/DSS-Induced CAC Model.
International journal of molecular sciences
El-Hindi K,Brachtendorf S,Hartel JC,Oertel S,Birod K,Merz N,Trautmann S,Thomas D,Weigert A,Schäufele TJ,Scholich K,Schiffmann S,Ulshöfer T,Utermöhlen O,Grösch S
61-7300 was used in Immunohistochemistry to show that CerS4 knockdown plays an important role in colitis and CAC, and sheds light on the effect of CerS4 on the T-cell signaling pathway.
Mon Feb 07 00:00:00 UTC 2022
Centella asiatica-Derived Endothelial Paracrine Restores Epithelial Barrier Dysfunction in Radiation-Induced Enteritis.
Cells
Kwak SY,Jang WI,Lee SB,Kim MJ,Park S,Cho SS,Kim H,Lee SJ,Shim S,Jang H
61-7300 was used in Immunohistochemistry to suggest that CA is an effective radio-mitigator against radiation-induced enteritis.
Tue Aug 16 00:00:00 UTC 2022
Intermittent Fasting Attenuates Hallmark Vascular and Neuronal Pathologies in a Mouse Model of Vascular Cognitive Impairment.
International journal of biological sciences
Rajeev V,Fann DY,Dinh QN,Kim HA,De Silva TM,Jo DG,Drummond GR,Sobey CG,Lai MKP,Chen CL,Arumugam TV
61-7300 was used in Western Blotting to assess the effect of intermittent fasting (IF) against chronic cerebral hypoperfusion-associated neurovascular pathologies and investigated its underlying mechanisms.
Tue Nov 29 00:00:00 UTC 2022
Luteolin Enhances Choroid Plexus 5-MTHF Brain Transport to Promote Hippocampal Neurogenesis in LOD Rats.
Frontiers in pharmacology
Li HZ,Liu KG,Zeng NX,Wu XF,Lu WJ,Xu HF,Yan C,Wu LL
61-7300 was used in Immunohistochemistry-immunofluorescence to suggest that luteolin could ameliorate CUMS-induced LOD-like behaviors by enhancing the folate brain transport.
Wed Apr 13 00:00:00 UTC 2022
2'-Fucosyllactose Ameliorates Chemotherapy-Induced Intestinal Mucositis by Protecting Intestinal Epithelial Cells Against Apoptosis.
Cellular and molecular gastroenterology and hepatology
Zhao G,Williams J,Washington MK,Yang Y,Long J,Townsend SD,Yan F
61-7300 was used in ELISA, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot to show a novel direct effect of 2'-FL in protecting small intestinal epithelial cells against apoptosis stimulated by 5-FU, which may contribute to prevention of 5-FU-induced intestinal mucositis.
Mon Apr 04 00:00:00 UTC 2022
Synergic Renoprotective Effects of Combined ASC Therapy with RAAS Blockade in Experimental Advanced CKD.
Stem cells international
Maires MPC,Pereira KR,Silva EKVB,Souza VHR,Teles F,Barbosa PF,Garnica MR,Ornellas FM,Noronha IL,Fanelli C
61-7300 was used in Immunohistochemistry to demonstrate that a subcapsular inoculation of ASC, associated with the administration of Losartan, exerted additional renoprotective effect in rats submitted to a severe model of established CKD, when compared to Losartan monotherapy, thus suggesting ASC may be a potential adjuvant to RAAS-blockade therapy currently employed in the conservative management of CKD.
Sun Aug 25 00:00:00 UTC 2024
Astrocytes regulate vascular endothelial responses to simulated deep space radiation in a human organ-on-a-chip model.
Frontiers in immunology
Verma SD,Passerat de la Chapelle E,Malkani S,Juran CM,Boyko V,Costes SV,Cekanaviciute E
61-7300 was used in Immunohistochemistry to show that simulated deep space radiation causes vascular permeability, oxidative stress, inflammation and delayed astrocyte activation in a pattern resembling CNS responses to brain injury.
Tue Oct 25 00:00:00 UTC 2022
Altered Expression of Zonula occludens-1 Affects Cardiac Na+ Channels and Increases Susceptibility to Ventricular Arrhythmias.
Cells
El Refaey M,Coles S,Musa H,Stevens TL,Wallace MJ,Murphy NP,Antwi-Boasiako S,Young LJ,Manring HR,Curran J,Makara MA,Sas K,Han M,Koenig SN,Skaf M,Kline CF,Janssen PML,Accornero F,Borzok MA,Mohler PJ
61-7300 was used in Western Blotting to suggest that zonula occludens-1 deficiency results in myocardial substrate susceptible to triggered arrhythmias.
Mon Feb 14 00:00:00 UTC 2022
Pan-claudin family interactome analysis reveals shared and specific interactions.
Cell reports
Suarez-Artiles L,Breiderhoff T,Girardello R,Gonschior H,Rodius S,Lesur A,Reimer U,Ramberger E,Perez-Hernandez D,Müller D,Mertins P,Dittmar G
61-7300 was used in Immunocytochemistry-immunofluorescence to study the pan-claudin family interactome, revealing their possible implications in localized biological processes in epithelial cells and their regulation by PTMs.
Tue Nov 08 00:00:00 UTC 2022
Upregulated flotillins and sphingosine kinase 2 derail AXL vesicular traffic to promote epithelial-mesenchymal transition.
Journal of cell science
Genest M,Comunale F,Planchon D,Govindin P,Noly D,Vacher S,Bièche I,Robert B,Malhotra H,Schoenit A,Tashireva LA,Casas J,Gauthier-Rouvière C,Bodin S
61-7300 was used in Immunocytochemistry-immunofluorescence to conclude that the deregulation of vesicular trafficking following flotillin upregulation, and through sphingosine kinase 2, emerges as a new mechanism of AXL overexpression and EMT-inducing signaling pathway activation.
Fri Apr 01 00:00:00 UTC 2022
Transcorneal but not transpalpebral electrical stimulation disrupts mucin homeostasis of the ocular surface.
BMC ophthalmology
Yang M,Lennikov A,Chang K,Ashok A,Lee C,Cho KS,Utheim TP,Dartt DA,Chen DF
61-7300 was used in Western Blotting to conclude that TcES, but not TpES, induces corneal epithelial damage in mice by disrupting mucin homeostasis, thus TpES may represent a safer and more effective ES approach for treating retinal neurodegeneration clinically.
Thu Dec 15 00:00:00 UTC 2022
Pericyte, but not astrocyte, hypoxia inducible factor-1 (HIF-1) drives hypoxia-induced vascular permeability in vivo.
Fluids and barriers of the CNS
Baumann J,Tsao CC,Patkar S,Huang SF,Francia S,Magnussen SN,Gassmann M,Vogel J,Köster-Hegmann C,Ogunshola OO
61-7300 was used in Immunohistochemistry-immunofluorescence to show that pericyte but not astrocyte HIF-1 stabilization modulates endothelial tight junction functionality and thereby plays a pivotal role in hypoxia-induced vascular dysfunction.
Sat Jan 15 00:00:00 UTC 2022
TSG-6 released from adipose stem cells-derived small extracellular vesicle protects against spinal cord ischemia reperfusion injury by inhibiting endoplasmic reticulum stress.
Stem cell research & therapy
Lu X,Lv C,Zhao Y,Wang Y,Li Y,Ji C,Wang Z,Ye W,Yu S,Bai J,Cai W
61-7300 was used in Western Blotting to find that ADSC-sEVs contain tumor necrosis factor (TNF)-stimulated gene-6 (TSG-6) whose overexpression inhibited ER stress in vivo by modulating the PI3K/AKT pathway.
Wed Jul 13 00:00:00 UTC 2022
Mitochondrial glutathione peroxidase 4 is indispensable for photoreceptor development and survival in mice.
The Journal of biological chemistry
Azuma K,Koumura T,Iwamoto R,Matsuoka M,Terauchi R,Yasuda S,Shiraya T,Watanabe S,Aihara M,Imai H,Ueta T
61-7300 was used in Immunohistochemistry to reveal novel functions of mGPx4 in supporting development and survival of photoreceptors in vivo.
Fri Apr 01 00:00:00 UTC 2022
The dietary fibre rhamnogalacturonan improves intestinal epithelial barrier function in a microbiota-independent manner.
British journal of pharmacology
Baggio CH,Shang J,Gordon MH,Stephens M,von der Weid PY,Nascimento AM,Román Y,Cipriani TR,MacNaughton WK
61-7300 was used in Immunocytochemistry to find that a polysaccharide, rhamnogalacturonan (RGal), from the plant Acmella oleracea, has direct effects on intestinal epithelial barrier function and determine the mechanism whereby RGal enhances epithelial barrier function.
Sat Jan 01 00:00:00 UTC 2022
Interaction of surfactant coated PLGA nanoparticles with in vitro human brain-like endothelial cells.
International journal of pharmaceutics
Moya ELJ,Lombardo SM,Vandenhaute E,Schneider M,Mysiorek C,Türeli AE,Kanda T,Shimizu F,Sano Y,Maubon N,Gosselet F,Günday-Türeli N,Dehouck MP
61-7300 was used in Immunocytochemistry-immunofluorescence to investigate two surfactant-coated poly(lactide-co-glycolide) (PLGA) nanoparticles, as formulations for delivery to the brain through the BBB, presenting different uptake profiles.
Fri Jun 10 00:00:00 UTC 2022
MARK2 and MARK4 Regulate Sertoli Cell BTB Dynamics Through Microtubule and Actin Cytoskeletons.
Endocrinology
Tang EI,Cheng CY
61-7300 was used in Western Blot to report the function of MARK4 and another isoform MARK2 in Sertoli cells at the BTB.
Tue Oct 11 00:00:00 UTC 2022
E-cadherin mediates apical membrane initiation site localisation during de novo polarisation of epithelial cavities.
The EMBO journal
Liang X,Weberling A,Hii CY,Zernicka-Goetz M,Buckley CE
61-7300 was used in Immunocytochemistry-immunofluorescence to suggest that there are two, interrelated mechanisms of apical polarity localisation: cell adhesion and cell division.
Thu Dec 15 00:00:00 UTC 2022
Zinc Supplementation Partially Decreases the Harmful Effects of a Cafeteria Diet in Rats but Does Not Prevent Intestinal Dysbiosis.
Nutrients
Squizani S,Jantsch J,Rodrigues FDS,Braga MF,Eller S,de Oliveira TF,Silveira AK,Moreira JCF,Giovenardi M,Porawski M,Guedes RP
61-7300 was used in Western Blotting to show that Zn could not protect obese animals from intestinal dysbiosis.
Thu Sep 22 00:00:00 UTC 2022
Lactic Acid Bacteria Strains Used as Starters for Kimchi Fermentation Protect the Disruption of Tight Junctions in the Caco-2 Cell Monolayer Model.
Journal of microbiology and biotechnology
Kang JY,Lee M,Song JH,Choi EJ,Kim DU,Lim SK,Kim N,Chang JY
61-7300 was used in Immunocytochemistry to investigate the effect of lactic acid bacteria (LAB) strains used as starters for kimchi fermentation, namely Lactococcus lactis WiKim0124, Companilactobacillus allii WiKim39, Leuconostoc mesenteroides WiKim0121 Leuconostoc mesenteroides WiKim33, and Leuconostoc mesenteroides WiKim32, on the intestinal epithelial tight junctions (TJs).
Wed Dec 28 00:00:00 UTC 2022
Deficiency in Lyst function leads to accumulation of secreted proteases and reduced retinal adhesion.
PloS one
Ji X,Zhao L,Umapathy A,Fitzmaurice B,Wang J,Williams DS,Chang B,Naggert JK,Nishina PM
61-7300 was used in Immunohistochemistry-immunofluorescence to show striking evidence that deficiency in LYST protein function leads to accumulation of photoreceptor outer segment phagosomes in retinal pigment epithelial cells, and reduces adhesion between photoreceptor outer segment and retinal pigment epithelial cells in a mouse model of Chediak-Higashi syndrome.
Wed Jul 24 00:00:00 UTC 2024
CDCP1 regulates retinal pigmented epithelial barrier integrity for the development of experimental autoimmune uveitis.
JCI insight
Zhang L,Borjini N,Lun Y,Parab S,Asonye G,Singh R,Bell BA,Bonilha VL,Ivanov A,Fox DA,Caspi RR,Lin F
61-7300 was used in Immunocytochemistry-immunoflourescence to suggest that CDCP1 on RPEs interacts with CD6 on T cells to induce RPE cytoskeleton remodeling and focal adhesion disruption, which open up the tight junctions to facilitate T cell infiltration for the development of uveitis.
Thu Sep 22 00:00:00 UTC 2022
Systemic Administration of Pegylated Arginase-1 Attenuates the Progression of Diabetic Retinopathy.
Cells
Abdelrahman AA,Bunch KL,Sandow PV,Cheng PN,Caldwell RB,Caldwell RW
61-7300 was used in Immunohistochemistry-immunofluorescence to hypothesize that the administration of a stable form of Arg1 would deplete L-arginine's availability for iNOS, thus decreasing inflammation and oxidative stress in the retina.
Fri Sep 16 00:00:00 UTC 2022
Busulfan impairs blood-testis barrier and spermatogenesis by increasing noncollagenous 1 domain peptide via matrix metalloproteinase 9.
Andrology
Jiang S,Xu Y,Fan Y,Hu Y,Zhang Q,Su W
61-7300 was used in Immunohistochemistry-immunofluorescence to demonstrate that elevated marix mettaloproteinase 9 and noncollagenous 1 participate in busulfan-induced blood-testis barrier disruption, which can be ameliorated by intervening with noncollagenous 1 production.
Tue Feb 01 00:00:00 UTC 2022
Quantifying Intracellular Viral Pathogen: Specimen Preparation, Visualization and Quantification of Multiple Immunofluorescent Signals in Fixed Human Airway Epithelium Cultured at Air-Liquid Interface.
Journal of personalized medicine
Wong SL,Pandzic E,Kardia E,Allan KM,Whan RM,Waters SA
61-7300 was used in Immunohistochemistry-immunofluorescence to present a detailed methodology using a graphical user interface (GUI) package to quantify the detected signals on a tiled whole membrane.
Fri Oct 07 00:00:00 UTC 2022
Engineered human blood-brain barrier microfluidic model for vascular permeability analyses.
Nature protocols
Hajal C,Offeddu GS,Shin Y,Zhang S,Morozova O,Hickman D,Knutson CG,Kamm RD
61-7300 was used in Immunohistochemistry (PFA fixed) to show that these properties, coupled with a brain endothelial expression profile and the capability to easily test several repeats with low reagent consumption, make this BBB model highly suitable for widespread use in academic and industrial laboratories.
Sat Jan 01 00:00:00 UTC 2022
Periodic formation of epithelial somites from human pluripotent stem cells.
Nature communications
Sanaki-Matsumiya M,Matsuda M,Gritti N,Nakaki F,Sharpe J,Trivedi V,Ebisuya M
61-7300 was used in Immunohistochemistry to report the generation of human somitoids, organoids that periodically form pairs of epithelial somite-like structures. Matrigel is essential for epithelialization but dispensable for the differentiation into somite cells. The amount of WNT signaling instructs the proportion of mesodermal lineages in somitoids. Somitoids provide a novel platform to study human somitogenesis.
Thu Apr 28 00:00:00 UTC 2022
Effects of TAMP family on the tight junction strand network and barrier function in epithelial cells.
Annals of the New York Academy of Sciences
Saito AC,Endo C,Fukazawa Y,Higashi T,Chiba H
61-7300 was used in Immunocytochemistry-immunofluorescence to suggest that marvelD3 does not affect the morphology of TJ strands and barrier function in MDCK II cells and that the carboxy-terminal cytoplasmic tail of tricellulin is dispensable for barrier improvement.
Tue Nov 01 00:00:00 UTC 2022
Microbial-derived metabolites induce actin cytoskeletal rearrangement and protect blood-brain barrier function.
iScience
Knox EG,Aburto MR,Tessier C,Nagpal J,Clarke G,O'Driscoll CM,Cryan JF
61-7300 was used in Immunocytochemistry-immunofluorescence to identify the actin cytoskeletal dynamics as another target further illuminating how SCFAs can influence BBB physiology.
Thu Dec 22 00:00:00 UTC 2022
A Novel Adult Murine Model of Typical Enteroaggregative Escherichia coli Infection Reveals Microbiota Dysbiosis, Mucus Secretion, and AAF/II-Mediated Expression and Localization of β-Catenin and Expression of MUC1 in Ileum.
Frontiers in cellular and infection microbiology
Moran-Garcia N,Lopez-Saucedo C,Becerra A,Meza-Segura M,Hernandez-Cazares F,Guerrero-Baez J,Galindo-Gómez S,Tsutsumi V,Schnoor M,Méndez-Tenorio A,Nataro JP,Estrada-Garcia T
61-7300 was used in Immunohistochemistry to develop a novel mouse model of EAEC infection, which mimics human infection, not an illness, revealing that EAEC 042 exerts its pathogenic effects in the mouse ileum and causes dysbiosis.
Fri Jun 17 00:00:00 UTC 2022
Molecular dynamics and functional characterization of I37R-CFTR lasso mutation provide insights into channel gating activity.
iScience
Wong SL,Awatade NT,Astore MA,Allan KM,Carnell MJ,Slapetova I,Chen PC,Capraro A,Fawcett LK,Whan RM,Griffith R,Ooi CY,Kuyucak S,Jaffe A,Waters SA
61-7300 was used in Immunohistochemistry to characterise 137R, a mutation located in the lasso motif of the CFTR chloride channel, by theratyping several CFTR modulators from both potentiator and corrector classes.
Fri Jan 21 00:00:00 UTC 2022
Intravenous transplantation of amnion-derived mesenchymal stem cells promotes functional recovery and alleviates intestinal dysfunction after spinal cord injury.
PloS one
Takamiya S,Kawabori M,Yamazaki K,Yamaguchi S,Tanimori A,Yamamoto K,Ohnishi S,Seki T,Konno K,Tha KK,Hashimoto D,Watanabe M,Houkin K,Fujimura M
61-7300 was used in Immunohistochemistry to investigate their effect on the associated gastrointestinal dysfunction.
Tue Jul 12 00:00:00 UTC 2022
Generation of Human Lung Organoid Cultures from Healthy and Tumor Tissue to Study Infectious Diseases.
Journal of virology
Salgueiro L,Kummer S,Sonntag-Buck V,Weiß A,Schneider MA,Kräusslich HG,Sotillo R
61-7300 was used in Immunocytochemistry-immunofluorescence to find that cancer-derived lung organoids were more sensitive to influenza A virus infection than those derived from healthy tissue and demonstrated a decreased innate immune response.
Wed Apr 13 00:00:00 UTC 2022
Supplementation with SCFAs Re-Establishes Microbiota Composition and Attenuates Hyperalgesia and Pain in a Mouse Model of NTG-Induced Migraine.
International journal of molecular sciences
Lanza M,Filippone A,Casili G,Giuffrè L,Scuderi SA,Paterniti I,Campolo M,Cuzzocrea S,Esposito E
61-7300 was used in Immunohistochemistry-immunofluorescence to provide corroborating evidence that SB and SP exert a protective effect on central sensitization induced by NTG through a modulation of intestinal microbiota, suggesting the potential application of SCFAs as novel supportive therapies for intestinal disfunction associated with migraine.
Wed Apr 27 00:00:00 UTC 2022
Voglibose Regulates the Secretion of GLP-1 Accompanied by Amelioration of Ileal Inflammatory Damage and Endoplasmic Reticulum Stress in Diabetic KKAy Mice.
International journal of molecular sciences
Fu Y,Ji W,Liu Q,Zhang L,Li C,Huan Y,Lei L,Gao X,Chen L,Feng C,Lei L,Zhai J,Li P,Cao H,Liu S,Shen Z
61-7300 was used in Western Blotting to show that voglibose enhanced the secretion of GLP-1, which contributed to the glycemic control in KKAy mice at least in part by regulating intestinal inflammation and the expression of ERS factors.
Wed Dec 14 00:00:00 UTC 2022
Protocols for Investigating the Epithelial Properties of Cardiac Progenitor Cells in the Mouse Embryo.
Methods in molecular biology (Clifton, N.J.)
Cortes C,De Bono C,Thellier C,Francou A,Kelly RG
61-7300 was used in Immunocytochemistry to studying the epithelial properties of cardiac progenitors in the dorsal pericardial wall during mouse heart development.
Fri Feb 18 00:00:00 UTC 2022
VDAC1 regulates neuronal cell loss after retinal trauma injury by a mitochondria-independent pathway.
Cell death & disease
de Sousa E,Móvio MI,de Lima-Vasconcellos TH,Dos Santos GB,Dos Santos Gomes T,Walter LT,da Silva DA,Rodrigues T,Cerchiaro G,Kihara AH
61-7300 was used in Western Blotting to conclude that VDAC1 is a putative therapeutic target in neuronal disorders since it integrates both death and survival cellular signaling.
Thu Apr 21 00:00:00 UTC 2022
Single-cell multiomics reveals the complexity of TGFβ signalling to chromatin in iPSC-derived kidney organoids.
Communications biology
Davis JL,Kennedy C,Clerkin S,Treacy NJ,Dodd T,Moss C,Murphy A,Brazil DP,Cagney G,Brougham DF,Murad R,Finlay D,Vuori K,Crean J
61-7300 was used in Immunohistochemistry-immunofluorescence to show an association between SMAD3 and the histone methyltransferase, EZH2, during cell differentiation; ChIP-seq revealed that SMAD3 and EZH2 co-occupy the genome in iPSCs and in iPSC-derived nephron progenitors.
Sun Nov 27 00:00:00 UTC 2022
High-throughput formation and image-based analysis of basal-in mammary organoids in 384-well plates.
Scientific reports
Lee S,Chang J,Kang SM,Parigoris E,Lee JH,Huh YS,Takayama S
61-7300 was used in Immunohistochemistry to profile early changes in size and circularity.
Mon Jan 10 00:00:00 UTC 2022
Altered Differentiation and Inflammation Profiles Contribute to Enhanced Innate Responses in Severe COPD Epithelium to Rhinovirus Infection.
Frontiers in medicine
Guo-Parke H,Linden D,Mousnier A,Scott IC,Killick H,Borthwick LA,Fisher AJ,Weldon S,Taggart CC,Kidney JC
61-7300 was used in Immunocytochemistry-immunoflourescence to evaluate barrier function, cellular architecture, the inflammatory response in severe COPD bronchial epithelium to human rhinovirus (HRV) induced pathological changes and innate immune responses.
Tue Mar 15 00:00:00 UTC 2022
Cell-Penetrating Peptides as Carriers for Transepithelial Drug Delivery.
Methods in molecular biology (Clifton, N.J.)
Panou DA,Diedrichsen RG,Kristensen M,Nielsen HM
61-7300 was used in Immunocytochemistry-immunofluorescence to explore the use of CPP-insulin physical mixture samples including the quantification of insulin by enzyme-linked immunosorbent assay (ELISA) is described.
Fri Jan 07 00:00:00 UTC 2022
Probiotic Cocktail Alleviates Intestinal Inflammation Through Improving Gut Microbiota and Metabolites in Colitis Mice.
Frontiers in cellular and infection microbiology
Zhu Y,Xu Y,Wang X,Rao L,Yan X,Gao R,Shen T,Zhou Y,Kong C,Zhou L
61-7300 was used in Western Blotting to establish a novel probiotic cocktail to investigate its therapeutic role in acute colitis mice.
Thu Jul 07 00:00:00 UTC 2022
Blood-brain barrier dysfunction in L-ornithine induced acute pancreatitis in rats and the direct effect of L-ornithine on cultured brain endothelial cells.
Fluids and barriers of the CNS
Walter FR,Harazin A,Tóth AE,Veszelka S,Santa-Maria AR,Barna L,Kincses A,Biczó G,Balla Z,Kui B,Maléth J,Cervenak L,Tubak V,Kittel Á,Rakonczay Z,Deli MA
61-7300 was used in Immunohistochemistry to suggest a direct effect of the cationic L-ornithine on brain endothelium. Endothelial surface glycocalyx injury was revealed both in vivo and in vitro, as an additional novel component of the BBB-related pathological changes in AP.
Thu Feb 17 00:00:00 UTC 2022
A predictive microfluidic model of human glioblastoma to assess trafficking of blood-brain barrier-penetrant nanoparticles.
Proceedings of the National Academy of Sciences of the United States of America
Straehla JP,Hajal C,Safford HC,Offeddu GS,Boehnke N,Dacoba TG,Wyckoff J,Kamm RD,Hammond PT
61-7300 was used in Immunocytochemistry-immunofluorescence to investigate the therapeutic potential of functionalized nanoparticles by encapsulating cisplatin and showed improved efficacy of these GBM-targeted nanoparticles both in vitro and in an in vivo orthotopic xenograft model.
Tue Jun 07 00:00:00 UTC 2022
Protocol for the setup and use of a human choroid plexus endothelial-epithelial two-cell-type in vitro model.
STAR protocols
Herold R,Borkowski J,Schwerk C,Stump-Guthier C,Lampe M,Ishikawa H,Muranyi W,Schroten H
61-7300 was used in Immunocytochemistry-immunofluorescence to describe the preparation of this model, the measurement of transepithelial electrical resistance (TEER), and immunofluorescence imaging-based analysis to determine the barrier function.
Fri Dec 16 00:00:00 UTC 2022
Evaluation of Caco-2 and human intestinal epithelial cells as in vitro models of colonic and small intestinal integrity.
Biochemistry and biophysics reports
Lopez-Escalera S,Wellejus A
61-7300 was used in Immunocytochemistry-immunoflourescence to investigate Human Intestinal Epithelial Cells (HIECs) as an alternative in vitro model.
Thu Sep 01 00:00:00 UTC 2022
β1 integrin monoclonal antibody treatment ameliorates cerebral cavernous malformations.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
McCurdy S,Lin J,Shenkar R,Moore T,Lightle R,Faurobert E,Lopez-Ramirez MA,Awad I,Ginsberg MH
61-7300 was used in Immunocytochemistry to conclude that targeting β1 integrin with an activated-specific antibody reduces acute murine CCM lesion development, which was found to be associated with suppression of endothelial ROCK activity.
Thu Dec 01 00:00:00 UTC 2022
Murine in utero exposure to simulated complex urban air pollution disturbs offspring gut maturation and microbiota during intestinal suckling-to-weaning transition in a sex-dependent manner.
Particle and fibre toxicology
Guilloteau E,Coll P,Lu Z,Djouina M,Cazaunau M,Waxin C,Bergé A,Caboche S,Gratien A,Al Marj E,Hot D,Dubuquoy L,Launay D,Vignal C,Lanone S,Body-Malapel M
61-7300 was used in Western Blotting to investigate if Prenatal realistic modelling of an urban air pollution event induced sex-specific precocious alterations of structural and immune intestinal development in mice.
Wed Jun 15 00:00:00 UTC 2022
RO4929097, a Selective γ-Secretase Inhibitor, Inhibits Subretinal Fibrosis Via Suppressing Notch and ERK1/2 Signaling in Laser-Induced Mouse Model.
Investigative ophthalmology & visual science
Zhang C,Qin S,Xie H,Qiu Q,Wang H,Zhang J,Luo D,Zhang J
61-7300 was used in Western Blotting to explore whether RO4929097, a specific γ-secretase inhibitor, could inhibit the subretinal fibrosis in laser-induced mouse model and the relevant molecular mechanisms.
Thu Sep 01 00:00:00 UTC 2022
Muramyl Dipeptide Administration Delays Alzheimer's Disease Physiopathology via NOD2 Receptors.
Cells
Piec PA,Pons V,Préfontaine P,Rivest S
61-7300 was used in Flow Cytometry, ELISA, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot to indicate that stimulation of the NOD2 receptor in innate immune cells is a promising therapeutic avenue with potential different mechanisms between males and females.
Tue Jul 19 00:00:00 UTC 2022
Glycine represses endoplasmic reticulum stress-related apoptosis and improves intestinal barrier by activating mammalian target of rapamycin complex 1 signaling.
Animal nutrition (Zhongguo xu mu shou yi xue hui)
Yang Y,Fan X,Ji Y,Li J,Dai Z,Wu Z
61-7300 was used in Immunocytochemistry to explore the protective effect and mechanism of glycine on apoptosis and dysfunction in intestinal barrier induced by brefeldin A, an endoplasmic reticulum stress inducer.
Tue Mar 01 00:00:00 UTC 2022
Addition of Chk1 inhibitor and BMP4 cooperatively promotes retinal tissue formation in self-organizing human pluripotent stem cell differentiation culture.
Regenerative therapy
Yamasaki S,Kuwahara A,Kishino A,Kimura T,Takahashi M,Mandai M
61-7300 was used in Immunohistochemistry to find that combined use of rhBMP4 and a Chk1 inhibitor cooperatively promoted retinal differentiation from hPSCs.
Tue Mar 01 00:00:00 UTC 2022
Immortalized human choroid plexus endothelial cells enable an advanced endothelial-epithelial two-cell type in vitro model of the choroid plexus.
iScience
Muranyi W,Schwerk C,Herold R,Stump-Guthier C,Lampe M,Fallier-Becker P,Weiß C,Sticht C,Ishikawa H,Schroten H
61-7300 was used in Immunocytochemistry-immunoflourescence to suggest that iHCPEnC present a tool that will contribute to the understanding of CP organ functions, especially endothelial-epithelial interplay.
Fri Jun 17 00:00:00 UTC 2022
DAPLE orchestrates apical actomyosin assembly from junctional polarity complexes.
The Journal of cell biology
Marivin A,Ho RX,Garcia-Marcos M
61-7300 was used in Immunocytochemistry to establish DAPLE as a direct molecular link between junctional polarity complexes and the formation of apical cytoskeletal assemblies that support epithelial cell shape.
Mon May 02 00:00:00 UTC 2022
DAPLE orchestrates apical actomyosin assembly from junctional polarity complexes.
The Journal of cell biology
Marivin A,Ho RX,Garcia-Marcos M
61-7300 was used in Immunocytochemistry to establish DAPLE as a direct molecular link between junctional polarity complexes and the formation of apical cytoskeletal assemblies that support epithelial cell shape.
Mon May 02 00:00:00 UTC 2022
Poria cocos polysaccharides exert prebiotic function to attenuate the adverse effects and improve the therapeutic outcome of 5-FU in ApcMin/+ mice.
Chinese medicine
Yin L,Huang G,Khan I,Su L,Xia W,Law BYK,Wong VKW,Wu Q,Wang J,Leong WK,Hsiao WLW
61-7300 was used in Immunohistochemistry to study whether Poria cocos polysaccharides (PCP), a traditional Chinese herbal medicine with various bioactivities and prebiotic effects, improves the therapeutic effect of 5-FU by restoring the homeostasis of the gut microenvironment and the commensal gut microflora.
Mon Oct 03 00:00:00 UTC 2022
Enhanced delivery of a low dose of aducanumab via FUS in 5×FAD mice, an AD model.
Translational neurodegeneration
Kong C,Yang EJ,Shin J,Park J,Kim SH,Park SW,Chang WS,Lee CH,Kim H,Kim HS,Chang JW
61-7300 was used in Immunohistochemistry-immunofluorescence to present an Alzheimer's disease (AD) treatment strategy through the synergistic effect of the combined therapy of focused ultrasound (FUS) and Aducanumab (Adu).
Tue Dec 27 00:00:00 UTC 2022
HIV-1 gp120 and tobacco smoke synergistically disrupt the integrity of the blood-brain barrier.
European journal of cell biology
Bhalerao A,Cucullo L
61-7300 was used in Western Blot to suggest that a potential synergistic effect between smoke exposure and gp120 can worsen the loss of BBB viability, possibly exacerbating NeuroAIDS progression.
Fri Dec 16 00:00:00 UTC 2022
Impairment of antiviral immune response and disruption of cellular functions by SARS-CoV-2 ORF7a and ORF7b.
iScience
García-García T,Fernández-Rodríguez R,Redondo N,de Lucas-Rius A,Zaldívar-López S,López-Ayllón BD,Suárez-Cárdenas JM,Jiménez-Marín Á,Montoya M,Garrido JJ
61-7300 was used in Immunocytochemistry-immunofluorescence to explore A549 cells transduced to express ORF7a and ORF7b on the pathological manifestation leading to COVID-19.
Fri Nov 18 00:00:00 UTC 2022
Endothelial Unc5B controls blood-brain barrier integrity.
Nature communications
Boyé K,Geraldo LH,Furtado J,Pibouin-Fragner L,Poulet M,Kim D,Nelson B,Xu Y,Jacob L,Maissa N,Agalliu D,Claesson-Welsh L,Ackerman SL,Eichmann A
61-7300 was used in Western Blot to identify Netrin-1-Unc5B signaling as a ligand-receptor pathway that regulates BBB integrity.
Fri Mar 04 00:00:00 UTC 2022
Vitamin D3 preserves blood retinal barrier integrity in an in vitro model of diabetic retinopathy.
Frontiers in pharmacology
Lazzara F,Longo AM,Giurdanella G,Lupo G,Platania CBM,Rossi S,Drago F,Anfuso CD,Bucolo C
61-7300 was used in Immunocytochemistry to provide new insights on the retinal protective role of vitamin D3, particularly as regard as the early phase of diabetic retinopathy, characterized by BRB breakdown and inflammation.
Tue Sep 13 00:00:00 UTC 2022
Targeted BRD4 protein degradation by dBET1 ameliorates acute ischemic brain injury and improves functional outcomes associated with reduced neuroinflammation and oxidative stress and preservation of blood-brain barrier integrity.
Journal of neuroinflammation
Liu L,Yang C,Lavayen BP,Tishko RJ,Larochelle J,Candelario-Jalil E
61-7300 was used in Western Blotting to identify a novel role of BET proteins in the mechanisms resulting in ischemic brain damage, which can be leveraged to develop novel therapies.
Mon Jun 27 00:00:00 UTC 2022
Proton Pump Inhibitor Pantoprazole Modulates Intestinal Microbiota and Induces TLR4 Signaling and Fibrosis in Mouse Liver.
International journal of molecular sciences
Assalin HB,De Almeida KCG,Guadagnini D,Santos A,Teixeira CJ,Bordin S,Rocha GZ,Saad MJA
61-7300 was used in Western Blotting to investigate the effect of pantoprazole treatment on TLR4 signaling and liver histology in C57BL/6J mice for 60 days, trying to correlate microbiota modulation with some aspects of liver injury.
Wed Nov 09 00:00:00 UTC 2022
Derivation and Characterization of Murine and Amphibian Müller Glia Cell Lines.
Translational vision science & technology
Gallo RA,Qureshi F,Strong TA,Lang SH,Pino KA,Dvoriantchikova G,Pelaez D
61-7300 was used in Western Blotting to establish Müller glia (MG) cell lines from the regeneration-competent frog and the regeneration-deficient mouse.
Fri Apr 01 00:00:00 UTC 2022
Derivation and Characterization of Murine and Amphibian Müller Glia Cell Lines.
Translational vision science & technology
Gallo RA,Qureshi F,Strong TA,Lang SH,Pino KA,Dvoriantchikova G,Pelaez D
61-7300 was used in Western Blotting to establish Müller glia (MG) cell lines from the regeneration-competent frog and the regeneration-deficient mouse.
Fri Apr 01 00:00:00 UTC 2022
Fabrication and Evaluation of Tubule-on-a-Chip with RPTEC/HUVEC Co-Culture Using Injection-Molded Polycarbonate Chips.
Micromachines
Lee JB,Kim H,Kim S,Sung GY
61-7300 was used in Immunocytochemistry to establish that the cell viability was higher in the 3 µm pore size than in the 0.4 µm, the cell culture performed better, and the drug secretion was enhanced when the pore size was large.
Wed Nov 09 00:00:00 UTC 2022
Transcranial focused ultrasound stimulation reduces vasogenic edema after middle cerebral artery occlusion in mice.
Neural regeneration research
Deng LD,Qi L,Suo Q,Wu SJ,Mamtilahun M,Shi RB,Liu Z,Sun JF,Tang YH,Zhang ZJ,Yang GY,Wang JX
61-7300 was used in Western Blotting to show that low-intensity ultrasound stimulation attenuated BBB disruption and edema formation, which suggests it may have therapeutic use in ischemic brain disease as a protector of BBB integrity.
Thu Sep 01 00:00:00 UTC 2022
Fibroblasts repair blood-brain barrier damage and hemorrhagic brain injury via TIMP2.
Cell reports
Xu L,Nirwane A,Xu T,Kang M,Devasani K,Yao Y
61-7300 was used in Western Blotting to suggest that Col1α1+ fibroblasts repair BBB damage in ICH via the paracellular pathway in a TIMP2-dependent manner.
Tue Nov 22 00:00:00 UTC 2022
Folic Acid Rescues Valproic Acid-Induced Morphogenesis Inhibition in Neural Rosettes Derived From Human Pluripotent Stem Cells.
Frontiers in cellular neuroscience
Zhang XZ,Huo HQ,Zhu YQ,Feng HY,Jiao J,Tan JX,Wang Y,Hu P,Xu ZF
61-7300 was used in Immunohistochemistry-immunofluorescence to show that VPA caused morphogenesis inhibition of lumen formation by altering cytoskeletal function and cell polarization, which could be rescued by FA supplement.
Sat Jul 16 00:00:00 UTC 2022
ILC1 drive intestinal epithelial and matrix remodelling.
Nature materials
Jowett GM,Norman MDA,Yu TTL,Rosell Arévalo P,Hoogland D,Lust ST,Read E,Hamrud E,Walters NJ,Niazi U,Chung MWH,Marciano D,Omer OS,Zabinski T,Danovi D,Lord GM,Hilborn J,Evans ND,Dreiss CA,Bozec L,Oommen OP,Lorenz CD,da Silva RMP,Neves JF,Gentleman E
61-7300 was used in Immunocytochemistry-immunoflourescence to develop gut organoid cocultures with type-1 innate lymphoid cells (ILC1) to dissect the impact of their accumulation in inflamed intestines.
Mon Feb 01 00:00:00 UTC 2021
Single-cell atlas of early human brain development highlights heterogeneity of human neuroepithelial cells and early radial glia.
Nature neuroscience
Eze UC,Bhaduri A,Haeussler M,Nowakowski TJ,Kriegstein AR
61-7300 was used in Immunohistochemistry to provide a comprehensive molecular and spatial atlas of early stages of human brain and cortical development.
Thu Apr 01 00:00:00 UTC 2021
KRT8 (keratin 8) attenuates necrotic cell death by facilitating mitochondrial fission-mediated mitophagy through interaction with PLEC (plectin).
Autophagy
Baek A,Son S,Baek YM,Kim DE
61-7300 was used in Immunohistochemistry to suggest that, by facilitating mitophagy, KRT8 protects RPE cells against necrotic cell death due to oxidative stress.
Wed Dec 01 00:00:00 UTC 2021
Long noncoding RNA ERLR mediates epithelial-mesenchymal transition of retinal pigment epithelial cells and promotes experimental proliferative vitreoretinopathy.
Cell death and differentiation
Yang S,Li H,Yao H,Zhang Y,Bao H,Wu L,Zhang C,Li M,Feng L,Zhang J,Zheng Z,Xu G,Wang F
61-7300 was used in Western Blot, Immunocytochemistry to study the role of a long noncoding RNA (lncRNA) named epithelial-mesenchymal transition-related lncRNA in etinal pigment epithelial (ERLR, LINC01705-201 (ENST00000438158.1)) in proliferative vitreoretinopathy and to explore the underlying mechanisms.
Sun Aug 01 00:00:00 UTC 2021
Long noncoding RNA ERLR mediates epithelial-mesenchymal transition of retinal pigment epithelial cells and promotes experimental proliferative vitreoretinopathy.
Cell death and differentiation
Yang S,Li H,Yao H,Zhang Y,Bao H,Wu L,Zhang C,Li M,Feng L,Zhang J,Zheng Z,Xu G,Wang F
61-7300 was used in Western Blot, Immunocytochemistry to study the role of a long noncoding RNA (lncRNA) named epithelial-mesenchymal transition-related lncRNA in etinal pigment epithelial (ERLR, LINC01705-201 (ENST00000438158.1)) in proliferative vitreoretinopathy and to explore the underlying mechanisms.
Sun Aug 01 00:00:00 UTC 2021
The CD44/COL17A1 pathway promotes the formation of multilayered, transformed epithelia.
Current biology : CB
Kozawa K,Sekai M,Ohba K,Ito S,Sako H,Maruyama T,Kakeno M,Shirai T,Kuromiya K,Kamasaki T,Kohashi K,Tanaka S,Ishikawa S,Sato N,Asano S,Suzuki H,Tanimura N,Mukai Y,Gotoh N,Tanino M,Tanaka S,Natsuga K,Soga T,Nakamura T,Yabuta Y,Saitou M,Ito T,Matsuura K,Tsunoda M,Kikumori T,Iida T,Mizutani Y,Miyai Y,Kaibuchi K,Enomoto A,Fujita Y
61-7300 was used in Western Blotting to suggest that CD44 and COL17A1 are crucial regulators for the clonal expansion of transformed cells within multilayered epithelia, thus being potential targets for early diagnosis and preventive treatment for precancerous lesions.
Mon Jul 26 00:00:00 UTC 2021
Silencing of lncRNA XIST impairs angiogenesis and exacerbates cerebral vascular injury after ischemic stroke.
Molecular therapy. Nucleic acids
Wang C,Dong J,Sun J,Huang S,Wu F,Zhang X,Pang D,Fu Y,Li L
61-7300 was used in Western Blot to evaluate the impact of long non-coding RNA X-inactive-specific transcript in acute cerebral ischemic stroke patients, middle cerebral artery occlusion mice, and oxygen-glucose deprivation and restoration brain endothelial cells.
Fri Dec 03 00:00:00 UTC 2021
Planar cell polarity induces local microtubule bundling for coordinated ciliary beating.
The Journal of cell biology
Nakayama S,Yano T,Namba T,Konishi S,Takagishi M,Herawati E,Nishida T,Imoto Y,Ishihara S,Takahashi M,Furuta K,Oiwa K,Tamura A,Tsukita S
61-7300 was used in Immunocytochemistry to show that the deficiency of Daple, a dishevelled-associating protein, in tracheal MCCs impaired the planar polarized apical MTs without affecting the core PCP proteins, causing significant defects in the BB orientation at the cell level but not the tissue level.
Mon Jul 05 00:00:00 UTC 2021
Alveolar epithelial glycocalyx shedding aggravates the epithelial barrier and disrupts epithelial tight junctions in acute respiratory distress syndrome.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Li J,Qi Z,Li D,Huang X,Qi B,Feng J,Qu J,Wang X
61-7300 was used in Immunocytochemistry to demonstrate that shedding of the alveolar epithelial glycocalyx aggravates the epithelial barrier and damages epithelial TJ proteins in ARDS, with the underlying mechanism involving the effect of HPA on ZO-1.
Fri Jan 01 00:00:00 UTC 2021
The CD36 Ligand-Promoted Autophagy Protects Retinal Pigment Epithelial Cells from Oxidative Stress.
Oxidative medicine and cellular longevity
Dorion MF,Mulumba M,Kasai S,Itoh K,Lubell WD,Ong H
61-7300 was used in Immunocytochemistry to report for the first time an autophagy-dependent protection of RPE cells from oxidative stress by a CD36 ligand.
Wed Jun 09 00:00:00 UTC 2021
Dietary Fish Hydrolysate Improves Memory Performance Through Microglial Signature Remodeling During Aging.
Frontiers in nutrition
Chataigner M,Lucas C,Di Miceli M,Pallet V,Laye S,Mehaignerie A,Bouvret E,Dinel AL,Joffre C
61-7300 was used in Immunohistochemistry to demonstrate that the hydrolysate supplementation for 8 weeks prevented short- and long-term memory decline during aging.
Sat Dec 11 00:00:00 UTC 2021
MAGI-1 PDZ2 Domain Blockade Averts Adenovirus Infection via Enhanced Proteolysis of the Apical Coxsackievirus and Adenovirus Receptor.
Journal of virology
Alghamri MS,Sharma P,Williamson TL,Readler JM,Yan R,Rider SD,Hostetler HA,Cool DR,Kolawole AO,Excoffon KJDA
61-7300 was used in Western Blot to show that the interactions between the MAGI-1 PDZ2 domain and CAREx8 would decrease the apical CAREx8 expression level and prevent AdV infection.
Thu Jun 10 00:00:00 UTC 2021
Melatonin maintains inner blood-retinal barrier via inhibition of p38/TXNIP/NF-κB pathway in diabetic retinopathy.
Journal of cellular physiology
Tang L,Zhang C,Yang Q,Xie H,Liu D,Tian H,Lu L,Xu JY,Li W,Xu G,Qiu Q,Liu K,Luo D,Xu GT,Zhang J
61-7300 was used in Western Blotting to show that in diabetic rat retinas, the leakage of iBRB and the expression of inflammatory factors (VEGF, TNF-α, IL-1β, ICAM-1, and MMP9) increased dramatically, while the expression of tight junction proteins (ZO-1, occludin, JAM-A, and claudin-5) decreased significantly.
Sun Aug 01 00:00:00 UTC 2021
Melatonin maintains inner blood-retinal barrier via inhibition of p38/TXNIP/NF-κB pathway in diabetic retinopathy.
Journal of cellular physiology
Tang L,Zhang C,Yang Q,Xie H,Liu D,Tian H,Lu L,Xu JY,Li W,Xu G,Qiu Q,Liu K,Luo D,Xu GT,Zhang J
61-7300 was used in Western Blotting to show that in diabetic rat retinas, the leakage of iBRB and the expression of inflammatory factors (VEGF, TNF-α, IL-1β, ICAM-1, and MMP9) increased dramatically, while the expression of tight junction proteins (ZO-1, occludin, JAM-A, and claudin-5) decreased significantly.
Sun Aug 01 00:00:00 UTC 2021
Clarithromycin Ameliorates Early Brain Injury After Subarachnoid Hemorrhage via Suppressing Periostin-Related Pathways in Mice.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
Kanamaru H,Kawakita F,Nishikawa H,Nakano F,Asada R,Suzuki H
61-7300 was used in Western Blotting to investigate whether Clarithromycin suppressed early brain injury after experimental Subarachnoid hemorrhage, focusing on blood-brain barrier (BBB) disruption, an important pathology of EBI.
Thu Jul 01 00:00:00 UTC 2021
A Pulmonary Vascular Model From Endothelialized Whole Organ Scaffolds.
Frontiers in bioengineering and biotechnology
Yuan Y,Leiby KL,Greaney AM,Raredon MSB,Qian H,Schupp JC,Engler AJ,Baevova P,Adams TS,Kural MH,Wang J,Obata T,Yoder MC,Kaminski N,Niklason LE
61-7300 was used in Immunocytochemistry-immunoflourescence to pave the way for using the whole organ engineering approach to model vascular diseases.
Thu May 12 00:00:00 UTC 2022
Diosmin Alleviates Venous Injury and Muscle Damage in a Mouse Model of Iliac Vein Stenosis.
Frontiers in cardiovascular medicine
Guo Z,Du X,Zhang Y,Su C,Ran F,Lu Q
61-7300 was used in Immunohistochemistry to elucidate the underlying molecular mechanism of chronic venous disease development.
Tue Feb 01 00:00:00 UTC 2022
Apical CLC-2 in retinal pigment epithelium is crucial for survival of the outer retina.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Hanke-Gogokhia C,Lehmann GL,Benedicto I,de la Fuente-Ortega E,Arshavsky VY,Schreiner R,Rodriguez-Boulan E
61-7300 was used in Immunohistochemistry to suggest that CLC-2 performs a critical homeostatic role in the subretinal compartment involving a chloride regulatory mechanism that is critical for the survival of both RPE and photoreceptors.
Thu Jul 01 00:00:00 UTC 2021
Dual therapy with zinc acetate and rifaximin prevents from ethanol-induced liver fibrosis by maintaining intestinal barrier integrity.
World journal of gastroenterology
Fujimoto Y,Kaji K,Nishimura N,Enomoto M,Murata K,Takeda S,Takaya H,Kawaratani H,Moriya K,Namisaki T,Akahane T,Yoshiji H
61-7300 was used in Western Blot, Immunohistochemistry to investigate the effects of a combined zinc acetate with rifaximin on liver fibrosis in a mouse alcoholic liver disease model.
Tue Dec 28 00:00:00 UTC 2021
Dual therapy with zinc acetate and rifaximin prevents from ethanol-induced liver fibrosis by maintaining intestinal barrier integrity.
World journal of gastroenterology
Fujimoto Y,Kaji K,Nishimura N,Enomoto M,Murata K,Takeda S,Takaya H,Kawaratani H,Moriya K,Namisaki T,Akahane T,Yoshiji H
61-7300 was used in Western Blot, Immunohistochemistry to investigate the effects of a combined zinc acetate with rifaximin on liver fibrosis in a mouse alcoholic liver disease model.
Tue Dec 28 00:00:00 UTC 2021
The laminin-binding integrins regulate nuclear factor κB-dependent epithelial cell polarity and inflammation.
Journal of cell science
Yazlovitskaya EM,Plosa E,Bock F,Viquez OM,Mernaugh G,Gewin LS,De Arcangelis A,Georges-Labouesse E,Sonnenberg A,Blackwell TS,Pozzi A,Zent R
61-7300 was used in Western Blotting to suggest that laminin-binding integrins play a key role in the maintenance of kidney tubule epithelial cell polarity and decrease pro-inflammatory cytokine secretion by regulating NF-κB-dependent signaling.
Wed Dec 15 00:00:00 UTC 2021
Automating Human Induced Pluripotent Stem Cell Culture and Differentiation of iPSC-Derived Retinal Pigment Epithelium for Personalized Drug Testing.
SLAS technology
Truong V,Viken K,Geng Z,Barkan S,Johnson B,Ebeling MC,Montezuma SR,Ferrington DA,Dutton JR
61-7300 was used in Immunocytochemistry to demonstrate scalable, reproducible culture and differentiation of hiPSC lines from individuals on the TECAN Fluent platform and illustrate the potential for end-to-end automation of hiPSC-based personalized drug testing.
Tue Jun 01 00:00:00 UTC 2021
Lycium barbarum Polysaccharide Ameliorates Heat-Stress-Induced Impairment of Primary Sertoli Cells and the Blood-Testis Barrier in Rat via Androgen Receptor and Akt Phosphorylation.
Evidence-based complementary and alternative medicine : eCAM
Hu S,Liu D,Liu S,Li C,Guo J
61-7300 was used in Western Blot to prove that LBP blocked the inhibitory effect on the proliferation activity of Sertoli cells after heat stress, reversed the dedifferentiation of Sertoli cells induced by heat stress, and ameliorated the structural integrity of the blood-testis barrier.
Sat Jul 03 00:00:00 UTC 2021
Permissive effect of GSK3β on profibrogenic plasticity of renal tubular cells in progressive chronic kidney disease.
Cell death & disease
Chen B,Wang P,Liang X,Jiang C,Ge Y,Dworkin LD,Gong R
61-7300 was used in Immunocytochemistry to suggest that GSK3β is likely a pragmatic therapeutic target for averting profibrogenic plasticity of TECs and improving renal fibrosis.
Fri Apr 30 00:00:00 UTC 2021
Characterization of Leptin Receptor+ Stromal Cells in Lymph Node.
Frontiers in immunology
Jiang L,Yilmaz M,Uehara M,Cavazzoni CB,Kasinath V,Zhao J,Naini SM,Li X,Banouni N,Fiorina P,Shin SR,Tullius SG,Bromberg JS,Sage PT,Abdi R
61-7300 was used in Immunohistochemistry to study the importance of LN stomal cell dysfunction to the pathogenesis of inflammatory responses in type 2 diabetes (T2D) in humans.
Wed Feb 23 00:00:00 UTC 2022
Extracorporeal Shock Wave Enhances the Cisplatin Efficacy by Improving Tissue Infiltration and Cellular Uptake in an Upper Urinary Tract Cancer Animal and Human-Derived Organoid Model.
Cancers
Luo HL,Liu HY,Chang YL,Su YL,Huang CC,Lin XJ,Chuang YC
61-7300 was used in Immunohistochemistry, Western Blot to show that LESW improved the cytotoxicity of cisplatin in the preclinical PDO model of UTUC.
Sat Sep 11 00:00:00 UTC 2021
Extracorporeal Shock Wave Enhances the Cisplatin Efficacy by Improving Tissue Infiltration and Cellular Uptake in an Upper Urinary Tract Cancer Animal and Human-Derived Organoid Model.
Cancers
Luo HL,Liu HY,Chang YL,Su YL,Huang CC,Lin XJ,Chuang YC
61-7300 was used in Immunohistochemistry, Western Blot to show that LESW improved the cytotoxicity of cisplatin in the preclinical PDO model of UTUC.
Sat Sep 11 00:00:00 UTC 2021
Protective Functions of ZO-2/Tjp2 Expressed in Hepatocytes and Cholangiocytes Against Liver Injury and Cholestasis.
Gastroenterology
Xu J,Kausalya PJ,Van Hul N,Caldez MJ,Xu S,Ong AGM,Woo WL,Mohamed Ali S,Kaldis P,Hunziker W
61-7300 was used in Western Blotting to characterize mice with liver-specific inactivation of Tjp2.
Sat May 01 00:00:00 UTC 2021
FBP17-mediated finger-like membrane protrusions in cell competition between normal and RasV12-transformed cells.
iScience
Kamasaki T,Miyazaki Y,Ishikawa S,Hoshiba K,Kuromiya K,Tanimura N,Mori Y,Tsutsumi M,Nemoto T,Uehara R,Suetsugu S,Itoh T,Fujita Y
61-7300 was used in Immunocytochemistry to show that the cdc42/FBP17 pathway induces characteristic protrusive structures at the interface between normal and RasV12 cells, which would play a positive role in the apical extrusion of RasV12 cells from epithelia.
Fri Sep 24 00:00:00 UTC 2021
Reticulocalbin 3 is involved in postnatal tendon development by regulating collagen fibrillogenesis and cellular maturation.
Scientific reports
Park NR,Shetye SS,Bogush I,Keene DR,Tufa S,Hudson DM,Archer M,Qin L,Soslowsky LJ,Dyment NA,Joeng KS
61-7300 was used in Immunohistochemistry-immunofluorescence to suggest that Rcn3 is a pivotal regulator of collagen fibrillogenesis and tenocyte maturation during postnatal tendon development.
Tue May 25 00:00:00 UTC 2021
ATPIF1 maintains normal mitochondrial structure which is impaired by CCM3 deficiency in endothelial cells.
Cell & bioscience
Wang K,Chen H,Zhou Z,Zhang H,Zhou HJ,Min W
61-7300 was used in Immunocytochemistry-Immunofluorescence to elucidate the role of cerebral cavernous malformations(CCM3) by RNA-seq screening of CCM3 knockout mice.
Sat Jan 09 00:00:00 UTC 2021
NMN Maintains Intestinal Homeostasis by Regulating the Gut Microbiota.
Frontiers in nutrition
Huang P,Jiang A,Wang X,Zhou Y,Tang W,Ren C,Qian X,Zhou Z,Gong A
61-7300 was used in Immunohistochemistry-paraffin to demonstrate that Nicotinamide mononucleotide (NMN) reduced intestinal mucosal permeability and exerts a protective effect on the intestinal tract.
Tue Aug 17 00:00:00 UTC 2021
Expression of E-Cadherin in Epithelial Cancer Cells Increases Cell Motility and Directionality through the Localization of ZO-1 during Collective Cell Migration.
Bioengineering (Basel, Switzerland)
Park SY,Jang H,Kim SY,Kim D,Park Y,Kee SH
61-7300 was used in Immunocytochemistry to examine cell motility using micropatterned free edge migration model with E-cadherin re-expressing EC96 cells derived from adenocarcinoma gastric (AGS) cell line.
Tue May 11 00:00:00 UTC 2021
The blood-brain barrier studied in vitro across species.
PloS one
Thomsen MS,Humle N,Hede E,Moos T,Burkhart A,Thomsen LB
61-7300 was used in Immunocytochemistry-immunoflourescence to investigate three species-specific in vitro blood brain barrier models, to investigate the underlying reason for the major variation observed in ransendothelial electrical resistance between species.
Tue Aug 31 00:00:00 UTC 2021
Plexin-B2 orchestrates collective stem cell dynamics via actomyosin contractility, cytoskeletal tension and adhesion.
Nature communications
Junqueira Alves C,Dariolli R,Haydak J,Kang S,Hannah T,Wiener RJ,DeFronzo S,Tejero R,Gusella GL,Ramakrishnan A,Alves Dias R,Wojcinski A,Kesari S,Shen L,Sobie EA,Rodrigues Furtado de Mendonça JP,Azeloglu EU,Zou H,Friedel RH
61-7300 was used in Immunocytochemistry to establish a significant function of Plexin-B2 in orchestrating cytoskeletal tension and cell-cell/cell-matrix adhesion, therefore solidifying the importance of collective cell mechanics in governing stem cell physiology and tissue morphogenesis.
Thu Oct 14 00:00:00 UTC 2021
A defined subset of clonal retinal stem cell spheres is biased to RPE differentiation.
iScience
Baakdhah TW,Coles B,van der Kooy D
61-7300 was used in Flow Cytometry to conclude that HP and LP spheres contain late RPE progenitors which are not affected by proliferative signals.
Fri Jun 25 00:00:00 UTC 2021
Complement Factor H-Related 3 Enhanced Inflammation and Complement Activation in Human RPE Cells.
Frontiers in immunology
Schäfer N,Rasras A,Ormenisan DM,Amslinger S,Enzmann V,Jägle H,Pauly D
61-7300 was used in Immunocytochemistry-immunofluorescence to suggest FHR-3 as an exogenous trigger molecule for the RPE cell "complosome" and as a putative target for a therapeutic approach for associated degenerative diseases.
Mon Feb 14 00:00:00 UTC 2022
Quercetin Alleviates Oxidative Damage by Activating Nuclear Factor Erythroid 2-Related Factor 2 Signaling in Porcine Enterocytes.
Nutrients
Jia H,Zhang Y,Si X,Jin Y,Jiang D,Dai Z,Wu Z
61-7300 was used in Western Blot to provide new insights into a function role of quercetin in maintaining intestinal homeostasis.
Tue Jan 26 00:00:00 UTC 2021
Expression pattern and prognostic impact of glycoprotein non-metastatic B (GPNMB) in triple-negative breast cancer.
Scientific reports
Huang YH,Chu PY,Chen JL,Huang CT,Huang CC,Tsai YF,Wang YL,Lien PJ,Tseng LM,Liu CY
61-7300 was used in Immunohistochemistry (Paraffin) to to explore the clinical significance of glycoprotein non-metastatic B in triple-negative breast cancers.
Wed Jun 09 00:00:00 UTC 2021
Single-Cell Transcriptomics Analysis of Human Small Antral Follicles.
International journal of molecular sciences
Fan X,Moustakas I,Bialecka M,Del Valle JS,Overeem AW,Louwe LA,Pilgram GSK,van der Westerlaken LAJ,Mei H,Chuva de Sousa Lopes SM
61-7300 was used in immunohistochemistry (paraffin)-immunofluorescence to generate a unique dataset of single-cell transcriptomics (SmartSeq2) consisting of the oocyte with surrounding GCs from several individual (non-dominant) small antral follicles isolated from adult human ovaries.
Thu Nov 04 00:00:00 UTC 2021
Histological analysis of the effects of thymoquinone on testicular damage in pentylenetetrazole-induced temporal lobe epilepsy model.
Andrologia
Karakaya FB,Yavuz M,Sirvanci S
61-7300 was used in Immunohistochemistry to investigate possible ameliorating effects of thymoquinone on testicular damage in an epilepsy model.
Mon Nov 01 00:00:00 UTC 2021
Genomic diversity contributes to the neuroinvasiveness of the Yellow fever French neurotropic vaccine.
NPJ vaccines
Bakoa F,Préhaud C,Beauclair G,Chazal M,Mantel N,Lafon M,Jouvenet N
61-7300 was used in Immunocytochemistry to conclude that viral population diversity is a critical factor for YFV vaccine neuroinvasiveness.
Mon Apr 26 00:00:00 UTC 2021
Morphologic changes in the cytoskeleton and adhesion apparatus during the conversion from pseudostratified single columnar to stratified squamous epithelium in the developing mouse esophagus.
Congenital anomalies
Getachew D,Kaneda R,Saeki Y,Matsumoto A,Otani H
61-7300 was used in Immunohistochemistry-immunofluorescence to suggest that dynamic remodeling of the cytoskeleton and adhesion apparatus is involved in the conversion from pseudostratified single columnar to stratified squamous morphology and is closely related with temporal perturbation of the AB-polarity and cessation of INM.
Fri Jan 01 00:00:00 UTC 2021
The expression, localisation and interactome of pigeon CRY2.
Scientific reports
Balay SD,Hochstoeger T,Vilceanu A,Malkemper EP,Snider W,Dürnberger G,Mechtler K,Schuechner S,Ogris E,Nordmann GC,Ushakova L,Nimpf S,Keays DA
61-7300 was used in Immunohistochemistry to investigate the expression, localisation and interactome of clCRY2 in the pigeon retina.
Wed Oct 13 00:00:00 UTC 2021
Involvement of the Choroid Plexus in the Pathogenesis of Niemann-Pick Disease Type C.
Frontiers in cellular neuroscience
Van Hoecke L,Van Cauwenberghe C,Dominko K,Van Imschoot G,Van Wonterghem E,Castelein J,Xie J,Claeys W,Vandendriessche C,Kremer A,Borghgraef P,De Rycke R,Hecimovic S,Vandenbroucke RE
61-7300 was used in immunohistochemistry (paraffin) to reveal for the first time that the choroid plexus and CSF EVs might play a role in the brain-related pathogenesis of NPC1.
Tue Nov 02 00:00:00 UTC 2021
Culture surface protein coatings affect the barrier properties and calcium signalling of hESC-RPE.
Scientific reports
Viheriälä T,Sorvari J,Ihalainen TO,Mörö A,Grönroos P,Schlie-Wolter S,Chichkov B,Skottman H,Nymark S,Ilmarinen T
61-7300 was used in Immunocytochemistry to investigate the role of retinal pigment epithelium basement membrane proteins type IV collagen, laminin, and nidogen-1 in the maturation and functionality of hESC-RPE after cryopreservation.
Wed Jan 13 00:00:00 UTC 2021
Early-Life Intervention Using Exogenous Fecal Microbiota Alleviates Gut Injury and Reduce Inflammation Caused by Weaning Stress in Piglets.
Frontiers in microbiology
Ma X,Zhang Y,Xu T,Qian M,Yang Z,Zhan X,Han X
61-7300 was used in Western Blot to explore the changes that happen in the structure and function of microbiota caused by weaning stress, and whether early-life fecal microbiota transplantation could alleviate weaning stress through modifying intestinal microbiota in weaned piglets.
Tue Jun 29 00:00:00 UTC 2021
Photodynamic Priming Modulates Endothelial Cell-Cell Junction Phenotype for Light-activated Remote Control of Drug Delivery.
IEEE journal of selected topics in quantum electronics : a publication of the IEEE Lasers and Electro-optics Society
Inglut CT,Gray KM,Vig S,Jung JW,Stabile J,Zhang Y,Stroka KM,Huang HC
61-7300 was used in Immunocytochemistry-immunofluorescence to suggest that PDP could safely reverse the mature brain endothelial junctions without killing the HBMECs.
Fri Nov 10 00:00:00 UTC 2023
Structural disruption of the blood-brain barrier in repetitive primary blast injury.
Fluids and barriers of the CNS
Uzunalli G,Herr S,Dieterly AM,Shi R,Lyle LT
61-7300 was used in Immunohistochemistry to provide analysis of the blood-brain barrier components after repetitive blast injury.
Thu Jan 07 00:00:00 UTC 2021
Epithelial-Specific TLR4 Knockout Challenges Current Evidence of TLR4 Homeostatic Control of Gut Permeability.
Inflammatory intestinal diseases
Crame EE,Bowen JM,Secombe KR,Coller JK,François M,Leifert W,Wardill HR
61-7300 was used in Immunohistochemistry to support the use of the Tlr4ΔIEC line in future models interrogating health and disease, confirming no confounding effects of genetic manipulation.
Wed Dec 01 00:00:00 UTC 2021
Gene therapy to the blood-brain barrier with resulting protein secretion as a strategy for treatment of Niemann Picks type C2 disease.
Journal of neurochemistry
Hede E,Christiansen CB,Heegaard CW,Moos T,Burkhart A
61-7300 was used in Immunocytochemistry-immunofluorescence to study how on-viral gene therapy to rat brain capillary endothelial cells (rBCECs) leads to protein secretion and signifies a method for NPC2 to target cells inside the central nervous system (CNS) otherwise inaccessible because of the presence of the blood-brain barrier (BBB).
Mon Feb 01 00:00:00 UTC 2021
Gene therapy to the blood-brain barrier with resulting protein secretion as a strategy for treatment of Niemann Picks type C2 disease.
Journal of neurochemistry
Hede E,Christiansen CB,Heegaard CW,Moos T,Burkhart A
61-7300 was used in Immunocytochemistry-immunofluorescence to study how on-viral gene therapy to rat brain capillary endothelial cells (rBCECs) leads to protein secretion and signifies a method for NPC2 to target cells inside the central nervous system (CNS) otherwise inaccessible because of the presence of the blood-brain barrier (BBB).
Mon Feb 01 00:00:00 UTC 2021
Altered Mucus Barrier Integrity and Increased Susceptibility to Colitis in Mice upon Loss of Telocyte Bone Morphogenetic Protein Signalling.
Cells
Reyes Nicolás V,Allaire JM,Alfonso AB,Pupo Gómez D,Pomerleau V,Giroux V,Boudreau F,Perreault N
61-7300 was used in Immunohistochemistry to investigate how the loss of BMP signalling in TCFoxL1+ influences the severity of inflammation and fosters epithelial recovery after inflammatory stress.
Fri Oct 29 00:00:00 UTC 2021
Claudin-9 constitutes tight junctions of folliculo-stellate cells in the anterior pituitary gland.
Scientific reports
Higashi AY,Higashi T,Furuse K,Ozeki K,Furuse M,Chiba H
61-7300 was used in Immunohistochemistry-wholemount to provide a first comprehensive molecular profile of TJs in the FS cells, and may lead us towards unveiling the FS cell functions.
Thu Nov 04 00:00:00 UTC 2021
The Role of Processed Aloe vera Gel in Intestinal Tight Junction: An In Vivo and In Vitro Study.
International journal of molecular sciences
Le Phan TH,Park SY,Jung HJ,Kim MW,Cho E,Shim KS,Shin E,Yoon JH,Maeng HJ,Kang JH,Oh SH
61-7300 was used in Immunocytochemistry, Western Blot to investigate the tight junction-modulating effects of processed Aloe vera gel.
Thu Jun 17 00:00:00 UTC 2021
The Role of Processed Aloe vera Gel in Intestinal Tight Junction: An In Vivo and In Vitro Study.
International journal of molecular sciences
Le Phan TH,Park SY,Jung HJ,Kim MW,Cho E,Shim KS,Shin E,Yoon JH,Maeng HJ,Kang JH,Oh SH
61-7300 was used in Immunocytochemistry, Western Blot to investigate the tight junction-modulating effects of processed Aloe vera gel.
Thu Jun 17 00:00:00 UTC 2021
Podocalyxin promotes an impermeable epithelium and inhibits pro-implantation factors to negatively regulate endometrial receptivity.
Scientific reports
Heng S,Samarajeewa N,Wang Y,Paule SG,Breen J,Nie G
61-7300 was used in Immunocytochemistry-immunofluorescence to investigate podocalyxin in embryonic implantation.
Tue Dec 14 00:00:00 UTC 2021
Transport of Dietary Anti-Inflammatory Peptide, γ-Glutamyl Valine (γ-EV), across the Intestinal Caco-2 Monolayer.
Nutrients
Guha S,Alvarez S,Majumder K
61-7300 was used in Western Blot, Immunocytochemistry to elucidate the mechanism of transport of γ-EV across Caco-2 cells.
Sat Apr 24 00:00:00 UTC 2021
Transport of Dietary Anti-Inflammatory Peptide, γ-Glutamyl Valine (γ-EV), across the Intestinal Caco-2 Monolayer.
Nutrients
Guha S,Alvarez S,Majumder K
61-7300 was used in Western Blot, Immunocytochemistry to elucidate the mechanism of transport of γ-EV across Caco-2 cells.
Sat Apr 24 00:00:00 UTC 2021
Reconstruction of Ultra-thin Alveolar-capillary Basement Membrane Mimics.
Advanced biology
Jain P,Nishiguchi A,Linz G,Wessling M,Ludwig A,Rossaint R,Möller M,Singh S
61-7300 was used in Immunocytochemistry to show that the interconnected BM mimic prevents barrier disruption and allows neutrophil transmigration, thereby demonstrating the physiological relevance of the thin nanofibrous meshes.
Sun Aug 01 00:00:00 UTC 2021
Butyrate Alleviates Cytokine-Induced Barrier Dysfunction by Modifying Claudin-2 Levels.
Biology
Huang X,Oshima T,Tomita T,Fukui H,Miwa H
61-7300 was used in Western Blot to suggest that butyrate is the main component of SCFAs to alleviate barrier dysfunction and that claudin-2 is the major target of this SCFA.
Tue Mar 09 00:00:00 UTC 2021
Induction of apically mistrafficked epiregulin disrupts epithelial polarity via aberrant EGFR signaling.
Journal of cell science
Singh B,Bogatcheva G,Krystofiak E,McKinley ET,Hill S,Rose KL,Higginbotham JN,Coffey RJ
61-7300 was used in Immunocytochemistry to show that induction of Y156A EREG in fully formed MDCK cysts results in direct and complete delivery of mutant EREG to the apical cell surface.
Wed Sep 15 00:00:00 UTC 2021
Topical Delivery of Rapamycin by Means of Microenvironment-Sensitive Core-Multi-Shell Nanocarriers: Assessment of Anti-Inflammatory Activity in an ex vivo Skin/T Cell Co-Culture Model.
International journal of nanomedicine
Rancan F,Guo X,Rajes K,Sidiropoulou P,Zabihi F,Hoffmann L,Hadam S,Blume-Peytavi U,Rühl E,Haag R,Vogt A
61-7300 was used in Immunohistochemistry to demonstrate that nanocarriers addressing features of diseased skin are promising approaches to improve the topical delivery of macrolide drugs.
Wed Nov 24 00:00:00 UTC 2021
Reversing pathology in a preclinical model of Alzheimer's disease by hacking cerebrovascular neoangiogenesis with advanced cancer therapeutics.
EBioMedicine
Singh CSB,Choi KB,Munro L,Wang HY,Pfeifer CG,Jefferies WA
61-7300 was used in Western Blotting to present evidence that repurposing anti-cancer drugs to modulate cerebrovascular neoangiogenesis, rather than directly targeting the amyloid cascade, may provide an effective treatment for AD and related vascular diseases of the brain.
Wed Sep 01 00:00:00 UTC 2021
Physiological response of the retinal pigmented epithelium to 3-ns pulse laser application, in vitro and in vivo.
Clinical & experimental ophthalmology
Wood JPM,Tahmasebi M,Casson RJ,Plunkett M,Chidlow G
61-7300 was used in Immunocytochemistry to demonstrate that 2RT laser targets RPE in vitro and in vivo, causing debridement of the cells and consequent stimulation of a wound-healing response leading to layer reformation.
Thu Jul 01 00:00:00 UTC 2021
Physiological response of the retinal pigmented epithelium to 3-ns pulse laser application, in vitro and in vivo.
Clinical & experimental ophthalmology
Wood JPM,Tahmasebi M,Casson RJ,Plunkett M,Chidlow G
61-7300 was used in Immunocytochemistry to demonstrate that 2RT laser targets RPE in vitro and in vivo, causing debridement of the cells and consequent stimulation of a wound-healing response leading to layer reformation.
Thu Jul 01 00:00:00 UTC 2021
Ramulus Mori (Sangzhi) Alkaloids (SZ-A) Ameliorate Glucose Metabolism Accompanied by the Modulation of Gut Microbiota and Ileal Inflammatory Damage in Type 2 Diabetic KKAy Mice.
Frontiers in pharmacology
Liu Q,Liu S,Cao H,Ji W,Li C,Huan Y,Lei L,Fu Y,Gao X,Liu Y,Shen Z
61-7300 was used in Western Blotting to investigate the mechanisms by which SZ-A ameliorates glucose metabolism in KKAy mice, an animal model of T2DM.
Tue May 04 00:00:00 UTC 2021
NLRP3 inhibition attenuates early brain injury and delayed cerebral vasospasm after subarachnoid hemorrhage.
Journal of neuroinflammation
Dodd WS,Noda I,Martinez M,Hosaka K,Hoh BL
61-7300 was used in Western Blot to observe a decrease in apoptosis of neurons in mice treated with MCC950.
Tue Jul 20 00:00:00 UTC 2021
Unravelling the Role of PAX2 Mutation in Human Focal Segmental Glomerulosclerosis.
Biomedicines
Longaretti L,Trionfini P,Brizi V,Xinaris C,Mele C,Breno M,Romano E,Giampietro R,Remuzzi G,Benigni A,Tomasoni S
61-7300 was used in Immunocytochemistry-immunoflourescence to support that the PAX2 mutation has a dual effect, first in renal organogenesis, which could account for a suboptimal nephron number at birth, and second in adult podocytes, which are more susceptible to cell death caused by environmental triggers.
Wed Dec 01 00:00:00 UTC 2021
Sectm1a Facilitates Protection against Inflammation-Induced Organ Damage through Promoting TRM Self-Renewal.
Molecular therapy : the journal of the American Society of Gene Therapy
Mu X,Fan H,Wang P,Li Y,Domenico K,Li Q,Wang X,Essandoh K,Chen J,Peng T,Fan GC
61-7300 was used in Western Blotting to demonstrate that Sectm1a contributes to stabling TRM populations through maintaining their self-renewal capacities, which benefits the host immune response to acute inflammation.
Wed Mar 03 00:00:00 UTC 2021
Transplantation of human corneal limbal epithelial cell sheet harvested on synthesized carboxymethyl cellulose and dopamine in a limbal stem cell deficiency.
Journal of tissue engineering and regenerative medicine
Lee H,Lee JH,Hong S,Sunwoo JH,Kim HT,Kim ES,Kim JY,Hwang C,Tchah H
61-7300 was used in Immunohistochemistry-immunofluorescence to evaluate the efficacy and safety of transplantation with human corneal limbal epithelial (HCLE) cell sheets cultured on carboxymethyl cellulose (CMC)-dopamine (DA)-coated substrates and harvested via enzymatic digestion of CMC with cellulase in a rabbit animal model of limbal stem cell deficiency (LSCD).
Mon Feb 01 00:00:00 UTC 2021
Rubicon prevents autophagic degradation of GATA4 to promote Sertoli cell function.
PLoS genetics
Yamamuro T,Nakamura S,Yamano Y,Endo T,Yanagawa K,Tokumura A,Matsumura T,Kobayashi K,Mori H,Enokidani Y,Yoshida G,Imoto H,Kawabata T,Hamasaki M,Kuma A,Kuribayashi S,Takezawa K,Okada Y,Ozawa M,Fukuhara S,Shinohara T,Ikawa M,Yoshimori T
61-7300 was used in Immunohistochemistry to propose that Rubicon promotes Sertoli cell function by preventing autophagic degradation of GATA4, and that this mechanism could be regulated by androgens.
Sun Aug 01 00:00:00 UTC 2021
Laminin alpha 5 regulates mammary gland remodeling through luminal cell differentiation and Wnt4-mediated epithelial crosstalk.
Development (Cambridge, England)
Englund JI,Ritchie A,Blaas L,Cojoc H,Pentinmikko N,Döhla J,Iqbal S,Patarroyo M,Katajisto P
61-7300 was used in Immunohistochemistry-immunofluorescence to reveal a surprising role for BM-protein expression in the luminal mammary epithelial cells, and highlight the function of Lama5 in mammary gland remodeling and luminal differentiation.
Tue Jun 15 00:00:00 UTC 2021
Cerebral Pericytes and Endothelial Cells Communicate through Inflammasome-Dependent Signals.
International journal of molecular sciences
Kozma M,Mészáros Á,Nyúl-Tóth Á,Molnár K,Costea L,Hernádi Z,Fazakas C,Farkas AE,Wilhelm I,Krizbai IA
61-7300 was used in Immunocytochemistry to demonstrate that the noncanonical inflammasome pathway can be induced in cerebral endothelial cells as well, leading to a further increase in the secretion of active interleukin-1β over that observed in response to activation of the canonical pathway.
Sun Jun 06 00:00:00 UTC 2021
Human umbilical cord mesenchymal stem cell-derived exosomal miR-27b attenuates subretinal fibrosis via suppressing epithelial-mesenchymal transition by targeting HOXC6.
Stem cell research & therapy
Li D,Zhang J,Liu Z,Gong Y,Zheng Z
61-7300 was used in Immunocytochemistry to propose a promising therapeutic agent for treating ocular fibrotic diseases and provide insights into the mechanism of action of hucMSC-Exo on subretinal fibrosis.
Thu Jan 07 00:00:00 UTC 2021
Ovariectomy-Induced Dysbiosis May Have a Minor Effect on Bone in Mice.
Microorganisms
Kosaka S,Nadatani Y,Higashimori A,Otani K,Fujimoto K,Nagata Y,Ominami M,Fukunaga S,Hosomi S,Kamata N,Tanaka F,Nagami Y,Taira K,Imoto S,Uematsu S,Watanabe T,Fujiwara Y
61-7300 was used in Western Blotting to determine the bone mineral density (BMD) and the expression of serum bone formation marker (procollagen type I N-terminal propeptide: PINP) and bone resorption marker (C-terminal telopeptide of collagen: CTX) by ELISA to evaluate ovariectomy-induced osteoporosis in ovariectomized (OVX) mice.
Fri Dec 10 00:00:00 UTC 2021
Voiding defects in acute radiation cystitis driven by urothelial barrier defect through loss of E-cadherin, ZO-1 and Uroplakin III.
Scientific reports
Zwaans BMM,Carabulea AL,Bartolone SN,Ward EP,Chancellor MB,Lamb LE
61-7300 was used in Immunohistochemistry to fully understand the bladder changes that characterize the different phases of radiation (hemorrhagic) cystitis (RC) and to determine the mechanism that induces the symptoms during the acute phase of RC.
Wed Sep 29 00:00:00 UTC 2021
Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing.
Nature biomedical engineering
Suh S,Choi EH,Leinonen H,Foik AT,Newby GA,Yeh WH,Dong Z,Kiser PD,Lyon DC,Liu DR,Palczewski K
61-7300 was used in Immunohistochemistry to show, in adult mice, that a subretinal injection of a lentivirus expressing an ABE and a single-guide RNA targeting a de novo nonsense mutation in the Rpe65 gene corrects the pathogenic mutation with up to 29% efficiency and with minimal formation of indel and off-target mutations, despite the absence of the canonical NGG sequence as a protospacer-adjacent motif.
Mon Feb 01 00:00:00 UTC 2021
Small extracellular vesicles ameliorate peripheral neuropathy and enhance chemotherapy of oxaliplatin on ovarian cancer.
Journal of extracellular vesicles
Zhang Y,Li C,Qin Y,Cepparulo P,Millman M,Chopp M,Kemper A,Szalad A,Lu X,Wang L,Zhang ZG
61-7300 was used in Western Blot to demonstrate that CEC-sEVs suppressed CIPN and enhanced chemotherapy of oxaliplatin in the mouse bearing ovarian tumour.
Mon Mar 01 00:00:00 UTC 2021
Citrus limon Peel Powder Reduces Intestinal Barrier Defects and Inflammation in a Colitic Murine Experimental Model.
Foods (Basel, Switzerland)
Tinh NTT,Sitolo GC,Yamamoto Y,Suzuki T
61-7300 was used in Western Blot to examine the ameliorative effects of lemon (Citrus limon) peel (LP) powder on intestinal inflammation and barrier defects in dextran sulfate sodium (DSS)-induced colitic mice.
Mon Jan 25 00:00:00 UTC 2021
An inducible Cre mouse for studying roles of the RPE in retinal physiology and disease.
JCI insight
Choi EH,Suh S,Einstein DE,Leinonen H,Dong Z,Rao SR,Fliesler SJ,Blackshaw S,Yu M,Peachey NS,Palczewski K,Kiser PD
61-7300 was used in ELISA, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot to indicate that Rpe65CreERT2 mice are well suited for studies of gene function and pathophysiology in the RPE.
Mon May 10 00:00:00 UTC 2021
Transverse aortic constriction induces gut barrier alterations, microbiota remodeling and systemic inflammation.
Scientific reports
Boccella N,Paolillo R,Coretti L,D'Apice S,Lama A,Giugliano G,Schiattarella GG,Cuomo M,d'Aquino I,Cavaliere G,Paciello O,Mollica MP,Mattace Raso G,Esposito G,Lembo F,Perrino C
61-7300 was used in Immunohistochemistry to analyse gut microbiota composition, intestinal barrier integrity, intestinal and serum cytokines and serum endotoxin levels in C57BL/6 mice undergoing pressure overload by transverse aortic constriction.
Thu Apr 01 00:00:00 UTC 2021
Fractalkine Is Linked to the Necrosome Pathway in Acute Pulmonary Inflammation.
Frontiers in medicine
Ngamsri KC,Gamper-Tsigaras J,Reutershan J,Konrad FM
61-7300 was used in Western Blot to link CX3CL1 to the necrosome complex in pulmonary inflammation and demonstrate a pivotal role of the necrosome complex in human PMNs.
Fri Apr 02 00:00:00 UTC 2021
Directed Differentiation of Human Pluripotent Stem Cells towards Corneal Endothelial-Like Cells under Defined Conditions.
Cells
Grönroos P,Ilmarinen T,Skottman H
61-7300 was used in Immunocytochemistry to generate CEnC-like cells from hPSCs with a defined, simple and fast differentiation method.
Fri Feb 05 00:00:00 UTC 2021
Functional roles for PIEZO1 and PIEZO2 in urothelial mechanotransduction and lower urinary tract interoception.
JCI insight
Dalghi MG,Ruiz WG,Clayton DR,Montalbetti N,Daugherty SL,Beckel JM,Carattino MD,Apodaca G
61-7300 was used in Immunohistochemistry to determine if PIEZO channels function as mechanosensors in stimulating voiding function by communicating the degree of bladder fullness to subjacent tissues.
Fri Oct 08 00:00:00 UTC 2021
Dynamic conversion of cell sorting patterns in aggregates of embryonic stem cells with differential adhesive affinity.
BMC developmental biology
Tse JD,Moore R,Meng Y,Tao W,Smith ER,Xu XX
61-7300 was used in Immunocytochemistry to patterns.
Wed Jan 06 00:00:00 UTC 2021
Dynamic conversion of cell sorting patterns in aggregates of embryonic stem cells with differential adhesive affinity.
BMC developmental biology
Tse JD,Moore R,Meng Y,Tao W,Smith ER,Xu XX
61-7300 was used in Immunocytochemistry to patterns.
Wed Jan 06 00:00:00 UTC 2021
Exosome-mediated delivery of an anti-angiogenic peptide inhibits pathological retinal angiogenesis.
Theranostics
Dong X,Lei Y,Yu Z,Wang T,Liu Y,Han G,Zhang X,Li Y,Song Y,Xu H,Du M,Yin H,Wang X,Yan H
61-7300 was used in Immunohistochemistry to show that KV11 itself has an anti-angiogenic effect through retro-orbital injection, but that this effect was greatly enhanced when delivered with EXOs.
Wed Jul 28 00:00:00 UTC 2021
Topical Ketotifen Fumarate Inhibits Choroidal Mast Cell Degranulation and Loss of Retinal Pigment Epithelial Cells in Rat Model for Geographic Atrophy.
Translational vision science & technology
Nizawa T,Bhutto IA,Tiwari A,Grebe RR,Alt J,Rais R,Edwards MM,Lutty GA
61-7300 was used in Immunohistochemistry to demonstrate that topical KTF successfully reduces GA-like phenotypes in a rat model and may provide a novel therapy for GA.
Wed Dec 01 00:00:00 UTC 2021
Nano-scale architecture of blood-brain barrier tight-junctions.
eLife
Sasson E,Anzi S,Bell B,Yakovian O,Zorsky M,Deutsch U,Engelhardt B,Sherman E,Vatine G,Dzikowski R,Ben-Zvi A
61-7300 was used in Immunohistochemistry to provide a unique perspective of BBB TJs and open new directions for understanding TJ functionality in biological barriers, ultimately enabling restoration in disease or modulation for drug delivery.
Fri Dec 24 00:00:00 UTC 2021
Zonula occludens 2 and Cell-Cell Contacts Are Required for Normal Nuclear Shape in Epithelia.
Cells
Hernández-Guzmán C,Gallego-Gutiérrez H,Chávez-Munguía B,Martín-Tapia D,González-Mariscal L
61-7300 was used in Immunocytochemistry to investigate cytoskeletal and nuclear requirements for epithelial nuclear shape.
Tue Sep 28 00:00:00 UTC 2021
Recombinant Annexin A2 Administration Improves Neurological Outcomes After Traumatic Brain Injury in Mice.
Frontiers in pharmacology
Cheng C,Wang X,Jiang Y,Li Y,Liao Z,Li W,Yu Z,Whalen MJ,Lok J,Dumont AS,Liu N,Wang X
61-7300 was used in Western Blot to test the hypothesis that Annexin A2 (ANXA2) might be a candidate for the development of cerebrovascular therapy in targeting early blood-brain barrier integrity disruption from post-traumatic brain injury, as well subacute/delayed cerebrovascular remodeling.
Fri Aug 20 00:00:00 UTC 2021
Metallothionein 2 activation by pravastatin reinforces epithelial integrity and ameliorates radiation-induced enteropathy.
EBioMedicine
Kwak SY,Jang WI,Park S,Cho SS,Lee SB,Kim MJ,Park S,Shim S,Jang H
61-7300 was used in Immunohistochemistry (Paraffin) to evaluate the radio-mitigative effects of pravastatin and the molecular mechanisms underlying epithelial integrity on radiation-induced enteropathy.
Mon Nov 01 00:00:00 UTC 2021
Metallothionein 2 activation by pravastatin reinforces epithelial integrity and ameliorates radiation-induced enteropathy.
EBioMedicine
Kwak SY,Jang WI,Park S,Cho SS,Lee SB,Kim MJ,Park S,Shim S,Jang H
61-7300 was used in Immunohistochemistry (Paraffin) to evaluate the radio-mitigative effects of pravastatin and the molecular mechanisms underlying epithelial integrity on radiation-induced enteropathy.
Mon Nov 01 00:00:00 UTC 2021
NLPR3 inflammasome inhibition alleviates hypoxic endothelial cell death in vitro and protects blood-brain barrier integrity in murine stroke.
Cell death & disease
Bellut M,Papp L,Bieber M,Kraft P,Stoll G,Schuhmann MK
61-7300 was used in Immunohistochemistry to study the survival of brain endothelial cells exposed to oxygen and glucose deprivation in vitro in the context of inflammasome inhibition with the NLR-family pyrin domain-containing protein 3 (NLRP3)-specific drug MCC950.
Mon Dec 20 00:00:00 UTC 2021
Cordycepin confers long-term neuroprotection via inhibiting neutrophil infiltration and neuroinflammation after traumatic brain injury.
Journal of neuroinflammation
Wei P,Wang K,Luo C,Huang Y,Misilimu D,Wen H,Jin P,Li C,Gong Y,Gao Y
61-7300 was used in Western Blot to provide significant clinical potentials to improve the quality of life for TBI patients.
Tue Jun 15 00:00:00 UTC 2021
Caffeine Protects Against Retinal Inflammation.
Frontiers in pharmacology
Conti F,Lazzara F,Romano GL,Platania CBM,Drago F,Bucolo C
61-7300 was used in Immunocytochemistry-immunofluorescence to investigate the potential protective effects of this methylxanthine in the retinal tissue using caffeine in vitro and in vivo paradigms of retinal inflammation.
Tue Jan 25 00:00:00 UTC 2022
The Na+, K+-ATPase β1 subunit regulates epithelial tight junctions via MRCKα.
JCI insight
Bai H,Zhou R,Barravecchia M,Norman R,Friedman A,Yu D,Lin X,Young JL,Dean DA
61-7300 was used in Western Blot to elucidate a novel mechanism by which NKA regulates epithelial tight junctions and identified potential drug targets for treating ARDS and other pulmonary diseases that are caused by barrier dysfunction.
Mon Feb 22 00:00:00 UTC 2021
Mechanisms of stretch-mediated skin expansion at single-cell resolution.
Nature
Aragona M,Sifrim A,Malfait M,Song Y,Van Herck J,Dekoninck S,Gargouri S,Lapouge G,Swedlund B,Dubois C,Baatsen P,Vints K,Han S,Tissir F,Voet T,Simons BD,Blanpain C
61-7300 was used in Immunohistochemistry to define the step-by-step mechanisms that control stretch-mediated tissue expansion at single-cell resolution in vivo.
Sat Aug 01 00:00:00 UTC 2020
Progenitor identification and SARS-CoV-2 infection in human distal lung organoids.
Nature
Salahudeen AA,Choi SS,Rustagi A,Zhu J,van Unen V,de la O SM,Flynn RA,Margalef-Català M,Santos AJM,Ju J,Batish A,Usui T,Zheng GXY,Edwards CE,Wagar LE,Luca V,Anchang B,Nagendran M,Nguyen K,Hart DJ,Terry JM,Belgrader P,Ziraldo SB,Mikkelsen TS,Harbury PB,Glenn JS,Garcia KC,Davis MM,Baric RS,Sabatti C,Amieva MR,Blish CA,Desai TJ,Kuo CJ
61-7300 was used in Immunohistochemistry-immunofluorescence to describe the development of a long-term feeder-free, chemically defined culture system for distal lung progenitors as organoids derived from single adult human alveolar epithelial type II (AT2) or KRT5+ basal cells.
Tue Dec 01 00:00:00 UTC 2020
Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart Disease.
Cell stem cell
Giacomelli E,Meraviglia V,Campostrini G,Cochrane A,Cao X,van Helden RWJ,Krotenberg Garcia A,Mircea M,Kostidis S,Davis RP,van Meer BJ,Jost CR,Koster AJ,Mei H,Míguez DG,Mulder AA,Ledesma-Terrón M,Pompilio G,Sala L,Salvatori DCF,Slieker RC,Sommariva E,de Vries AAF,Giera M,Semrau S,Tertoolen LGJ,Orlova VV,Bellin M,Mummery CL
61-7300 was used in Immunocytochemistry-immunoflourescence to demonstrate that tri-cellular combinations of hiPSC-derived CMs, cardiac fibroblasts (CFs), and cardiac endothelial cells also enhance maturation in easily constructed, scaffold-free, three-dimensional microtissues (MTs).
Thu Jun 04 00:00:00 UTC 2020
Brain tight junction protein expression in sepsis in an autopsy series.
Critical care (London, England)
Erikson K,Tuominen H,Vakkala M,Liisanantti JH,Karttunen T,Syrjälä H,Ala-Kokko TI
61-7300 was used in Immunohistochemistry to investigate the expression of tight junction proteins related to endothelial permeability in brain autopsy specimens in critically ill patients deceased with sepsis and analyzed the relationship of BBB damage with measures of systemic inflammation and systemic organ dysfunction.
Mon Jun 29 00:00:00 UTC 2020
MCH Neurons Regulate Permeability of the Median Eminence Barrier.
Neuron
Jiang H,Gallet S,Klemm P,Scholl P,Folz-Donahue K,Altmüller J,Alber J,Heilinger C,Kukat C,Loyens A,Müller-Fielitz H,Sundaram S,Schwaninger M,Prevot V,Brüning JC
61-7300 was used in Immunocytochemistry to reveal that MCH neurons directly regulate permeability of the ME barrier, linking the activity of energy state and sleep regulatory neurons to the regulation of hormone accessibility to the ARC.
Wed Jul 22 00:00:00 UTC 2020
Exosome-Mediated Crosstalk between Keratinocytes and Macrophages in Cutaneous Wound Healing.
ACS nano
Zhou X,Brown BA,Siegel AP,El Masry MS,Zeng X,Song W,Das A,Khandelwal P,Clark A,Singh K,Guda PR,Gorain M,Timsina L,Xuan Y,Jacobson SC,Novotny MV,Roy S,Agarwal M,Lee RJ,Sen CK,Clemmer DE,Ghatak S
61-7300 was used in Immunohistochemistry to provide insight wherein Exoκ-GFP is recognized as a major contributor that regulates macrophage trafficking and epithelial barrier properties postinjury.
Tue Oct 27 00:00:00 UTC 2020
Use of EpiAlveolar Lung Model to Predict Fibrotic Potential of Multiwalled Carbon Nanotubes.
ACS nano
Barosova H,Maione AG,Septiadi D,Sharma M,Haeni L,Balog S,O'Connell O,Jackson GR,Brown D,Clippinger AJ,Hayden P,Petri-Fink A,Stone V,Rothen-Rutishauser B
61-7300 was used in Immunohistochemistry to develop a three-dimensional alveolar model (EpiAlveolar) consisting of human primary alveolar epithelial cells, fibroblasts, and endothelial cells, with or without macrophages for predicting long-term responses to aerosols.
Tue Apr 28 00:00:00 UTC 2020
HIF-1α is involved in blood-brain barrier dysfunction and paracellular migration of bacteria in pneumococcal meningitis.
Acta neuropathologica
Devraj G,Guérit S,Seele J,Spitzer D,Macas J,Khel MI,Heidemann R,Braczynski AK,Ballhorn W,Günther S,Ogunshola OO,Mittelbronn M,Ködel U,Monoranu CM,Plate KH,Hammerschmidt S,Nau R,Devraj K,Kempf VAJ
61-7300 was used in Immunohistochemistry to demonstrate paracellular migration of bacteria across BBB and a critical role for HIF-1α/VEGF therein and hence propose targeting this pathway to prevent BBB dysfunction and ensuing brain damage in infections.
Sat Aug 01 00:00:00 UTC 2020
Inflammation of the Embryonic Choroid Plexus Barrier following Maternal Immune Activation.
Developmental cell
Cui J,Shipley FB,Shannon ML,Alturkistani O,Dani N,Webb MD,Sugden AU,Andermann ML,Lehtinen MK
61-7300 was used in Immunohistochemistry to present that the embryonic ChP forms a functional brain barrier that can mount an inflammatory response to external insults.
Mon Dec 07 00:00:00 UTC 2020
Human iPSC Modeling Reveals Mutation-Specific Responses to Gene Therapy in a Genotypically Diverse Dominant Maculopathy.
American journal of human genetics
Sinha D,Steyer B,Shahi PK,Mueller KP,Valiauga R,Edwards KL,Bacig C,Steltzer SS,Srinivasan S,Abdeen A,Cory E,Periyasamy V,Siahpirani AF,Stone EM,Tucker BA,Roy S,Pattnaik BR,Saha K,Gamm DM
61-7300 was used in Immunocytochemistry to test the potential of gene augmentation to treat Best disease, using induced pluripotent stem cell-derived retinal pigment epithelium (iPSC-RPE).
Thu Aug 06 00:00:00 UTC 2020
Engineering the mode of morphogenetic signal presentation to promote branching from salivary gland spheroids in 3D hydrogels.
Acta biomaterialia
Samuel RZ,Lei P,Nam K,Baker OJ,Andreadis ST
61-7300 was used in Immunocytochemistry to show that co-culture of rat parotid Par-C10 cells with mesenchymal stem cells produces migrating branches of gland cells into the L1p-FH and identify FGF-7 as the principal morphogenetic signal responsible for branching.
Sun Mar 15 00:00:00 UTC 2020
In-Depth Study of Transmembrane Mucins in Association with Intestinal Barrier Dysfunction During the Course of T Cell Transfer and DSS-Induced Colitis.
Journal of Crohn's & colitis
Breugelmans T,Van Spaendonk H,De Man JG,De Schepper HU,Jauregui-Amezaga A,Macken E,Lindén SK,Pintelon I,Timmermans JP,De Winter BY,Smet A
61-7300 was used in Immunohistochemistry to study the association between mucin expression, inflammation and intestinal permeability in experimental colitis.
Thu Jul 30 00:00:00 UTC 2020
Luteolin prevents irinotecan-induced intestinal mucositis in mice through antioxidant and anti-inflammatory properties.
British journal of pharmacology
Boeing T,de Souza P,Speca S,Somensi LB,Mariano LNB,Cury BJ,Ferreira Dos Anjos M,Quintão NLM,Dubuqoy L,Desreumax P,da Silva LM,de Andrade SF
61-7300 was used in Immunohistochemistry (Paraffin) to evaluate the activity of the flavonoid luteolin, which has never been tested for this purpose despite its biological potential.
Fri May 01 00:00:00 UTC 2020
Quantitative analysis and virulence phenotypes of atypical enteropathogenic Escherichia coli (EPEC) acquired from diarrheal stool samples from a Midwest US hospital.
Gut microbes
Carlino MJ,Kralicek SE,Santiago SA,Sitaraman LM,Harrington AT,Hecht GA
61-7300 was used in Immunocytochemistry to isolate and characterize EPEC from diarrhea samples identified as EPEC positive by BioFire Gastrointestinal Panel (GIP).
Mon Nov 09 00:00:00 UTC 2020
MiR-22-3p inhibits fibrotic cataract through inactivation of HDAC6 and increase of α-tubulin acetylation.
Cell proliferation
Wang X,Wang L,Sun Y,Chen B,Xiong L,Chen J,Huang M,Wu J,Tan X,Zheng Y,Huang S,Liu Y
61-7300 was used in Immunohistochemistry to suggest that miR-22-3p prevents lens fibrotic progression by targeting HDAC6 thereby promoting α-tubulin acetylation. The 'miR-22-HDAC6-α-tubulin (de)acetylation' signalling axis may be therapeutic targets for the treatment of fibrotic cataract.
Sun Nov 01 00:00:00 UTC 2020
Tanycyte ablation in the arcuate nucleus and median eminence increases obesity susceptibility by increasing body fat content in male mice.
Glia
Yoo S,Cha D,Kim S,Jiang L,Cooke P,Adebesin M,Wolfe A,Riddle R,Aja S,Blackshaw S
61-7300 was used in Immunohistochemistry to demonstrate a role for tanycytes in regulating fat metabolism.
Thu Oct 01 00:00:00 UTC 2020
Correlations between α-Linolenic Acid-Improved Multitissue Homeostasis and Gut Microbiota in Mice Fed a High-Fat Diet.
mSystems
Gao X,Chang S,Liu S,Peng L,Xie J,Dong W,Tian Y,Sheng J
61-7300 was used in ELISA to systematically investigate the effects of ALA on the body composition, glucose homeostasis, hyperlipidemia, metabolic endotoxemia and systemic inflammation, white adipose tissue (WAT) homeostasis, liver homeostasis, intestinal homeostasis, and gut microbiota of mice fed an HFD (HFD mice).
Tue Nov 03 00:00:00 UTC 2020
Metformin Protects ARPE-19 Cells from Glyoxal-Induced Oxidative Stress.
Oxidative medicine and cellular longevity
Qu S,Zhang C,Liu D,Wu J,Tian H,Lu L,Xu GT,Liu F,Zhang J
61-7300 was used in Immunocytochemistry-immunoflourescence to demonstrate that metformin maintained the barrier functions of RPE cells both in vivo and in vitro.
Wed Dec 16 00:00:00 UTC 2020
The JAK-Inhibitor Tofacitinib Rescues Human Intestinal Epithelial Cells and Colonoids from Cytokine-Induced Barrier Dysfunction.
Inflammatory bowel diseases
Sayoc-Becerra A,Krishnan M,Fan S,Jimenez J,Hernandez R,Gibson K,Preciado R,Butt G,McCole DF
61-7300 was used in Western Blotting to determine if JAK inhibition by tofacitinib can rescue cytokine-induced barrier dysfunction in intestinal epithelial cells (IECs).
Tue Feb 11 00:00:00 UTC 2020
RAB6 GTPase regulates mammary secretory function by controlling the activation of STAT5.
Development (Cambridge, England)
Cayre S,Faraldo MM,Bardin S,Miserey-Lenkei S,Deugnier MA,Goud B
61-7300 was used in Immunohistochemistry-immunofluorescence to reveal a crucial role for RAB6A/A' in the lactogenic function of the mammary gland and suggest that the trafficking pathways controlled by RAB6A/A' depend on cell-type specialization and tissue context.
Thu Oct 08 00:00:00 UTC 2020
Placental gene editing via trophectoderm-specific Tat-Cre/loxP recombination.
Development (Cambridge, England)
Ozguldez HO,Fan R,Bedzhov I
61-7300 was used in Immunohistochemistry-immunofluorescence to establish a simple, fast and efficient method for trophectodermal Tat-Cre/loxP recombination.
Fri Jul 03 00:00:00 UTC 2020
Proteoglycan IMPG2 Shapes the Interphotoreceptor Matrix and Modulates Vision.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Salido EM,Ramamurthy V
61-7300 was used in Immunohistochemistry (Frozen) to determine the role of these proteoglycans in retinal physiology and the pathologic mechanisms that lead to vision loss, we generated mouse models lacking IMPG1/IMPG2.
Wed May 13 00:00:00 UTC 2020
YAP Mediates Hair Cell Regeneration in Balance Organs of Chickens, But LATS Kinases Suppress Its Activity in Mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Rudolf MA,Andreeva A,Kozlowski MM,Kim CE,Moskowitz BA,Anaya-Rocha A,Kelley MW,Corwin JT
61-7300 was used in Immunohistochemistry to investigate whether the capacity to activate YAP correlates with regenerative capacity in acceleration-sensing utricles of chickens and mice of both sexes.
Wed May 13 00:00:00 UTC 2020
Axl Deficiency Promotes the Neuroinvasion of Japanese Encephalitis Virus by Enhancing IL-1α Production from Pyroptotic Macrophages.
Journal of virology
Wang ZY,Zhen ZD,Fan DY,Qin CF,Han DS,Zhou HN,Wang PG,An J
61-7300 was used in Immunohistochemistry-immunofluorescence to demonstrate the protective role of Axl in antagonizing severe Japanese encephalitis (JE) and shows that the use of IL-1α antagonist may prevent severe JE.
Mon Aug 17 00:00:00 UTC 2020
RBFOX1 Regulates the Permeability of the Blood-Tumor Barrier via the LINC00673/MAFF Pathway.
Molecular therapy oncolytics
Shen S,Yang C,Liu X,Zheng J,Liu Y,Liu L,Ma J,Ma T,An P,Lin Y,Cai H,Wang D,Li Z,Zhao L,Xue Y
61-7300 was used in Western Blotting to demonstrate that overexpression of RNA-binding Fox-1 homolog 1 (RBFOX1) increases blood-tumour barrier permeability through the LINC00673/MAFF pathway, potentially providing a future target to enhance blood-tumour barrier permeability.
Fri Jun 26 00:00:00 UTC 2020
Expression of R345W-Fibulin-3 Induces Epithelial-Mesenchymal Transition in Retinal Pigment Epithelial Cells.
Frontiers in cell and developmental biology
Zhou M,Weber SR,Zhao Y,Chen H,Barber AJ,Grillo SL,Wills CA,Wang HG,Hulleman JD,Sundstrom JM
61-7300 was used in Immunocytochemistry-immunoflourescence to investigate the effects of R345W-Fibulin-3 expression on RPE cell phenotype.
Fri Apr 15 00:00:00 UTC 2022
Ppp2r2a Knockout Mice Reveal That Protein Phosphatase 2A Regulatory Subunit, PP2A-B55α, Is an Essential Regulator of Neuronal and Epidermal Embryonic Development.
Frontiers in cell and developmental biology
Panicker N,Coutman M,Lawlor-O'Neill C,Kahl RGS,Roselli S,Verrills NM
61-7300 was used in Immunocytochemistry to report the generation of the first knockout mouse for the Ppp2r2a gene, encoding the PP2A-B55α regulatory subunit, using CRISPR/Cas9.
Tue Jul 30 00:00:00 UTC 2024
Optimisation of a Novel Bio-Substrate as a Treatment for Atrophic Age-Related Macular Degeneration.
Frontiers in bioengineering and biotechnology
McCormick R,Pearce I,Kaye S,Haneef A
61-7300 was used in Immunocytochemistry-immunoflourescence to demonstrate that novel bioactive substrates, poly(lactic acid-co-glycolic acid) or poly(glycolic acid), can act as a potential treatment for atrophic age-related macular degeneration (AMD) by restoring the waste/exchange pathway and preventing vision loss.
Mon Sep 28 00:00:00 UTC 2020
Enhancement of aberrantly modified integrin‑mediated cell motility in multicellular tumor spheroids.
International journal of oncology
Kim B,Im NR,Yang TD,Kim J,Jung KY,Kim TH,Baek SK
61-7300 was used in Western Blot to conclude that the alteration of E‚cadherin expression and presence of low‚MW β1 integrin in MTS may enhance cell motility via the upregulation of EMT signaling molecules that may be intensified by blocking E‚cadherin.
Mon Jun 01 00:00:00 UTC 2020
Loss of Rab6a in the small intestine causes lipid accumulation and epithelial cell death from lactation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Iwaki A,Moriwaki K,Sobajima T,Taniguchi M,Yoshimura SI,Kunii M,Kanda S,Kamada Y,Miyoshi E,Harada A
61-7300 was used in Immunohistochemistry to indicate that Rab6a plays a crucial role in regulating the lipid transport and maintaining tissue integrity.
Wed Jul 01 00:00:00 UTC 2020
Lnc00462717 regulates the permeability of the blood-brain tumor barrier through interaction with PTBP1 to inhibit the miR-186-5p/Occludin signaling pathway.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Zhang C,Zhang X,Wang J,Di F,Xue Y,Lin X,Zhang Y,Zhang H,Zhang Z,Gu Y
61-7300 was used in Western Blot to demonstrate if a novel molecular pathway in blood-brain tumor barrier exists that may provide a potential innovative strategy for glioma therapy.
Sat Aug 01 00:00:00 UTC 2020
Role of monocarboxylate transporters in regulating metabolic homeostasis in the outer retina: Insight gained from cell-specific Bsg deletion.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Han JYS,Kinoshita J,Bisetto S,Bell BA,Nowak RA,Peachey NS,Philp NJ
61-7300 was used in Immunocytochemistry to characterize mice with conditional deletion of Bsg in rods (RodΔBsg), cones (ConeBsg), or retinal pigment epithelial cells (RPEΔBsg) and suggest that the regulation of lactate levels in the RPE and the subretinal space is essential for the viability and function of photoreceptors.
Wed Apr 01 00:00:00 UTC 2020
Maltodextrin-induced intestinal injury in a neonatal mouse model.
Disease models & mechanisms
Singh P,Sanchez-Fernandez LL,Ramiro-Cortijo D,Ochoa-Allemant P,Perides G,Liu Y,Medina-Morales E,Yakah W,Freedman SD,Martin CR
61-7300 was used in Immunocytochemistry to test in neonatal mice the effect of maltodextrin, a complex carbohydrate, on the risk of intestinal injury.
Thu Aug 27 00:00:00 UTC 2020
Molecular mechanism mediating enteric bacterial translocation after severe burn: the role of cystic fibrosis transmembrane conductance regulator.
Burns & trauma
Liu X,Chen Y,You B,Peng Y,Chen Y,Yang Z,Zhang Y,Chen J
61-7300 was used in Immunocytochemistry to illustrate that CFTR and downstream signaling were critical in modulating the intestinal epithelial junction and EBT post severe burn.
Wed Apr 20 00:00:00 UTC 2022
Nimbolide inhibits tumor growth by restoring hepatic tight junction protein expression and reduced inflammation in an experimental hepatocarcinogenesis.
World journal of gastroenterology
Ram AK,Vairappan B,Srinivas BH
61-7300 was used in Western Blotting to investigate the effect of nimbolide on tight junction proteins, cell cycle progression, and hepatic inflammation in a mouse model of hepatocellular carcinoma.
Mon Dec 07 00:00:00 UTC 2020
Snail induces epithelial cell extrusion by regulating RhoA contractile signalling and cell-matrix adhesion.
Journal of cell science
Wee K,Hediyeh-Zadeh S,Duszyc K,Verma S,N Nanavati B,Khare S,Varma A,Daly RJ,Yap AS,Davis MJ,Budnar S
61-7300 was used in Western Blot, Immunocytochemistry to analyse the ability of Snail to promote the morphogenetic phenomenon of epithelial cell extrusion.
Mon Jul 06 00:00:00 UTC 2020
Snail induces epithelial cell extrusion by regulating RhoA contractile signalling and cell-matrix adhesion.
Journal of cell science
Wee K,Hediyeh-Zadeh S,Duszyc K,Verma S,N Nanavati B,Khare S,Varma A,Daly RJ,Yap AS,Davis MJ,Budnar S
61-7300 was used in Western Blot, Immunocytochemistry to analyse the ability of Snail to promote the morphogenetic phenomenon of epithelial cell extrusion.
Mon Jul 06 00:00:00 UTC 2020
Inflammation-like changes in the urothelium of Lifr-deficient mice and LIFR-haploinsufficient humans with urinary tract anomalies.
Human molecular genetics
Christians A,Weiss AC,Martens H,Klopf MG,Hennies I,Haffner D,Kispert A,Weber RG
61-7300 was used in Immunocytochemistry to suggest that LIFR signaling is required in the epithelium of the urinary tract to suppress an antimicrobial response under homeostatic conditions and that genetically induced inflammation-like changes underlie CAKUT pathogenesis in Lifr deficiency and LIFR haploinsufficiency.
Fri May 08 00:00:00 UTC 2020
Heterozygous Loss of Yap1 in Mice Causes Progressive Cataracts.
Investigative ophthalmology & visual science
Lu Q,Zhang Y,Kasetti RB,Gaddipati S,Cvm NK,Borchman D,Li Q
61-7300 was used in Immunohistochemistry to determine that Yap1 haplodeficiency leads to cataracts in mice due to a disruption in Crim1 expression which alters lens epithelial cell proliferation.
Thu Oct 01 00:00:00 UTC 2020
Systemic Inflammation by Collagen-Induced Arthritis Affects the Progression of Age-Related Macular Degeneration Differently in Two Mouse Models of the Disease.
Investigative ophthalmology & visual science
Schnabolk G,Obert E,Banda NK,Rohrer B
61-7300 was used in Immunohistochemistry to suggest systemic inflammation by CIA results in increased pathology in a dry AMD model, whereas it reduces lesions in a wet AMD model.
Tue Dec 01 00:00:00 UTC 2020
Expression of Tight Junction Proteins According to Functional Dyspepsia Subtype and Sex.
Journal of neurogastroenterology and motility
Lee JY,Kim N,Choi YJ,Park JH,Ashktorab H,Smoot DT,Lee DH
61-7300 was used in Western Blotting to determine whether the expression of tight junction proteins (TJPs) differs depending on the subtype of functional dyspepsia (FD) and sex.
Thu Apr 30 00:00:00 UTC 2020
Expression of Neurotrophic Factors, Tight Junction Proteins, and Cytokines According to the Irritable Bowel Syndrome Subtype and Sex.
Journal of neurogastroenterology and motility
Lee JY,Kim N,Park JH,Nam RH,Lee SM,Song CH,Kim G,Na HY,Choi YJ,Kim JJ,Lee DH
61-7300 was used in Immunohistochemistry to study neurotrophic factors and IL-1β in irritable bowel syndrome constipation and ZO-1 in female irritable bowel syndrome diarrhoea.
Thu Jan 30 00:00:00 UTC 2020
Expression of Neurotrophic Factors, Tight Junction Proteins, and Cytokines According to the Irritable Bowel Syndrome Subtype and Sex.
Journal of neurogastroenterology and motility
Lee JY,Kim N,Park JH,Nam RH,Lee SM,Song CH,Kim G,Na HY,Choi YJ,Kim JJ,Lee DH
61-7300 was used in Immunohistochemistry to study neurotrophic factors and IL-1β in irritable bowel syndrome constipation and ZO-1 in female irritable bowel syndrome diarrhoea.
Thu Jan 30 00:00:00 UTC 2020
Pioglitazone Attenuates Experimental Colitis-Associated Hyperalgesia through Improving the Intestinal Barrier Dysfunction.
Inflammation
Huang Y,Wang C,Tian X,Mao Y,Hou B,Sun Y,Gu X,Ma Z
61-7300 was used in Western Blotting to investigate biological roles of pioglitazone in relieving colitis-associated pain hypersensitivity by a PPARγ tight junction protein-dependent mechanism during the course of dextran sodium sulfate (DSS)-induced intestinal inflammation.
Wed Apr 01 00:00:00 UTC 2020
Synergistic interactions of PlGF and VEGF contribute to blood-retinal barrier breakdown through canonical NFκB activation.
Experimental cell research
Lennikov A,Mukwaya A,Fan L,Saddala MS,De Falco S,Huang H
61-7300 was used in Western Blot, Immunohistochemistry to investigate the role of placental growth factor/vascular endothelial growth factor (PlGF-VEGF) heterodimers involved in the blood-retinal barrier breakdown and the associated mechanism.
Tue Dec 15 00:00:00 UTC 2020
Synergistic interactions of PlGF and VEGF contribute to blood-retinal barrier breakdown through canonical NFκB activation.
Experimental cell research
Lennikov A,Mukwaya A,Fan L,Saddala MS,De Falco S,Huang H
61-7300 was used in Western Blot, Immunohistochemistry to investigate the role of placental growth factor/vascular endothelial growth factor (PlGF-VEGF) heterodimers involved in the blood-retinal barrier breakdown and the associated mechanism.
Tue Dec 15 00:00:00 UTC 2020
Synergistic interactions of PlGF and VEGF contribute to blood-retinal barrier breakdown through canonical NFκB activation.
Experimental cell research
Lennikov A,Mukwaya A,Fan L,Saddala MS,De Falco S,Huang H
61-7300 was used in Western Blot, Immunohistochemistry to investigate the role of placental growth factor/vascular endothelial growth factor (PlGF-VEGF) heterodimers involved in the blood-retinal barrier breakdown and the associated mechanism.
Tue Dec 15 00:00:00 UTC 2020
Synergistic interactions of PlGF and VEGF contribute to blood-retinal barrier breakdown through canonical NFκB activation.
Experimental cell research
Lennikov A,Mukwaya A,Fan L,Saddala MS,De Falco S,Huang H
61-7300 was used in Western Blot, Immunohistochemistry to investigate the role of placental growth factor/vascular endothelial growth factor (PlGF-VEGF) heterodimers involved in the blood-retinal barrier breakdown and the associated mechanism.
Tue Dec 15 00:00:00 UTC 2020
Genetic Deletion or Pharmacological Inhibition of Cyclooxygenase-2 Reduces Blood-Brain Barrier Damage in Experimental Ischemic Stroke.
Frontiers in neurology
Yang C,Yang Y,DeMars KM,Rosenberg GA,Candelario-Jalil E
61-7300 was used in Western Blotting to show that MMP-9 is an important downstream effector contributing to COX-2-mediated neurovascular damage in ischemic stroke.
Mon Sep 28 00:00:00 UTC 2020
Prevention of excessive exercise-induced adverse effects in rats with Bacillus subtilis BSB3.
Journal of applied microbiology
Ducray HAG,Globa L,Pustovyy O,Roberts MD,Rudisill M,Vodyanoy V,Sorokulova I
61-7300 was used in Immunohistochemistry-immunofluorescence to characterize efficacy of the Bacillus subtilis BSB3 (BSB3) strain in the prevention of excessive exercise-induced side effects and in maintaining stability of the gut microbiota.
Wed Apr 01 00:00:00 UTC 2020
TGF-β1 relieves epithelial-mesenchymal transition reduction in hypospadias induced by DEHP in rats.
Pediatric research
Zhou Y,Huang F,Liu Y,Li D,Zhou Y,Shen L,Long C,Liu X,Wei G
61-7300 was used in Immunohistochemistry (Paraffin) to reveal the preventative effect of TGF-β1 in hypospadias induced by DEHP via the reduction of EMT.
Sun Mar 01 00:00:00 UTC 2020
The HIF target ATG9A is essential for epithelial barrier function and tight junction biogenesis.
Molecular biology of the cell
Dowdell AS,Cartwright IM,Goldberg MS,Kostelecky R,Ross T,Welch N,Glover LE,Colgan SP
61-7300 was used in Immunocytochemistry to identify HIF transcriptional targets in Intestinal epithelial cells.
Tue Sep 15 00:00:00 UTC 2020
Transition of podosomes into zipper-like structures in macrophage-derived multinucleated giant cells.
Molecular biology of the cell
Balabiyev A,Podolnikova NP,Mursalimov A,Lowry D,Newbern JM,Roberson RW,Ugarova TP
61-7300 was used in Immunocytochemistry to reveal hitherto unrecognized actin-based zipper-like structures (ZLSs) that arise between MGCs formed on the surface of implanted biomaterials.
Sat Aug 15 00:00:00 UTC 2020
Effect of ultra‑wide‑band electromagnetic pulses on blood‑brain barrier permeability in rats.
Molecular medicine reports
Gao P,Chen Q,Hu J,Lin Y,Lin J,Guo Q,Yue H,Zhou Y,Zeng L,Li J,Ding G,Guo G
61-7300 was used in Immunohistochemistry to develop a safe and effective technology that opens the blood brain barrier (BBB) to improve treatment options for CNS diseases.
Thu Oct 01 00:00:00 UTC 2020
Eugenol attenuates inflammatory response and enhances barrier function during lipopolysaccharide-induced inflammation in the porcine intestinal epithelial cells.
Journal of animal science
Hui Q,Ammeter E,Liu S,Yang R,Lu P,Lahaye L,Yang C
61-7300 was used in Western Blot to a low dose of eugenol attenuated inflammatory responses and enhanced selectively permeable barrier function during LPS-induced inflammation in the IPEC-J2 cell line.
Sat Aug 01 00:00:00 UTC 2020
Cisplatin-Induced Stria Vascularis Damage Is Associated with Inflammation and Fibrosis.
Neural plasticity
Zhang N,Cai J,Xu L,Wang H,Liu W
61-7300 was used in Immunohistochemistry-immunofluorescence to determine that cisplantin induces stria vascularis damage via fibrosis and inflammation and generates complex expression changes of cell junctions.
Thu Sep 09 00:00:00 UTC 2021
Exosome/microvesicle content is altered in leucine-rich repeat kinase 2 mutant induced pluripotent stem cell-derived neural cells.
The Journal of comparative neurology
Candelario KM,Balaj L,Zheng T,Skog J,Scheffler B,Breakefield X,Schüle B,Steindler DA
61-7300 was used in Immunocytochemistry to show that EMVs have the potential to serve as sensitive biomarkers of disease state in both idiopathic and gene-identified PD patients and that following gene-editing, EMVs reflect a corrected state.
Fri May 01 00:00:00 UTC 2020
A Semiautomated, Phenotypic, In Vitro Scratch Assay for Assessing Retinal Pigment Epithelial Cell Wound Healing.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
Storm T,Wilson I,Campbell R,Bolinches-Amorós A,Russell AJ,Davies SG,Barnard AR,MacLaren RE
61-7300 was used in Immunocytochemistry to establish a semiautomated, in vitro, wound healing assay workflow for targeted screening of compounds able to influence RPE wound healing.
Fri May 01 00:00:00 UTC 2020
An Intestine-on-a-Chip Model of Plug-and-Play Modularity to Study Inflammatory Processes.
SLAS technology
Gijzen L,Marescotti D,Raineri E,Nicolas A,Lanz HL,Guerrera D,van Vught R,Joore J,Vulto P,Peitsch MC,Hoeng J,Lo Sasso G,Kurek D
61-7300 was used in Immunohistochemistry to develop an immunocompetent 3D perfused intestine-on-a-chip platform for studying intestinal inflammation.
Tue Dec 01 00:00:00 UTC 2020
Hypertonic saline improves brain edema resulting from traumatic brain injury by suppressing the NF-κB/IL-1β signaling pathway and AQP4.
Experimental and therapeutic medicine
Zhang H,Liu J,Liu Y,Su C,Fan G,Lu W,Feng L
61-7300 was used in Western Blotting to investigate the therapeutic mechanism of hypertonic saline (HS) in brain edema in terms of aquaporins and inflammatory factors.
Sun Nov 01 00:00:00 UTC 2020
Sigma-1 receptor activation-induced glycolytic ATP production and endothelial barrier enhancement.
Microcirculation (New York, N.Y. : 1994)
Motawe ZY,Farsaei F,Abdelmaboud SS,Cuevas J,Breslin JW
61-7300 was used in Immunocytochemistry to suggest that endothelial σ1 may prove beneficial as a novel therapeutic target for reducing microvascular hyperpermeability and counteracting mitochondrial dysfunction.
Sat Aug 01 00:00:00 UTC 2020
Simvastatin, edaravone and dexamethasone protect against kainate-induced brain endothelial cell damage.
Fluids and barriers of the CNS
Barna L,Walter FR,Harazin A,Bocsik A,Kincses A,Tubak V,Jósvay K,Zvara Á,Campos-Bedolla P,Deli MA
61-7300 was used in Immunohistochemistry to examine the direct effects of kainate on cultured cells of the blood-brain barrier and to test three anti-inflammatory and antioxidant drugs used in clinical practice, simvastatin, edaravone and dexamethasone, to protect against kainate-induced changes.
Mon Feb 10 00:00:00 UTC 2020
Intestinal Enteroid Culture for Human Astroviruses.
Bio-protocol
Owusu IA,Mirabelli C,Kolawole AO
61-7300 was used in Immunocytochemistry to describe HAstV infection in epithelium-only human intestinal enteroids (HIE) isolated from biopsy-derived intestinal crypts.
Mon Jul 20 00:00:00 UTC 2020
Doxorubicin increases permeability of murine small intestinal epithelium and cultured T84 monolayers.
Scientific reports
Cray P,Sheahan BJ,Cortes JE,Dekaney CM
61-7300 was used in Immunocytochemistry-immunoflourescence to conclude that doxorubicin increases paracellular transit of macromolecules through intestinal epithelium.
Tue Dec 08 00:00:00 UTC 2020
Reduced Post-ischemic Brain Injury in Transient Receptor Potential Vanilloid 4 Knockout Mice.
Frontiers in neuroscience
Tanaka K,Matsumoto S,Yamada T,Yamasaki R,Suzuki M,Kido MA,Kira JI
61-7300 was used in Western Blotting to clarify whether brain injury following transient middle cerebral artery occlusion (tMCAO) is ameliorated in Transient receptor potential vanilloid 4 knockout (Trpv4-/- ) mice.
Thu Apr 14 00:00:00 UTC 2022
Tightening the retinal glia limitans attenuates neuroinflammation after optic nerve injury.
Glia
Lefevere E,Salinas-Navarro M,Andries L,Noterdaeme L,Etienne I,Van Wonterghem E,Vinckier S,Davis BM,Van Bergen T,Van Hove I,Movahedi K,Vandenbroucke RE,Moons L,De Groef L
61-7300 was used in Immunohistochemistry-immunofluorescence to investigate the structure and function of the glia limitans, and reveal that the blood-retina barrier and glia limitans function as a coordinated double barrier to limit infiltration of leukocytes and immune molecules.
Tue Dec 01 00:00:00 UTC 2020
Retinal capillary degeneration and blood-retinal barrier disruption in murine models of Alzheimer's disease.
Acta neuropathologica communications
Shi H,Koronyo Y,Fuchs DT,Sheyn J,Wawrowsky K,Lahiri S,Black KL,Koronyo-Hamaoui M
61-7300 was used in Western Blotting to evaluate the retinas of transgenic APPSWE/PS1ΔE9 mouse models of AD (ADtg mice) and wild-type mice at different ages for capillary degeneration, PDGFRβ expression, vascular amyloidosis, permeability and inner BRB tight-junction molecules.
Mon Nov 23 00:00:00 UTC 2020
Significant Changes in Trans-Epithelial Barrier Proteins of Adenoid Tissue with Atopic Status in Children.
Turkish thoracic journal
Yılmaz Ö,Şimşek Y,İnan S,Buga Ö,Eskiizmir G,Pınar E,Kanık E,Yüksel H
61-7300 was used in Immunohistochemistry to evaluate the relationship between the status of cross-epithelial barrier elements in adenoid tissue lymphoepithelium and inhalant allergen sensitization.
Wed Jul 01 00:00:00 UTC 2020
The blood-brain barrier is disrupted in Machado-Joseph disease/spinocerebellar ataxia type 3: evidence from transgenic mice and human post-mortem samples.
Acta neuropathologica communications
Duarte Lobo D,Nobre RJ,Oliveira Miranda C,Pereira D,Castelhano J,Sereno J,Koeppen A,Castelo-Branco M,Pereira de Almeida L
61-7300 was used in Western Blotting to demonstrate that blood-brain barrier (BBB) impairment in Machado-Joseph disease/SCA type 3 (MJD/SCA3).
Mon Aug 31 00:00:00 UTC 2020
Targeting NOX4 alleviates sepsis-induced acute lung injury via attenuation of redox-sensitive activation of CaMKII/ERK1/2/MLCK and endothelial cell barrier dysfunction.
Redox biology
Jiang J,Huang K,Xu S,Garcia JGN,Wang C,Cai H
61-7300 was used in Western Blotting to identify a novel, selective and causal role of NOX4 (versus other NOX isoforms) in inducing lung EC barrier dysfunction and injury/mortality in a preclinical CLP-induced septic model, which involves redox-sensitive activation of CaMKII/ERK1/2/MLCK pathway. Targeting NOX4 may therefore prove to an innovative therapeutic option that is markedly effective in treating ALI/ARDS.
Tue Sep 01 00:00:00 UTC 2020
Loss of mural cell-derived laminin aggravates hemorrhagic brain injury.
Journal of neuroinflammation
Gautam J,Xu L,Nirwane A,Nguyen B,Yao Y
61-7300 was used in Immunohistochemistry and Western Blotting to suggest that mural cell-derived laminin attenuates blood-brain barrier (BBB) damage in intracerebral hemorrhage (ICH) via decreasing caveolin-1 and thus transcytosis, regulates brain water homeostasis, and plays a beneficial role in ICH.
Mon Apr 06 00:00:00 UTC 2020
Loss of mural cell-derived laminin aggravates hemorrhagic brain injury.
Journal of neuroinflammation
Gautam J,Xu L,Nirwane A,Nguyen B,Yao Y
61-7300 was used in Immunohistochemistry and Western Blotting to suggest that mural cell-derived laminin attenuates blood-brain barrier (BBB) damage in intracerebral hemorrhage (ICH) via decreasing caveolin-1 and thus transcytosis, regulates brain water homeostasis, and plays a beneficial role in ICH.
Mon Apr 06 00:00:00 UTC 2020
MiR-34a Interacts with Cytochrome c and Shapes Stroke Outcomes.
Scientific reports
Hu H,Hone EA,Provencher EAP,Sprowls SA,Farooqi I,Corbin DR,Sarkar SN,Hollander JM,Lockman PR,Simpkins JW,Ren X
61-7300 was used in Immunohistochemistry to provide the first description of miR-34a affecting stroke outcomes and may lead to discovery of new mechanisms and treatments for cerebrovascular and neurodegenerative diseases such as stroke.
Mon Feb 24 00:00:00 UTC 2020
KLF4 alleviates cerebral vascular injury by ameliorating vascular endothelial inflammation and regulating tight junction protein expression following ischemic stroke.
Journal of neuroinflammation
Zhang X,Wang L,Han Z,Dong J,Pang D,Fu Y,Li L
61-7300 was used in Western Blotting to examine the correlation between serum levels of CAMs/KLF4 and infarct volume in acute CIS patients.
Tue Apr 07 00:00:00 UTC 2020
Experimental design of a culture approach for corneal endothelial cells of New Zealand white rabbit.
Heliyon
Montalvo-Parra MD,Vidal-Paredes IA,Calzada-Rodríguez CE,Cárdenas-Rodríguez IT,Torres-Guerrero GF,Gómez-Elizondo D,López-Martínez M,Zavala J,Valdez-García JE
61-7300 was used in Immunocytochemistry to set a culture approach to guarantee CEC expansion, as well as functionality for their potential use in tissue engineering and in vivo analyses.
Thu Oct 01 00:00:00 UTC 2020
Neutrophil Extracellular Traps Impair Intestinal Barrier Function during Experimental Colitis.
Biomedicines
Lin EY,Lai HJ,Cheng YK,Leong KQ,Cheng LC,Chou YC,Peng YC,Hsu YH,Chiang HS
61-7300 was used in Immunohistochemistry-immunofluorescence to study the effects of intravenous administration of DNase I on NET activity and how this impacts gut epithelial barrier function in acute colitis.
Wed Aug 05 00:00:00 UTC 2020
Novel developmental bases for the evolution of hypobranchial muscles in vertebrates.
BMC biology
Kusakabe R,Higuchi S,Tanaka M,Kadota M,Nishimura O,Kuratani S
61-7300 was used in Immunohistochemistry to explore the evolution of vertebrate hypobranchial muscle.
Wed Sep 09 00:00:00 UTC 2020
Increased intestinal permeability and gut dysbiosis in the R6/2 mouse model of Huntington's disease.
Scientific reports
Stan TL,Soylu-Kucharz R,Burleigh S,Prykhodko O,Cao L,Franke N,Sjögren M,Haikal C,Hållenius F,Björkqvist M
61-7300 was used in Western Blotting to show an increased intestinal permeability and dysbiosis in R6/2 mice and further studies investigating the clinical relevance of these findings are warranted.
Mon Oct 26 00:00:00 UTC 2020
The detrimental effects of stress-induced glucocorticoid exposure on mouse uterine receptivity and decidualization.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Zheng HT,Zhang HY,Chen ST,Li MY,Fu T,Yang ZM
61-7300 was used in Western Blotting to explore the effects of GCs exposure on uterine receptivity, decidualization, and their underlying mechanisms in mice.
Sun Nov 01 00:00:00 UTC 2020
Jedi-1 deficiency increases sensory neuron excitability through a non-cell autonomous mechanism.
Scientific reports
Trevisan AJ,Bauer MB,Brindley RL,Currie KPM,Carter BD
61-7300 was used in Immunohistochemistry to investigate the function of this receptor in vivo using Jedi-1 null mice.
Tue Jan 28 00:00:00 UTC 2020
The Combination of Scutellaria baicalensis Georgi and Sophora japonica L. ameliorate Renal Function by Regulating Gut Microbiota in Spontaneously Hypertensive Rats.
Frontiers in pharmacology
Guan Y,Chen K,Quan D,Kang L,Yang D,Wu H,Yan M,Wu S,Lv L,Zhang G
61-7300 was used in Western Blotting to demonstrate the positive effects of Scutellaria baicalensis Georgi (SB) and Sophora japonica L. (SJ) in a rat model of hypertensive nephropathy, indicated that the treatment of SB and SJ by improving the intestinal barrier function, increasing SCFAs, reducing inflammation, decreasing IS, and inhibiting oxidative stress reactions.
Wed Mar 03 00:00:00 UTC 2021
Modulation of NLRP3 Inflammasome Attenuated Inflammatory Response Associated to Diarrhea-Predominant Irritable Bowel Syndrome.
Biomedicines
Scuderi SA,Casili G,Lanza M,Filippone A,Paterniti I,Esposito E,Campolo M
61-7300 was used in Immunohistochemistry to demonstrate that IBS-D induced NLRP3 inflammasome pathway activation, accompanied by the production of proinflammatory response.
Fri Nov 20 00:00:00 UTC 2020
The tight junction protein TJP1 regulates the feeding-modulated hepatic circadian clock.
Nature communications
Liu Y,Zhang Y,Li T,Han J,Wang Y
61-7300 was used in Western Blot to provide a previously uncharacterized mechanistic insight into how feeding modulates the hepatic circadian clock.
Thu Jan 30 00:00:00 UTC 2020
Connexin36 localization along axon initial segments in the mammalian CNS.
International journal of physiology, pathophysiology and pharmacology
Thomas D,Senecal JM,Lynn BD,Traub RD,Nagy JI
61-7300 was used in Immunocytochemistry-immunoflourescence to add to the neuronal subcellular locations at which Cx36 is deployed, and raise possibilities for its involvement in novel functions in the AIS compartment.
Fri Jan 29 00:00:00 UTC 2021
Isolation of Mouse Cerebral Microvasculature for Molecular and Single-Cell Analysis.
Frontiers in cellular neuroscience
Paraiso HC,Wang X,Kuo PC,Furnas D,Scofield BA,Chang FL,Yen JH,Yu IC
61-7300 was used in Western Blotting to demonstrate that cells in the single-cell suspensions are highly viable and suitable for single-cell RNA-sequencing analysis.
Mon Sep 28 00:00:00 UTC 2020
Isolation of Mouse Cerebral Microvasculature for Molecular and Single-Cell Analysis.
Frontiers in cellular neuroscience
Paraiso HC,Wang X,Kuo PC,Furnas D,Scofield BA,Chang FL,Yen JH,Yu IC
61-7300 was used in Western Blotting to demonstrate that cells in the single-cell suspensions are highly viable and suitable for single-cell RNA-sequencing analysis.
Mon Sep 28 00:00:00 UTC 2020
mtDNA-STING pathway promotes necroptosis-dependent enterocyte injury in intestinal ischemia reperfusion.
Cell death & disease
Zhang X,Wu J,Liu Q,Li X,Li S,Chen J,Hong Z,Wu X,Zhao Y,Ren J
61-7300 was used in Immunohistochemistry to indicate that mtDNA-STING signaling can contribute to intestinal I/R injury by promoting IEC necroptosis.
Fri Dec 11 00:00:00 UTC 2020
Specific Frequency Electroacupuncture Stimulation Transiently Enhances the Permeability of the Blood-Brain Barrier and Induces Tight Junction Changes.
Frontiers in neuroscience
Zhang S,Gong P,Zhang J,Mao X,Zhao Y,Wang H,Gan L,Lin X
61-7300 was used in Western Blot, Immunohistochemistry to propose that specific frequency EA can transiently open the BBB and may be related to the change of tight junctions (TJ).
Sat Oct 31 00:00:00 UTC 2020
Specific Frequency Electroacupuncture Stimulation Transiently Enhances the Permeability of the Blood-Brain Barrier and Induces Tight Junction Changes.
Frontiers in neuroscience
Zhang S,Gong P,Zhang J,Mao X,Zhao Y,Wang H,Gan L,Lin X
61-7300 was used in Western Blot, Immunohistochemistry to propose that specific frequency EA can transiently open the BBB and may be related to the change of tight junctions (TJ).
Sat Oct 31 00:00:00 UTC 2020
A Method for Developing Novel 3D Cornea-on-a-Chip Using Primary Murine Corneal Epithelial and Endothelial Cells.
Frontiers in pharmacology
Bai J,Fu H,Bazinet L,Birsner AE,D'Amato RJ
61-7300 was used in Immunocytochemistry-immunoflourescence to describe a novel method for a primary cell-based corneal microphysiological system which aims to recapitulate the basic functions of the in vivo cornea and to study topically applied ocular drug permeation.
Mon Sep 28 00:00:00 UTC 2020
Development of a human in vitro blood-brain tumor barrier model of diffuse intrinsic pontine glioma to better understand the chemoresistance.
Fluids and barriers of the CNS
Deligne C,Hachani J,Duban-Deweer S,Meignan S,Leblond P,Carcaboso AM,Sano Y,Shimizu F,Kanda T,Gosselet F,Dehouck MP,Mysiorek C
61-7300 was used in Immunocytochemistry to develop a syngeneic human blood-brain tumor barrier model to understand how the presence of diffuse intrinsic pontine glioma(DIPG) impacts the structure and function of brain capillary endothelial cells.
Tue Jun 02 00:00:00 UTC 2020
Preliminary Assessment of the Mucosal Toxicity of Tea Tree (Melaleuca alternifolia) and Rosemary (Rosmarinus officinalis) Essential Oils on Novel Porcine Uterus Models.
International journal of molecular sciences
Bertocchi M,Rigillo A,Elmi A,Ventrella D,Aniballi C,G Scorpio D,Scozzoli M,Bettini G,Forni M,Bacci ML
61-7300 was used in Immunohistochemistry (Paraffin) to develop and validate in vitro and ex vivo models of porcine uterine mucosa for the evaluation of mucosal toxicity of essential oils.
Sat May 09 00:00:00 UTC 2020
Cell-Type-Specific Complement Profiling in the ABCA4-/- Mouse Model of Stargardt Disease.
International journal of molecular sciences
Jabri Y,Biber J,Diaz-Lezama N,Grosche A,Pauly D
61-7300 was used in Immunohistochemistry to suggest an overactive complement cascade in the ABCA4-/- retinae that possibly contributes to pathological alterations, including microglial activation and neurodegeneration.
Wed Nov 11 00:00:00 UTC 2020
Topical Delivery of Curcumin by Choline-Calix[4]arene-Based Nanohydrogel Improves Its Therapeutic Effect on a Psoriasis Mouse Model.
International journal of molecular sciences
Filippone A,Consoli GML,Granata G,Casili G,Lanza M,Ardizzone A,Cuzzocrea S,Esposito E,Paterniti I
61-7300 was used in Immunohistochemistry to investigate the therapeutic efficacy of a nanohydrogel drug delivery system in treating psoriasis.
Fri Jul 17 00:00:00 UTC 2020
Interferon-β alleviates delayed tPA-induced adverse effects via modulation of MMP3/9 production in ischemic stroke.
Blood advances
Kuo PC,Weng WT,Scofield BA,Furnas D,Paraiso HC,Intriago AJ,Bosi KD,Yu IC,Yen JH
61-7300 was used in Immunohistochemistry to investigate whether Interferon-β could be coadministered with Tissue plasminogen activator tPA to alleviate delayed tPA-induced adverse effects.
Tue Sep 22 00:00:00 UTC 2020
Non-Human Primate Blood-Brain Barrier and In Vitro Brain Endothelium: From Transcriptome to the Establishment of a New Model.
Pharmaceutics
Chaves C,Do TM,Cegarra C,Roudières V,Tolou S,Thill G,Rocher C,Didier M,Lesuisse D
61-7300 was used in Immunocytochemistry to compare the blood-brain barrier features of NHP transciptome of isolated brain microcapillaries and in vitro-selected brain endothelial cells.
Wed Oct 14 00:00:00 UTC 2020
Challenging human somatic testicular cell reassembly by protein kinase inhibition -setting up a functional in vitro test system.
Scientific reports
Mincheva M,Wistuba J,Brenker C,Schlatt S
61-7300 was used in Immunohistochemistry-immunofluorescence to demonstrate the responsiveness of primary human testicular cells to experimental perturbations by exogenous administration of a protein kinase inhibitor known to interfere with in vitro cord formation.
Tue Jun 02 00:00:00 UTC 2020
Behavioral and neurophysiological taste responses to sweet and salt are diminished in a model of subclinical intestinal inflammation.
Scientific reports
Pittman DW,Dong G,Brantly AM,He L,Nelson TS,Kogan S,Powell J,McCluskey LP
61-7300 was used in Immunohistochemistry (Frozen) to investigate the effect of gut inflammation on gut-taste bud interactions using lipopolysccharides.
Mon Oct 19 00:00:00 UTC 2020
Conjugation of Therapeutic PSD-95 Inhibitors to the Cell-Penetrating Peptide Tat Affects Blood-Brain Barrier Adherence, Uptake, and Permeation.
Pharmaceutics
Kristensen M,Kucharz K,Felipe Alves Fernandes E,Strømgaard K,Schallburg Nielsen M,Cederberg Helms HC,Bach A,Ulrikkaholm Tofte-Hansen M,Irene Aldana Garcia B,Lauritzen M,Brodin B
61-7300 was used in Immunocytochemistry to demonstrate that attachment of NR2B9c or N-dimer to Tat affects both the chemical stability and the ability of the resulting construct to interact with and permeate the BBB.
Tue Jul 14 00:00:00 UTC 2020
Differential expression of cell-cell junction proteins in the testis, epididymis, and ductus deferens of domestic turkeys (Meleagris gallopavo) with white and yellow semen.
Poultry science
Pardyak L,Kaminska A,Brzoskwinia M,Hejmej A,Kotula-Balak M,Jankowski J,Ciereszko A,Bilinska B
61-7300 was used in Immunohistochemistry (Paraffin) to provide new information on the localization and expression of cell-cell junction proteins in the testis, epididymis, and ductus deferens of domestic turkeys, and compare expression of junctional protein genes between 2 turkey population, one that produces white normal semen (WNS) and the other that produces yellow abnormal semen.
Wed Jan 01 00:00:00 UTC 2020
Amyloid-β Precursor Protein APP Down-Regulation Alters Actin Cytoskeleton-Interacting Proteins in Endothelial Cells.
Cells
Ristori E,Cicaloni V,Salvini L,Tinti L,Tinti C,Simons M,Corti F,Donnini S,Ziche M
61-7300 was used in Western Blot to identify and investigate major cellular targets of APP down-regulation in endothelial cells.
Thu Nov 19 00:00:00 UTC 2020
Tracking cells in epithelial acini by light sheet microscopy reveals proximity effects in breast cancer initiation.
eLife
Alladin A,Chaible L,Garcia Del Valle L,Sabine R,Loeschinger M,Wachsmuth M,Hériché JK,Tischer C,Jechlinger M
61-7300 was used in Immunocytochemistry-immunoflourescence to study how tumors arise from a malignant cells within an intact epithelium.
Tue Jul 21 00:00:00 UTC 2020
Epithelial-specific isoforms of protein 4.1R promote adherens junction assembly in maturing epithelia.
The Journal of biological chemistry
Huang SC,Liang JY,Vu LV,Yu FH,Ou AC,Ou JP,Zhang HS,Burnett KM,Benz EJ
61-7300 was used in Western Blotting to describe a role for epithelial-specific isoforms containing exon 17b and excluding exon 16 4.1R (4.1R+17b) in epithelial adherens junctions.
Fri Jan 03 00:00:00 UTC 2020
Blocking Connexin-43 mediated hemichannel activity protects against early tubular injury in experimental chronic kidney disease.
Cell communication and signaling : CCS
Price GW,Chadjichristos CE,Kavvadas P,Tang SCW,Yiu WH,Green CR,Potter JA,Siamantouras E,Squires PE,Hills CE
61-7300 was used in Immunohistochemistry to suggest that Cx43 mediated ATP release represents an initial trigger in early tubular injury via its actions on the adherens and tight junction complex.
Mon May 25 00:00:00 UTC 2020
Transcriptomic profiles reveal differences in zinc metabolism, inflammation, and tight junction proteins in duodenum from cholesterol gallstone subjects.
Scientific reports
Riveras E,Azocar L,Moyano TC,Ocares M,Molina H,Romero D,Roa JC,Valbuena JR,Gutiérrez RA,Miquel JF
61-7300 was used in Immunohistochemistry-immunofluorescence to identify the role of the small intestine in GSD pathogenesis.
Mon May 04 00:00:00 UTC 2020
Astragalus mongholicus Bunge and Panax Notoginseng Formula (A&P) Combined With Bifidobacterium Contribute a Renoprotective Effect in Chronic Kidney Disease Through Inhibiting Macrophage Inflammatory Response in Kidney and Intestine.
Frontiers in physiology
Rui-Zhi T,Hui D,Jian-Chun L,Xia Z,Xiao-Jia W,Dan W,Jun-Ming F,Li W
61-7300 was used in Western Blotting to explore the role of A&P and Bifidobacterium combination treatment in regulation of inflammatory response of macrophage in kidney and intestine of CKD mouse, as well as the potential molecular mechanism.
Fri Dec 18 00:00:00 UTC 2020
Transcriptome-Wide Analysis of CXCR5 Deficient Retinal Pigment Epithelial (RPE) Cells Reveals Molecular Signatures of RPE Homeostasis.
Biomedicines
Saddala MS,Lennikov A,Mukwaya A,Huang H
61-7300 was used in Immunohistochemistry to explore molecular signatures associated with deficiency of CXCR5 in RPE cells.
Mon Jun 01 00:00:00 UTC 2020
Mechano-modulatory synthetic niches for liver organoid derivation.
Nature communications
Sorrentino G,Rezakhani S,Yildiz E,Nuciforo S,Heim MH,Lutolf MP,Schoonjans K
61-7300 was used in Immunocytochemistry to report the establishment of a chemically defined and mechano-modulatory 3D culture system for mouse and human hepatic progenitors and organoids for basic research and regenerative medicine applications.
Fri Jul 10 00:00:00 UTC 2020
Zika Virus Infection Promotes Local Inflammation, Cell Adhesion Molecule Upregulation, and Leukocyte Recruitment at the Blood-Brain Barrier.
mBio
Clé M,Desmetz C,Barthelemy J,Martin MF,Constant O,Maarifi G,Foulongne V,Bolloré K,Glasson Y,De Bock F,Blaquiere M,Dehouck L,Pirot N,Tuaillon E,Nisole S,Najioullah F,Van de Perre P,Cabié A,Marchi N,Gosselet F,Simonin Y,Salinas S
61-7300 was used in Immunocytochemistry-immunoflourescence to suggest a complex interplay between ZIKV and the BBB, which may trigger local inflammation, leukocyte recruitment, and possible cerebral vasculature impairment.
Tue Aug 04 00:00:00 UTC 2020
Pericyte-like differentiation of human adipose-derived mesenchymal stem cells: An in vitro study.
World journal of stem cells
Mannino G,Gennuso F,Giurdanella G,Conti F,Drago F,Salomone S,Furno DL,Bucolo C,Giuffrida R
61-7300 was used in Immunocytochemistry to test in vitro strategies to obtain pericyte-like differentiation of human adipose-derived mesenchymal stem cells.
Mon Oct 26 00:00:00 UTC 2020
DL-3n-Butylphthalide Improves Blood-Brain Barrier Integrity in Rat After Middle Cerebral Artery Occlusion.
Frontiers in cellular neuroscience
Mamtilahun M,Wei Z,Qin C,Wang Y,Tang Y,Shen FX,Tian HL,Zhang Z,Yang GY
61-7300 was used in Western Blot, Immunohistochemistry to conclude that NBP protected blood-brain barrier integrity and attenuated brain injury in the acute phase of ischemic stroke by decreasing AQP4 expression and MMP-9 enzyme activity.
Sat Jan 30 00:00:00 UTC 2021
DL-3n-Butylphthalide Improves Blood-Brain Barrier Integrity in Rat After Middle Cerebral Artery Occlusion.
Frontiers in cellular neuroscience
Mamtilahun M,Wei Z,Qin C,Wang Y,Tang Y,Shen FX,Tian HL,Zhang Z,Yang GY
61-7300 was used in Western Blot, Immunohistochemistry to conclude that NBP protected blood-brain barrier integrity and attenuated brain injury in the acute phase of ischemic stroke by decreasing AQP4 expression and MMP-9 enzyme activity.
Sat Jan 30 00:00:00 UTC 2021
The spleen mediates chronic sleep restriction-mediated enhancement of LPS-induced neuroinflammation, cognitive deficits, and anxiety-like behavior.
Aging
Xu D,Zhang Y,Xie B,Yao H,Yuan Y,Yuan S,Zhang J
61-7300 was used in Western Blotting to indicate that the spleen was essential for CRSR-induced exacerbation of LPS-induced brain damage.
Mon Aug 03 00:00:00 UTC 2020
Loss of CLN3, the gene mutated in juvenile neuronal ceroid lipofuscinosis, leads to metabolic impairment and autophagy induction in retinal pigment epithelium.
Biochimica et biophysica acta. Molecular basis of disease
Zhong Y,Mohan K,Liu J,Al-Attar A,Lin P,Flight RM,Sun Q,Warmoes MO,Deshpande RR,Liu H,Jung KS,Mitov MI,Lin N,Butterfield DA,Lu S,Liu J,Moseley HNB,Fan TWM,Kleinman ME,Wang QJ
61-7300 was used in Immunohistochemistry to suggest possible links among metabolic impairment, autophagy induction and lysosomal storage, as well as between retinal pigment epithelium atrophy/degeneration and vision loss in juvenile neuronal ceroid lipofuscinosis.
Thu Oct 01 00:00:00 UTC 2020
Luminal preloading with hydrogen-rich saline ameliorates ischemia-reperfusion injury following intestinal transplantation in rats.
Pediatric transplantation
Yamamoto H,Aokage T,Igawa T,Hirayama T,Seya M,Ishikawa-Aoyama M,Nojima T,Nakao A,Naito H
61-7300 was used in Western Blotting to investigate the cytoprotective efficacy of intraluminally administered hydrogen-rich saline on cold IR injury in intestinal transplantation.
Sun Nov 01 00:00:00 UTC 2020
Neutrophil extracellular traps released by neutrophils impair revascularization and vascular remodeling after stroke.
Nature communications
Kang L,Yu H,Yang X,Zhu Y,Bai X,Wang R,Cao Y,Xu H,Luo H,Lu L,Shi MJ,Tian Y,Fan W,Zhao BQ
61-7300 was used in Western Blotting to show that neutrophils accumulate in the peri-infarct cortex during all stages of ischemic stroke.
Tue May 19 00:00:00 UTC 2020
CLEC14A deficiency exacerbates neuronal loss by increasing blood-brain barrier permeability and inflammation.
Journal of neuroinflammation
Kim Y,Lee S,Zhang H,Lee S,Kim H,Kim Y,Won MH,Kim YM,Kwon YG
61-7300 was used in Western Blot to suggest that activation of VEGFR-2 in CLEC14A-KO mice aggravates ischemic stroke by exacerbating cerebral vascular leakage and increasing neuronal inflammation after ischemia-reperfusion injury.
Tue Feb 04 00:00:00 UTC 2020
Resveratrol Modulates the Gut Microbiota and Inflammation to Protect Against Diabetic Nephropathy in Mice.
Frontiers in pharmacology
Cai TT,Ye XL,Li RR,Chen H,Wang YY,Yong HJ,Pan ML,Lu W,Tang Y,Miao H,Snijders AM,Mao JH,Liu XY,Lu YB,Ding DF
61-7300 was used in Immunohistochemistry to detemine whether the anti-DN effects of resveratrol are mediated through modulation of the gut microbiota using the genetic db/db mouse model of DN. To demonstrate that resveratrol treatment of db/db mice relieves a series of clinical indicators of DN and they show that resveratrol improves intestinal barrier function and ameliorates intestinal permeability and inflammation.
Tue Oct 06 00:00:00 UTC 2020
Purified IgG from aquaporin-4 neuromyelitis optica spectrum disorder patients alters blood-brain barrier permeability.
PloS one
Cobo-Calvo A,Ruiz A,Richard C,Blondel S,Cavagna S,Strazielle N,Ghersi-Egea JF,Giraudon P,Marignier R
61-7300 was used in Immunohistochemistry-immunofluorescence to evaluate the effect of human immunoglobulins from neuromyelitis optica spectrum disorders (NMOSD) patients (NMO-IgG) on blood-brain barrier (BBB) properties.
Thu Oct 22 00:00:00 UTC 2020
Yin Yang 1 is critical for mid-hindbrain neuroepithelium development and involved in cerebellar agenesis.
Molecular brain
Dong X,Kwan KM
61-7300 was used in Immunohistochemistry to demonstrate the involvement of Yin yang 1 (Yy1) in cerebellar agenesis and its critical function in mouse early Mid-hindbrain neuroepithelium maintenance and development.
Thu Jul 23 00:00:00 UTC 2020
Testin regulates the blood-testis barrier via disturbing occludin/ZO-1 association and actin organization.
Journal of cellular physiology
Su L,Wang Z,Xie S,Hu D,Cheng YC,Mruk DD,Guan Y
61-7300 was used in Western Blotting to suggest that besides as a monitor for Sertoli-germ cell junction integrity, testin is also an essential molecule to maintain Sertoli-Sertoli junctions.
Tue Sep 01 00:00:00 UTC 2020
Testin regulates the blood-testis barrier via disturbing occludin/ZO-1 association and actin organization.
Journal of cellular physiology
Su L,Wang Z,Xie S,Hu D,Cheng YC,Mruk DD,Guan Y
61-7300 was used in Western Blotting to suggest that besides as a monitor for Sertoli-germ cell junction integrity, testin is also an essential molecule to maintain Sertoli-Sertoli junctions.
Tue Sep 01 00:00:00 UTC 2020
Stachyose Improves the Effects of Berberine on Glucose Metabolism by Regulating Intestinal Microbiota and Short-Chain Fatty Acids in Spontaneous Type 2 Diabetic KKAy Mice.
Frontiers in pharmacology
Cao H,Li C,Lei L,Wang X,Liu S,Liu Q,Huan Y,Sun S,Shen Z
61-7300 was used in Western Blotting to find that the combination of BBR and Sta is more effective than BBR alone in blood glucose control, improvement of insulin resistance and islet functions, inflammatory mediators decrease, and maintenance of intestinal barrier integrity.
Sat Mar 30 00:00:00 UTC 2024
Testisin/Prss21 deficiency causes increased vascular permeability and a hemorrhagic phenotype during luteal angiogenesis.
PloS one
Peroutka RJ,Buzza MS,Mukhopadhyay S,Johnson TA,Driesbaugh KH,Antalis TM
61-7300 was used in Immunocytochemistry to identify testisin as a novel regulator of VE-cadherin adhesions during angiogenesis and indicate a potential new target for regulating neovascular integrity and associated pathologies.
Fri Aug 28 00:00:00 UTC 2020
Antiviral Activity of Type I, II, and III Interferons Counterbalances ACE2 Inducibility and Restricts SARS-CoV-2.
mBio
Busnadiego I,Fernbach S,Pohl MO,Karakus U,Huber M,Trkola A,Stertz S,Hale BG
61-7300 was used in Immunocytochemistry-immunoflourescence to investigated properties of type I (β), II (γ), and III (λ1) interferons (IFNs), potent immune cytokines that are normally produced during infection and that upregulate IFN-stimulated gene (ISG) effectors to limit virus replication.
Thu Sep 10 00:00:00 UTC 2020
A New Human Blood-Retinal Barrier Model Based on Endothelial Cells, Pericytes, and Astrocytes.
International journal of molecular sciences
Fresta CG,Fidilio A,Caruso G,Caraci F,Giblin FJ,Leggio GM,Salomone S,Drago F,Bucolo C
61-7300 was used in Immunocytochemistry to find an activation of immune response-regulating signaling pathways (Nrf2 and HO-1).
Thu Feb 27 00:00:00 UTC 2020
Impaired Airway Epithelial Barrier Integrity in Response to Stenotrophomonas maltophilia Proteases, Novel Insights Using Cystic Fibrosis Bronchial Epithelial Cell Secretomics.
Frontiers in immunology
Molloy K,Cagney G,Dillon ET,Wynne K,Greene CM,McElvaney NG
61-7300 was used in Western Blot to demonstrate destruction of the CFBE41o- TJC provide a novel insight regarding the virulence of S. maltophilia and may explain the possible injurious effects of this bacterium on the CF bronchial epithelium and the pathogenic mechanism leading to lethal pulmonary hemorrhage.
Fri Feb 19 00:00:00 UTC 2021
Vascular Tumor Recapitulated in Endothelial Cells from hiPSCs Engineered to Express the SERPINE1-FOSB Translocation.
Cell reports. Medicine
van IJzendoorn DGP,Salvatori DCF,Cao X,van den Hil F,Briaire-de Bruijn IH,de Jong D,Mei H,Mummery CL,Szuhai K,Bovée JVMG,Orlova VV
61-7300 was used in Immunocytochemistry-immunoflourescence to engineer the PHE chromosomal translocation into human induced pluripotent stem cells (hiPSCs) using CRISPR/Cas9 and differentiate these into ECs.
Tue Dec 22 00:00:00 UTC 2020
Bile Acid Sequestrant, Sevelamer Ameliorates Hepatic Fibrosis with Reduced Overload of Endogenous Lipopolysaccharide in Experimental Nonalcoholic Steatohepatitis.
Microorganisms
Tsuji Y,Kaji K,Kitade M,Kaya D,Kitagawa K,Ozutsumi T,Fujinaga Y,Takaya H,Kawaratani H,Namisaki T,Moriya K,Akahane T,Yoshiji H
61-7300 was used in Western Blotting to investigate the effect of sevelamer, a hydrophilic bile acid sequestrant, on hepatic fibrosis in a murine NASH model.
Fri Jun 19 00:00:00 UTC 2020
In vivo and ex vivo assessment of bladder hyper-permeability and using molecular targeted magnetic resonance imaging to detect claudin-2 in a mouse model for interstitial cystitis.
PloS one
Smith N,Saunders D,Lerner M,Zalles M,Mamedova N,Cheong D,Mohammadi E,Yuan T,Luo Y,Hurst RE,Greenwood-Van Meerveld B,Towner RA
61-7300 was used in Immunohistochemistry (Paraffin) to determine if the URO-MCP-1 mouse model for bladder IC/BPS is associated with in vivo bladder hyper-permeability, as measured by contrast-enhanced MRI (CE-MRI), and assess whether molecular-targeted MRI (mt-MRI) can visualize in vivo claudin-2 expression as a result of bladder hyper-permeability.
Fri Nov 20 00:00:00 UTC 2020
Regulatory Effect of Lactobacillus brevis Bmb6 on Gut Barrier Functions in Experimental Colitis.
Foods (Basel, Switzerland)
Shin MY,Yong CC,Oh S
61-7300 was used in Immunohistochemistry to investigate the regulatory effects of L. brevis Bmb6 on he tight junction (TJ) barrier to ameliorate colitis-symptoms.
Thu Jul 02 00:00:00 UTC 2020
Transporter-Mediated Mitochondrial GSH Depletion Leading to Mitochondrial Dysfunction and Rescue with αB Crystallin Peptide in RPE Cells.
Antioxidants (Basel, Switzerland)
Sreekumar PG,Wang M,Spee C,Sadda SR,Kannan R
61-7300 was used in Immunocytochemistry-Immunofluorescence to investigate the suppression of OGC and DIC and the effect of aB crystallin co-treatment on RPE cell death and mitochondrial function.
Tue May 12 00:00:00 UTC 2020
AhR activation defends gut barrier integrity against damage occurring in obesity.
Molecular metabolism
Postal BG,Ghezzal S,Aguanno D,André S,Garbin K,Genser L,Brot-Laroche E,Poitou C,Soula H,Leturque A,Clément K,Carrière V
61-7300 was used in Immunocytochemistry to study the causal relationship between AhR activation and gut inflammation in obesity.
Tue Sep 01 00:00:00 UTC 2020
AAV-Mediated Gene Delivery to 3D Retinal Organoids Derived from Human Induced Pluripotent Stem Cells.
International journal of molecular sciences
Garita-Hernandez M,Routet F,Guibbal L,Khabou H,Toualbi L,Riancho L,Reichman S,Duebel J,Sahel JA,Goureau O,Dalkara D
61-7300 was used in Immunohistochemistry to explore some of the mechanisms of cell attachment of AAVs and reports long-term gene expression resulting from gene delivery in retinal organoids.
Mon Feb 03 00:00:00 UTC 2020
Endothelial Cell Orientation and Polarity Are Controlled by Shear Stress and VEGF Through Distinct Signaling Pathways.
Frontiers in physiology
Vion AC,Perovic T,Petit C,Hollfinger I,Bartels-Klein E,Frampton E,Gordon E,Claesson-Welsh L,Gerhardt H
61-7300 was used in Western Blot to show using flow-induced shear stress and VEGF-A treatment on endothelial cells in vitro, that the response to the magnitude of a mechanical stimulus is influenced by the concentration of a chemical stimulus, and vice versa.
Sat Mar 20 00:00:00 UTC 2021
IL-1β strengthens the physical barrier in gingival epithelial cells.
Tissue barriers
Stolte KN,Pelz C,Yapto CV,Raguse JD,Dommisch H,Danker K
61-7300 was used in Western Blot, Immunocytochemistry to assess the influence of IL-1β on the transepithelial electrical resistance and in particular on tight junctions in vitro in human stratified squamous epithelium models.
Thu Jul 02 00:00:00 UTC 2020
IL-1β strengthens the physical barrier in gingival epithelial cells.
Tissue barriers
Stolte KN,Pelz C,Yapto CV,Raguse JD,Dommisch H,Danker K
61-7300 was used in Western Blot, Immunocytochemistry to assess the influence of IL-1β on the transepithelial electrical resistance and in particular on tight junctions in vitro in human stratified squamous epithelium models.
Thu Jul 02 00:00:00 UTC 2020
Retinal Distribution and Extracellular Activity of Granzyme B: A Serine Protease That Degrades Retinal Pigment Epithelial Tight Junctions and Extracellular Matrix Proteins.
Frontiers in immunology
Matsubara JA,Tian Y,Cui JZ,Zeglinski MR,Hiroyasu S,Turner CT,Granville DJ
61-7300 was used in Immunohistochemistry to reveal that GzmB is present in RPE and choroidal mast cells.
Fri Mar 26 00:00:00 UTC 2021
Shank2 Binds to aPKC and Controls Tight Junction Formation with Rap1 Signaling during Establishment of Epithelial Cell Polarity.
Cell reports
Sasaki K,Kojitani N,Hirose H,Yoshihama Y,Suzuki H,Shimada M,Takayanagi A,Yamashita A,Nakaya MA,Hirano H,Takahashi H,Ohno S
61-7300 was used in Western Blot, Immunocytochemistry to identify an epithelial isoform of Shank2 as a mediator of the aPKC-PAR complex.
Tue Apr 07 00:00:00 UTC 2020
Shank2 Binds to aPKC and Controls Tight Junction Formation with Rap1 Signaling during Establishment of Epithelial Cell Polarity.
Cell reports
Sasaki K,Kojitani N,Hirose H,Yoshihama Y,Suzuki H,Shimada M,Takayanagi A,Yamashita A,Nakaya MA,Hirano H,Takahashi H,Ohno S
61-7300 was used in Western Blot, Immunocytochemistry to identify an epithelial isoform of Shank2 as a mediator of the aPKC-PAR complex.
Tue Apr 07 00:00:00 UTC 2020
In situ-Like Aerosol Inhalation Exposure for Cytotoxicity Assessment Using Airway-on-Chips Platforms.
Frontiers in bioengineering and biotechnology
Elias-Kirma S,Artzy-Schnirman A,Das P,Heller-Algazi M,Korin N,Sznitman J
61-7300 was used in Immunocytochemistry to present a novel airway-on-chip exposure platform that emulates the epithelium of human bronchial airways with critical cellular barrier functions at an air-liquid interface (ALI).
Thu Mar 28 00:00:00 UTC 2024
Generation of Blastocyst-like Structures from Mouse Embryonic and Adult Cell Cultures.
Cell
Li R,Zhong C,Yu Y,Liu H,Sakurai M,Yu L,Min Z,Shi L,Wei Y,Takahashi Y,Liao HK,Qiao J,Deng H,Nuñez-Delicado E,Rodriguez Esteban C,Wu J,Izpisua Belmonte JC
61-7300 was used in Immunocytochemistry-Immunofluorescence to study the generation of blastoids from mouse extended pluripotent stemcells using a newly developed 3D differentiation system.
Thu Oct 17 00:00:00 UTC 2019
Sperm Flagellar 1 Binds Actin in Intestinal Epithelial Cells and Contributes to Formation of Filopodia and Lamellipodia.
Gastroenterology
Tapia R,Perez-Yepez EA,Carlino MJ,Karandikar UC,Kralicek SE,Estes MK,Hecht GA
61-7300 was used in Immunocytochemistry-immunoflourescence to investigate the distribution, localisation and impact of CLAMP knock-down in migrating SKCO-15 cells using scratch-wound assays, and in and human intestinal enteroids established from biopsies of a single donor.
Sun Dec 01 00:00:00 UTC 2019
Massive centriole production can occur in the absence of deuterosomes in multiciliated cells.
Nature cell biology
Mercey O,Levine MS,LoMastro GM,Rostaing P,Brotslaw E,Gomez V,Kumar A,Spassky N,Mitchell BJ,Meunier A,Holland AJ
61-7300 was used in Immunohistochemistry (PFA fixed) to show that the centriole number is set independently of their nucleation platforms and suggest that massive centriole production in multiciliated cells (MCCs) is a robust process that can self-organize.
Sun Dec 01 00:00:00 UTC 2019
Wnt/β-catenin links oxidative stress to podocyte injury and proteinuria.
Kidney international
Zhou L,Chen X,Lu M,Wu Q,Yuan Q,Hu C,Miao J,Zhang Y,Li H,Hou FF,Nie J,Liu Y
61-7300 was used in Immunocytochemistry-immunoflourescence to show that the Wnt/β-catenin pathway is involved in mediating oxidative stress-induced podocyte dysfunction.
Mon Apr 01 00:00:00 UTC 2019
The microstructure of laminin-111 compensates for dystroglycan loss in mammary epithelial cells in downstream expression of milk proteins.
Biomaterials
Kent AJ,Mayer N,Inman JL,Hochman-Mendez C,Bissell MJ,Robertson C
61-7300 was used in Immunocytochemistry to investigate if artificially polymerised laminin-111(Ln-1) could compensate for the loss of dystroglycan to form Ln-1 networks.
Tue Oct 01 00:00:00 UTC 2019
In vitro and in vivo effects of a mycotoxin, deoxynivalenol, and a trace metal, cadmium, alone or in a mixture on the intestinal barrier.
Environment international
Luo S,Terciolo C,Bracarense APFL,Payros D,Pinton P,Oswald IP
61-7300 was used in Western Blot to evaluate the combined toxicicty of deoxynivalenol and cadmium on the intestinal barrier function in vitro and in vivo.
Fri Nov 01 00:00:00 UTC 2019
A human organoid system that self-organizes to recapitulate growth and differentiation of a benign mammary tumor.
Proceedings of the National Academy of Sciences of the United States of America
Florian S,Iwamoto Y,Coughlin M,Weissleder R,Mitchison TJ
61-7300 was used in Immunocytochemistry to introduce a Matrigel-free culture approach for a mammary cell line isolated from a patient with a benign breast lesion, and investigate the formation of cell aggregates.
Tue Jun 04 00:00:00 UTC 2019
Advanced age promotes colonic dysfunction and gut-derived lung infection after stroke.
Aging cell
Wen SW,Shim R,Ho L,Wanrooy BJ,Srikhanta YN,Prame Kumar K,Nicholls AJ,Shen SJ,Sepehrizadeh T,de Veer M,Srikanth VK,Ma H,Phan TG,Lyras D,Wong CHY
61-7300 was used in Immunohistochemistry-immunofluorescence to demonstrate that exacerbated dysfunction of the intestinal barrier in advanced age promotes translocation of gut-derived bacteria and contributes to the increased risk to poststroke bacterial infection.
Tue Oct 01 00:00:00 UTC 2019
Claudins and JAM-A coordinately regulate tight junction formation and epithelial polarity.
The Journal of cell biology
Otani T,Nguyen TP,Tokuda S,Sugihara K,Sugawara T,Furuse K,Miura T,Ebnet K,Furuse M
61-7300 was used in Western Blotting to demonstrate that claudins and JAM-A coordinately regulate tight junctions (TJ) formation and epithelial polarity.
Mon Oct 07 00:00:00 UTC 2019
The Wave complex controls epidermal morphogenesis and proliferation by suppressing Wnt-Sox9 signaling.
The Journal of cell biology
Cohen J,Raviv S,Adir O,Padmanabhan K,Soffer A,Luxenburg C
61-7300 was used in Western Blotting to identify how the Wave complex proteins ABI1 and Wave2 orchestrate the development on the skin epidermis.
Mon Apr 01 00:00:00 UTC 2019
Decreased ω-6:ω-3 PUFA ratio attenuates ethanol-induced alterations in intestinal homeostasis, microbiota, and liver injury.
Journal of lipid research
Warner DR,Warner JB,Hardesty JE,Song YL,King TN,Kang JX,Chen CY,Xie S,Yuan F,Prodhan MAI,Ma X,Zhang X,Rouchka EC,Maddipati KR,Whitlock J,Li EC,Wang GP,McClain CJ,Kirpich IA
61-7300 was used in Immunohistochemistry (Paraffin) to suggest that ω-3 PUFA enrichment or treatment with resolvins can attenuate the disruption in intestinal homeostasis caused by EtOH consumption and systemic inflammation with a concomitant reduction in liver injury.
Sun Dec 01 00:00:00 UTC 2019
A CRISPR Screen Identifies the Cell Polarity Determinant Crumbs 3 as an Adeno-associated Virus Restriction Factor in Hepatocytes.
Journal of virology
Madigan VJ,Tyson TO,Yuziuk JA,Pillai M,Moller-Tank S,Asokan A
61-7300 was used in Immunocytochemistry-immunoflourescence to show Crumbs 3, an apical polarity determinant, also influences the ability of virions to bind and enter the cells.
Fri Nov 01 00:00:00 UTC 2019
Serine Threonine Kinase 17A Maintains the Epithelial State in Colorectal Cancer Cells.
Molecular cancer research : MCR
Short SP,Thompson JJ,Bilotta AJ,Chen X,Revetta FL,Washington MK,Williams CS
61-7300 was used in Immunocytochemistry-immunoflourescence to indicate a novel role for STK17A in regulation of epithelial phenotypes and indicate its functional contribution to CRC invasion and metastasis.
Mon Apr 01 00:00:00 UTC 2019
Serine Threonine Kinase 17A Maintains the Epithelial State in Colorectal Cancer Cells.
Molecular cancer research : MCR
Short SP,Thompson JJ,Bilotta AJ,Chen X,Revetta FL,Washington MK,Williams CS
61-7300 was used in Immunocytochemistry-immunoflourescence to indicate a novel role for STK17A in regulation of epithelial phenotypes and indicate its functional contribution to CRC invasion and metastasis.
Mon Apr 01 00:00:00 UTC 2019
Tracking adiponectin biodistribution via fluorescence molecular tomography indicates increased vascular permeability after streptozotocin-induced diabetes.
American journal of physiology. Endocrinology and metabolism
Yoon N,Dadson K,Dang T,Chu T,Noskovicova N,Hinz B,Raignault A,Thorin E,Kim S,Jeon JS,Jonkman J,McKee TD,Grant J,Peterson JD,Kelly SP,Sweeney G
61-7300 was used in Immunohistochemistry to determine whether vascular permeability plays an important role in regulating adiponectin action.
Fri Nov 01 00:00:00 UTC 2019
mTORC1/rpS6 signaling complex modifies BTB transport function: an in vivo study using the adjudin model.
American journal of physiology. Endocrinology and metabolism
Yan M,Li L,Mao B,Li H,Li SYT,Mruk D,Silvestrini B,Lian Q,Ge R,Cheng CY
61-7300 was used in Western Blot, Immunohistochemistry (Paraffin) to demonstrate that combining overexpression of p-rpS6-MT with a male contraceptive (e.g., adjudin) potentiate the drug bioavailability by modifying the blood-testis barrier.
Mon Jul 01 00:00:00 UTC 2019
mTORC1/rpS6 signaling complex modifies BTB transport function: an in vivo study using the adjudin model.
American journal of physiology. Endocrinology and metabolism
Yan M,Li L,Mao B,Li H,Li SYT,Mruk D,Silvestrini B,Lian Q,Ge R,Cheng CY
61-7300 was used in Western Blot, Immunohistochemistry (Paraffin) to demonstrate that combining overexpression of p-rpS6-MT with a male contraceptive (e.g., adjudin) potentiate the drug bioavailability by modifying the blood-testis barrier.
Mon Jul 01 00:00:00 UTC 2019
Characterization of the polarized endothelial secretome.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Wei H,Sundararaman A,Dickson E,Rennie-Campbell L,Cross E,Heesom KJ,Mellor H
61-7300 was used in Immunohistochemistry to present an optimized system for the analysis of polarized secretion from endothelial cells.
Fri Nov 01 00:00:00 UTC 2019
Changes in brain kynurenine levels via gut microbiota and gut-barrier disruption induced by chronic ethanol exposure in mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Giménez-Gómez P,Pérez-Hernández M,O'Shea E,Caso JR,Martín-Hernandez D,Cervera LA,Centelles MLG,Gutiérrez-Lopez MD,Colado MI
61-7300 was used in Western Blotting to study Ethanol (EtOH) exposure effects on Trp metabolism and the involvement of gut microbiota.
Fri Nov 01 00:00:00 UTC 2019
Hypertonic saline downregulates endothelial cell-derived VEGF expression and reduces blood-brain barrier permeability induced by cerebral ischaemia via the VEGFR2/eNOS pathway.
International journal of molecular medicine
Wang Q,Deng Y,Huang L,Zeng W,Chen S,Lv B,Jiang W,Han Y,Ding H,Wen M,Zeng H
61-7300 was used in Western Blotting to demonstrate how hypertonic saline acts upon the VEGFR2/eNOS pathway to reduce blood-brain barrier permeability induced by cerebral ischaemia.
Sun Sep 01 00:00:00 UTC 2019
Hypertonic saline downregulates endothelial cell-derived VEGF expression and reduces blood-brain barrier permeability induced by cerebral ischaemia via the VEGFR2/eNOS pathway.
International journal of molecular medicine
Wang Q,Deng Y,Huang L,Zeng W,Chen S,Lv B,Jiang W,Han Y,Ding H,Wen M,Zeng H
61-7300 was used in Western Blotting to demonstrate how hypertonic saline acts upon the VEGFR2/eNOS pathway to reduce blood-brain barrier permeability induced by cerebral ischaemia.
Sun Sep 01 00:00:00 UTC 2019
Protease-activated receptor-1 contributes to renal injury and interstitial fibrosis during chronic obstructive nephropathy.
Journal of cellular and molecular medicine
Waasdorp M,de Rooij DM,Florquin S,Duitman J,Spek CA
61-7300 was used in Western Blotting to show that PAR-1 activation on tubular epithelial cells reduces expression of epithelial markers and simultaneously induces mesenchymal marker expression reminiscent of epithelial-to-mesenchymal transition.
Fri Feb 01 00:00:00 UTC 2019
Protease-activated receptor-1 contributes to renal injury and interstitial fibrosis during chronic obstructive nephropathy.
Journal of cellular and molecular medicine
Waasdorp M,de Rooij DM,Florquin S,Duitman J,Spek CA
61-7300 was used in Western Blotting to show that PAR-1 activation on tubular epithelial cells reduces expression of epithelial markers and simultaneously induces mesenchymal marker expression reminiscent of epithelial-to-mesenchymal transition.
Fri Feb 01 00:00:00 UTC 2019
p53 deletion rescues lethal microcephaly in a mouse model with neural stem cell abscission defects.
Human molecular genetics
Little JN,Dwyer ND
61-7300 was used in Immunohistochemistry to elucidate both NSC apoptosis and abscission mechanisms that could underlie human microcephaly or other brain malformations.
Fri Feb 01 00:00:00 UTC 2019
Polarized AAVR expression determines infectivity by AAV gene therapy vectors.
Gene therapy
Hamilton BA,Li X,Pezzulo AA,Abou Alaiwa MH,Zabner J
61-7300 was used in Immunocytochemistry to investigate the localisation of AAV receptors in human airway epithelia.
Sat Jun 01 00:00:00 UTC 2019
Substrate Elasticity Governs Differentiation of Renal Tubule Cells in Prolonged Culture.
Tissue engineering. Part A
Love HD,Ao M,Jorgensen S,Swearingen L,Ferrell N,Evans R,Gewin L,Harris RC,Zent R,Roy S,Fissell WH
61-7300 was used in Immunocytochemistry-immunoflourescence to show that in vitro substrate mechanical properties, such as elasticity, dictate differentiation of cultured renal proximal tubule cells.
Mon Jul 01 00:00:00 UTC 2019
One-week exposure to a free-choice high-fat high-sugar diet does not disrupt blood-brain barrier permeability in fed or overnight fasted rats.
Nutritional neuroscience
Rijnsburger M,Unmehopa UA,Eggels L,Serlie MJ,la Fleur SE
61-7300 was used in Western Blot to investigate the effect of a high fat high sugar diet on the blood brain barrier permeability in rats.
Thu Aug 01 00:00:00 UTC 2019
E-cadherin is downregulated in benign prostatic hyperplasia and required for tight junction formation and permeability barrier in the prostatic epithelial cell monolayer.
The Prostate
Li F,Pascal LE,Stolz DB,Wang K,Zhou Y,Chen W,Xu Y,Chen Y,Dhir R,Parwani AV,Nelson JB,DeFranco DB,Yoshimura N,Balasubramani GK,Gingrich JR,Maranchie JK,Jacobs BL,Davies BJ,Hrebinko RL,Bigley JD,McBride D,Guo P,He D,Wang Z
61-7300 was used in Western Blotting to indicate that tight junctions are compromised in BPH and loss of E-cadherin is potentially an important underlying mechanism, suggesting targeting E-cadherin loss could be a potential approach to prevent or treat BPH.
Thu Aug 01 00:00:00 UTC 2019
Tunicamycin-induced photoreceptor atrophy precedes degeneration of retinal capillaries with minimal effects on retinal ganglion and pigment epithelium cells.
Experimental eye research
Wang S,Liu Y,Tan JW,Hu T,Zhang HF,Sorenson CM,Smith JA,Sheibani N
61-7300 was used in Immunohistochemistry to propose that endoplasmic reticulum stress mediated dysfunction and/or loss of photoreceptor cells in response to inflammation and oxidative stress could precede retinal vascular and neuronal dysfunction and degeneration.
Tue Oct 01 00:00:00 UTC 2019
Ferulic acid protects against heat stress-induced intestinal epithelial barrier dysfunction in IEC-6 cells via the PI3K/Akt-mediated Nrf2/HO-1 signaling pathway.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
He S,Guo Y,Zhao J,Xu X,Song J,Wang N,Liu Q
61-7300 was used in Western Blotting to study the role of ferulic acid in protection of IEC-6 cells from heat stress-induced intestinal epithelial barrier dysfunction.
Tue Jan 01 00:00:00 UTC 2019
Vascular regeneration in adult mouse cochlea stimulated by VEGF-A165 and driven by NG2-derived cells ex vivo.
Hearing research
Wang X,Zhang J,Li G,Sai N,Han J,Hou Z,Kachelmeier A,Shi X
61-7300 was used in Immunohistochemistry-immunofluorescence to demonstrates that damaged strial microvessels can be regenerated by reprogramming NG2-derived angiogenic cells.
Sat Jun 01 00:00:00 UTC 2019
Phenotypic characteristics of human bone marrow-derived endothelial progenitor cells in vitro support cell effectiveness for repair of the blood-spinal cord barrier in ALS.
Brain research
Garbuzova-Davis S,Ehrhart J,Mustafa H,Llauget A,Boccio KJ,Sanberg PR,Appel SH,Borlongan CV
61-7300 was used in Immunocytochemistry-immunoflourescence to characterize human bone marrow endothelial progenitor cell in vitro under normogenic conditions.
Sun Dec 01 00:00:00 UTC 2019
Microtubules are required for the maintenance of planar cell polarity in monociliated floorplate cells.
Developmental biology
Mathewson AW,Berman DG,Moens CB
61-7300 was used in Immunohistochemistry-wholemount to investigate the complex interactions between PCP proteins and the MT cytoskeleton using a zebrafish neural tube.
Thu Aug 01 00:00:00 UTC 2019
Regulation of blood-testis barrier dynamics by the mTORC1/rpS6 signaling complex: An in vitro study.
Asian journal of andrology
Li LX,Wu SW,Yan M,Lian QQ,Ge RS,Cheng CY
61-7300 was used in Western Blotting to study the mechanisms underlying the regulation of support cytoskeletal remodelling by biomolecules.
Mon May 18 00:00:00 UTC 2020
The Y227N mutation affects bestrophin-1 protein stability and impairs sperm function in a mouse model of Best vitelliform macular dystrophy.
Biology open
Milenkovic A,Schmied D,Tanimoto N,Seeliger MW,Sparrow JR,Weber BHF
61-7300 was used in Immunocytochemistry-immunoflourescence to show that mice carrying the Best1 Y227N mutation reveal a reproducible pathologic phenotype and thus provide a valuable in vivo tool to evaluate efficacy of drug therapies aimed at restoring Best1 protein stability and function.
Tue Jul 02 00:00:00 UTC 2019
Cdc42 is involved in NC1 peptide-regulated BTB dynamics through actin and microtubule cytoskeletal reorganization.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Su W,Cheng CY
61-7300 was used in Immunocytochemistry to show that this NC1 peptide regulates testis function by inducing Sertoli cell blood-testis barrier (BTB) remodeling and is also capable of inducing elongate spermatid exfoliation through its disruptive effects on the organization of actin- and microtubule (MT)-based cytoskeletons at these cell adhesion sites.
Sun Dec 01 00:00:00 UTC 2019
Cdc42 is involved in NC1 peptide-regulated BTB dynamics through actin and microtubule cytoskeletal reorganization.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Su W,Cheng CY
61-7300 was used in Immunocytochemistry to show that this NC1 peptide regulates testis function by inducing Sertoli cell blood-testis barrier (BTB) remodeling and is also capable of inducing elongate spermatid exfoliation through its disruptive effects on the organization of actin- and microtubule (MT)-based cytoskeletons at these cell adhesion sites.
Sun Dec 01 00:00:00 UTC 2019
mTORC1/rpS6 and spermatogenic function in the testis-insights from the adjudin model.
Reproductive toxicology (Elmsford, N.Y.)
Wu S,Yan M,Li L,Mao B,Wong CKC,Ge R,Lian Q,Cheng CY
61-7300 was used in Immunohistochemistry to yield important insights regarding the role of mTORC1/rpS6 signaling complex in regulating BTB homeostasis.
Tue Oct 01 00:00:00 UTC 2019
The Interplay Between E-Cadherin, Connexin 43, and Zona Occludens 1 in Retinal Pigment Epithelial Cells.
Investigative ophthalmology & visual science
Bao H,Yang S,Li H,Yao H,Zhang Y,Zhang J,Xu G,Jin H,Wang F
61-7300 was used in Immunohistochemistry to provide new insights in RPE disorders such as proliferative vitreoretinopathy.
Mon Dec 02 00:00:00 UTC 2019
Probiotics Prevents Sensitization to Oral Antigen and Subsequent Increases in Intestinal Tight Junction Permeability in Juvenile-Young Adult Rats.
Microorganisms
Tulyeu J,Kumagai H,Jimbo E,Watanabe S,Yokoyama K,Cui L,Osaka H,Mieno M,Yamagata T
61-7300 was used in Immunohistochemistry to explore the mechanism responsible for changes in the morphology and function of the intestinal barrier using a rat model of food allergy, focusing on the contribution of intestinal microbiota.
Wed Oct 16 00:00:00 UTC 2019
Expression of a CARD Slows the Retinal Degeneration of a Geographic Atrophy Mouse Model.
Molecular therapy. Methods & clinical development
Young BM,Jones K,Massengill MT,Walsh E,Li H,Lewin AS,Ildefonso CJ
61-7300 was used in Immunohistochemistry-immunofluorescence to study the effectiveness of an adeno-associated virus (AAV)-delivered CARD as treatment for oxidative damage within the retinal pigment epithelium of mice.
Fri Sep 13 00:00:00 UTC 2019
AAV-Mediated Gene Augmentation Therapy Restores Critical Functions in Mutant PRPF31+/- iPSC-Derived RPE Cells.
Molecular therapy. Methods & clinical development
Brydon EM,Bronstein R,Buskin A,Lako M,Pierce EA,Fernandez-Godino R
61-7300 was used in Immunocytochemistry to test the hypothesis that PRPF31-related RP is amenable to treatment by adeno-associated virus (AAV)-mediated gene augmentation therapy.
Fri Dec 13 00:00:00 UTC 2019
Erythropoietin protects outer blood-retinal barrier in experimental diabetic retinopathy by up-regulating ZO-1 and occludin.
Clinical & experimental ophthalmology
Zhang C,Xie H,Yang Q,Yang Y,Li W,Tian H,Lu L,Wang F,Xu JY,Gao F,Wang J,Jin C,Xu G,Xu GT,Zhang J
61-7300 was used in Immunocytochemistry, Immunohistochemistry, and Western Blotting to study in vitro with ARPE-19 cells confirmed these changes, and the protective effect of EPO was abolished by sEPOR. Gö6976 and digoxin rescued the tight junction and barrier function in glyoxal-treated ARPE-19 cells.In early diabetic rats, the outer BRB might be more severely damaged and its breakdown is the major factor for retinal oedema.
Sun Dec 01 00:00:00 UTC 2019
Erythropoietin protects outer blood-retinal barrier in experimental diabetic retinopathy by up-regulating ZO-1 and occludin.
Clinical & experimental ophthalmology
Zhang C,Xie H,Yang Q,Yang Y,Li W,Tian H,Lu L,Wang F,Xu JY,Gao F,Wang J,Jin C,Xu G,Xu GT,Zhang J
61-7300 was used in Immunocytochemistry, Immunohistochemistry, and Western Blotting to study in vitro with ARPE-19 cells confirmed these changes, and the protective effect of EPO was abolished by sEPOR. Gö6976 and digoxin rescued the tight junction and barrier function in glyoxal-treated ARPE-19 cells.In early diabetic rats, the outer BRB might be more severely damaged and its breakdown is the major factor for retinal oedema.
Sun Dec 01 00:00:00 UTC 2019
Erythropoietin protects outer blood-retinal barrier in experimental diabetic retinopathy by up-regulating ZO-1 and occludin.
Clinical & experimental ophthalmology
Zhang C,Xie H,Yang Q,Yang Y,Li W,Tian H,Lu L,Wang F,Xu JY,Gao F,Wang J,Jin C,Xu G,Xu GT,Zhang J
61-7300 was used in Immunocytochemistry, Immunohistochemistry, and Western Blotting to study in vitro with ARPE-19 cells confirmed these changes, and the protective effect of EPO was abolished by sEPOR. Gö6976 and digoxin rescued the tight junction and barrier function in glyoxal-treated ARPE-19 cells.In early diabetic rats, the outer BRB might be more severely damaged and its breakdown is the major factor for retinal oedema.
Sun Dec 01 00:00:00 UTC 2019
Erythropoietin protects outer blood-retinal barrier in experimental diabetic retinopathy by up-regulating ZO-1 and occludin.
Clinical & experimental ophthalmology
Zhang C,Xie H,Yang Q,Yang Y,Li W,Tian H,Lu L,Wang F,Xu JY,Gao F,Wang J,Jin C,Xu G,Xu GT,Zhang J
61-7300 was used in Immunocytochemistry, Immunohistochemistry, and Western Blotting to study in vitro with ARPE-19 cells confirmed these changes, and the protective effect of EPO was abolished by sEPOR. Gö6976 and digoxin rescued the tight junction and barrier function in glyoxal-treated ARPE-19 cells.In early diabetic rats, the outer BRB might be more severely damaged and its breakdown is the major factor for retinal oedema.
Sun Dec 01 00:00:00 UTC 2019
Erythropoietin protects outer blood-retinal barrier in experimental diabetic retinopathy by up-regulating ZO-1 and occludin.
Clinical & experimental ophthalmology
Zhang C,Xie H,Yang Q,Yang Y,Li W,Tian H,Lu L,Wang F,Xu JY,Gao F,Wang J,Jin C,Xu G,Xu GT,Zhang J
61-7300 was used in Immunocytochemistry, Immunohistochemistry, and Western Blotting to study in vitro with ARPE-19 cells confirmed these changes, and the protective effect of EPO was abolished by sEPOR. Gö6976 and digoxin rescued the tight junction and barrier function in glyoxal-treated ARPE-19 cells.In early diabetic rats, the outer BRB might be more severely damaged and its breakdown is the major factor for retinal oedema.
Sun Dec 01 00:00:00 UTC 2019
Erythropoietin protects outer blood-retinal barrier in experimental diabetic retinopathy by up-regulating ZO-1 and occludin.
Clinical & experimental ophthalmology
Zhang C,Xie H,Yang Q,Yang Y,Li W,Tian H,Lu L,Wang F,Xu JY,Gao F,Wang J,Jin C,Xu G,Xu GT,Zhang J
61-7300 was used in Immunocytochemistry, Immunohistochemistry, and Western Blotting to study in vitro with ARPE-19 cells confirmed these changes, and the protective effect of EPO was abolished by sEPOR. Gö6976 and digoxin rescued the tight junction and barrier function in glyoxal-treated ARPE-19 cells.In early diabetic rats, the outer BRB might be more severely damaged and its breakdown is the major factor for retinal oedema.
Sun Dec 01 00:00:00 UTC 2019
Microglial Depletion with Clodronate Liposomes Increases Proinflammatory Cytokine Levels, Induces Astrocyte Activation, and Damages Blood Vessel Integrity.
Molecular neurobiology
Han X,Li Q,Lan X,El-Mufti L,Ren H,Wang J
61-7300 was used in Western Blot to suggest that intracerebral administration of clodronate liposomes into brain parenchyma can deplete microglia, but can also damage other brain cells and blood vessel integrity.
Sun Sep 01 00:00:00 UTC 2019
Claudin-12 is not required for blood-brain barrier tight junction function.
Fluids and barriers of the CNS
Castro Dias M,Coisne C,Baden P,Enzmann G,Garrett L,Becker L,Hölter SM,Hrabě de Angelis M,Deutsch U,Engelhardt B
61-7300 was used in Western Blotting to study the role and localisation of claudin-12.
Thu Sep 12 00:00:00 UTC 2019
Impact of Docetaxel on blood-brain barrier function and formation of breast cancer brain metastases.
Journal of experimental & clinical cancer research : CR
Bernatz S,Ilina EI,Devraj K,Harter PN,Mueller K,Kleber S,Braun Y,Penski C,Renner C,Halder R,Jennewein L,Solbach C,Thorsen F,Pestalozzi BC,Mischo A,Mittelbronn M
61-7300 was used in Immunohistochemistry to identify tubulin family members and tetraspanin-2 as potential contributors for the destabilization of the blood-brain barrier.
Tue Oct 29 00:00:00 UTC 2019
Impact of Docetaxel on blood-brain barrier function and formation of breast cancer brain metastases.
Journal of experimental & clinical cancer research : CR
Bernatz S,Ilina EI,Devraj K,Harter PN,Mueller K,Kleber S,Braun Y,Penski C,Renner C,Halder R,Jennewein L,Solbach C,Thorsen F,Pestalozzi BC,Mischo A,Mittelbronn M
61-7300 was used in Immunohistochemistry to identify tubulin family members and tetraspanin-2 as potential contributors for the destabilization of the blood-brain barrier.
Tue Oct 29 00:00:00 UTC 2019
Sexual Dimorphism in Immune Development and in Response to Nutritional Intervention in Neonatal Piglets.
Frontiers in immunology
Christoforidou Z,Mora Ortiz M,Poveda C,Abbas M,Walton G,Bailey M,Lewis MC
61-7300 was used in Immunohistochemistry to explore potential early sex disparity underlying both mucosal immune development and systemic responses to novel antigen.
Tue Nov 10 00:00:00 UTC 2020
Prediction of Drug Permeability Using In Vitro Blood-Brain Barrier Models with Human Induced Pluripotent Stem Cell-Derived Brain Microvascular Endothelial Cells.
BioResearch open access
Ohshima M,Kamei S,Fushimi H,Mima S,Yamada T,Yamamoto T
61-7300 was used in Immunocytochemistry to conclude that iPSC-BBB models make it possible to predict BBB permeability, and employing coculturing can improve iPSC-BBB function.
Thu Oct 01 00:00:00 UTC 2020
Effect of Manitoba-Grown Red-Osier Dogwood Extracts on Recovering Caco-2 Cells from H2O2-Induced Oxidative Damage.
Antioxidants (Basel, Switzerland)
Yang R,Hui Q,Jiang Q,Liu S,Zhang H,Wu J,Lin F,O K,Yang C
61-7300 was used in Western Blotting to investigate the antioxidant effects of red-osier dogwood extracts (RDE) on an oxidative damage model of Caco-2 cells.
Sun Jul 28 00:00:00 UTC 2019
Influence of a Hyperglycemic Microenvironment on a Diabetic Versus Healthy Rat Vascular Endothelium Reveals Distinguishable Mechanistic and Phenotypic Responses.
Frontiers in physiology
Haspula D,Vallejos AK,Moore TM,Tomar N,Dash RK,Hoffmann BR
61-7300 was used in Immunocytochemistry-immunoflourescence to study the effect of hyperglycaemia on the diisruption of molecular mechanisms in endothelial cells under diabetic and non-diabetic states.
Tue May 25 00:00:00 UTC 2021
Glucocorticoids exert differential effects on the endothelium in an in vitro model of the blood-retinal barrier.
Acta ophthalmologica
van der Wijk AE,Canning P,van Heijningen RP,Vogels IMC,van Noorden CJF,Klaassen I,Schlingemann RO
61-7300 was used in Immunocytochemistry to investigate whether TA was able to prevent barrier disruption after stimulation with VEGF or cytokines.
Fri Mar 01 00:00:00 UTC 2019
HDAC3 inhibition prevents oxygen glucose deprivation/reoxygenation-induced transendothelial permeability by elevating PPARγ activity in vitro.
Journal of neurochemistry
Zhao Q,Yu Z,Zhang F,Huang L,Xing C,Liu N,Xu Y,Wang X
61-7300 was used in Western Blotting to indicate that HDAC3 inhibition might comprise a new therapeutic target for reducing blood-brain barrier integrity disruption and vascular dysfunctions in neurological disorders.
Mon Apr 01 00:00:00 UTC 2019
CRISPR-Cas9-mediated therapeutic editing of Rpe65 ameliorates the disease phenotypes in a mouse model of Leber congenital amaurosis.
Science advances
Jo DH,Song DW,Cho CS,Kim UG,Lee KJ,Lee K,Park SW,Kim D,Kim JH,Kim JS,Kim S,Kim JH,Lee JM
61-7300 was used in Immunohistochemistry to perform CRISPR-Cas9-mediated therapeutic correction of a disease-associated nonsense mutation in Rpe65 in rd12 mice, a model of human LCA.
Tue Oct 01 00:00:00 UTC 2019
Pepsin Triggers Neutrophil Migration Across Acid Damaged Lung Epithelium.
Scientific reports
Hurley BP,Jugo RH,Snow RF,Samuels TL,Yonker LM,Mou H,Johnston N,Rosen R
61-7300 was used in Immunohistochemistry-immunofluorescence to indicate the potential for proton pump inhibitor usage to raise concentrations of pepsin in gastric fluid, which may enhance the pathological impact of micro-aspirations in children with extraesophageal reflux.
Tue Sep 24 00:00:00 UTC 2019
Pretreatment with probiotic Enterococcus faecium NCIMB 11181 ameliorates necrotic enteritis-induced intestinal barrier injury in broiler chickens.
Scientific reports
Wu Y,Zhen W,Geng Y,Wang Z,Guo Y
61-7300 was used in Western Blotting to investigate the protective effects of probiotic E. faecium NCIMB 11181 on necrotic enteritis (NE) - induced intestinal barrier injury in broiler chickens.
Tue Jul 16 00:00:00 UTC 2019
Syncytiotrophoblast of Placentae from Women with Zika Virus Infection Has Altered Tight Junction Protein Expression and Increased Paracellular Permeability.
Cells
Miranda J,Martín-Tapia D,Valdespino-Vázquez Y,Alarcón L,Espejel-Nuñez A,Guzmán-Huerta M,Muñoz-Medina JE,Shibayama M,Chávez-Munguía B,Estrada-Gutiérrez G,Lievano S,Ludert JE,González-Mariscal L
61-7300 was used in Western Blotting to determine whether ZIKV can open the paracellular pathway of STB cells which have been seen to be resistant to ZIKV infections.
Sun Sep 29 00:00:00 UTC 2019
gH625-liposomes as tool for pituitary adenylate cyclase-activating polypeptide brain delivery.
Scientific reports
Iachetta G,Falanga A,Molino Y,Masse M,Jabès F,Mechioukhi Y,Laforgia V,Khrestchatisky M,Galdiero S,Valiante S
61-7300 was used in Immunocytochemistry to investigate the efficiency of liposomes functionalized on their surface with gH625 to promote the brain uptake of neuroprotective peptide PACAP (pituitary adenylate cyclase-activating polypeptide).
Mon Jun 24 00:00:00 UTC 2019
Arresting proliferation improves the cell identity of corneal endothelial cells in the New Zealand rabbit.
Molecular vision
Rodríguez-Barrientos CA,Trevino V,Zavala J,Montalvo-Parra MD,Guerrero-Ramírez GI,Aguirre-Gamboa R,Valdez-García JE
61-7300 was used in Immunocytochemistry to suggest that stabilization is useful for studying the plasticity of the corneal endothelium's morphology, and stabilization is proposed as a necessary step in corneal endothelium engineering.
Fri Jun 19 00:00:00 UTC 2020
Pharmacological cholesterol depletion disturbs ciliogenesis and ciliary function in developing zebrafish.
Communications biology
Maerz LD,Burkhalter MD,Schilpp C,Wittekindt OH,Frick M,Philipp M
61-7300 was used in Immunocytochemistry-immunoflourescence to study the effect of cholesterol on the regulation of ciliogenesis.
Thu Apr 02 00:00:00 UTC 2020
Derivation of Mouse Haploid Trophoblast Stem Cells.
Cell reports
Cui T,Jiang L,Li T,Teng F,Feng G,Wang X,He Z,Guo L,Xu K,Mao Y,Wang L,Yuan X,Wang L,Li W,Zhou Q
61-7300 was used in Immunocytochemistry-immunoflourescence to demonstrate the capability of the haTSCs to undergo genetic manipulation and facilitate genome-wide screening in the trophoblast lineage.
Tue Jan 08 00:00:00 UTC 2019
CLIC4 regulates late endosomal trafficking and matrix degradation activity of MMP14 at focal adhesions in RPE cells.
Scientific reports
Hsu KS,Otsu W,Li Y,Wang HC,Chen S,Tsang SH,Chuang JZ,Sung CH
61-7300 was used in Western Blotting to demonstrate that CLIC4 is a novel matrix microenvironment modulator and a novel regulator for late endosomal cargo sorting. Moreover, the late endosomal sorting of MMP14 actively regulates its surface activation in RPE cells.
Thu Aug 22 00:00:00 UTC 2019
Regulation of cilia abundance in multiciliated cells.
eLife
Nanjundappa R,Kong D,Shim K,Stearns T,Brody SL,Loncarek J,Mahjoub MR
61-7300 was used in Immunocytochemistry-immunoflourescence to demonstrate that a cell-intrinsic surface area-dependent mechanism controls centriole and cilia abundance in multiciliated cell.
Fri Apr 26 00:00:00 UTC 2019
Determining the Replication Kinetics and Cellular Tropism of Influenza D Virus on Primary Well-Differentiated Human Airway Epithelial Cells.
Viruses
Holwerda M,Kelly J,Laloli L,Stürmer I,Portmann J,Stalder H,Dijkman R
61-7300 was used in Immunocytochemistry-immunoflourescence to provide insight into ICV cell tropism and why IDV-directed antibodies are detected among humans with occupational exposure to livestock.
Wed Apr 24 00:00:00 UTC 2019
Isolation and initial propagation of guinea pig adenovirus (GPAdV) in Cavia porcellus cell lines.
F1000Research
Kajon AE,Li X,Gonzalez G,Core S,Hofmann-Sieber H,Leng S
61-7300 was used in Immunocytochemistry to demonstrate the feasibility of propagating GPAdV in cultures of immortalized lines of GP cells of a variety of types, thus establishing a critical foundation for the development of a robust culture platform for virus stock production and titration.
Mon Jun 15 00:00:00 UTC 2020
BMP7 antagonizes proliferative vitreoretinopathy through retinal pigment epithelial fibrosis in vivo and in vitro.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Yao H,Ge T,Zhang Y,Li M,Yang S,Li H,Wang F
61-7300 was used in Immunocytochemistry to provide direct evidence of the ability of BMP7 in PVR inhibition and the potential of BMP7 for use in PVR therapeutic intervention.-Yao, H., Ge, T., Zhang, Y., Li, M., Yang, S., Li, H., Wang, F. BMP7 antagonizes proliferative vitreoretinopathy through retinal pigment epithelial fibrosis in vivo and in vitro.
Fri Mar 01 00:00:00 UTC 2019
BMP7 antagonizes proliferative vitreoretinopathy through retinal pigment epithelial fibrosis in vivo and in vitro.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Yao H,Ge T,Zhang Y,Li M,Yang S,Li H,Wang F
61-7300 was used in Immunocytochemistry to provide direct evidence of the ability of BMP7 in PVR inhibition and the potential of BMP7 for use in PVR therapeutic intervention.-Yao, H., Ge, T., Zhang, Y., Li, M., Yang, S., Li, H., Wang, F. BMP7 antagonizes proliferative vitreoretinopathy through retinal pigment epithelial fibrosis in vivo and in vitro.
Fri Mar 01 00:00:00 UTC 2019
Transfusion of Resting Platelets Reduces Brain Hemorrhage After Intracerebral Hemorrhage and tPA-Induced Hemorrhage After Cerebral Ischemia.
Frontiers in neuroscience
Luo H,Wei L,Lu L,Kang L,Cao Y,Yang X,Bai X,Fan W,Zhao BQ
61-7300 was used in Western Blot to investigate whether platelets could reduce tPA-induced deterioration of cerebrovascular integrity and lead to less hemorrhagic transformation.
Mon Jul 15 00:00:00 UTC 2024
Transfusion of Resting Platelets Reduces Brain Hemorrhage After Intracerebral Hemorrhage and tPA-Induced Hemorrhage After Cerebral Ischemia.
Frontiers in neuroscience
Luo H,Wei L,Lu L,Kang L,Cao Y,Yang X,Bai X,Fan W,Zhao BQ
61-7300 was used in Western Blot to investigate whether platelets could reduce tPA-induced deterioration of cerebrovascular integrity and lead to less hemorrhagic transformation.
Mon Jul 15 00:00:00 UTC 2024
Specifically Sized Hyaluronan (35 kDa) Prevents Ethanol-Induced Disruption of Epithelial Tight Junctions Through a layilin-Dependent Mechanism in Caco-2 Cells.
Alcoholism, clinical and experimental research
Bellos DA,Sharma D,McMullen MR,Wat J,Saikia P,de la Motte CA,Nagy LE
61-7300 was used in Immunocytochemistry to indicate that HA35 interacts with layilin on intestinal epithelial cells and maintains intestinal tight junction integrity during short-term EtOH exposure.
Sun Sep 01 00:00:00 UTC 2019
Loss of PGC-1α in RPE induces mesenchymal transition and promotes retinal degeneration.
Life science alliance
Rosales MAB,Shu DY,Iacovelli J,Saint-Geniez M
61-7300 was used in Immunocytochemistry to establish that PGC-1α is required to maintain the functional and phenotypical status of retinal pigment epithelium by supporting the cells' oxidative metabolism and autography-mediated repression of epithelial to mesenchymal transition.
Sat Jun 01 00:00:00 UTC 2019
Human Brain Endothelial CXCR2 is Inflammation-Inducible and Mediates CXCL5- and CXCL8-Triggered Paraendothelial Barrier Breakdown.
International journal of molecular sciences
Haarmann A,Schuhmann MK,Silwedel C,Monoranu CM,Stoll G,Buttmann M
61-7300 was used in Immunocytochemistry to study the potential role of CXCL5/CXCL8 receptor 2 (CXCR2) as a regulator of paraendothelial brain barrier function.
Wed Jan 30 00:00:00 UTC 2019
Establishment of Primary Transgenic Human Airway Epithelial Cell Cultures to Study Respiratory Virus-Host Interactions.
Viruses
Jonsdottir HR,Marti S,Geerts D,Rodriguez R,Thiel V,Dijkman R
61-7300 was used in Immunohistochemistry-immunofluorescence to produce a protocol that allows the molecular characterisation of virus-host interactions in human respiratory epithelium by genetically modifying human airway epithelial cell cultures.
Tue Aug 13 00:00:00 UTC 2019
A Simulated Microgravity Environment Causes a Sustained Defect in Epithelial Barrier Function.
Scientific reports
Alvarez R,Stork CA,Sayoc-Becerra A,Marchelletta RR,Prisk GK,McCole DF
61-7300 was used in Western Blotting to identify if simulated microgravity alters intestinal epithelial barrier function (permeability), and susceptibility to barrier disrupting agents.
Tue Nov 26 00:00:00 UTC 2019
High-fat diet-mediated dysbiosis exacerbates NSAID-induced small intestinal damage through the induction of interleukin-17A.
Scientific reports
Sugimura N,Otani K,Watanabe T,Nakatsu G,Shimada S,Fujimoto K,Nadatani Y,Hosomi S,Tanaka F,Kamata N,Taira K,Nagami Y,Tanigawa T,Uematsu S,Fujiwara Y
61-7300 was used in Western Blotting to demonstrate aggravation of NSAID-induced small intestinal is the result of of high-fat diet induced microbial dysbiosis causing microinflammation through the induction of IL-17A and increase in intestinal permeability.
Thu Nov 14 00:00:00 UTC 2019
Endothelium-Derived Semaphorin 3G Regulates Hippocampal Synaptic Structure and Plasticity via Neuropilin-2/PlexinA4.
Neuron
Tan C,Lu NN,Wang CK,Chen DY,Sun NH,Lyu H,Körbelin J,Shi WX,Fukunaga K,Lu YM,Han F
61-7300 was used in Western Blot to highlight the role of vascular endothelial cells in regulating cognitive function through intercellular communication with neurons in the hippocampus.
Wed Mar 06 00:00:00 UTC 2019
Expansion and contraction of the umbrella cell apical junctional ring in response to bladder filling and voiding.
Molecular biology of the cell
Eaton AF,Clayton DR,Ruiz WG,Griffiths SE,Rubio ME,Apodaca G
61-7300 was used in Western Blot to indicate that a mechanism by which the umbrella cells retain continuity during cyclical changes in volume is the expansion and contraction of their AJR, processes regulated by the actomyosin cytoskeleton and membrane trafficking events.
Mon Jul 22 00:00:00 UTC 2019
Capturing the Onset of Bacterial Pulmonary Infection in Acini-On-Chips.
Advanced biosystems
Artzy-Schnirman A,Zidan H,Elias-Kirma S,Ben-Porat L,Tenenbaum-Katan J,Carius P,Fishler R,Schneider-Daum N,Lehr CM,Sznitman J
61-7300 was used in Immunocytochemistry to develop microfluidic-based acini-on-chips that mimic more closely the native acinar airways at a true scale with an anatomically inspired, multigeneration alveolated tree are presented and an inhalation-like maneuver.
Sun Sep 01 00:00:00 UTC 2019
Zika virus induces strong inflammatory responses and impairs homeostasis and function of the human retinal pigment epithelium.
EBioMedicine
Simonin Y,Erkilic N,Damodar K,Clé M,Desmetz C,Bolloré K,Taleb M,Torriano S,Barthelemy J,Dubois G,Lajoix AD,Foulongne V,Tuaillon E,Van de Perre P,Kalatzis V,Salinas S
61-7300 was used in Immunocytochemistry to suggest that ZIKV has a highly efficient ocular tropism, which creates a strong inflammatory environment that could have acute or chronic adverse effects.
Tue Jan 01 00:00:00 UTC 2019
Zika virus induces strong inflammatory responses and impairs homeostasis and function of the human retinal pigment epithelium.
EBioMedicine
Simonin Y,Erkilic N,Damodar K,Clé M,Desmetz C,Bolloré K,Taleb M,Torriano S,Barthelemy J,Dubois G,Lajoix AD,Foulongne V,Tuaillon E,Van de Perre P,Kalatzis V,Salinas S
61-7300 was used in Immunocytochemistry to suggest that ZIKV has a highly efficient ocular tropism, which creates a strong inflammatory environment that could have acute or chronic adverse effects.
Tue Jan 01 00:00:00 UTC 2019
Effects of Claudin-1 on the Action of Clostridium perfringens Enterotoxin in Caco-2 Cells.
Toxins
Mehdizadeh Gohari I,Li J,Navarro M,Uzal F,McClane B
61-7300 was used in Western Blotting to show that CLDN-1 positively and negatively influences Clostridium perfringens enterotoxin (CPE) action.
Wed Oct 09 00:00:00 UTC 2019
The Use of High-Throughput Transcriptomics to Identify Pathways with Therapeutic Significance in Podocytes.
International journal of molecular sciences
Solanki AK,Srivastava P,Rahman B,Lipschutz JH,Nihalani D,Arif E
61-7300 was used in Immunohistochemistry to investigate the molecular signature of podocyte injury by performing transcriptome analysis of cultured human podocytes injured either with PAN (puromycin aminonucleoside) or doxorubicin/adriamycin (ADR).
Tue Dec 31 00:00:00 UTC 2019
Occludin knockdown is not sufficient to induce transepithelial macromolecule passage.
Tissue barriers
Richter JF,Hildner M,Schmauder R,Turner JR,Schumann M,Reiche J
61-7300 was used in Immunocytochemistry-immunoflourescence to study the role of Occludin in macromolecule passage at single cell-cell junctions.
Tue Jul 21 00:00:00 UTC 2020
ARID1A and PI3-kinase pathway mutations in the endometrium drive epithelial transdifferentiation and collective invasion.
Nature communications
Wilson MR,Reske JJ,Holladay J,Wilber GE,Rhodes M,Koeman J,Adams M,Johnson B,Su RW,Joshi NR,Patterson AL,Shen H,Leach RE,Teixeira JM,Fazleabas AT,Chandler RL
61-7300 was used in Immunohistochemistry to show that monoallelic loss of ARID1A in the mouse endometrial epithelium is sufficient for vaginal bleeding when combined with PI3K activation.
Wed Aug 07 00:00:00 UTC 2019
HDAC3 inhibition prevents blood-brain barrier permeability through Nrf2 activation in type 2 diabetes male mice.
Journal of neuroinflammation
Zhao Q,Zhang F,Yu Z,Guo S,Liu N,Jiang Y,Lo EH,Xu Y,Wang X
61-7300 was used in Immunocytochemistry-immunoflourescence to study the role of histone deacetylase 3 in type 2 diabetes mellitus.
Fri May 17 00:00:00 UTC 2019
HDAC3 inhibition prevents blood-brain barrier permeability through Nrf2 activation in type 2 diabetes male mice.
Journal of neuroinflammation
Zhao Q,Zhang F,Yu Z,Guo S,Liu N,Jiang Y,Lo EH,Xu Y,Wang X
61-7300 was used in Immunocytochemistry-immunoflourescence to study the role of histone deacetylase 3 in type 2 diabetes mellitus.
Fri May 17 00:00:00 UTC 2019
Attenuated Amiloride-Sensitive Current and Augmented Calcium-Activated Chloride Current in Marsh Rice Rat (Oryzomys palustris) Airways.
iScience
Kuan SP,Liao YJ,Davis KM,Messer JG,Zubcevic J,Aguirre JI,Reznikov LR
61-7300 was used in Immunocytochemistry to indicate that the airway of the rice rat has unique ion transport adaptations to aid survival in the salt marsh environment.
Fri Sep 27 00:00:00 UTC 2019
Attenuated Amiloride-Sensitive Current and Augmented Calcium-Activated Chloride Current in Marsh Rice Rat (Oryzomys palustris) Airways.
iScience
Kuan SP,Liao YJ,Davis KM,Messer JG,Zubcevic J,Aguirre JI,Reznikov LR
61-7300 was used in Immunocytochemistry to indicate that the airway of the rice rat has unique ion transport adaptations to aid survival in the salt marsh environment.
Fri Sep 27 00:00:00 UTC 2019
Glibenclamide ameliorates the disrupted blood-brain barrier in experimental intracerebral hemorrhage by inhibiting the activation of NLRP3 inflammasome.
Brain and behavior
Xu F,Shen G,Su Z,He Z,Yuan L
61-7300 was used in Western Blotting to explore the neuroprotective effects of glibenclamide on intracerebral hemorrhage and the mechanisms behind them.
Mon Apr 01 00:00:00 UTC 2019
Merging organoid and organ-on-a-chip technology to generate complex multi-layer tissue models in a human retina-on-a-chip platform.
eLife
Achberger K,Probst C,Haderspeck J,Bolz S,Rogal J,Chuchuy J,Nikolova M,Cora V,Antkowiak L,Haq W,Shen N,Schenke-Layland K,Ueffing M,Liebau S,Loskill P
61-7300 was used in Immunohistochemistry to show that this interaction enhances the formation of outer segment-like structures and the establishment of in vivo-like physiological processes such as outer segment phagocytosis and calcium dynamics.
Tue Aug 27 00:00:00 UTC 2019
Targeting the HIV-infected brain to improve ischemic stroke outcome.
Nature communications
Bertrand L,Méroth F,Tournebize M,Leda AR,Sun E,Toborek M
61-7300 was used in Immunohistochemistry-immunofluorescence to present in vivo analysis of the relationship between HIV and stroke outcome.
Wed May 01 00:00:00 UTC 2019
FODMAP diet modulates visceral nociception by lipopolysaccharide-mediated intestinal inflammation and barrier dysfunction.
The Journal of clinical investigation
Zhou SY,Gillilland M,Wu X,Leelasinjaroen P,Zhang G,Zhou H,Ye B,Lu Y,Owyang C
61-7300 was used in Western Blotting to demonstrate how a high FODMAP diet leads to high levels of fecal lipopolysaccharides, gut dysbiosis and visceral hypersensitivity, and propose a low FODMAP diet as beneficial to IBS patients.
Tue Jan 02 00:00:00 UTC 2018
Postpartum increases in cerebral edema and inflammation in response to placental ischemia during pregnancy.
Brain, behavior, and immunity
Clayton AM,Shao Q,Paauw ND,Giambrone AB,Granger JP,Warrington JP
61-7300 was used in Western Blotting to suggest that 2 months postpartum, neuroinflammation, along with decreased occludin expression, may partly explain posterior cortical edema in rats with history of placental ischemia.
Tue May 01 00:00:00 UTC 2018
Deficiency in intestinal epithelial O-GlcNAcylation predisposes to gut inflammation.
EMBO molecular medicine
Zhao M,Xiong X,Ren K,Xu B,Cheng M,Sahu C,Wu K,Nie Y,Huang Z,Blumberg RS,Han X,Ruan HB
61-7300 was used in Western Blotting to reveal that protein O-GlcNAcylation in intestinal epithelial cells controls key regulatory mechanisms to maintain mucosal homeostasis.
Wed Aug 01 00:00:00 UTC 2018
Neural progenitor fate decision defects, cortical hypoplasia and behavioral impairment in Celsr1-deficient mice.
Molecular psychiatry
Boucherie C,Boutin C,Jossin Y,Schakman O,Goffinet AM,Ris L,Gailly P,Tissir F
61-7300 was used in Immunohistochemistry-wholemount to show that the communication between forebrain meninges and apical neural progenitor cells is essential to cortical development and that the basal compartment of apical neural progenitor cell is key to this communication process.
Thu Mar 01 00:00:00 UTC 2018
Sleep deprivation disrupts the lacrimal system and induces dry eye disease.
Experimental & molecular medicine
Li S,Ning K,Zhou J,Guo Y,Zhang H,Zhu Y,Zhang L,Jia C,Chen Y,Sol Reinach P,Liu Z,Li W
61-7300 was used in Immunohistochemistry-immunofluorescence to observe the effect of sleep deficiency on ocular surface health to benefit the diagnosis and treatment of sleep-disorder-related ocular surface diseases.
Fri Mar 02 00:00:00 UTC 2018
MicroRNA-Mediated Therapy Modulating Blood-Brain Barrier Disruption Improves Vascular Cognitive Impairment.
Arteriosclerosis, thrombosis, and vascular biology
Toyama K,Spin JM,Deng AC,Huang TT,Wei K,Wagenhäuser MU,Yoshino T,Nguyen H,Mulorz J,Kundu S,Raaz U,Adam M,Schellinger IN,Jagger A,Tsao PS
61-7300 was used in Immunohistochemistry to provide the first evidence that the TNFα-miR-501-3p-ZO-1 axis plays an important role in the pathogenesis of cerebral hypoperfusion-induced working memory deficits and white matter lesions, as a result of blood-brain barrier breakdown via tight junction disruption.
Fri Jun 01 00:00:00 UTC 2018
Calprotectin protects against experimental colonic inflammation in mice.
British journal of pharmacology
Aranda CJ,Ocón B,Arredondo-Amador M,Suárez MD,Zarzuelo A,Chazin WJ,Martínez-Augustin O,Sánchez de Medina F
61-7300 was used in Immunohistochemistry to study the role of calprotectin in intestinal inflammation, using the dextran sulfate sodium model of colitis in mice.
Mon Oct 01 00:00:00 UTC 2018
CLAMP/Spef1 regulates planar cell polarity signaling and asymmetric microtubule accumulation in the Xenopus ciliated epithelia.
The Journal of cell biology
Kim SK,Zhang S,Werner ME,Brotslaw EJ,Mitchell JW,Altabbaa MM,Mitchell BJ
61-7300 was used in Immunohistochemistry-immunofluorescence to hypothesize that CLAMP facilitates the establishment of cell polarity and promotes the asymmetric accumulation of MTs downstream of the establishment of proper PCP.
Mon May 07 00:00:00 UTC 2018
Genome Editing in Neuroepithelial Stem Cells to Generate Human Neurons with High Adenosine-Releasing Capacity.
Stem cells translational medicine
Poppe D,Doerr J,Schneider M,Wilkens R,Steinbeck JA,Ladewig J,Tam A,Paschon DE,Gregory PD,Reik A,Müller CE,Koch P,Brüstle O
61-7300 was used in Immunocytochemistry-immunoflourescence to establish that extensive adenosine release could be triggered by excitation of differentiated neuronal cultures, suggesting an an activity-dependent regulation of adenosine supply.
Fri Jun 01 00:00:00 UTC 2018
β1-integrin-matrix interactions modulate cerebral microvessel endothelial cell tight junction expression and permeability.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Izawa Y,Gu YH,Osada T,Kanazawa M,Hawkins BT,Koziol JA,Papayannopoulou T,Spatz M,Del Zoppo GJ
61-7300 was used in Immunohistochemistry-immunofluorescence to study how interruptions to β1-integrin-matrix adhesion lead to increased permeability in the the blood-brain barrier.
Sun Apr 01 00:00:00 UTC 2018
β1-integrin-matrix interactions modulate cerebral microvessel endothelial cell tight junction expression and permeability.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Izawa Y,Gu YH,Osada T,Kanazawa M,Hawkins BT,Koziol JA,Papayannopoulou T,Spatz M,Del Zoppo GJ
61-7300 was used in Immunohistochemistry-immunofluorescence to study how interruptions to β1-integrin-matrix adhesion lead to increased permeability in the the blood-brain barrier.
Sun Apr 01 00:00:00 UTC 2018
Functional redundancy of frizzled 3 and frizzled 6 in planar cell polarity control of mouse hair follicles.
Development (Cambridge, England)
Dong B,Vold S,Olvera-Jaramillo C,Chang H
61-7300 was used in Immunohistochemistry-immunofluorescence to demonstrate that the randomly oriented hair phenotype observed in frizzled 6 (Fzd6) mutants results from a partial loss of the polarity, due to the functional redundancy of another closely related frizzled gene, Fzd3.
Mon Oct 08 00:00:00 UTC 2018
Proliferation-independent role of NF2 (merlin) in limiting biliary morphogenesis.
Development (Cambridge, England)
Benhamouche-Trouillet S,O'Loughlin E,Liu CH,Polacheck W,Fitamant J,McKee M,El-Bardeesy N,Chen CS,McClatchey AI
61-7300 was used in Immunohistochemistry-immunofluorescence to suggest that NF2 normally limits biliary morphogenesis by coordinating lumen expansion and cell architecture.
Mon Apr 30 00:00:00 UTC 2018
Dynein 1 supports spermatid transport and spermiation during spermatogenesis in the rat testis.
American journal of physiology. Endocrinology and metabolism
Wen Q,Tang EI,Lui WY,Lee WM,Wong CKC,Silvestrini B,Cheng CY
61-7300 was used in Western Blotting to investigate the role of dynein 1 in supporting the transport of spermatids and organelles across the seminiferous epithelium during spermatogenesis.
Thu Nov 01 00:00:00 UTC 2018
Regulation of blood-testis barrier assembly in vivo by germ cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Li XY,Zhang Y,Wang XX,Jin C,Wang YQ,Sun TC,Li J,Tang JX,Batool A,Deng SL,Chen SR,Cheng CY,Liu YX
61-7300 was used in Immunocytochemistry-immunoflourescence to study the role of germ cells in blood testis barrier assembly.
Thu Mar 01 00:00:00 UTC 2018
Retinoic acid signaling is essential for maintenance of the blood-retinal barrier.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Pollock LM,Xie J,Bell BA,Anand-Apte B
61-7300 was used in Immunohistochemistry-wholemount to study the molecular and cellular pathways involved in the maintenance of the blood-retinal barrier.
Mon Oct 01 00:00:00 UTC 2018
0.005% Preservative-Free Latanoprost Induces Dry Eye-Like Ocular Surface Damage via Promotion of Inflammation in Mice.
Investigative ophthalmology & visual science
Yang Y,Huang C,Lin X,Wu Y,Ouyang W,Tang L,Ye S,Wang Y,Li W,Zhang X,Liu Z
61-7300 was used in Immunohistochemistry-wholemount to investigate the side effects of preservative-free 0.005% latanoprost on the murine ocular surface.
Mon Jul 02 00:00:00 UTC 2018
Knockout of ClC-2 reveals critical functions of adherens junctions in colonic homeostasis and tumorigenicity.
American journal of physiology. Gastrointestinal and liver physiology
Jin Y,Ibrahim D,Magness ST,Blikslager AT
61-7300 was used in Immunohistochemistry (Frozen) to demonstrate that in the absence of CIC-2, adherens junctions are disrupted, revealing critical functions of the junctional structures, such as maintenance of homeostasis and differentiation.
Sat Dec 01 00:00:00 UTC 2018
Human Primary Cell-Based Organotypic Microtissues for Modeling Small Intestinal Drug Absorption.
Pharmaceutical research
Ayehunie S,Landry T,Stevens Z,Armento A,Hayden P,Klausner M
61-7300 was used in Immunohistochemistry to assess the relative contributions of failure of cell division, cell-cell fusion and the number of centrosomes with mature/mother centrioles, examined by immunofluorescence in a tissue microarray (TMA) of human melanomas and benign nevi.
Fri Feb 23 00:00:00 UTC 2018
Reassembly of adult human testicular cells: can testis cord-like structures be created in vitro?
Molecular human reproduction
Mincheva M,Sandhowe-Klaverkamp R,Wistuba J,Redmann K,Stukenborg JB,Kliesch S,Schlatt S
61-7300 was used in Immunohistochemistry to observe basic morphological features resembling in vivo testicular cords, however, the proof of functionality (e.g. support of germ cells) will need further studies.
Thu Feb 01 00:00:00 UTC 2018
Effects of 17β-Estradiol on Colonic Permeability and Inflammation in an Azoxymethane/Dextran Sulfate Sodium-Induced Colitis Mouse Model.
Gut and liver
Song CH,Kim N,Sohn SH,Lee SM,Nam RH,Na HY,Lee DH,Surh YJ
61-7300 was used in Immunohistochemistry to study the effect of estradiol treatment on colonic permeability, tight junction disruption and inflammation in an induced colitis mouse model.
Thu Nov 15 00:00:00 UTC 2018
HDAC inhibitors, trichostatin A and valproic acid, increase E‑cadherin and vimentin expression but inhibit migration and invasion of cholangiocarcinoma cells.
Oncology reports
Wang JH,Lee EJ,Ji M,Park SM
61-7300 was used in Western Blotting to conclude that treatment of biliary cancer with HDAC inhibitors, trionchostatin A and valproic acid, should be should be considered with caution due to their abilities to augment both E-cadherin and vimentin expression in cholangiocarcinoma cells.
Sun Jul 01 00:00:00 UTC 2018
Genetically induced microtubule disruption in the mouse intestine impairs intracellular organization and transport.
Molecular biology of the cell
Muroyama A,Terwilliger M,Dong B,Suh H,Lechler T
61-7300 was used in Immunohistochemistry to study the role of enterocyte microtubules in organelle organisation.
Sun Jul 01 00:00:00 UTC 2018
Requirement of the F-actin-binding activity of l-afadin for enhancing the formation of adherens and tight junctions.
Genes to cells : devoted to molecular & cellular mechanisms
Sakakibara S,Maruo T,Miyata M,Mizutani K,Takai Y
61-7300 was used in Western Blotting to indicate that the F-actin-binding activity of l-afadin is required for enhancing the formation of both AJs and TJs.
Thu Mar 01 00:00:00 UTC 2018
Immunohistochemistry in Investigative and Toxicologic Pathology.
Toxicologic pathology
Janardhan KS,Jensen H,Clayton NP,Herbert RA
61-7300 was used in Immunohistochemistry to review the technical aspects of immunohistochemistry, the variables that affect the results, interpretation, and reproducibility of IHC results.
Sun Jul 01 00:00:00 UTC 2018
A filter-free blood-brain barrier model to quantitatively study transendothelial delivery of nanoparticles by fluorescence spectroscopy.
Journal of controlled release : official journal of the Controlled Release Society
De Jong E,Williams DS,Abdelmohsen LKEA,Van Hest JCM,Zuhorn IS
61-7300 was used in Immunocytochemistry-immunofluorescence to screen for suitable nanocarriers, and to study the process of transcytosis, a cultured polarized monolayer of brain microvascular endothelial cells on an extracellular matrix-coated porous membrane filter widely used as an in vitro blood-brain barrier (BBB) model.
Sat Nov 10 00:00:00 UTC 2018
PyMT-1099, a versatile murine cell model for EMT in breast cancer.
Scientific reports
Saxena M,Kalathur RKR,Neutzner M,Christofori G
61-7300 was used in Immunocytochemistry to study and characterise epithelial PyMT-1099 cancer cells from the MMTV-PyMT mouse model of breast cancer and report on processes of epithelial-mesenchymal transition.
Tue Aug 14 00:00:00 UTC 2018
Epithelial Cdc42 Deletion Induced Enamel Organ Defects and Cystogenesis.
Journal of dental research
Zheng J,Nie X,He L,Yoon AJ,Wu L,Zhang X,Vats M,Schiff MD,Xiang L,Tian Z,Ling J,Mao JJ
61-7300 was used in Immunohistochemistry to suggest that excessive cell death and disrupted cell-cell connections may be among multiple factors responsible for the observed cystic lesions in Cdc42 mutant enamel organs.
Thu Nov 01 00:00:00 UTC 2018
Nephrotoxicity and Kidney Transport Assessment on 3D Perfused Proximal Tubules.
The AAPS journal
Vormann MK,Gijzen L,Hutter S,Boot L,Nicolas A,van den Heuvel A,Vriend J,Ng CP,Nieskens TTG,van Duinen V,de Wagenaar B,Masereeuw R,Suter-Dick L,Trietsch SJ,Wilmer M,Joore J,Vulto P,Lanz HL
61-7300 was used in Immunohistochemistry-immunofluorescence to demonstrate that we developed a functional 3D perfused proximal tubule model with advanced renal epithelial characteristics that can be used for drug screening studies.
Tue Aug 14 00:00:00 UTC 2018
Human Huntington's Disease iPSC-Derived Cortical Neurons Display Altered Transcriptomics, Morphology, and Maturation.
Cell reports
Mehta SR,Tom CM,Wang Y,Bresee C,Rushton D,Mathkar PP,Tang J,Mattis VB
61-7300 was used in Immunocytochemistry to demonstrate that HD patient iPSCs can successfully differentiate toward a cortical fate in culture, the resulting neurons display altered transcriptomics, morphological and functional phenotypes indicative of altered corticogenesis in HD.
Tue Oct 23 00:00:00 UTC 2018
Oncostatin M-induced blood-brain barrier impairment is due to prolonged activation of STAT3 signaling in vitro.
Journal of cellular biochemistry
Takata F,Dohgu S,Matsumoto J,Machida T,Sakaguchi S,Kimura I,Yamauchi A,Kataoka Y
61-7300 was used in Western Blotting to suggest that OSM-induced sustained increases in STAT3 phosphorylation levels largely contribute to BBB impairment.
Thu Nov 01 00:00:00 UTC 2018
Developmental SMAD6 loss leads to blood vessel hemorrhage and disrupted endothelial cell junctions.
Developmental biology
Wylie LA,Mouillesseaux KP,Chong DC,Bautch VL
61-7300 was used in Immunohistochemistry to show that SMAD6 is essential for proper blood vessel function during murine development, where it appears to stabilize endothelial junctions to prevent hemorrhage and aberrant angiogenesis.
Mon Oct 15 00:00:00 UTC 2018
Vitamin D Receptor Deletion Leads to the Destruction of Tight and Adherens Junctions in Lungs.
Tissue barriers
Chen H,Lu R,Zhang YG,Sun J
61-7300 was used in Western Blotting to study the role of the vitamin D receptor in lung barrier integrity.
Mon Apr 01 00:00:00 UTC 2019
Delivery of CR2-fH Using AAV Vector Therapy as Treatment Strategy in the Mouse Model of Choroidal Neovascularization.
Molecular therapy. Methods & clinical development
Schnabolk G,Parsons N,Obert E,Annamalai B,Nasarre C,Tomlinson S,Lewin AS,Rohrer B
61-7300 was used in Immunohistochemistry to test an alternative approach of AAV-mediated delivery (AAV5-VMD2-CR2-fH or AAV5-VMD2-mCherry) using subretinal delivery in C57BL/6J mice.
Fri Jun 15 00:00:00 UTC 2018
Reactive astrocytic S1P3 signaling modulates the blood-tumor barrier in brain metastases.
Nature communications
Gril B,Paranjape AN,Woditschka S,Hua E,Dolan EL,Hanson J,Wu X,Kloc W,Izycka-Swieszewska E,Duchnowska R,Pęksa R,Biernat W,Jassem J,Nayyar N,Brastianos PK,Hall OM,Peer CJ,Figg WD,Pauly GT,Robinson C,Difilippantonio S,Bialecki E,Metellus P,Schneider JP,Steeg PS
61-7300 was used in Immunocytochemistry-immunoflourescence to study the role of neuroinflammatory astrocytic S1P3 in blood brain barrier permeability.
Fri Jul 13 00:00:00 UTC 2018
Afadin Downregulation by Helicobacter pylori Induces Epithelial to Mesenchymal Transition in Gastric Cells.
Frontiers in microbiology
Marques MS,Melo J,Cavadas B,Mendes N,Pereira L,Carneiro F,Figueiredo C,Leite M
61-7300 was used in Western Blotting to show that Afadin is downregulated by H. pylori infection in vitro and in vivo and its downregulated leads to the emergence of epithelial-to-mesenchymal transition, which can contribute to gastric carcinogenesis.
Thu Oct 01 00:00:00 UTC 2020
Stromal fibroblast activation protein alpha promotes gastric cancer progression via epithelial-mesenchymal transition through Wnt/ β-catenin pathway.
BMC cancer
Liu J,Huang C,Peng C,Xu F,Li Y,Yutaka Y,Xiong B,Yang X
61-7300 was used in Western Blotting to investigate the influence of fibroblast activation protein alpha (FAP) derived from cancer-associated fibroblasts (CAFs), as well as potential mechanism of epithelial mesenchymal transition (EMT), on gastric cancer (GC) progression.
Mon Nov 12 00:00:00 UTC 2018
GDNF enhances human blood-nerve barrier function in vitro via MAPK signaling pathways.
Tissue barriers
Dong C,Ubogu EE
61-7300 was used in Immunocytochemistry to study the mechanisms of human blood-nerve barrier (BNB) formation and ascertain the downstream signalling pathway involved in the process. To determine the molecular changes that may occur at human BNB intercellular junctions under the influence of glial-derived neurotrophic factor (GDNF).
Mon Apr 01 00:00:00 UTC 2019
Nephron-specific knockin of the PIKfyve-binding-deficient Vac14L156R mutant results in albuminuria and mesangial expansion.
American journal of physiology. Renal physiology
Michgehl U,Skryabin BV,Bayraktar S,Vollenbröker B,Ciarimboli G,Heitplatz B,Van Marck V,Gröne HJ,Pavenstädt H,Weide T
61-7300 was used in Immunocytochemistry-immunoflourescence to suggest that increased albuminuria of Vac14L156R-overexpressing mice is a consequence of a lowered endo- and transcytosis of albumin in renal tubules.
Thu Nov 01 00:00:00 UTC 2018
Protective Effects of L-902,688, a Prostanoid EP4 Receptor Agonist, against Acute Blood-Brain Barrier Damage in Experimental Ischemic Stroke.
Frontiers in neuroscience
DeMars KM,McCrea AO,Siwarski DM,Sanz BD,Yang C,Candelario-Jalil E
61-7300 was used in Western Blotting to show for the first time that pharmacological activation of EP4 with L-902,688 is neuroprotective in ischemic stroke by reducing MMP-3/-9 and BBB damage.
Thu Oct 01 00:00:00 UTC 2020
The atypical mitogen-activated protein kinase ERK3 is essential for establishment of epithelial architecture.
The Journal of biological chemistry
Takahashi C,Miyatake K,Kusakabe M,Nishida E
61-7300 was used in Immunohistochemistry-immunofluorescence to show that extracellular signal-regulated kinase 3 (ERK3), a poorly characterized atypical mitogen-activated protein kinase (MAPK), regulates the epithelial architecture in vertebrates.
Fri Jun 01 00:00:00 UTC 2018
Evaluating the origin and virulence of a Helicobacter pylori cagA-positive strain isolated from a non-human primate.
Scientific reports
Hashi K,Imai C,Yahara K,Tahmina K,Hayashi T,Azuma T,Miyabe-Nishiwaki T,Sato H,Matsuoka M,Niimi S,Okamoto M,Hatakeyama M
61-7300 was used in Immunohistochemistry-immunofluorescence to isolate an H. pylori strain (Hp_TH2099) naturally infecting the stomach of a housed macaque, indicating a zoonotic feature of H. pylori infection.
Mon Oct 29 00:00:00 UTC 2018
Epithelial expression and function of trypsin-3 in irritable bowel syndrome.
Gut
Rolland-Fourcade C,Denadai-Souza A,Cirillo C,Lopez C,Jaramillo JO,Desormeaux C,Cenac N,Motta JP,Larauche M,Taché Y,Vanden Berghe P,Neunlist M,Coron E,Kirzin S,Portier G,Bonnet D,Alric L,Vanner S,Deraison C,Vergnolle N
61-7300 was used in Immunocytochemistry-immunoflourescence to show visceral hypersensitivity is induced by active protease trypsin 3 which is produced and released by the intestinal epithelium in irritable bowel syndrome.
Sun Oct 01 00:00:00 UTC 2017
Differentiation of Human Pluripotent Stem Cells into Functional Lung Alveolar Epithelial Cells.
Cell stem cell
Jacob A,Morley M,Hawkins F,McCauley KB,Jean JC,Heins H,Na CL,Weaver TE,Vedaie M,Hurley K,Hinds A,Russo SJ,Kook S,Zacharias W,Ochs M,Traber K,Quinton LJ,Crane A,Davis BR,White FV,Wambach J,Whitsett JA,Cole FS,Morrisey EE,Guttentag SH,Beers MF,Kotton DN
61-7300 was used in Immunocytochemistry to show PSC-derived AEC2s provide a platform for disease modeling and future functional regeneration of the distal lung.
Thu Oct 05 00:00:00 UTC 2017
Autophagy and KRT8/keratin 8 protect degeneration of retinal pigment epithelium under oxidative stress.
Autophagy
Baek A,Yoon S,Kim J,Baek YM,Park H,Lim D,Chung H,Kim DE
61-7300 was used in Immunohistochemistry-immunofluorescence to suggest that pharmacological manipulation of KRT8 upregulation through autophagy with combined inhibition of the MAPK1/3 pathway may be attractive therapeutic strategies for the treatment of age-related macular degeneration.
Wed Feb 01 00:00:00 UTC 2017
Size-selective opening of the blood-brain barrier by targeting endothelial sphingosine 1-phosphate receptor 1.
Proceedings of the National Academy of Sciences of the United States of America
Yanagida K,Liu CH,Faraco G,Galvani S,Smith HK,Burg N,Anrather J,Sanchez T,Iadecola C,Hla T
617300 was used in immunohistochemistry - free floating and western blot to describe a role for sphingosine 1-phosphate receptor-1 in regulating blood brain barrier permeability
Tue Apr 25 00:00:00 UTC 2017
Complement modulation in the retinal pigment epithelium rescues photoreceptor degeneration in a mouse model of Stargardt disease.
Proceedings of the National Academy of Sciences of the United States of America
Lenis TL,Sarfare S,Jiang Z,Lloyd MB,Bok D,Radu RA
61-7300 was used in Immunohistochemistry to attempt to rescue the phenotype in STGD1 mice by increasing expression of CRRY in the RPE using a gene therapy approach.
Tue Apr 11 00:00:00 UTC 2017
Cell-cell adhesion accounts for the different orientation of columnar and hepatocytic cell divisions.
The Journal of cell biology
Lázaro-Diéguez F,Müsch A
61-7300 was used in Immunocytochemistry to describe a rescue mechanism that drives substrate-parallel spindle alignment of quasi-diagonal metaphase spindles in anaphase.
Mon Nov 06 00:00:00 UTC 2017
Cell-cell adhesion accounts for the different orientation of columnar and hepatocytic cell divisions.
The Journal of cell biology
Lázaro-Diéguez F,Müsch A
61-7300 was used in Immunocytochemistry to describe a rescue mechanism that drives substrate-parallel spindle alignment of quasi-diagonal metaphase spindles in anaphase.
Mon Nov 06 00:00:00 UTC 2017
Dopamine enhances duodenal epithelial permeability via the dopamine D5 receptor in rodent.
Acta physiologica (Oxford, England)
Feng XY,Zhang DN,Wang YA,Fan RF,Hong F,Zhang Y,Li Y,Zhu JX
61-7300 was used in Western Blotting to demonstrate that dopamine enhances duodenal permeability in rats.
Mon May 01 00:00:00 UTC 2017
Direct and efficient transfection of mouse neural stem cells and mature neurons by in vivo mRNA electroporation.
Development (Cambridge, England)
Bugeon S,de Chevigny A,Boutin C,Coré N,Wild S,Bosio A,Cremer H,Beclin C
61-7300 was used in Immunohistochemistry-wholemount to demonstrate in vivo mRNA electroporation as a direct and efficient tool for the manipulation of neural stem cells and postmitotic neurons.
Wed Nov 01 00:00:00 UTC 2017
TRPV4 Regulates Tight Junctions and Affects Differentiation in a Cell Culture Model of the Corneal Epithelium.
Journal of cellular physiology
Martínez-Rendón J,Sánchez-Guzmán E,Rueda A,González J,Gulias-Cañizo R,Aquino-Jarquín G,Castro-Muñozledo F,García-Villegas R
61-7300 was used in immunocytochemistry to investigate the role of TRPV4 in a corneal epithelial cell model
Sat Jul 01 00:00:00 UTC 2017
Human salivary peptide histatin-1 stimulates epithelial and endothelial cell adhesion and barrier function.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
van Dijk IA,Ferrando ML,van der Wijk AE,Hoebe RA,Nazmi K,de Jonge WJ,Krawczyk PM,Bolscher JGM,Veerman ECI,Stap J
61-7300 was used in Immunocytochemistry-immunoflourescence to explore the effects of Hst1 on cellular barrier function.
Fri Sep 01 00:00:00 UTC 2017
Human salivary peptide histatin-1 stimulates epithelial and endothelial cell adhesion and barrier function.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
van Dijk IA,Ferrando ML,van der Wijk AE,Hoebe RA,Nazmi K,de Jonge WJ,Krawczyk PM,Bolscher JGM,Veerman ECI,Stap J
61-7300 was used in Immunocytochemistry-immunoflourescence to explore the effects of Hst1 on cellular barrier function.
Fri Sep 01 00:00:00 UTC 2017
Regulation of spermatogenesis by a local functional axis in the testis: role of the basement membrane-derived noncollagenous 1 domain peptide.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Chen H,Mruk DD,Lee WM,Cheng CY
61-7300 was used in Immunocytochemistry to report that NC1 domain derived from collagen α3(IV) chain-a major structural component of the BM-was capable of inducing BTB remodeling.
Tue Aug 01 00:00:00 UTC 2017
Regulation of spermatogenesis by a local functional axis in the testis: role of the basement membrane-derived noncollagenous 1 domain peptide.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Chen H,Mruk DD,Lee WM,Cheng CY
61-7300 was used in Immunocytochemistry to report that NC1 domain derived from collagen α3(IV) chain-a major structural component of the BM-was capable of inducing BTB remodeling.
Tue Aug 01 00:00:00 UTC 2017
Regulation of spermatogenesis by a local functional axis in the testis: role of the basement membrane-derived noncollagenous 1 domain peptide.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Chen H,Mruk DD,Lee WM,Cheng CY
61-7300 was used in Immunocytochemistry to report that NC1 domain derived from collagen α3(IV) chain-a major structural component of the BM-was capable of inducing BTB remodeling.
Tue Aug 01 00:00:00 UTC 2017
Regulation of the blood-testis barrier by a local axis in the testis: role of laminin α2 in the basement membrane.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Gao Y,Mruk D,Chen H,Lui WY,Lee WM,Cheng CY
617300 was used in immunocytochemistry and western blot to explore how laminin2 in the basement membrane modulates the blood testis barrier dynamics during spermatogenesis
Wed Feb 01 00:00:00 UTC 2017
Targeting the tight junction protein, zonula occludens-1, with the connexin43 mimetic peptide, αCT1, reduces VEGF-dependent RPE pathophysiology.
Journal of molecular medicine (Berlin, Germany)
Obert E,Strauss R,Brandon C,Grek C,Ghatnekar G,Gourdie R,Rohrer B
61-7300 was used in Immunohistochemistry-immunofluorescence to study the effect of zonula-occludens-1 on maintenance of blood-retina barrier integrity and reduction of retinal pigment epithelium pathophysiology.
Mon May 01 00:00:00 UTC 2017
Deep nuclear invaginations are linked to cytoskeletal filaments - integrated bioimaging of epithelial cells in 3D culture.
Journal of cell science
Jorgens DM,Inman JL,Wojcik M,Robertson C,Palsdottir H,Tsai WT,Huang H,Bruni-Cardoso A,López CS,Bissell MJ,Xu K,Auer M
61-7300 was used in Immunohistochemistry-immunofluorescence to support a physical and/or mechanical link from the desmosomes and hemidesmosomes to the nucleus, which had previously been hypothesized but now is visualized for the first time.
Sun Jan 01 00:00:00 UTC 2017
Lamin Cleavage: A Reliable Marker for Studying Staurosporine-Induced Apoptosis in Corneal Tissue.
Investigative ophthalmology & visual science
Mahajan S,Thieme D,Czugala M,Kruse FE,Fuchsluger TA
61-7300 was used in Immunohistochemistry-immunofluorescence to identify a robust apoptosis marker suitable for both quantification and back-to-back analyses of programmed cell death and to define specific upstream targets for apoptosis in corneal cells.
Wed Nov 01 00:00:00 UTC 2017
Establishment, maintenance and functional integrity of the blood-testis barrier in organotypic cultures of fresh and frozen/thawed prepubertal mouse testes.
Molecular human reproduction
Rondanino C,Maouche A,Dumont L,Oblette A,Rives N
61-7300 was used in Immunohistochemistry to show that organotypic cultures allow the establishment and maintenance of major blood-testis barrier (BTB) components and the formation of a functional BTB in mouse testicular tissues.
Mon May 01 00:00:00 UTC 2017
Urban fine particulate matter exposure causes male reproductive injury through destroying blood-testis barrier (BTB) integrity.
Toxicology letters
Cao XN,Shen LJ,Wu SD,Yan C,Zhou Y,Xiong G,Wang YC,Liu Y,Liu B,Tang XL,Guo M,Liu DY,Long CL,Sun M,He DW,Lin T,Wei GH
617300 was used in immunohistochemistry - paraffin section and western blot to elucidate how particulate matter impairs male reproduction
Sun Jan 15 00:00:00 UTC 2017
Variants of β-casofensin, a bioactive milk peptide, differently modulate the intestinal barrier: In vivo and ex vivo studies in rats.
Journal of dairy science
Bruno J,Nicolas A,Pesenti S,Schwarz J,Simon JL,Léonil J,Plaisancié P
61-7300 was used in Western Blotting to compare the intestinal effects of Β-casofensin A2 and its 3 main variants: A1, A3, and B.
Mon May 01 00:00:00 UTC 2017
Possible role of HIWI2 in modulating tight junction proteins in retinal pigment epithelial cells through Akt signaling pathway.
Molecular and cellular biochemistry
Sivagurunathan S,Palanisamy K,Arunachalam JP,Chidambaram S
617300 was used in immunocytochemistry and western blot to report the presence of PIWI-like proteins in somatic cells and the possible role of HIWI2 in preserving the functional integrity of epithelial cells
Wed Mar 01 00:00:00 UTC 2017
Effects of MMP12 on cell motility and inflammation during corneal epithelial repair.
Experimental eye research
Wolf M,Maltseva I,Clay SM,Pan P,Gajjala A,Chan MF
61-7300 was used in Immunohistochemistry-immunofluorescence to support the theory that the enzyme MMP12 promotes early repair processes following corneal epithelial injury by enhancing epithelial cell migration and neutrophil infiltration.
Sat Jul 01 00:00:00 UTC 2017
Development of an in vitro co-culture model to mimic the human intestine in healthy and diseased state.
Toxicology in vitro : an international journal published in association with BIBRA
Kämpfer AAM,Urbán P,Gioria S,Kanase N,Stone V,Kinsner-Ovaskainen A
61-7300 was used in Immunocytochemistry-immunoflourescence to establish a co-culture of Caco-2 and PMA-differentiated THP-1 cells that mimics the intestine in healthy and controlled inflamed states.
Fri Dec 01 00:00:00 UTC 2017
Culture media-based selection of endothelial cells, pericytes, and perivascular-resident macrophage-like melanocytes from the young mouse vestibular system.
Hearing research
Zhang J,Chen S,Cai J,Hou Z,Wang X,Kachelmeier A,Shi X
61-7300 was used in immunocytochemistry to develop a novel method for obtaining perivascular-resident macrophage-like melanocytes, pericytes, and endothelial cells primary cells to study the vestibular blood-labyrinth barrier
Wed Mar 01 00:00:00 UTC 2017
ROCK1 but not ROCK2 contributes to RhoA signaling and NMIIA-mediated contractility at the epithelial zonula adherens.
Molecular biology of the cell
Priya R,Liang X,Teo JL,Duszyc K,Yap AS,Gomez GA
617300 was used in immunocytochemistry to analyze differential functional effects for rho kinases 1 and 2 at the epithelial zonula adherens
Sun Jan 01 00:00:00 UTC 2017
FK506 suppresses hypoxia‑induced inflammation and protects tight junction function via the CaN‑NFATc1 signaling pathway in retinal microvascular epithelial cells.
Molecular medicine reports
Hu Y,Yang B,Xu Y,Jiang L,Tsui CK,Liang X
61-7300 was used in Western Blotting to report that FK506 suppressed injury to the tight junctions and downregulated the expression of inflammatory cytokines in hypoxia-induced mRMECs via the CaN-NFATc1 signaling pathway.
Wed Nov 01 00:00:00 UTC 2017
Pten facilitates epiblast epithelial polarization and proamniotic lumen formation in early mouse embryos.
Developmental dynamics : an official publication of the American Association of Anatomists
Meng Y,Cai KQ,Moore R,Tao W,Tse JD,Smith ER,Xu XX
61-7300 was used in Immunohistochemistry-immunofluorescence to show that phosphatase and tensin homologue on chromosome 10 is required for proamniotic cavity formation by establishing polarity for epiblast cells to form a rosette that expands into the proamniotic lumen.
Sat Jul 01 00:00:00 UTC 2017
Membrane-free culture and real-time barrier integrity assessment of perfused intestinal epithelium tubes.
Nature communications
Trietsch SJ,Naumovska E,Kurek D,Setyawati MC,Vormann MK,Wilschut KJ,Lanz HL,Nicolas A,Ng CP,Joore J,Kustermann S,Roth A,Hankemeier T,Moisan A,Vulto P
61-7300 was used in Immunohistochemistry to develop a microfluidic device supporting the growth and function of extracellular matrix-supported intestinal tubules, and evaluate the effect of staurosporine and acetylsalicylic acid on barrier integrity.
Tue Aug 15 00:00:00 UTC 2017
Human Organ Chip Models Recapitulate Orthotopic Lung Cancer Growth, Therapeutic Responses, and Tumor Dormancy In Vitro.
Cell reports
Hassell BA,Goyal G,Lee E,Sontheimer-Phelps A,Levy O,Chen CS,Ingber DE
61-7300 was used in Immunocytochemistry-immunoflourescence to explain the reason behind high level of resistance to therapy in cancer patients with minimal residual disease in regions of the lung that remain functionally aerated and mobile.
Tue Oct 10 00:00:00 UTC 2017
Context-dependent compensation among phosphatidylserine-recognition receptors.
Scientific reports
Penberthy KK,Rival C,Shankman LS,Raymond MH,Zhang J,Perry JSA,Lee CS,Han CZ,Onengut-Gumuscu S,Palczewski K,Lysiak JJ,Ravichandran KS
61-7300 was used in Immunohistochemistry-immunofluorescence to establish that not all phagocytic receptors are functionally equal, and that compensation among specific engulfment receptors is context and tissue dependent.
Tue Nov 07 00:00:00 UTC 2017
miR-1199-5p and Zeb1 function in a double-negative feedback loop potentially coordinating EMT and tumour metastasis.
Nature communications
Diepenbruck M,Tiede S,Saxena M,Ivanek R,Kalathur RKR,Lüönd F,Meyer-Schaller N,Christofori G
61-7300 was used in Western Blot to report the identification of miR-1199-5p, as a repressor of EMT, tumour cell invasion and metastasis, which comparable to miR-200 family members targets Zeb1 mRNA for degradation.
Fri Oct 27 00:00:00 UTC 2017
miR-1199-5p and Zeb1 function in a double-negative feedback loop potentially coordinating EMT and tumour metastasis.
Nature communications
Diepenbruck M,Tiede S,Saxena M,Ivanek R,Kalathur RKR,Lüönd F,Meyer-Schaller N,Christofori G
61-7300 was used in Western Blot to report the identification of miR-1199-5p, as a repressor of EMT, tumour cell invasion and metastasis, which comparable to miR-200 family members targets Zeb1 mRNA for degradation.
Fri Oct 27 00:00:00 UTC 2017
miR-1199-5p and Zeb1 function in a double-negative feedback loop potentially coordinating EMT and tumour metastasis.
Nature communications
Diepenbruck M,Tiede S,Saxena M,Ivanek R,Kalathur RKR,Lüönd F,Meyer-Schaller N,Christofori G
61-7300 was used in Western Blot to report the identification of miR-1199-5p, as a repressor of EMT, tumour cell invasion and metastasis, which comparable to miR-200 family members targets Zeb1 mRNA for degradation.
Fri Oct 27 00:00:00 UTC 2017
miR-1199-5p and Zeb1 function in a double-negative feedback loop potentially coordinating EMT and tumour metastasis.
Nature communications
Diepenbruck M,Tiede S,Saxena M,Ivanek R,Kalathur RKR,Lüönd F,Meyer-Schaller N,Christofori G
61-7300 was used in Western Blot to report the identification of miR-1199-5p, as a repressor of EMT, tumour cell invasion and metastasis, which comparable to miR-200 family members targets Zeb1 mRNA for degradation.
Fri Oct 27 00:00:00 UTC 2017
Dry age-related macular degeneration like pathology in aged 5XFAD mice: Ultrastructure and microarray analysis.
Oncotarget
Park SW,Im S,Jun HO,Lee K,Park YJ,Kim JH,Park WJ,Lee YH,Kim JH
61-7300 was used in Immunohistochemistry to analyse the ultrastructure of the retinal pigment epithelium (RPE) of 5XFAD mice, using transmission electron microscopy.
Tue Jun 20 00:00:00 UTC 2017
Epithelial-mesenchymal transformation and apoptosis in rat urethra development.
Pediatric research
Zhou Y,Liu X,Huang F,Liu Y,Cao X,Shen L,Long C,He D,Lin T,Wei G
61-7300 was used in Immunohistochemistry to provide new insights into the mechanisms involved in embryonal development of the urethra.
Fri Dec 01 00:00:00 UTC 2017
Epi/perineural and Schwann Cells as Well as Perineural Sheath Integrity are Affected Following 2,4-D Exposure.
Neurotoxicity research
Sharifi Pasandi M,Hosseini Shirazi F,Gholami MR,Salehi H,Najafzadeh N,Mazani M,Ghasemi Hamidabadi H,Niapour A
61-7300 was used in Western Blotting to indicate that oxidative stress, apoptosis of epi/perineural and Schwann cell and impaired blood-nerve barrier may have contributed to nerve damage following 2,4-D exposure.
Wed Nov 01 00:00:00 UTC 2017
Epi/perineural and Schwann Cells as Well as Perineural Sheath Integrity are Affected Following 2,4-D Exposure.
Neurotoxicity research
Sharifi Pasandi M,Hosseini Shirazi F,Gholami MR,Salehi H,Najafzadeh N,Mazani M,Ghasemi Hamidabadi H,Niapour A
61-7300 was used in Western Blotting to indicate that oxidative stress, apoptosis of epi/perineural and Schwann cell and impaired blood-nerve barrier may have contributed to nerve damage following 2,4-D exposure.
Wed Nov 01 00:00:00 UTC 2017
Appropriately differentiated ARPE-19 cells regain phenotype and gene expression profiles similar to those of native RPE cells.
Molecular vision
Samuel W,Jaworski C,Postnikova OA,Kutty RK,Duncan T,Tan LX,Poliakov E,Lakkaraju A,Redmond TM
617300 was used in immunocytochemistry to identify conditions in which low-passage ARPE-19 cells express genes specific to native human RPE cells
Fri Feb 09 00:00:00 UTC 2018
Caffeine Prevents Blood Retinal Barrier Damage in a Model, In Vitro, of Diabetic Macular Edema.
Journal of cellular biochemistry
Maugeri G,D'Amico AG,Rasà DM,La Cognata V,Saccone S,Federico C,Cavallaro S,D'Agata V
61-7300 was used in Western Blotting to demonstrate that caffeine is able to prevent outer BRB damage by inhibiting apoptotic cell death induced by hyperglycemic/hypoxic insult since it downregulates the proapoptotic Bax and upregulates the anti-apoptotic Bcl-2 genes.
Tue Aug 01 00:00:00 UTC 2017
Generation of retinal pigmented epithelium from iPSCs derived from the conjunctiva of donors with and without age related macular degeneration.
PloS one
Geng Z,Walsh PJ,Truong V,Hill C,Ebeling M,Kapphahn RJ,Montezuma SR,Yuan C,Roehrich H,Ferrington DA,Dutton JR
617300 was used in immunohistochemistry to establish an application to generate retinal pigmented epithelium from induced pluripotent stem cells
Thu Aug 17 00:00:00 UTC 2017
Effect of PPAR-β/δ agonist GW0742 treatment in the acute phase response and blood-brain barrier permeability following brain injury.
Translational research : the journal of laboratory and clinical medicine
Chehaibi K,le Maire L,Bradoni S,Escola JC,Blanco-Vaca F,Slimane MN
617300 was used in western blot to report the effects of peroxisome proliferator-activated receptor beta/delta agonist on the acute phase response after brain injury
Sat Apr 01 00:00:00 UTC 2017
Proliferation-independent regulation of organ size by Fgf/Notch signaling.
eLife
Kozlovskaja-Gumbrienė A,Yi R,Alexander R,Aman A,Jiskra R,Nagelberg D,Knaut H,McClain M,Piotrowski T
617300 was used in immunohistochemistry to find Notch signaling is integral for Wnt and Fgf signaling feedback loop coordinating cell migration
Fri Jan 13 00:00:00 UTC 2017
Stem Cell Derived Retinal Pigment Epithelium: The Role of Pigmentation as Maturation Marker and Gene Expression Profile Comparison with Human Endogenous Retinal Pigment Epithelium.
Stem cell reviews and reports
Bennis A,Jacobs JG,Catsburg LAE,Ten Brink JB,Koster C,Schlingemann RO,van Meurs J,Gorgels TGMF,Moerland PD,Heine VM,Bergen AA
61-7300 was used in Immunocytochemistry-immunoflourescence to discover how pigmentation stages reflect developmental stages and functionality of PSC-derived retinal pigment epithelium cells.
Sun Oct 01 00:00:00 UTC 2017
Hypertension in rats is associated with an increased permeability of the colon to TMA, a gut bacteria metabolite.
PloS one
Jaworska K,Huc T,Samborowska E,Dobrowolski L,Bielinska K,Gawlak M,Ufnal M
61-7300 was used in Immunohistochemistry-immunofluorescence to study the relationship between hypertension and changes in colon permeability to trimethylamine.
Tue Jan 16 00:00:00 UTC 2018
Mitosis can drive cell cannibalism through entosis.
eLife
Durgan J,Tseng YY,Hamann JC,Domart MC,Collinson L,Hall A,Overholtzer M,Florey O
61-7300 was used in Immunocytochemistry to uncover an intriguing link between cell division and cannibalism, of significance to both cancer and chemotherapy.
Tue Jul 11 00:00:00 UTC 2017
From the Cover: Comparative Proteomics Reveals Silver Nanoparticles Alter Fatty Acid Metabolism and Amyloid Beta Clearance for Neuronal Apoptosis in a Triple Cell Coculture Model of the Blood-Brain Barrier.
Toxicological sciences : an official journal of the Society of Toxicology
Lin HC,Ho MY,Tsen CM,Huang CC,Wu CC,Huang YJ,Hsiao IL,Chuang CY
61-7300 was used in Immunocytochemistry-immunofluorescence to suggest that AgNP exposure might cause Aβ deposition and inflammation for subsequent neuronal cell apoptosis to potentially induce AD progression.
Sat Jul 01 00:00:00 UTC 2017
Leptospira interrogans causes quantitative and morphological disturbances in adherens junctions and other biological groups of proteins in human endothelial cells.
PLoS neglected tropical diseases
Sato H,Coburn J
61-7300 was used in Immunocytochemistry to elucidate the pathogenic mechanisms of Leptospira interrogans infection.
Sat Jul 01 00:00:00 UTC 2017
Blood flow drives lumen formation by inverse membrane blebbing during angiogenesis in vivo.
Nature cell biology
Gebala V,Collins R,Geudens I,Phng LK,Gerhardt H
61-7300 was used in immunohistochemistry to assess the drive of lumen formation via blood flow through inverse membrane blebbing during angiogenesis in vivo
Fri Apr 01 00:00:00 UTC 2016
Analgesic drug delivery via recombinant tissue plasminogen activator and microRNA-183-triggered opening of the blood-nerve barrier.
Biomaterials
Yang S,Krug SM,Heitmann J,Hu L,Reinhold AK,Sauer S,Bosten J,Sommer C,Fromm M,Brack A,Rittner HL
61-7300 was used in western blot to study the effect of microRNA-183 and analgesic drug delivery by recombinant tissue plasminogen activator in opening of the blood-nerve barrier
Tue Mar 01 00:00:00 UTC 2016
ANGPTL4-αvβ3 interaction counteracts hypoxia-induced vascular permeability by modulating Src signalling downstream of vascular endothelial growth factor receptor 2.
The Journal of pathology
Gomez Perdiguero E,Liabotis-Fontugne A,Durand M,Faye C,Ricard-Blum S,Simonutti M,Augustin S,Robb BM,Paques M,Valenzuela DM,Murphy AJ,Yancopoulos GD,Thurston G,Galaup A,Monnot C,Germain S
61-7300 was used in Immunohistochemistry-immunofluorescence to demonstrate that Angptl4-deficient mice show increased vascular leakage in vivo in a model of laser-induced choroidal neovascularization, indicating that this newly identified ANGPTL4-αvβ3 axis might be a target for pharmaceutical intervention in pathological conditions.
Thu Dec 01 00:00:00 UTC 2016
Altered Prostasin (CAP1/Prss8) Expression Favors Inflammation and Tissue Remodeling in DSS-induced Colitis.
Inflammatory bowel diseases
Keppner A,Malsure S,Nobile A,Auberson M,Bonny O,Hummler E
61-7300 was used in Western Blotting to demonstrate a protective role of colonic prostasin expression against experimental colitis, and thus represent a susceptibility gene in the development of inflammatory bowel disease.
Thu Dec 01 00:00:00 UTC 2016
Gonadotropin suppression in men leads to a reduction in claudin-11 at the Sertoli cell tight junction.
Human reproduction (Oxford, England)
McCabe MJ,Tarulli GA,Laven-Law G,Matthiesson KL,Meachem SJ,McLachlan RI,Dinger ME,Stanton PG
61-7300 was used in immunohistochemistry - paraffin section to study a reduction in claudin-11 at the sertoli cell tight junction by gonadotropin suppression in men
Fri Apr 01 00:00:00 UTC 2016
Human alveolar epithelial cells expressing tight junctions to model the air-blood barrier.
ALTEX
Kuehn A,Kletting S,de Souza Carvalho-Wodarz C,Repnik U,Griffiths G,Fischer U,Meese E,Huwer H,Wirth D,May T,Schneider-Daum N,Lehr CM
61-7300 was used in immunocytochemistry to utilize human alveolar epithelial cells expressing tight junctions as an air-blood barrier model
Tue Jan 17 00:00:00 UTC 2017
Generation and functional characterization of epithelial cells with stable expression of SLC26A9 Cl- channels.
American journal of physiology. Lung cellular and molecular physiology
Salomon JJ,Spahn S,Wang X,Füllekrug J,Bertrand CA,Mall MA
61-7300 was used in immunocytochemistry to study epithelial cells with stable expression of SLC26A9 Cl-channels by generation and functional characterization
Fri Apr 01 00:00:00 UTC 2016
TLR4-Dependent Claudin-1 Internalization and Secretagogue-Mediated Chloride Secretion Regulate Irinotecan-Induced Diarrhea.
Molecular cancer therapeutics
Wardill HR,Bowen JM,Van Sebille YZ,Secombe KR,Coller JK,Ball IA,Logan RM,Gibson RJ
61-7300 was used in Immunohistochemistry to suggest that TLR4-dependent claudin-1 internalization and secondary anion secretion contribute to irinotecan-induced diarrhea.
Tue Nov 01 00:00:00 UTC 2016
Acetylated bacterial cellulose coated with urinary bladder matrix as a substrate for retinal pigment epithelium.
Colloids and surfaces. B, Biointerfaces
Gonçalves S,Rodrigues IP,Padrão J,Silva JP,Sencadas V,Lanceros-Mendez S,Girão H,Gama FM,Dourado F,Rodrigues LR
61-7300 was used in immunocytochemistry to characterize a substrate for retinal pigment epithelium that is acetylated bacterial cellulose coated with urinary bladder matrix
Tue Mar 01 00:00:00 UTC 2016
293 cells express both epithelial as well as mesenchymal cell adhesion molecules.
International journal of molecular medicine
Inada M,Izawa G,Kobayashi W,Ozawa M
61-7300 was used in immunocytochemistry and western blot to determine expression of epithelial as well as mesenchymal cell adhesion molecules in 293 cells
Wed Jun 01 00:00:00 UTC 2016
Scribble is required for pregnancy-induced alveologenesis in the adult mammary gland.
Journal of cell science
Baker L,BeGora M,Au Yeung F,Feigin ME,Rosenberg AZ,Lowe SW,Kislinger T,Muthuswamy SK
61-7300 was used in immunohistochemistry to assess the adult mammary gland and its requirement for scribble for pregnancy-induced alveologenesis
Wed Jun 15 00:00:00 UTC 2016
Coronin 1B supports RhoA signaling at cell-cell junctions through Myosin II.
Cell cycle (Georgetown, Tex.)
Priya R,Wee K,Budnar S,Gomez GA,Yap AS,Michael M
61-7300 was used in Immunocytochemistry to demonstrate a key role for Coronin 1B in maintaining a junctional pool of non-muscle Myosin II.
Wed Nov 16 00:00:00 UTC 2016
The levels of epithelial anchor proteins β-catenin and zona occludens-1 are altered by E7 of human papillomaviruses 5 and 8.
The Journal of general virology
Heuser S,Hufbauer M,Marx B,Tok A,Majewski S,Pfister H,Akgül B
61-7300 was used in Immunohistochemistry to provide evidence that Β-catenin and ZO-1 are direct targets of E7 of the oncogenic Β-HPV types 5 and 8.
Mon Feb 01 00:00:00 UTC 2016
Hematopoietic Stem Cells Transplantation Can Normalize Thyroid Function in a Cystinosis Mouse Model.
Endocrinology
Gaide Chevronnay HP,Janssens V,Van Der Smissen P,Rocca CJ,Liao XH,Refetoff S,Pierreux CE,Cherqui S,Courtoy PJ
61-7300 was used in immunohistochemistry - paraffin section to evaluate the use of hematopoietic stem cell transplantation for cystinotic thyroid and study the underlying mechanisms
Fri Apr 01 00:00:00 UTC 2016
Maternal Obesity in the Mouse Compromises the Blood-Brain Barrier in the Arcuate Nucleus of Offspring.
Endocrinology
Kim DW,Glendining KA,Grattan DR,Jasoni CL
61-7300 was used in immunohistochemistry - frozen section to determine compromises in the blood-brain barrier in the arcuate nucleus of offspring due to maternal obesity in the mouse
Wed Jun 01 00:00:00 UTC 2016
Dual effects of a high-protein diet on DSS-treated mice during colitis resolution phase.
American journal of physiology. Gastrointestinal and liver physiology
Lan A,Blais A,Coelho D,Capron J,Maarouf M,Benamouzig R,Lancha AH,Walker F,Tomé D,Blachier F
61-7300 was used in Western Blot to study the impact of the dietary protein level on the process of colonic mucosal inflammation and subsequent recovery by feeding DSS-treated mice with either a normoproteic (NP) or a high-protein (HP) isocaloric diet from the beginning of the 5-day dextran sulfate sodium (DSS) treatment to 14 days later.
Sat Oct 01 00:00:00 UTC 2016
Interleukin 1alpha-induced disruption of the Sertoli cell cytoskeleton affects gap junctional communication.
Cellular signalling
Chojnacka K,Bilinska B,Mruk DD
61-7300 was used in immunocytochemistry to characterize disruption of the sertolic cell cytoskeleton by interleukin 1alpha and its affect on gap junctional communication
Sun May 01 00:00:00 UTC 2016
A reductionist metastasis-on-a-chip platform for in vitro tumor progression modeling and drug screening.
Biotechnology and bioengineering
Skardal A,Devarasetty M,Forsythe S,Atala A,Soker S
61-7300 was used in immunohistochemistry - paraffin section to study an in vitro model for tumor progression modeling and drug screening by using a reductionist metastasis-on-a-chip platform
Thu Sep 01 00:00:00 UTC 2016
Specific deletion of AMP-activated protein kinase (α1AMPK) in mouse Sertoli cells modifies germ cell quality.
Molecular and cellular endocrinology
Bertoldo MJ,Guibert E,Faure M,Guillou F,Ramé C,Nadal-Desbarats L,Foretz M,Viollet B,Dupont J,Froment P
61-7300 was used in western blot to elucidate a deletion of AMP-activated protein kinase in mouse Sertoli cells that modify germ cell quality
Sat Mar 05 00:00:00 UTC 2016
MicroRNA-107 prevents amyloid-beta induced blood-brain barrier disruption and endothelial cell dysfunction by targeting Endophilin-1.
Experimental cell research
Liu W,Cai H,Lin M,Zhu L,Gao L,Zhong R,Bi S,Xue Y,Shang X
61-7300 was used in immunocytochemistry and western blot to study the prevention of amyloid-beta induced blood-brain barrier disruption and endothelial cell dysfunction by targeting Endophilin-1 by MicroRNA-107
Sun May 01 00:00:00 UTC 2016
A novel in vitro platform for the study of SN38-induced mucosal damage and the development of Toll-like receptor 4-targeted therapeutic options.
Experimental biology and medicine (Maywood, N.J.)
Wardill HR,Gibson RJ,Van Sebille YZ,Secombe KR,Logan RM,Bowen JM
61-7300 was used in immunocytochemistry to utilize a unique in vitro platform to learn about development of Toll-like receptor 4-targeted therapeutic options and the study of SN38-induced mucosal damage
Fri Jul 01 00:00:00 UTC 2016
Adropin reduces paracellular permeability of rat brain endothelial cells exposed to ischemia-like conditions.
Peptides
Yang C,DeMars KM,Hawkins KE,Candelario-Jalil E
61-7300 was used in western blot to study the reduction of paracellular permeability of rat brain endothelial cells exposed to ischemia-like conditions by adropin
Fri Jul 01 00:00:00 UTC 2016
Tight junction defects are seen in the buccal mucosa of patients receiving standard dose chemotherapy for cancer.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
Wardill HR,Logan RM,Bowen JM,Van Sebille YZ,Gibson RJ
61-7300 was used in immunohistochemistry to assess epithelial tight junctions, cytokine production, and matrix metalloproteinase profiles in patients undergoing chemotherapy.
Fri Apr 01 00:00:00 UTC 2016
Reduced insulin secretion function is associated with pancreatic islet redistribution of cell adhesion molecules (CAMS) in diabetic mice after prolonged high-fat diet.
Histochemistry and cell biology
Falcão VT,Maschio DA,de Fontes CC,Oliveira RB,Santos-Silva JC,Almeida AC,Vanzela EC,Cartaxo MT,Carvalho CP,Collares-Buzato CB
61-7300 was used in immunohistochemistry - paraffin section and western blot to characterize the association with pancreatic islet redistribution of cell adhesion molecules (CAMS) and reduced insulin secretion function in diabetic mice after prolonged hi
Fri Jul 01 00:00:00 UTC 2016
Rab35 GTPase couples cell division with initiation of epithelial apico-basal polarity and lumen opening.
Nature communications
Klinkert K,Rocancourt M,Houdusse A,Echard A
61-7300 was used in immunocytochemistry to analyze the relationship between Rab35 GTPase cell division and initiation of epithelial apico-basal polarity and lumen opening
Mon Apr 04 00:00:00 UTC 2016
Attenuation of Blood-Brain Barrier Breakdown and Hyperpermeability by Calpain Inhibition.
The Journal of biological chemistry
Alluri H,Grimsley M,Anasooya Shaji C,Varghese KP,Zhang SL,Peddaboina C,Robinson B,Beeram MR,Huang JH,Tharakan B
61-7300 was used in Immunocytochemistry to test the effect of calpain inhibition on the BBB following traumatic insults to the brain.
Fri Dec 30 00:00:00 UTC 2016
Overexpression of PRL7D1 in Leydig Cells Causes Male Reproductive Dysfunction in Mice.
International journal of molecular sciences
Liu Y,Su X,Hao J,Chen M,Liu W,Liao X,Li G
61-7300 was used in western blot to determine the cause of male reproductive dysfunction in mice due to overexpression of PRL7D1 in Leydig cells
Wed Jan 13 00:00:00 UTC 2016
The blood-tendon barrier: identification and characterisation of a novel tissue barrier in tendon blood vessels.
European cells & materials
Lehner C,Gehwolf R,Ek JC,Korntner S,Bauer H,Bauer HC,Traweger A,Tempfer H
61-7300 was used in immunohistochemistry - paraffin section to characterize and identify a novel tissue barrier in tendon blood vessels
Thu May 26 00:00:00 UTC 2016
Hypotonic Stress-induced Down-regulation of Claudin-1 and -2 Mediated by Dephosphorylation and Clathrin-dependent Endocytosis in Renal Tubular Epithelial Cells.
The Journal of biological chemistry
Fujii N,Matsuo Y,Matsunaga T,Endo S,Sakai H,Yamaguchi M,Yamazaki Y,Sugatani J,Ikari A
61-7300 was used in Immunocytochemistry to suggest that hypotonic stress induces dephosphorylation, clathrin-dependent endocytosis, and degradation of claudin-1 and.
Fri Nov 18 00:00:00 UTC 2016
Adapting coculture in vitro models of the blood-brain barrier for use in cancer research: maintaining an appropriate endothelial monolayer for the assessment of transendothelial migration.
Laboratory investigation; a journal of technical methods and pathology
Vandenhaute E,Drolez A,Sevin E,Gosselet F,Mysiorek C,Dehouck MP
61-7300 was used in Immunohistochemistry to adapt an existing in vitro model of the human blood-brain barrier for use in studying cancer cell transmigration.
Sun May 01 00:00:00 UTC 2016
Rescue of perfluorooctanesulfonate (PFOS)-mediated Sertoli cell injury by overexpression of gap junction protein connexin 43.
Scientific reports
Li N,Mruk DD,Chen H,Wong CK,Lee WM,Cheng CY
61-7300 was used in immunocytochemistry and western blot to characterize overexpression of gap junction protein connexin 43 by rescue of perfluorooctanesulfonate (PFOS)-mediated sertoli cell injury
Wed Jul 20 00:00:00 UTC 2016
Alix-mediated assembly of the actomyosin-tight junction polarity complex preserves epithelial polarity and epithelial barrier.
Nature communications
Campos Y,Qiu X,Gomero E,Wakefield R,Horner L,Brutkowski W,Han YG,Solecki D,Frase S,Bongiovanni A,d'Azzo A
61-7300 was used in western blot to analyze preservation of epithelial polarity and epithelial barrier by alix-mediated assembly of the actomyosin-tight junction polarity complex
Thu Jun 23 00:00:00 UTC 2016
Polarity protein Crumbs homolog-3 (CRB3) regulates ectoplasmic specialization dynamics through its action on F-actin organization in Sertoli cells.
Scientific reports
Gao Y,Lui WY,Lee WM,Cheng CY
61-7300 was used in western blot report that crumbs homolog 3 is an actin microfilament regulator
Thu Jun 30 00:00:00 UTC 2016
PLEKHA7 Recruits PDZD11 to Adherens Junctions to Stabilize Nectins.
The Journal of biological chemistry
Guerrera D,Shah J,Vasileva E,Sluysmans S,Méan I,Jond L,Poser I,Mann M,Hyman AA,Citi S
61-7300 was used in western blot to study recruitment of PDZD11 to adherens junctions to stabilize nectins via PLEKHA7
Fri May 20 00:00:00 UTC 2016
Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell- and patient-derived tumor organoids.
Nature medicine
Huang L,Holtzinger A,Jagan I,BeGora M,Lohse I,Ngai N,Nostro C,Wang R,Muthuswamy LB,Crawford HC,Arrowsmith C,Kalloger SE,Renouf DJ,Connor AA,Cleary S,Schaeffer DF,Roehrl M,Tsao MS,Gallinger S,Keller G,Muthuswamy SK
61-7300 was used in immunohistochemistry - paraffin section to analyze a model for ductal pancreatic cancer and drug screening
Sun Nov 01 00:00:00 UTC 2015
Feedback regulation through myosin II confers robustness on RhoA signalling at E-cadherin junctions.
Nature cell biology
Priya R,Gomez GA,Budnar S,Verma S,Cox HL,Hamilton NA,Yap AS
61-7300 was used in immunocytochemistry to identify factors that regulate the stability of the RhoA zone
Thu Oct 01 00:00:00 UTC 2015
Control of cell-cell forces and collective cell dynamics by the intercellular adhesome.
Nature cell biology
Bazellières E,Conte V,Elosegui-Artola A,Serra-Picamal X,Bintanel-Morcillo M,Roca-Cusachs P,Muñoz JJ,Sales-Pardo M,Guimerà R,Trepat X
61-7300 was used in immunohistochemistry to elucidate the contributions of cell-cell adhesion proteins to intercellular force and epithelial tissue dynamics.
Wed Apr 01 00:00:00 UTC 2015
Vessel maturation schedule determines vulnerability to neuronal injuries of prematurity.
The Journal of clinical investigation
Licht T,Dor-Wollman T,Ben-Zvi A,Rothe G,Keshet E
61-7300 was used in immunohistochemistry - paraffin section to evaluate an animal model for periventricular leukomalacia
Mon Mar 02 00:00:00 UTC 2015
Genetically engineered SCN5A mutant pig hearts exhibit conduction defects and arrhythmias.
The Journal of clinical investigation
Park DS,Cerrone M,Morley G,Vasquez C,Fowler S,Liu N,Bernstein SA,Liu FY,Zhang J,Rogers CS,Priori SG,Chinitz LA,Fishman GI
61-7300 was used in immunohistochemistry and western blot to identify the role of SCN5A mutations in cardiac functions
Thu Jan 01 00:00:00 UTC 2015
Endothelial Gαq/11 is required for VEGF-induced vascular permeability and angiogenesis.
Cardiovascular research
Sivaraj KK,Li R,Albarran-Juarez J,Wang S,Tischner D,Grimm M,Swiercz JM,Offermanns S,Wettschureck N
61-7300 was used in western blot to assess the role of Gαq/11 in VEGF-dependent regulation of vascular permeability and angiogenesis.
Thu Oct 01 00:00:00 UTC 2015
Barrier Function of the Repaired Skin Is Disrupted Following Arrest of Dicer in Keratinocytes.
Molecular therapy : the journal of the American Society of Gene Therapy
Ghatak S,Chan YC,Khanna S,Banerjee J,Weist J,Roy S,Sen CK
61-7300 was used in immunohistochemistry - frozen section and western blot to describe a miRNA-dependent mechanism of Dicer in reestablishing the barrier function of the skin post-wounding
Wed Jul 01 00:00:00 UTC 2015
Abnormalities in Expression of Structural, Barrier and Differentiation Related Proteins, and Chondroitin Sulfate in Feline and Human Interstitial Cystitis.
The Journal of urology
Hauser PJ,VanGordon SB,Seavey J,Sofinowski TM,Ramadan M,Abdullah S,Buffington CA,Hurst RE
61-7300 was used in immunohistochemistry - paraffin section to assess the proteome in the urothelium of cats diagnosed with feline interstitial cystitis and compare it to the proteome of patients with human interstitial cystitis/bladder pain syndrome
Sat Aug 01 00:00:00 UTC 2015
EGF regulates claudin-2 and -4 expression through Src and STAT3 in MDCK cells.
Journal of cellular physiology
García-Hernández V,Flores-Maldonado C,Rincon-Heredia R,Verdejo-Torres O,Bonilla-Delgado J,Meneses-Morales I,Gariglio P,Contreras RG
61-7300 was used in immunocytochemistry to investigate the effect of EGF on claudin-2 and -4 expression in MDCK cells.
Thu Jan 01 00:00:00 UTC 2015
Identification of CCL2, RARRES2 and EFNB2 as host cell factors that influence the multistep replication of respiratory syncytial virus.
Virus research
Shirato K,Ujike M,Kawase M,Matsuyama S
61-7300 was used in immunocytochemistry to identify host cell factors involved in the replication of respiratory syncytial virus
Wed Dec 02 00:00:00 UTC 2015
TPN-associated intestinal epithelial cell atrophy is modulated by TLR4/EGF signaling pathways.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Freeman JJ,Feng Y,Demehri FR,Dempsey PJ,Teitelbaum DH
61-7300 was used in immunocytochemistry to study the modulatory effect of TLR4/EGF signaling pathways on TPN-associated intestinal epithelial cell atrophy.
Wed Jul 01 00:00:00 UTC 2015
Actin-bundling protein plastin 3 is a regulator of ectoplasmic specialization dynamics during spermatogenesis in the rat testis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Li N,Mruk DD,Wong CK,Lee WM,Han D,Cheng CY
61-7300 was used in immunohistochemistry and western blot to study the role of plastin 3 in ectoplasmic specialization dynamics during spermatogenesis in the rat testis
Tue Sep 01 00:00:00 UTC 2015
EB1 regulates tubulin and actin cytoskeletal networks at the sertoli cell blood-testis barrier in male rats: an in vitro study.
Endocrinology
Tang EI,Mok KW,Lee WM,Cheng CY
61-7300 was used in western blot to study the role of EB1 in tubulin and actin cytoskeletal networks at the sertoli cell blood-testis barrier
Sun Feb 01 00:00:00 UTC 2015
Overexpression of miR-18a negatively regulates myocyte enhancer factor 2D to increase the permeability of the blood-tumor barrier via Krüppel-like factor 4-mediated downregulation of zonula occluden-1, claudin-5, and occludin.
Journal of neuroscience research
Zhao YY,Zhao LN,Wang P,Miao YS,Liu YH,Wang ZH,Ma J,Li Z,Li ZQ,Xue YX
61-7300 was used in immunocytochemistry and western blot to elucidate the effects and mechanism of miR-18a on the permeability of the blood-tumor barrier.
Tue Dec 01 00:00:00 UTC 2015
Nephrin, a transmembrane protein, is involved in pancreatic beta-cell survival signaling.
Molecular and cellular endocrinology
Kapodistria K,Tsilibary EP,Politis P,Moustardas P,Charonis A,Kitsiou P
61-7300 was used in western blot to investigate the role of nephrin in beta-cell survival signaling
Thu Jan 15 00:00:00 UTC 2015
Short communication: Glucagon-like peptide-2 and coccidiosis alter tight junction gene expression in the gastrointestinal tract of dairy calves.
Journal of dairy science
Walker MP,Evock-Clover CM,Elsasser TH,Connor EE
61-7300 was used in immunohistochemistry to study the effect of glucagon-like peptide-2 and coccidiosis on tight junction gene expression in the gastrointestinal tract of dairy calves.
Fri May 01 00:00:00 UTC 2015
Liver-Tumor Hybrid Organoids for Modeling Tumor Growth and Drug Response In Vitro.
Annals of biomedical engineering
Skardal A,Devarasetty M,Rodman C,Atala A,Soker S
61-7300 was used in immunocytochemistry and immunohistochemistry to investigate using liver-tumor organoids for in vitro modeling of liver metastasis
Thu Oct 01 00:00:00 UTC 2015
Heterogeneity between triple negative breast cancer cells due to differential activation of Wnt and PI3K/AKT pathways.
Experimental cell research
Martínez-Revollar G,Garay E,Martin-Tapia D,Nava P,Huerta M,Lopez-Bayghen E,Meraz-Cruz N,Segovia J,González-Mariscal L
61-7300 was used in western blot to characterize two clones from triple negative breast MDA-MB-231 cancer cells
Sun Nov 15 00:00:00 UTC 2015
Increasing fat content from 20 to 45 wt% in a complex diet induces lower endotoxemia in parallel with an increased number of intestinal goblet cells in mice.
Nutrition research (New York, N.Y.)
Benoit B,Laugerette F,Plaisancié P,Géloën A,Bodennec J,Estienne M,Pineau G,Bernalier-Donadille A,Vidal H,Michalski MC
61-7300 was used in western blot to test if increasing dietary lipid consumption results in increased endotoxemia, low-grade inflammation, and metabolic and intestinal alterations
Wed Apr 01 00:00:00 UTC 2015
Expression of tight-junction proteins in human proximal small intestinal mucosa before and after Roux-en-Y gastric bypass surgery.
Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery
Casselbrant A,Elias E,Fändriks L,Wallenius V
61-7300 was used in western blot to study tight-junction proteins in human proximal small intestinal mucosa before and after Roux-en-Y gastric bypass surgery
Fri Jan 15 00:00:00 UTC 2016
ETB receptor-mediated MMP-9 activation induces vasogenic edema via ZO-1 protein degradation following status epilepticus.
Neuroscience
Kim JY,Ko AR,Hyun HW,Kang TC
61-7300 was used in immunohistochemistry and western blot to investigate the molecular and physiological involved in vasogenic edema formation.
Thu Sep 24 00:00:00 UTC 2015
MgcRacGAP restricts active RhoA at the cytokinetic furrow and both RhoA and Rac1 at cell-cell junctions in epithelial cells.
Molecular biology of the cell
Breznau EB,Semack AC,Higashi T,Miller AL
61-7300 was used in western blot to investigate the role of MgcRacGAP in cell-cell junctions
Wed Jul 01 00:00:00 UTC 2015
Musashi-1 maintains blood-testis barrier structure during spermatogenesis and regulates stress granule formation upon heat stress.
Molecular biology of the cell
ErLin S,WenJie W,LiNing W,BingXin L,MingDe L,Yan S,RuiFa H
61-7300 was used in western blot to study the role of Musashi-1 in blood-testis barrier structure during spermatogenesis
Fri May 15 00:00:00 UTC 2015
Biophysical characterization of interactions between the C-termini of peripheral nerve claudins and the PDZ₁ domain of zonula occludens.
Biochemical and biophysical research communications
Wu J,Peng D,Zhang Y,Lu Z,Voehler M,Sanders CR,Li J
61-7300 was used in ChIP assay to investigate the specific roles of the 3 C-terminal claudin residues by assessing their interactions with PDZ1 of ZO2.
Fri Mar 27 00:00:00 UTC 2015
Development of a Bronchial Wall Model: Triple Culture on a Decellularized Porcine Trachea.
Tissue engineering. Part C, Methods
Melo E,Kasper JY,Unger RE,Farré R,Kirkpatrick CJ
61-7300 was used in immunocytochemistry to describe a bronchial wall coculture model using decellularized, porcine luminal trachea membrane and three relevant human cell types
Tue Sep 01 00:00:00 UTC 2015
Roundabout 4 regulates blood-tumor barrier permeability through the modulation of ZO-1, Occludin, and Claudin-5 expression.
Journal of neuropathology and experimental neurology
Cai H,Liu W,Xue Y,Shang X,Liu J,Li Z,Wang P,Liu L,Hu Y,Liu Y
61-7300 was used in immunocytochemistry and western blot to study how knockdown of Robo4 alters the blood-tumor barrier.
Thu Jan 01 00:00:00 UTC 2015
Characterization of the equine blood-testis barrier during tubular development in normal and cryptorchid stallions.
Theriogenology
Rode K,Sieme H,Richterich P,Brehm R
61-7300 was used in immunohistochemistry - paraffin section and western blot to characterize the equine blood-testis barrier during tubular development in normal and cryptorchid stallions
Tue Sep 15 00:00:00 UTC 2015
Effects of low-level laser irradiation on proliferation and functional protein expression in human RPE cells.
Lasers in medical science
Dang Y,Wu W,Xu Y,Mu Y,Xu K,Wu H,Zhu Y,Zhang C
61-7300 was used in immunocytochemistry to investigate the effects of low level laser irradiation on retinal pigment epithelia.
Tue Dec 01 00:00:00 UTC 2015
Injury to the blood-testis barrier after low-dose-rate chronic radiation exposure in mice.
Radiation protection dosimetry
Son Y,Heo K,Bae MJ,Lee CG,Cho WS,Kim SD,Yang K,Shin IS,Lee MY,Kim JS
61-7300 was used in western blot to determine effects of low-dose-rate chronic radiation on male fertility.
Sun Nov 01 00:00:00 UTC 2015
HGF/c-Met signaling promotes liver progenitor cell migration and invasion by an epithelial-mesenchymal transition-independent, phosphatidyl inositol-3 kinase-dependent pathway in an in vitro model.
Biochimica et biophysica acta
Suárez-Causado A,Caballero-Díaz D,Bertrán E,Roncero C,Addante A,García-Álvaro M,Fernández M,Herrera B,Porras A,Fabregat I,Sánchez A
61-7300 was used in western blot to determine the role of the HGF/c-Met pathway in regulating oval cell migratory and invasive properties.
Thu Oct 01 00:00:00 UTC 2015
A Triple Culture Model of the Blood-Brain Barrier Using Porcine Brain Endothelial cells, Astrocytes and Pericytes.
PloS one
Thomsen LB,Burkhart A,Moos T
61-7300 was used in immunohistochemistry to assess porcine brain endothelial cells in co-culture with porcine astrocytes and pericytes.
Tue May 17 00:00:00 UTC 2016
Paclitaxel-induced lung injury and its amelioration by parecoxib sodium.
Scientific reports
Liu WJ,Zhong ZJ,Cao LH,Li HT,Zhang TH,Lin WQ
61-7300 was used in immunohistochemistry to study the mechanism of paclitaxel-induced lung injury and how parecoxib sodium suppresses injury.
Mon Aug 10 00:00:00 UTC 2015
Generation of highly enriched populations of optic vesicle-like retinal cells from human pluripotent stem cells.
Current protocols in stem cell biology
Ohlemacher SK,Iglesias CL,Sridhar A,Gamm DM,Meyer JS
61-7300 was used in immunocytochemistry to describe a method to differentiate human pluripotent stem cells into retinal cell types
Mon Feb 02 00:00:00 UTC 2015
A three-dimensional model of the human blood-brain barrier to analyse the transport of nanoparticles and astrocyte/endothelial interactions.
F1000Research
Sreekanthreddy P,Gromnicova R,Davies H,Phillips J,Romero IA,Male D
61-7300 was used in immunocytochemistry to study a model of the human blood-brain barrier in 3D to analyze astrocyte/endothelial interactions and transport of nanoparticles
Mon Feb 15 00:00:00 UTC 2016
The long noncoding RNA TUG1 regulates blood-tumor barrier permeability by targeting miR-144.
Oncotarget
Cai H,Xue Y,Wang P,Wang Z,Li Z,Hu Y,Li Z,Shang X,Liu Y
61-7300 was used in immunocytochemistry and western blot to determine the role of lncRNAs in blood tumor barrier permeability
Fri Aug 14 00:00:00 UTC 2015
Gene expression and functional annotation of human choroid plexus epithelium failure in Alzheimer's disease.
BMC genomics
Bergen AA,Kaing S,ten Brink JB,Gorgels TG,Janssen SF
61-7300 was used in immunohistochemistry - frozen section to research the role of gene expression and function of human choroid plexus epithelium disorder in Alzheimer's disease
Mon Nov 16 00:00:00 UTC 2015
Lipopolysaccharide-induced middle ear inflammation disrupts the cochlear intra-strial fluid-blood barrier through down-regulation of tight junction proteins.
PloS one
Zhang J,Chen S,Hou Z,Cai J,Dong M,Shi X
61-7300 was used in immunocytochemistry, in-cell western blot, and western blot to characterize disruption of the cochlear intra-strail fluid-blood barrier through tight junction proteins down-regulation due to lipopolysaccharide-induced middle ear inflam
Thu Feb 18 00:00:00 UTC 2016
Molecular profiling of the residual disease of triple-negative breast cancers after neoadjuvant chemotherapy identifies actionable therapeutic targets.
Cancer discovery
Balko JM,Giltnane JM,Wang K,Schwarz LJ,Young CD,Cook RS,Owens P,Sanders ME,Kuba MG,Sánchez V,Kurupi R,Moore PD,Pinto JA,Doimi FD,Gómez H,Horiuchi D,Goga A,Lehmann BD,Bauer JA,Pietenpol JA,Ross JS,Palmer GA,Yelensky R,Cronin M,Miller VA,Stephens PJ,Arteaga CL
61-7300 was used in immunocytochemistry to study treatment resistance mechanisms in triple-negative breast cancers.
Sat Feb 01 00:00:00 UTC 2014
Inhibition of PKC-θ preserves cardiac function and reduces fibrosis in streptozotocin-induced diabetic cardiomyopathy.
British journal of pharmacology
Li Z,Abdullah CS,Jin ZQ
61-7300 was used in immunohistochemistry - paraffin section to test if inhibition of PKC-θ protect diabetic hearts by suppressing T-cell stimulation and maintaining tight junction integrity.
Sun Jun 01 00:00:00 UTC 2014
Lipopolysaccharide precipitates hepatic encephalopathy and increases blood-brain barrier permeability in mice with acute liver failure.
Liver international : official journal of the International Association for the Study of the Liver
Chastre A,Bélanger M,Nguyen BN,Butterworth RF
61-7300 was used in western blot to study the effect of endotoxemia on the progression of encephalopathy in relation to BBB permeability during acute liver failure
Sat Mar 01 00:00:00 UTC 2014
Radial intercalation is regulated by the Par complex and the microtubule-stabilizing protein CLAMP/Spef1.
The Journal of cell biology
Werner ME,Mitchell JW,Putzbach W,Bacon E,Kim SK,Mitchell BJ
61-7300 was used in immunohistochemistry to examine directed cell migration within an epithelial tissue
Mon Aug 04 00:00:00 UTC 2014
Clostridium difficile toxins facilitate bacterial colonization by modulating the fence and gate function of colonic epithelium.
The Journal of infectious diseases
Kasendra M,Barrile R,Leuzzi R,Soriani M
61-7300 was used in immunocytochemistry to describe how Clostridium difficile toxin A and B contribute to colonization.
Tue Apr 01 00:00:00 UTC 2014
The RAB5-GEF function of RIN1 regulates multiple steps during Listeria monocytogenes infection.
Traffic (Copenhagen, Denmark)
Balaji K,French CT,Miller JF,Colicelli J
61-7300 was used in immunocytochemistry to examine the function of R1N1 in regards to Listeria monocytogenes infection
Sat Nov 01 00:00:00 UTC 2014
Glutamate prevents intestinal atrophy via luminal nutrient sensing in a mouse model of total parenteral nutrition.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Xiao W,Feng Y,Holst JJ,Hartmann B,Yang H,Teitelbaum DH
61-7300 was used in immunohistochemistry - frozen section and western blot to examine how glutamate modulates intestinal epithelial cell growth and epithelial barrier function during total parenteral nutrition
Thu May 01 00:00:00 UTC 2014
β2 integrin-mediated crawling on endothelial ICAM-1 and ICAM-2 is a prerequisite for transcellular neutrophil diapedesis across the inflamed blood-brain barrier.
Journal of immunology (Baltimore, Md. : 1950)
Gorina R,Lyck R,Vestweber D,Engelhardt B
61-7300 was used in immunocytochemistry to investigate mechanisms that govern neutrophil migration across the blood brain barrier.
Wed Jan 01 00:00:00 UTC 2014
Bleeding propensity of cavernous malformations: impact of tight junction alterations on the occurrence of overt hematoma.
Journal of neurosurgery
Jakimovski D,Schneider H,Frei K,Kennes LN,Bertalanffy H
61-7300 was used in immunohistochemistry - frozen section to study the role of tight junction alterations in cavernous malformations
Mon Sep 01 00:00:00 UTC 2014
Amelioration of hypoxia and LPS-induced intestinal epithelial barrier dysfunction by emodin through the suppression of the NF-κB and HIF-1α signaling pathways.
International journal of molecular medicine
Lei Q,Qiang F,Chao D,Di W,Guoqian Z,Bo Y,Lina Y
61-7300 was used in western blot to demonstrate that emodin attenuates LPS- and hypoxia/reoxygenation-induced intestinal epithelial barrier dysfunction by inhibiting the HIF-1alpha and NF-kappaB signaling pathways, which regulate tight junctions.
Mon Dec 01 00:00:00 UTC 2014
A PKA-ezrin-Cx43 signaling complex controls gap junction communication and thereby trophoblast cell fusion.
Journal of cell science
Pidoux G,Gerbaud P,Dompierre J,Lygren B,Solstad T,Evain-Brion D,Taskén K
61-7300 was used in immunocytochemistry to study ezrin, Cx43 and PKA in cell fusion in cytotrophoblasts.
Wed Oct 01 00:00:00 UTC 2014
rpS6 regulates blood-testis barrier dynamics through Akt-mediated effects on MMP-9.
Journal of cell science
Mok KW,Mruk DD,Cheng CY
Sat Nov 15 00:00:00 UTC 2014
rpS6 regulates blood-testis barrier dynamics through Akt-mediated effects on MMP-9.
Journal of cell science
Mok KW,Mruk DD,Cheng CY
Sat Nov 15 00:00:00 UTC 2014
Intraluminal acid activates esophageal nodose C fibers after mast cell activation.
American journal of physiology. Gastrointestinal and liver physiology
Zhang S,Liu Z,Heldsinger A,Owyang C,Yu S
61-7300 was used in western blot to investigate the effect of intraluminal acid on esophageal nodose C fibers after mast cell activation
Sat Feb 01 00:00:00 UTC 2014
The angiopoietin1-Akt pathway regulates barrier function of the cultured spinal cord microvascular endothelial cells through Eps8.
Experimental cell research
Liu X,Zhou X,Yuan W
61-7300 was used in immunohistochemistry, immunoprecipitation, and western blot to investigate their role of angiopoietin 1 in regulating the blood-spinal cord barrier
Wed Oct 15 00:00:00 UTC 2014
Pasture v. standard dairy cream in high-fat diet-fed mice: improved metabolic outcomes and stronger intestinal barrier.
The British journal of nutrition
Benoit B,Plaisancié P,Géloën A,Estienne M,Debard C,Meugnier E,Loizon E,Daira P,Bodennec J,Cousin O,Vidal H,Laugerette F,Michalski MC
61-7300 was used in western blot to determine the metabolic outcomes of cows fed high fat diet
Thu Aug 28 00:00:00 UTC 2014
Novel human renal proximal tubular cell line for the production of complex proteins.
Journal of biotechnology
Fliedl L,Manhart G,Kast F,Katinger H,Kunert R,Grillari J,Wieser M,Grillari-Voglauer R
61-7300 was used in immunocytochemistry to develop and assess using a human cell line to generate glycosylation proteins
Sun Apr 20 00:00:00 UTC 2014
IL-1β and TGF-β weaken the placental barrier through destruction of tight junctions: an in vivo and in vitro study.
Placenta
Tossetta G,Paolinelli F,Avellini C,Salvolini E,Ciarmela P,Lorenzi T,Emanuelli M,Toti P,Giuliante R,Gesuita R,Crescimanno C,Voltolini C,Di Primio R,Petraglia F,Castellucci M,Marzioni D
61-7300 was used in immunohistochemistry to investigate chorioamnionitis.
Tue Jul 01 00:00:00 UTC 2014
Inhibition of RHO-ROCK signaling enhances ICM and suppresses TE characteristics through activation of Hippo signaling in the mouse blastocyst.
Developmental biology
Kono K,Tamashiro DA,Alarcon VB
61-7300 was used in immunohistochemistry to investigate the roles of RHO-ROCK and Hippo signaling in the specification of the trophectoderm and inner cell mass lineages.
Wed Oct 01 00:00:00 UTC 2014
Long-term ketamine abuse induces cystitis in rats by impairing the bladder epithelial barrier.
Molecular biology reports
Gu D,Huang J,Yin Y,Shan Z,Zheng S,Wu P
61-7300 was used in immunocytochemistry and western blot to examine the effects of long-term ketamine abuse on the inducement of cystitis in rats.
Sat Nov 01 00:00:00 UTC 2014
Autonomous stimulation of cancer cell plasticity by the human NKG2D lymphocyte receptor coexpressed with its ligands on cancer cells.
PloS one
Cai X,Dai Z,Reeves RS,Caballero-Benitez A,Duran KL,Delrow JJ,Porter PL,Spies T,Groh V
61-7300 was used in immunocytochemistry and western blot to analyze cancer cell plasticity autonomous stimulation by human NKG2D lymphocyte receptor coexpressed with its ligands on cancer cells
Wed Jun 10 00:00:00 UTC 2015
ZO proteins redundantly regulate the transcription factor DbpA/ZONAB.
The Journal of biological chemistry
Spadaro D,Tapia R,Jond L,Sudol M,Fanning AS,Citi S
61-7300 was used in western blot to study the role of ZO proteins in the regulation of transcription factor DbpA/ZONAB
Fri Aug 08 00:00:00 UTC 2014
The generation of kidney organoids by differentiation of human pluripotent cells to ureteric bud progenitor-like cells.
Nature protocols
Xia Y,Sancho-Martinez I,Nivet E,Rodriguez Esteban C,Campistol JM,Izpisua Belmonte JC
61-7300 was used in immunocytochemistry to develop methods for the differentiation of human pluripotent stem cells into ureteric bud progenitor-like cells.
Sat Nov 01 00:00:00 UTC 2014
Tropomyosin isoforms support actomyosin biogenesis to generate contractile tension at the epithelial zonula adherens.
Cytoskeleton (Hoboken, N.J.)
Caldwell BJ,Lucas C,Kee AJ,Gaus K,Gunning PW,Hardeman EC,Yap AS,Gomez GA
61-7300 was used in immunocytochemistry to examine the role of tropomyosin isoforms in actomyosin biogenesis
Mon Dec 01 00:00:00 UTC 2014
Brain microvascular endothelial cells resist elongation due to curvature and shear stress.
Scientific reports
Ye M,Sanchez HM,Hultz M,Yang Z,Bogorad M,Wong AD,Searson PC
61-7300 was used in Immunohistochemistry to show that brain microvascular endothelial cells resist elongation in response to curvature and shear stress.
Tue Apr 15 00:00:00 UTC 2014
Tight junctional localization of claudin-16 is regulated by syntaxin 8 in renal tubular epithelial cells.
The Journal of biological chemistry
Ikari A,Tonegawa C,Sanada A,Kimura T,Sakai H,Hayashi H,Hasegawa H,Yamaguchi M,Yamazaki Y,Endo S,Matsunaga T,Sugatani J
Fri May 09 00:00:00 UTC 2014
Tight junctional localization of claudin-16 is regulated by syntaxin 8 in renal tubular epithelial cells.
The Journal of biological chemistry
Ikari A,Tonegawa C,Sanada A,Kimura T,Sakai H,Hayashi H,Hasegawa H,Yamaguchi M,Yamazaki Y,Endo S,Matsunaga T,Sugatani J
Fri May 09 00:00:00 UTC 2014
Tight junctional localization of claudin-16 is regulated by syntaxin 8 in renal tubular epithelial cells.
The Journal of biological chemistry
Ikari A,Tonegawa C,Sanada A,Kimura T,Sakai H,Hayashi H,Hasegawa H,Yamaguchi M,Yamazaki Y,Endo S,Matsunaga T,Sugatani J
Fri May 09 00:00:00 UTC 2014
Tight junctional localization of claudin-16 is regulated by syntaxin 8 in renal tubular epithelial cells.
The Journal of biological chemistry
Ikari A,Tonegawa C,Sanada A,Kimura T,Sakai H,Hayashi H,Hasegawa H,Yamaguchi M,Yamazaki Y,Endo S,Matsunaga T,Sugatani J
Fri May 09 00:00:00 UTC 2014
Tight junctional localization of claudin-16 is regulated by syntaxin 8 in renal tubular epithelial cells.
The Journal of biological chemistry
Ikari A,Tonegawa C,Sanada A,Kimura T,Sakai H,Hayashi H,Hasegawa H,Yamaguchi M,Yamazaki Y,Endo S,Matsunaga T,Sugatani J
Fri May 09 00:00:00 UTC 2014
Tight junctional localization of claudin-16 is regulated by syntaxin 8 in renal tubular epithelial cells.
The Journal of biological chemistry
Ikari A,Tonegawa C,Sanada A,Kimura T,Sakai H,Hayashi H,Hasegawa H,Yamaguchi M,Yamazaki Y,Endo S,Matsunaga T,Sugatani J
Fri May 09 00:00:00 UTC 2014
Estrogen receptor alpha deficiency protects against development of cognitive impairment in murine lupus.
Journal of neuroinflammation
Cunningham MA,Wirth JR,Freeman LR,Boger HA,Granholm AC,Gilkeson GS
61-7300 was used in western blot to test if ERalpha modulates blood-brain barrier integrity and/or neuroinflammation in lupus-prone mice
Tue Dec 16 00:00:00 UTC 2014
Myosin Vb mediated plasma membrane homeostasis regulates peridermal cell size and maintains tissue homeostasis in the zebrafish epidermis.
PLoS genetics
Sidhaye J,Phatak M,Banerjee S,Mulay A,Deshpande O,Bhide S,Jacob T,Gehring I,Nuesslein-Volhard C,Sonawane M
61-7300 was used in immunohistochemistry to demonstrate the importance of Myosin Vb-dependent cell size regulation in epidermal homeostasis
Mon Sep 01 00:00:00 UTC 2014
FAK transduces extracellular forces that orient the mitotic spindle and control tissue morphogenesis.
Nature communications
Petridou NI,Skourides PA
61-7300 was used in Immunohistochemistry-wholemount to suggest that FAK transduces external forces to the cell cortex.
Fri Oct 24 00:00:00 UTC 2014
A neurovascular blood-brain barrier in vitro model.
Methods in molecular biology (Clifton, N.J.)
Zehendner CM,White R,Hedrich J,Luhmann HJ
61-7300 was used in immunocytochemistry to describe a murine blood-brain barrier coculture model that includes neurons, astrocytes, and brain endothelial cells.
Mon Sep 29 00:00:00 UTC 2014
Directed differentiation of human pluripotent cells to ureteric bud kidney progenitor-like cells.
Nature cell biology
Xia Y,Nivet E,Sancho-Martinez I,Gallegos T,Suzuki K,Okamura D,Wu MZ,Dubova I,Esteban CR,Montserrat N,Campistol JM,Izpisua Belmonte JC
61-7300 was used in immunocytochemistry to describe a method to differentiate human pluripotent cells into ureteric-bud-committed renal progenitor-like cells.
Sun Dec 01 00:00:00 UTC 2013
Application of a new wall-less plate technology to complex multistep cell-based investigations using suspension cells.
Blood
Quiñones GA,Moore TI,Nicholes K,Lee H,Kim S,Sun L,Jeon NL,Stephan JP
61-7300 was used in immunocytochemistry to develop a DropArray cell-based assay to evaluate tumor cell killing by cytotoxic T cells.
Thu Feb 14 00:00:00 UTC 2013
Isolation and culture of endothelial cells, pericytes and perivascular resident macrophage-like melanocytes from the young mouse ear.
Nature protocols
Neng L,Zhang W,Hassan A,Zemla M,Kachelmeier A,Fridberger A,Auer M,Shi X
61-7300 was used in immunocytochemistry to describe a growth medium-based method to gather cochlear endothelial cells, pericytes and perivascular resident macrophage-like melanocytes
Mon Apr 01 00:00:00 UTC 2013
Epicardial function of canonical Wnt-, Hedgehog-, Fgfr1/2-, and Pdgfra-signalling.
Cardiovascular research
Rudat C,Norden J,Taketo MM,Kispert A
61-7300 was used in immunohistochemistry to assess the contribution of canonical Wnt-, Hedgehog-, Fibroblast growth factor receptor/2-, and platelet-derived growth factor receptor alpha-signaling in murine epicardial development.
Sun Dec 01 00:00:00 UTC 2013
Organotypic brain slices: a model to study the neurovascular unit micro-environment in epilepsies.
Fluids and barriers of the CNS
Morin-Brureau M,De Bock F,Lerner-Natoli M
61-7300 was used in immunohistochemistry - free floating and western blot to develop an organotypic brain slice culture as a model to study the role of the neurovascular unit in epilepsy and other neurological disorders.
Thu Feb 07 00:00:00 UTC 2013
HIV-1 Tat C modulates expression of miRNA-101 to suppress VE-cadherin in human brain microvascular endothelial cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Mishra R,Singh SK
61-7300 was used in western blot to demonstrate the effect of HIV-1 Tat C on miRNA-101 expression in human brain microvascular endothelial cells
Wed Apr 03 00:00:00 UTC 2013
Cryo-immunoelectron microscopy of adherent cells improved by the use of electrospun cell culture substrates.
Traffic (Copenhagen, Denmark)
Schmiedinger T,Vogel GF,Eiter O,Pfaller K,Kaufmann WA,Flörl A,Gutleben K,Schönherr S,Witting B,Lechleitner TW,Ebner HL,Seppi T,Hess MW
61-7300 was used in immunocytochemistry to study electrospun nanofibres.
Thu Aug 01 00:00:00 UTC 2013
Entamoeba histolytica exacerbates epithelial tight junction permeability and proinflammatory responses in Muc2(-/-) mice.
The American journal of pathology
Kissoon-Singh V,Moreau F,Trusevych E,Chadee K
61-7300 was used in immunohistochemistry (frozen) to examine innate responses to Entamoeba histolytica in wild-type and MUC-2-deficient mice.
Fri Mar 01 00:00:00 UTC 2013
Prevention of rt-PA induced blood-brain barrier component degradation by the poly(ADP-ribose)polymerase inhibitor PJ34 after ischemic stroke in mice.
Experimental neurology
Teng F,Beray-Berthat V,Coqueran B,Lesbats C,Kuntz M,Palmier B,Garraud M,Bedfert C,Slane N,Bérézowski V,Szeremeta F,Hachani J,Scherman D,Plotkine M,Doan BT,Marchand-Leroux C,Margaill I
61-7300 was used in western blot to evaluate the protective effect of the poly(ADP-ribose)polymerase inhibitor PJ34 against vascular toxicity
Tue Oct 01 00:00:00 UTC 2013
The role of CDX2 in Caco-2 cell differentiation.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
Natoli M,Christensen J,El-Gebali S,Felsani A,Anderle P
61-7300 was used in immunocytochemistry to examine the effect of CDX2 expression in Caco-2 cells over time on a genome-wide level.
Sun Sep 01 00:00:00 UTC 2013
Epigenetic modulation of the miR-200 family is associated with transition to a breast cancer stem-cell-like state.
Journal of cell science
Lim YY,Wright JA,Attema JL,Gregory PA,Bert AG,Smith E,Thomas D,Lopez AF,Drew PA,Khew-Goodall Y,Goodall GJ
61-7300 was used in immunocytochemistry to use immortalized human mammary epithelial cells to investigate the regulation of the miR-200 family during their conversion to a stem-like phenotype.
Wed May 15 00:00:00 UTC 2013
A new human primary epithelial cell culture model to study conjunctival inflammation.
Investigative ophthalmology & visual science
García-Posadas L,Arranz-Valsero I,López-García A,Soriano-Romaní L,Diebold Y
61-7300 was used in immunocytochemistry and western blot to develop an optimized method to expand culture human conjunctival epithelial cells from cadaveric donor samples.
Tue Oct 29 00:00:00 UTC 2013
Retinoic acid promotes Sertoli cell differentiation and antagonises activin-induced proliferation.
Molecular and cellular endocrinology
Nicholls PK,Harrison CA,Rainczuk KE,Wayne Vogl A,Stanton PG
61-7300 was used in immunocytochemistry to study the cellular and molecular basis of retinoid actions upon Sertoli cell differentiation.
Thu Sep 05 00:00:00 UTC 2013
Electromagnetic-pulse-induced activation of p38 MAPK pathway and disruption of blood-retinal barrier.
Toxicology letters
Li HJ,Guo LM,Yang LL,Zhou YC,Zhang YJ,Guo J,Xie XJ,Guo GZ
61-7300 was used in western blot to assess the effects of electromagnetic pulse exposure on the permeability of the blood-retinal barrier.
Thu Jun 20 00:00:00 UTC 2013
A novel c-Met inhibitor, MK8033, synergizes with carboplatin plus paclitaxel to inhibit ovarian cancer cell growth.
Oncology reports
Marchion DC,Bicaku E,Xiong Y,Bou Zgheib N,Al Sawah E,Stickles XB,Judson PL,Lopez AS,Cubitt CL,Gonzalez-Bosquet J,Wenham RM,Apte SM,Berglund A,Lancaster JM
61-7300 was used in immunocytochemistry and western blot to investigate HGF/c-Met signaling in ovarian cancer.
Wed May 01 00:00:00 UTC 2013
Ameliorative effect of PACAP and VIP against increased permeability in a model of outer blood retinal barrier dysfunction.
Peptides
Scuderi S,D'Amico AG,Castorina A,Imbesi R,Carnazza ML,D'Agata V
61-7300 was used in western blot to study changes in the blood retinal barrier in diabetic macular edema.
Tue Jan 01 00:00:00 UTC 2013
E-cadherin supports steady-state Rho signaling at the epithelial zonula adherens.
Differentiation; research in biological diversity
Priya R,Yap AS,Gomez GA
61-7300 was used in immunocytochemistry to study how E-cadherin contributes to Rho signaling.
Tue Oct 01 00:00:00 UTC 2013
Endothelial cell, pericyte, and perivascular resident macrophage-type melanocyte interactions regulate cochlear intrastrial fluid-blood barrier permeability.
Journal of the Association for Research in Otolaryngology : JARO
Neng L,Zhang F,Kachelmeier A,Shi X
61-7300 was used in immunohistochemistry to examine the role of endothelial cell, pericyte, and perivascular resident macrophage-type melanocyte in cochlear intrastrial fluid-blood barrier permeability
Mon Apr 01 00:00:00 UTC 2013
The reversible increase in tight junction permeability induced by capsaicin is mediated via cofilin-actin cytoskeletal dynamics and decreased level of occludin.
PloS one
Shiobara T,Usui T,Han J,Isoda H,Nagumo Y
61-7300 was used in immunocytochemistry and western blot to study the molecular mechanisms underlying the reversible effects of capsaicin on tight junction permeability.
Mon Jul 07 00:00:00 UTC 2014
An essential role for insulin and IGF1 receptors in regulating sertoli cell proliferation, testis size, and FSH action in mice.
Molecular endocrinology (Baltimore, Md.)
Pitetti JL,Calvel P,Zimmermann C,Conne B,Papaioannou MD,Aubry F,Cederroth CR,Urner F,Fumel B,Crausaz M,Docquier M,Herrera PL,Pralong F,Germond M,Guillou F,Jégou B,Nef S
61-7300 was used in immunohistochemistry - paraffin section to test if the IGF system is required for germ cell and Sertoli cells development and function.
Wed May 01 00:00:00 UTC 2013
PAR2-induced inflammatory responses in human kidney tubular epithelial cells.
American journal of physiology. Renal physiology
Vesey DA,Suen JY,Seow V,Lohman RJ,Liu L,Gobe GC,Johnson DW,Fairlie DP
61-7300 was used in immunocytochemistry to determine the inflammatory gene and protein expression induced by PAR2 activation in human kidney tubular epithelial cells.
Fri Mar 15 00:00:00 UTC 2013
Using Xenopus skin to study cilia development and function.
Methods in enzymology
Werner ME,Mitchell BJ
61-7300 was used in Immunocytochemistry to describe basic molecular and embryological manipulations and imaging techniques that have proven particularly useful for understanding the polarized beating of cilia and the generation of directed fluid flow (Werner Mitchell, 2012).
Wed Sep 11 00:00:00 UTC 2013
Zona occludens-2 protects against podocyte dysfunction induced by ADR in mice.
American journal of physiology. Renal physiology
Bautista-García P,Reyes JL,Martín D,Namorado MC,Chavez-Munguía B,Soria-Castro E,Huber O,González-Mariscal L
61-7300 was used in immunohistochemistry - free floating to assess the relationship between zona occludens-2 and the Wnt/β-catenin pathway in podocyte injury and proteinuria.
Tue Jan 01 00:00:00 UTC 2013
NC1 domain of collagen α3(IV) derived from the basement membrane regulates Sertoli cell blood-testis barrier dynamics.
Spermatogenesis
Wong EW,Cheng CY
61-7300 was used in western blot to study how Sertoli cell blood-testis +C309:C312 barrier dynamics are regulated by the NC1 domain of collagen alpha3(IV) derived from the basement membrane
Mon Apr 01 00:00:00 UTC 2013
Tumor type-dependent function of the par3 polarity protein in skin tumorigenesis.
Cancer cell
Iden S,van Riel WE,Schäfer R,Song JY,Hirose T,Ohno S,Collard JG
61-7300 was used in immunocytochemistry to identify a dual function of Par3 in skin cancer.
Tue Sep 11 00:00:00 UTC 2012
Tbx18 function in epicardial development.
Cardiovascular research
Greulich F,Farin HF,Schuster-Gossler K,Kispert A
61-7300 was used in immunohistochemistry to elucidate the role of Tbx8 using transgenic mice.
Sat Dec 01 00:00:00 UTC 2012
Focal adhesion kinase-Tyr407 and -Tyr397 exhibit antagonistic effects on blood-testis barrier dynamics in the rat.
Proceedings of the National Academy of Sciences of the United States of America
Lie PP,Mruk DD,Mok KW,Su L,Lee WM,Cheng CY
Tue Jul 31 00:00:00 UTC 2012
Focal adhesion kinase-Tyr407 and -Tyr397 exhibit antagonistic effects on blood-testis barrier dynamics in the rat.
Proceedings of the National Academy of Sciences of the United States of America
Lie PP,Mruk DD,Mok KW,Su L,Lee WM,Cheng CY
Tue Jul 31 00:00:00 UTC 2012
Perivascular-resident macrophage-like melanocytes in the inner ear are essential for the integrity of the intrastrial fluid-blood barrier.
Proceedings of the National Academy of Sciences of the United States of America
Zhang W,Dai M,Fridberger A,Hassan A,Degagne J,Neng L,Zhang F,He W,Ren T,Trune D,Auer M,Shi X
Tue Jun 26 00:00:00 UTC 2012
Perivascular-resident macrophage-like melanocytes in the inner ear are essential for the integrity of the intrastrial fluid-blood barrier.
Proceedings of the National Academy of Sciences of the United States of America
Zhang W,Dai M,Fridberger A,Hassan A,Degagne J,Neng L,Zhang F,He W,Ren T,Trune D,Auer M,Shi X
Tue Jun 26 00:00:00 UTC 2012
ETV5 transcription factor is overexpressed in ovarian cancer and regulates cell adhesion in ovarian cancer cells.
International journal of cancer
Llauradó M,Abal M,Castellví J,Cabrera S,Gil-Moreno A,Pérez-Benavente A,Colás E,Doll A,Dolcet X,Matias-Guiu X,Vazquez-Levin M,Reventós J,Ruiz A
61-7300 was used in western blot to study the role of ETV5 in epithelial ovarian cancer.
Sun Apr 01 00:00:00 UTC 2012
Differential effects of flavonoids on barrier integrity in human intestinal Caco-2 cells.
Journal of agricultural and food chemistry
Noda S,Tanabe S,Suzuki T
Wed May 09 00:00:00 UTC 2012
Role of caspases in cytokine-induced barrier breakdown in human brain endothelial cells.
Journal of immunology (Baltimore, Md. : 1950)
Lopez-Ramirez MA,Fischer R,Torres-Badillo CC,Davies HA,Logan K,Pfizenmaier K,Male DK,Sharrack B,Romero IA
61-7300 was used in immunocytochemistry and western blot to study the role of caspases in cytokine-induced barrier breakdown during neuroinflammation
Sat Sep 15 00:00:00 UTC 2012
Cingulin is dispensable for epithelial barrier function and tight junction structure, and plays a role in the control of claudin-2 expression and response to duodenal mucosa injury.
Journal of cell science
Guillemot L,Schneider Y,Brun P,Castagliuolo I,Pizzuti D,Martines D,Jond L,Bongiovanni M,Citi S
Thu Nov 01 00:00:00 UTC 2012
Cingulin is dispensable for epithelial barrier function and tight junction structure, and plays a role in the control of claudin-2 expression and response to duodenal mucosa injury.
Journal of cell science
Guillemot L,Schneider Y,Brun P,Castagliuolo I,Pizzuti D,Martines D,Jond L,Bongiovanni M,Citi S
Thu Nov 01 00:00:00 UTC 2012
Overexpression of the gap junction protein Cx43 as found in diabetic foot ulcers can retard fibroblast migration.
Cell biology international
Mendoza-Naranjo A,Cormie P,Serrano AE,Wang CM,Thrasivoulou C,Sutcliffe JE,Gilmartin DJ,Tsui J,Serena TE,Phillips AR,Becker DL
61-7300 was used in immunocytochemistry and immunohistochemistry - frozen section to assess connexin 43 in diabetic foot ulcers.
Sun Jul 01 00:00:00 UTC 2012
AST-120 ameliorates epithelial-to-mesenchymal transition and interstitial fibrosis in the kidneys of chronic kidney disease rats.
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation
Bolati D,Shimizu H,Niwa T
61-7300 was used in immunohistochemistry - paraffin section to test if AST-20 inhibits epithelial-to-mesenchymal transition in the kidneys.
Sun Jan 01 00:00:00 UTC 2012
Interferon-gamma signals via an ERK1/2-ARF6 pathway to promote bacterial internalization by gut epithelia.
Cellular microbiology
Smyth D,McKay CM,Gulbransen BD,Phan VC,Wang A,McKay DM
61-7300 was used in immunocytochemistry to examine how IFNγ affects transcellular traffic of commensal bacteria.
Wed Aug 01 00:00:00 UTC 2012
Epiprofin/Sp6 regulates Wnt-BMP signaling and the establishment of cellular junctions during the bell stage of tooth development.
Cell and tissue research
Ibarretxe G,Aurrekoetxea M,Crende O,Badiola I,Jimenez-Rojo L,Nakamura T,Yamada Y,Unda F
61-7300 was used in immunohistochemistry to examine the role of Epfn in the formation of cell junctions in dental cells and in the regulation of junction-associated signal transduction pathways.
Mon Oct 01 00:00:00 UTC 2012
Good Caco-2 cell culture practices.
Toxicology in vitro : an international journal published in association with BIBRA
Natoli M,Leoni BD,D'Agnano I,Zucco F,Felsani A
61-7300 was used in immunocytochemistry to optimize culturing conditions for using Caco-2 cells as a model of the intestinal barrier.
Sat Dec 01 00:00:00 UTC 2012
Two strikingly different signaling pathways are induced by meningococcal type IV pili on endothelial and epithelial cells.
Infection and immunity
Lécuyer H,Nassif X,Coureuil M
Sun Jan 01 00:00:00 UTC 2012
Desmosomal adhesiveness is developmentally regulated in the mouse embryo and modulated during trophectoderm migration.
Developmental biology
Kimura TE,Merritt AJ,Lock FR,Eckert JJ,Fleming TP,Garrod DR
61-7300 was used in immunohistochemistry - frozen section to test if initial weak adhesion would be followed by acquisition of hyper-adhesion by desmosomes.
Sat Sep 15 00:00:00 UTC 2012
Two novel EGFP insertion alleles reveal unique aspects of Pax2 function in embryonic and adult kidneys.
Developmental biology
Soofi A,Levitan I,Dressler GR
61-7300 was used in immunohistochemistry - paraffin section to characterize two new alleles of Pax2.
Tue May 01 00:00:00 UTC 2012
ZIP2 and ZIP4 mediate age-related zinc fluxes across the retinal pigment epithelium.
Journal of molecular neuroscience : MN
Leung KW,Gvritishvili A,Liu Y,Tombran-Tink J
61-7300 was used in immunohistochemistry to investigate zinc levels in aging retinal pigment epithelial cells.
Sun Jan 01 00:00:00 UTC 2012
Cx43 associates with Na(v)1.5 in the cardiomyocyte perinexus.
The Journal of membrane biology
Rhett JM,Ongstad EL,Jourdan J,Gourdie RG
61-7300 was used in Immunocytochemistry-immunoflourescence to provide a detailed characterization of the structure of the perinexus at the gap junctions edge.
Sun Jul 01 00:00:00 UTC 2012
Antibody development and use in chromogenic and fluorescent immunostaining.
Methods in molecular biology (Clifton, N.J.)
Dubaissi E,Panagiotaki N,Papalopulu N,Vize PD
61-7300 was used in Western Blotting to show that the main limiting element in Xenopus immunostaining techniques has always been the availability of antibodies that work well on fixed whole embryos, a problem that persists.
Thu Jan 31 00:00:00 UTC 2013
Targeting Cx43 and N-cadherin, which are abnormally upregulated in venous leg ulcers, influences migration, adhesion and activation of Rho GTPases.
PloS one
Mendoza-Naranjo A,Cormie P,Serrano AE,Hu R,O'Neill S,Wang CM,Thrasivoulou C,Power KT,White A,Serena T,Phillips AR,Becker DL
61-7300 was used in immunocytochemistry, immunohistochemistry, and western blot to discuss treatments for venous leg ulcers.
Thu Sep 20 00:00:00 UTC 2012
Lentiviral transduction of rat Sertoli cells as a means to modify gene expression.
Spermatogenesis
Nicholls PK,Stanton PG,Rainczuk KE,Qian H,Gregorevic P,Harrison CA
61-7300 was used in immunocytochemistry to describe a method to transduce rat Sertoli cells.
Mon Oct 01 00:00:00 UTC 2012
Using 32-cell stage Xenopus embryos to probe PCP signaling.
Methods in molecular biology (Clifton, N.J.)
Lee HS,Sokol SY,Moody SA,Daar IO
61-7300 was used in immunohistochemistry - paraffin section to discuss methods to study adhesion proteins and cell movement in Xenopus embryos.
Thu Apr 26 00:00:00 UTC 2012
The T box transcription factor TBX2 promotes epithelial-mesenchymal transition and invasion of normal and malignant breast epithelial cells.
PloS one
Wang B,Lindley LE,Fernandez-Vega V,Rieger ME,Sims AH,Briegel KJ
61-7300 was used in immunohistochemistry to elucidate the role of TBX2 in tumor invasion.
Wed Nov 28 00:00:00 UTC 2012
Py2T murine breast cancer cells, a versatile model of TGFβ-induced EMT in vitro and in vivo.
PloS one
Waldmeier L,Meyer-Schaller N,Diepenbruck M,Christofori G
61-7300 was used in immunohistochemistry to develop a novel cellular model of epithelial-to-mesenchymal transition based on the use of mouse Py2T breast cancer cells.
Wed Apr 24 00:00:00 UTC 2013
Identification of new binding partners of the chemosensory signaling protein Gγ13 expressed in taste and olfactory sensory cells.
Frontiers in cellular neuroscience
Liu Z,Fenech C,Cadiou H,Grall S,Tili E,Laugerette F,Wiencis A,Grosmaitre X,Montmayeur JP
61-7300 was used in immunohistochemistry to identify binding partners of mouse G protein gamma 13 subunit
Tue Oct 02 00:00:00 UTC 2012
Role of tight junction proteins in gastroesophageal reflux disease.
BMC gastroenterology
Mönkemüller K,Wex T,Kuester D,Fry LC,Kandulski A,Kropf S,Roessner A,Malfertheiner P
61-7300 was used in immunohistochemistry to determine the expression pattern of selected components involved in the formation of tight junctions in relation to gastroesophageal reflux disease
Thu Sep 20 00:00:00 UTC 2012
The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence.
Science (New York, N.Y.)
Alvarez JI,Dodelet-Devillers A,Kebir H,Ifergan I,Fabre PJ,Terouz S,Sabbagh M,Wosik K,Bourbonnière L,Bernard M,van Horssen J,de Vries HE,Charron F,Prat A
Fri Dec 23 00:00:00 UTC 2011
The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence.
Science (New York, N.Y.)
Alvarez JI,Dodelet-Devillers A,Kebir H,Ifergan I,Fabre PJ,Terouz S,Sabbagh M,Wosik K,Bourbonnière L,Bernard M,van Horssen J,de Vries HE,Charron F,Prat A
Fri Dec 23 00:00:00 UTC 2011
Claudin-1 induced sealing of blood-brain barrier tight junctions ameliorates chronic experimental autoimmune encephalomyelitis.
Acta neuropathologica
Pfeiffer F,Schäfer J,Lyck R,Makrides V,Brunner S,Schaeren-Wiemers N,Deutsch U,Engelhardt B
61-7300 was used in immunohistochemistry (frozen) to assess the effects of stabilizing the blood brain barrier function by therapeutic targeting tight junction proteins for experimental autoimmune encephalomyelitis.
Tue Nov 01 00:00:00 UTC 2011
Significance of marrow-derived nicotinamide adenine dinucleotide phosphate oxidase in experimental ischemic stroke.
Annals of neurology
Tang XN,Zheng Z,Giffard RG,Yenari MA
61-7300 was used in western blot to assess the effect of NOX2 derived from immune cells in the brain and in blood cells in experimental stroke.
Sat Oct 01 00:00:00 UTC 2011
Tight junctions in brain barriers during central nervous system inflammation.
Antioxidants & redox signaling
Coisne C,Engelhardt B
61-7300 was used in immunohistochemistry to discuss the mechanisms by which the blood brain barrier and the blood-cerebrospinal fluid barrier are dysregulated during inflammation.
Thu Sep 01 00:00:00 UTC 2011
Roles of pre-treatment time and junctional proteins in Caco-2 cell microparticle uptake.
International journal of pharmaceutics
Moyes SM,Morris JF,Carr KE
61-7300 was used in immunocytochemistry to assess the effects of ethanol or ice on transepithelial resistance and microparticle uptake using Caco-2 cells.
Mon Apr 04 00:00:00 UTC 2011
IKK1 control of epidermal differentiation is modulated by notch signaling.
The American journal of pathology
Xin Y,Lu Q,Li Q
61-7300 was used in immunohistochemistry - paraffin section to investigate how IkappaB kinase 1 regulates epidermal differentiation and tumor suppression in the skin
Fri Apr 01 00:00:00 UTC 2011
Cyclooxygenase-2 deficiency leads to intestinal barrier dysfunction and increased mortality during polymicrobial sepsis.
Journal of immunology (Baltimore, Md. : 1950)
Fredenburgh LE,Velandia MM,Ma J,Olszak T,Cernadas M,Englert JA,Chung SW,Liu X,Begay C,Padera RF,Blumberg RS,Walsh SR,Baron RM,Perrella MA
Tue Nov 15 00:00:00 UTC 2011
Cyclooxygenase-2 deficiency leads to intestinal barrier dysfunction and increased mortality during polymicrobial sepsis.
Journal of immunology (Baltimore, Md. : 1950)
Fredenburgh LE,Velandia MM,Ma J,Olszak T,Cernadas M,Englert JA,Chung SW,Liu X,Begay C,Padera RF,Blumberg RS,Walsh SR,Baron RM,Perrella MA
Tue Nov 15 00:00:00 UTC 2011
ZO-1 determines adherens and gap junction localization at intercalated disks.
American journal of physiology. Heart and circulatory physiology
Palatinus JA,O'Quinn MP,Barker RJ,Harris BS,Jourdan J,Gourdie RG
61-7300 was used in western blot to study the contribution of ZO-1 to cell-cell junction localization
Tue Feb 01 00:00:00 UTC 2011
Indoxyl sulfate induces epithelial-to-mesenchymal transition in rat kidneys and human proximal tubular cells.
American journal of nephrology
Bolati D,Shimizu H,Higashiyama Y,Nishijima F,Niwa T
61-7300 was used in immunohistochemistry - paraffin section and western blot to test if indoxyl sulfate induces epithelial-to-mesenchymal transition in the kidneys.
Tue Mar 20 00:00:00 UTC 2012
Synthetic gelatinases inhibitor attenuates electromagnetic pulse-induced blood-brain barrier disruption by inhibiting gelatinases-mediated ZO-1 degradation in rats.
Toxicology
Qiu LB,Zhou Y,Wang Q,Yang LL,Liu HQ,Xu SL,Qi YH,Ding GR,Guo GZ
61-7300 was used in western blot to test if the degradation of ZO-1 by gelatinases contributes to electromagnetic pulse-induced blood brain barrier permeability.
Mon Jul 11 00:00:00 UTC 2011
Comparison of tight junction protein expression in the ciliary epithelia of mouse, rabbit, cat and human eyes.
Biotechnic & histochemistry : official publication of the Biological Stain Commission
Karim MJ,Biswas S,Bhattacherjee P,Paterson CA
61-7300 was used in immunohistochemistry to investigate if the expression pattern of tight junction proteins in mice, rabbits, and cats resemble those of humans
Wed Jun 01 00:00:00 UTC 2011
Hepatocyte nuclear factor 4 alpha is associated with mesenchymal-epithelial transition in developing kidneys of C57BL/6 mice.
The Journal of veterinary medical science
Kanazawa T,Ichii O,Otsuka S,Namiki Y,Hashimoto Y,Kon Y
61-7300 was used in immunohistochemistry to determine the mechanism of mesenchymal-epithelial transition during nephrogenesis.
Sun May 01 00:00:00 UTC 2011
Invasive behavior of ulcerative colitis-associated carcinoma is related to reduced expression of CD44 extracellular domain: comparison with sporadic colon carcinoma.
Diagnostic pathology
Mikami T,Yoshida T,Numata Y,Kikuchi M,Araki K,Nakada N,Okayasu I
Thu Apr 07 00:00:00 UTC 2011
Caspase-3 contributes to ZO-1 and Cl-5 tight-junction disruption in rapid anoxic neurovascular unit damage.
PloS one
Zehendner CM,Librizzi L,de Curtis M,Kuhlmann CR,Luhmann HJ
61-7300 was used in immunohistochemistry to determine the impact of acute cerebral ischemia on tight junction protein arrangement and the role of caspase-3 in this process.
Tue Feb 22 00:00:00 UTC 2011
Immunomapping of desmosomal and nondesmosomal adhesion molecules in healthy canine footpad, haired skin and buccal mucosal epithelia: comparison with canine pemphigus foliaceus serum immunoglobulin G staining patterns.
Veterinary dermatology
Bizikova P,Linder KE,Olivry T
61-7300 was used in Immunohistochemistry-immunofluorescence to confirm the immunological heterogeneity of cPF immunoglobulin G autoantibodies. Moreover, the major indirect immunofluorescence staining pattern and the inability of most cPF sera to label the buccal mucosa closely matched that of desmocollin-1.
Fri Apr 01 00:00:00 UTC 2011
Immunomapping of desmosomal and nondesmosomal adhesion molecules in healthy canine footpad, haired skin and buccal mucosal epithelia: comparison with canine pemphigus foliaceus serum immunoglobulin G staining patterns.
Veterinary dermatology
Bizikova P,Linder KE,Olivry T
61-7300 was used in Immunohistochemistry-immunofluorescence to confirm the immunological heterogeneity of cPF immunoglobulin G autoantibodies. Moreover, the major indirect immunofluorescence staining pattern and the inability of most cPF sera to label the buccal mucosa closely matched that of desmocollin-1.
Fri Apr 01 00:00:00 UTC 2011
Isolation and properties of an in vitro human outer blood-retinal barrier model.
Methods in molecular biology (Clifton, N.J.)
Hamilton RD,Leach L
61-7300 was used in immunocytochemistry to characterize an invitro human outer blood-retinal barrier model
Wed Jun 01 00:00:00 UTC 2011
Embolus extravasation is an alternative mechanism for cerebral microvascular recanalization.
Nature
Lam CK,Yoo T,Hiner B,Liu Z,Grutzendler J
Thu May 27 00:00:00 UTC 2010
Embolus extravasation is an alternative mechanism for cerebral microvascular recanalization.
Nature
Lam CK,Yoo T,Hiner B,Liu Z,Grutzendler J
Thu May 27 00:00:00 UTC 2010
RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis.
Nature
Gonzalez-Suarez E,Jacob AP,Jones J,Miller R,Roudier-Meyer MP,Erwert R,Pinkas J,Branstetter D,Dougall WC
61-7300 was used in immunohistochemistry - paraffin section to investigate the involvement of RANK ligand in mammary tumorigenesis.
Thu Nov 04 00:00:00 UTC 2010
Claudin-1 has tumor suppressive activity and is a direct target of RUNX3 in gastric epithelial cells.
Gastroenterology
Chang TL,Ito K,Ko TK,Liu Q,Salto-Tellez M,Yeoh KG,Fukamachi H,Ito Y
Fri Jan 01 00:00:00 UTC 2010
Claudin-1 has tumor suppressive activity and is a direct target of RUNX3 in gastric epithelial cells.
Gastroenterology
Chang TL,Ito K,Ko TK,Liu Q,Salto-Tellez M,Yeoh KG,Fukamachi H,Ito Y
Fri Jan 01 00:00:00 UTC 2010
Claudin-1 has tumor suppressive activity and is a direct target of RUNX3 in gastric epithelial cells.
Gastroenterology
Chang TL,Ito K,Ko TK,Liu Q,Salto-Tellez M,Yeoh KG,Fukamachi H,Ito Y
Fri Jan 01 00:00:00 UTC 2010
Claudin-1 has tumor suppressive activity and is a direct target of RUNX3 in gastric epithelial cells.
Gastroenterology
Chang TL,Ito K,Ko TK,Liu Q,Salto-Tellez M,Yeoh KG,Fukamachi H,Ito Y
Fri Jan 01 00:00:00 UTC 2010
Claudin-1 has tumor suppressive activity and is a direct target of RUNX3 in gastric epithelial cells.
Gastroenterology
Chang TL,Ito K,Ko TK,Liu Q,Salto-Tellez M,Yeoh KG,Fukamachi H,Ito Y
Fri Jan 01 00:00:00 UTC 2010
Claudin-1 has tumor suppressive activity and is a direct target of RUNX3 in gastric epithelial cells.
Gastroenterology
Chang TL,Ito K,Ko TK,Liu Q,Salto-Tellez M,Yeoh KG,Fukamachi H,Ito Y
Fri Jan 01 00:00:00 UTC 2010
Microarray analysis of retinal endothelial tip cells identifies CXCR4 as a mediator of tip cell morphology and branching.
Blood
Strasser GA,Kaminker JS,Tessier-Lavigne M
61-7300 was used in immunohistochemistry to identify genes critical for tip cell function using microarrays and explore the role of CXCR4 in the neonatal retina
Thu Jun 17 00:00:00 UTC 2010
Persistent hepatitis C virus infection in microscale primary human hepatocyte cultures.
Proceedings of the National Academy of Sciences of the United States of America
Ploss A,Khetani SR,Jones CT,Syder AJ,Trehan K,Gaysinskaya VA,Mu K,Ritola K,Rice CM,Bhatia SN
61-7300 was used in immunocytochemistry to show that the entire hepatitis C virus life cycle is recapitulated in micropatterned cocultures of primary human hepatocytes
Tue Feb 16 00:00:00 UTC 2010
Matrix metalloproteinase-9 mediates hypoxia-induced vascular leakage in the brain via tight junction rearrangement.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Bauer AT,Bürgers HF,Rabie T,Marti HH
61-7300 was used in immunohistochemistry and western blot to examine the effect of prolonged hypoxia on blood-brain barrier integrity in vivo
Thu Apr 01 00:00:00 UTC 2010
Pax6-dependent Shroom3 expression regulates apical constriction during lens placode invagination.
Development (Cambridge, England)
Plageman TF,Chung MI,Lou M,Smith AN,Hildebrand JD,Wallingford JB,Lang RA
61-7300 was used in immunocytochemistry to study mechanisms of epithelial morphogenesis in the vertebrate lens
Mon Feb 01 00:00:00 UTC 2010
Adjudin-mediated Sertoli-germ cell junction disassembly affects Sertoli cell barrier function in vitro and in vivo.
The international journal of biochemistry & cell biology
Su L,Cheng CY,Mruk DD
61-7300 was used in immunocytochemistry and western blot to test if the function of the blood-testis barrier in affected by adjudin
Mon Nov 01 00:00:00 UTC 2010
The tumor suppressor merlin is required for cell cycle exit, terminal differentiation, and cell polarity in the developing murine lens.
Investigative ophthalmology & visual science
Wiley LA,Dattilo LK,Kang KB,Giovannini M,Beebe DC
61-7300 was used in immunohistochemistry - paraffin section to determine the role of NF2 in fiber cell differentiation
Thu Jul 01 00:00:00 UTC 2010
Learning to predict relapse in invasive ductal carcinomas based on the subcellular localization of junctional proteins.
Breast cancer research and treatment
Asgarian N,Hu X,Aktary Z,Chapman KA,Lam L,Chibbar R,Mackey J,Greiner R,Pasdar M
61-7300 was used in immunohistochemistry - paraffin section to develop an efficient prognostic classifier of breast cancer based on the abundance and localization of several junctional proteins
Tue Jun 01 00:00:00 UTC 2010
The role of protein kinase C in the opening of blood-brain barrier induced by electromagnetic pulse.
Toxicology
Qiu LB,Ding GR,Li KC,Wang XW,Zhou Y,Zhou YC,Li YR,Guo GZ
61-7300 was used in immunohistochemistry - paraffin section and western blot to use rats to determine the role of protein kinase C signaling in electromagnetic pulse-induced blood-brain barrier permeability
Tue Jun 29 00:00:00 UTC 2010
Assessing the role of claudins in maintaining the integrity of epididymal tight junctions using novel human epididymal cell lines.
Biology of reproduction
Dubé E,Dufresne J,Chan PT,Hermo L,Cyr DG
61-7300 was used in immunocytochemistry to generate and characterize 2 human epidermis-derived cell lines
Tue Jun 01 00:00:00 UTC 2010
Cell polarity regulator PARD6B is essential for trophectoderm formation in the preimplantation mouse embryo.
Biology of reproduction
Alarcon VB
61-7300 was used in immunocytochemistry to elucidate the role of partitioning defective genes in trophectoderm differentiation and blastocyst formation
Wed Sep 01 00:00:00 UTC 2010
Effects of long-term progesterone on developmental and functional aspects of porcine uterine epithelia and vasculature: progesterone alone does not support development of uterine glands comparable to that of pregnancy.
Reproduction (Cambridge, England)
Bailey DW,Dunlap KA,Frank JW,Erikson DW,White BG,Bazer FW,Burghardt RC,Johnson GA
61-7300 was used in immunohistochemistry (frozen) immunofluorescence to show that progesterone affects luminal epithelium, glandular epithelium (GE), and vascular development and histoarchitecture.
Fri Oct 01 00:00:00 UTC 2010
Differential distribution of tight junction proteins suggests a role for tanycytes in blood-hypothalamus barrier regulation in the adult mouse brain.
The Journal of comparative neurology
Mullier A,Bouret SG,Prevot V,Dehouck B
Thu Apr 01 00:00:00 UTC 2010
Cooperation of nectin-1 and nectin-3 is required for normal ameloblast function and crown shape development in mouse teeth.
Developmental dynamics : an official publication of the American Association of Anatomists
Yoshida T,Miyoshi J,Takai Y,Thesleff I
61-7300 was used in immunohistochemistry - paraffin section to characterize the teeth of nectin-1;nectin-3 compound mouse mutants.
Fri Oct 01 00:00:00 UTC 2010
Epithelial-mesenchymal transition in rhesus monkey embryonic stem cell colonies: the role of culturing conditions.
In vitro cellular & developmental biology. Animal
Maranca-Hüwel B,Denker HW
61-7300 was used in immunocytochemistry to develop an in vitro model to study gastrulation of primates
Tue Jun 01 00:00:00 UTC 2010
Arecoline induced disruption of expression and localization of the tight junctional protein ZO-1 is dependent on the HER 2 expression in human endometrial Ishikawa cells.
BMC cell biology
Giri S,Poindexter KM,Sundar SN,Firestone GL
61-7300 was used in immunocytochemistry and western blot to discuss the systemic effects on signaling pathways induced by arecoline treatment
Tue Jul 06 00:00:00 UTC 2010
Allogeneic human mesenchymal stem cells restore epithelial protein permeability in cultured human alveolar type II cells by secretion of angiopoietin-1.
The Journal of biological chemistry
Fang X,Neyrinck AP,Matthay MA,Lee JW
Fri Aug 20 00:00:00 UTC 2010
Multiple primary cilia modulate the fluid transcytosis in choroid plexus epithelium.
Traffic (Copenhagen, Denmark)
Narita K,Kawate T,Kakinuma N,Takeda S
61-7300 was used in Immunocytochemistry to suggest that the clusters of primary cilia in CPECs act as a sensitive chemosensor to regulate CSF production.
Mon Feb 01 00:00:00 UTC 2010
A protocol for the culture and differentiation of highly polarized human retinal pigment epithelial cells.
Nature protocols
Sonoda S,Spee C,Barron E,Ryan SJ,Kannan R,Hinton DR
61-7300 was used in immunocytochemistry to describe an in vitro protocol for the differentiation of human retinal pigment epithelial cells into a highly polarized and functional monolayer
Tue Jun 30 00:00:00 UTC 2009
Directed evolution of adeno-associated virus to an infectious respiratory virus.
Proceedings of the National Academy of Sciences of the United States of America
Excoffon KJ,Koerber JT,Dickey DD,Murtha M,Keshavjee S,Kaspar BK,Zabner J,Schaffer DV
61-7300 was used in immunocytochemistry to use directed evolution in an organotypic human airway model to generate a highly infectious adeno-associated virus
Tue Mar 10 00:00:00 UTC 2009
Complete focal adhesion kinase deficiency in the mammary gland causes ductal dilation and aberrant branching morphogenesis through defects in Rho kinase-dependent cell contractility.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
van Miltenburg MH,Lalai R,de Bont H,van Waaij E,Beggs H,Danen EH,van de Water B
61-7300 was used in immunohistochemistry - paraffin section to determine the role and mechanism of focal adhesion kinase-mediated signaling in mammary gland development and differentiation.
Thu Oct 01 00:00:00 UTC 2009
Disruption of the blood-testis barrier integrity by bisphenol A in vitro: is this a suitable model for studying blood-testis barrier dynamics?
The international journal of biochemistry & cell biology
Li MW,Mruk DD,Lee WM,Cheng CY
61-7300 was used in immunocytochemistry and western blot to examine the effects of bisphenol A on the reproductive tract of male rats
Sun Nov 01 00:00:00 UTC 2009
Drug transporter, P-glycoprotein (MDR1), is an integrated component of the mammalian blood-testis barrier.
The international journal of biochemistry & cell biology
Su L,Cheng CY,Mruk DD
61-7300 was used in immunocytochemistry and western blot to determine the role of P-glycoprotein in the blood-testis barrier
Tue Dec 01 00:00:00 UTC 2009
A novel role for SED1 (MFG-E8) in maintaining the integrity of the epididymal epithelium.
Journal of cell science
Raymond AS,Shur BD
61-7300 was used in immunocytochemistry to test if SED1 has a tissue-intrinsic role in the epididymis
Sun Mar 15 00:00:00 UTC 2009
Dietary glutamine and oral antibiotics each improve indexes of gut barrier function in rat short bowel syndrome.
American journal of physiology. Gastrointestinal and liver physiology
Tian J,Hao L,Chandra P,Jones DP,Willams IR,Gewirtz AT,Ziegler TR
61-7300 was used in western blot to assess the effects of dietary glutamine or oral antibiotics on the gut barrier function in a rat model of short bowel syndrome
Sun Feb 01 00:00:00 UTC 2009
Tamoxifen and ICI 182,780 increase Bcl-2 levels and inhibit growth of breast carcinoma cells by modulating PI3K/AKT, ERK and IGF-1R pathways independent of ERalpha.
Breast cancer research and treatment
Lam L,Hu X,Aktary Z,Andrews DW,Pasdar M
61-7300 was used in immunocytochemistry and western blot to examine the effects of estrogen withdrawal on mammary epithelial cell lines
Tue Dec 01 00:00:00 UTC 2009
Expression of tight-junction proteins in the inflamed and clinically uninvolved skin in patients with venous leg ulcers.
Clinical and experimental dermatology
Zorko MS,Veranic P,Leskovec NK,Pavlović MD,Lunder T
61-7300 was used in immunohistochemistry - frozen section to examine tight junction protein expression in venous leg ulcers
Tue Dec 01 00:00:00 UTC 2009
The food contaminant deoxynivalenol, decreases intestinal barrier permeability and reduces claudin expression.
Toxicology and applied pharmacology
Pinton P,Nougayrède JP,Del Rio JC,Moreno C,Marin DE,Ferrier L,Bracarense AP,Kolf-Clauw M,Oswald IP
61-7300 was used in immunocytochemistry to examine the effects of deoxynivalenol on the intestinal epithelium
Fri May 15 00:00:00 UTC 2009
Zyxin mediates actin fiber reorganization in epithelial-mesenchymal transition and contributes to endocardial morphogenesis.
Molecular biology of the cell
Mori M,Nakagami H,Koibuchi N,Miura K,Takami Y,Koriyama H,Hayashi H,Sabe H,Mochizuki N,Morishita R,Kaneda Y
61-7300 was used in western blot to report that zyxin reorganizes actin fibers and enhances cell motility in response to TGF-beta1
Wed Jul 01 00:00:00 UTC 2009
Intestinal cytoskeleton degradation precedes tight junction loss following hemorrhagic shock.
Shock (Augusta, Ga.)
Thuijls G,de Haan JJ,Derikx JP,Daissormont I,Hadfoune M,Heineman E,Buurman WA
61-7300 was used in immunohistochemistry - frozen section and western blot to elucidate the molecular mechanisms by which hemorrhagic shock results in loss of barrier function
Sun Feb 01 00:00:00 UTC 2009
Sertoli cell Dicer is essential for spermatogenesis in mice.
Developmental biology
Papaioannou MD,Pitetti JL,Ro S,Park C,Aubry F,Schaad O,Vejnar CE,Kühne F,Descombes P,Zdobnov EM,McManus MT,Guillou F,Harfe BD,Yan W,Jégou B,Nef S
61-7300 was used in immunohistochemistry - paraffin section to study the functions of Dicer in mouse Sertoli cell function
Sun Feb 01 00:00:00 UTC 2009
A cell polarity protein aPKClambda is required for eye lens formation and growth.
Developmental biology
Sugiyama Y,Akimoto K,Robinson ML,Ohno S,Quinlan RA
61-7300 was used in immunohistochemistry - paraffin section to report a role for aPKClambda in the development of the lens fulcrum
Tue Dec 15 00:00:00 UTC 2009
Tight junctions in Hailey-Hailey and Darier's diseases.
Dermatology reports
Raiko L,Leinonen P,Hägg PM,Peltonen J,Oikarinen A,Peltonen S
61-7300 was used in immunohistochemistry (frozen) to study the expression and dynamics of the tight junction proteins during the disruption of desmosomes in Hailey-Hailey disease and Darier's disease lesions.
Mon Nov 16 00:00:00 UTC 2009
Impaired transcription factor interplay in addition to advanced glycation end products suppress podocalyxin expression in high glucose-treated human podocytes.
American journal of physiology. Renal physiology
Drossopoulou GI,Tsotakos NE,Tsilibary EC
61-7300 was used in western blot to explore the regulation of podocalyxin expression after long-term exposure to glucose
Tue Sep 01 00:00:00 UTC 2009
Increased intraocular insulin-like growth factor-I triggers blood-retinal barrier breakdown.
The Journal of biological chemistry
Haurigot V,Villacampa P,Ribera A,Llombart C,Bosch A,Nacher V,Ramos D,Ayuso E,Segovia JC,Bueren JA,Ruberte J,Bosch F
61-7300 was used in immunohistochemistry - paraffin section to investigate the role of insulin-like growth factor-I in the breakdown of the blood-retinal barrier
Fri Aug 21 00:00:00 UTC 2009
Stepwise differentiation of pluripotent stem cells into retinal cells.
Nature protocols
Osakada F,Ikeda H,Sasai Y,Takahashi M
61-7300 was used in Immunocytochemistry-immunofluorescence to describe a protocol for generating retinal cells from ES cells by stepwise treatment with defined factors.
Wed Sep 16 00:00:00 UTC 2009
Postshock intervention with high-lipid enteral nutrition reduces inflammation and tissue damage.
Annals of surgery
de Haan JJ,Lubbers T,Hadfoune M,Luyer MD,Dejong CH,Buurman WA,Greve JW
61-7300 was used in immunohistochemistry to study the effects of high-lipid enteral nutrition in a setting of developing inflammation and tissue damage
Sat Nov 01 00:00:00 UTC 2008
Dicer inactivation leads to progressive functional and structural degeneration of the mouse retina.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Damiani D,Alexander JJ,O'Rourke JR,McManus M,Jadhav AP,Cepko CL,Hauswirth WW,Harfe BD,Strettoi E
Wed May 07 00:00:00 UTC 2008
Distinct molecular composition of blood and lymphatic vascular endothelial cell junctions establishes specific functional barriers within the peripheral lymph node.
European journal of immunology
Pfeiffer F,Kumar V,Butz S,Vestweber D,Imhof BA,Stein JV,Engelhardt B
61-7300 was used in immunohistochemistry to examine the architecture of cellular junctions present in blood and lymphatic vessel endothelium in peripheral lymph nodes
Fri Aug 01 00:00:00 UTC 2008
Epithelial-to-mesenchymal transition is a potential pathway leading to podocyte dysfunction and proteinuria.
The American journal of pathology
Li Y,Kang YS,Dai C,Kiss LP,Wen X,Liu Y
61-7300 was used in immunocytochemistry, immunohistochemistry - paraffin section, and western blot to test if podocytes undergo an epithelial-to-mesenchymal transition after injury
Fri Feb 01 00:00:00 UTC 2008
Combinatorial interaction between CCM pathway genes precipitates hemorrhagic stroke.
Disease models & mechanisms
Gore AV,Lampugnani MG,Dye L,Dejana E,Weinstein BM
61-7300 was used in immunocytochemistry to examine the effects of concurrently knocking down several genes in the cerebral cavernous malformations pathway
Tue Apr 14 00:00:00 UTC 2009
Cellular differentiation in three-dimensional lung cell cultures.
Cancer biology & therapy
Vertrees RA,Zwischenberger JB,Boor PJ,Popov V,McCarthy M,Solley TN,Goodwin TJ
61-7300 was used in immunohistochemistry to discuss the development of three-dimensional cell cultures
Sat Mar 01 00:00:00 UTC 2008
Localization studies of rare missense mutations in cystic fibrosis transmembrane conductance regulator (CFTR) facilitate interpretation of genotype-phenotype relationships.
Human mutation
Krasnov KV,Tzetis M,Cheng J,Guggino WB,Cutting GR
61-7300 was used in immunocytochemistry to determine the functional consequences of rare disease-associated amino acid substitutions in the cystic fibrosis transmembrane conductance regulator
Sat Nov 01 00:00:00 UTC 2008
Expression and localisation of apical junctional complex proteins in lens epithelial cells.
Experimental eye research
Sugiyama Y,Prescott AR,Tholozan FM,Ohno S,Quinlan RA
61-7300 was used in immunohistochemistry and western blot to determine the composition of the apical junctional complex present in lens epithelial cells
Tue Jul 01 00:00:00 UTC 2008
Functional and developmental analysis of the blood-brain barrier in zebrafish.
Brain research bulletin
Jeong JY,Kwon HB,Ahn JC,Kang D,Kwon SH,Park JA,Kim KW
61-7300 was used in immunohistochemistry and western blot to examine the endothelial tight junction-based blood brain barrier of zebrafish
Fri Mar 28 00:00:00 UTC 2008
Ablation of Cx47 in transgenic mice leads to the loss of MUPP1, ZONAB and multiple connexins at oligodendrocyte-astrocyte gap junctions.
The European journal of neuroscience
Li X,Penes M,Odermatt B,Willecke K,Nagy JI
Wed Oct 01 00:00:00 UTC 2008
Griffonia simplicifolia isolectin B4 identifies a specific subpopulation of angiogenic blood vessels following contusive spinal cord injury in the adult mouse.
The Journal of comparative neurology
Benton RL,Maddie MA,Minnillo DR,Hagg T,Whittemore SR
Sat Mar 01 00:00:00 UTC 2008
Different expression of occludin and ZO-1 in primary and metastatic liver tumors.
Pathology oncology research : POR
Orbán E,Szabó E,Lotz G,Kupcsulik P,Páska C,Schaff Z,Kiss A
61-7300 was used in immunohistochemistry - paraffin section to discover differences between occludin and ZO-1 expression in normal liver samples, HCCs, and colorectal liver metastases
Mon Sep 01 00:00:00 UTC 2008
Rapid identification of differentiation markers from whole epithelial cells by matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry and statistical analysis.
Rapid communications in mass spectrometry : RCM
Marvin-Guy LF,Duncan P,Wagnière S,Antille N,Porta N,Affolter M,Kussmann M
61-7300 was used in immunocytochemistry to identify markers for cellular differentiation
Tue Apr 01 00:00:00 UTC 2008
Localization of claudin-5 and ZO-1 in rat spleen sinus endothelial cells.
Histochemistry and cell biology
Uehara K,Uehara A
61-7300 was used in immunohistochemistry - frozen section to study the spatial and functional relationships between tight and adherens junctions in the sinus endothelial cells of rat spleen
Tue Jan 01 00:00:00 UTC 2008
Gap junction remodelling in human heart failure is associated with increased interaction of connexin43 with ZO-1.
Cardiovascular research
Bruce AF,Rothery S,Dupont E,Severs NJ
61-7300 was used in Western Blotting and Immunopreciptation to show failing heart in human is associated with increased co-localisation of connexin43 with ZO-1.
Sat Mar 01 00:00:00 UTC 2008
Gap junction remodelling in human heart failure is associated with increased interaction of connexin43 with ZO-1.
Cardiovascular research
Bruce AF,Rothery S,Dupont E,Severs NJ
61-7300 was used in Western Blotting and Immunopreciptation to show failing heart in human is associated with increased co-localisation of connexin43 with ZO-1.
Sat Mar 01 00:00:00 UTC 2008
Inducible overexpression of cingulin in stably transfected MDCK cells does not affect tight junction organization and gene expression.
Molecular membrane biology
Paschoud S,Citi S
61-7300 was used in immunocytochemistry and western blot to study the effects of cingulin overexpression
Tue Jan 01 00:00:00 UTC 2008
Rapid reversal of human intestinal ischemia-reperfusion induced damage by shedding of injured enterocytes and reepithelialisation.
PloS one
Derikx JP,Matthijsen RA,de Bruïne AP,van Bijnen AA,Heineman E,van Dam RM,Dejong CH,Buurman WA
61-7300 was used in immunohistochemistry to develop a model of human intestinal ischemia-reperfusion
Wed Mar 04 00:00:00 UTC 2009
Dishevelled controls apical docking and planar polarization of basal bodies in ciliated epithelial cells.
Nature genetics
Park TJ,Mitchell BJ,Abitua PB,Kintner C,Wallingford JB
61-7300 was used in Immunohistochemistry to demonstrate previously undescribed functions for PCP signaling components and suggest that a common signaling apparatus governs both apical docking and planar polarization of basal bodies.
Tue Jul 01 00:00:00 UTC 2008
Gap junction adhesion is necessary for radial migration in the neocortex.
Nature
Elias LA,Wang DD,Kriegstein AR
Thu Aug 23 00:00:00 UTC 2007
Angiogenesis is associated with blood-brain barrier permeability in temporal lobe epilepsy.
Brain : a journal of neurology
Rigau V,Morin M,Rousset MC,de Bock F,Lebrun A,Coubes P,Picot MC,Baldy-Moulinier M,Bockaert J,Crespel A,Lerner-Natoli M
61-7300 was used in immunohistochemistry to compare hippocampi from temporal lobe epilepsy patients with those from non-epileptic patients
Sun Jul 01 00:00:00 UTC 2007
Tubular epithelial cell dedifferentiation is driven by the helix-loop-helix transcriptional inhibitor Id1.
Journal of the American Society of Nephrology : JASN
Li Y,Yang J,Luo JH,Dedhar S,Liu Y
61-7300 was used in immunocytochemistry and immunohistochemistry - frozen section to identify genes expressed in TGF-beta1-mediated epithelial-to-mesenchymal transition
Thu Feb 01 00:00:00 UTC 2007
PINCH-1 promotes tubular epithelial-to-mesenchymal transition by interacting with integrin-linked kinase.
Journal of the American Society of Nephrology : JASN
Li Y,Dai C,Wu C,Liu Y
61-7300 was used in immunocytochemistry to test if PINCH1 is involved in the epithelial-to-mesenchymal transition
Sat Sep 01 00:00:00 UTC 2007
Gene replacement reveals a specific role for E-cadherin in the formation of a functional trophectoderm.
Development (Cambridge, England)
Kan NG,Stemmler MP,Junghans D,Kanzler B,de Vries WN,Dominis M,Kemler R
61-7300 was used in immunohistochemistry - paraffin section to elucidate the contribution of E-cadherin to trophectoderm formation in vivo.
Mon Jan 01 00:00:00 UTC 2007
Abnormal development of urogenital organs in Dlgh1-deficient mice.
Development (Cambridge, England)
Iizuka-Kogo A,Ishidao T,Akiyama T,Senda T
61-7300 was used in immunohistochemistry to characterize Dlgh1 knockout mice
Tue May 01 00:00:00 UTC 2007
Astrovirus increases epithelial barrier permeability independently of viral replication.
Journal of virology
Moser LA,Carter M,Schultz-Cherry S
61-7300 was used in immunocytochemistry to report that capsid contributes to astrovirus infection-induced diarrhea
Thu Nov 01 00:00:00 UTC 2007
Paracellular permeability restricts airway epithelial responses to selectively allow activation by mediators at the basolateral surface.
Journal of immunology (Baltimore, Md. : 1950)
Humlicek AL,Manzel LJ,Chin CL,Shi L,Excoffon KJ,Winter MC,Shasby DM,Look DC
61-7300 was used in immunocytochemistry to test if airway epithelial polarity allows different responses to basolateral and apical stimuli that may modulate inflammation
Tue May 15 00:00:00 UTC 2007
Localization of ZO-1 in the nucleolus of corneal fibroblasts.
Investigative ophthalmology & visual science
Benezra M,Greenberg RS,Masur SK
61-7300 was used in immunocytochemistry and western blot to test if stimuli associated with wounding induce nuclear translocation of ZO-1
Tue May 01 00:00:00 UTC 2007
ZO-2 silencing in epithelial cells perturbs the gate and fence function of tight junctions and leads to an atypical monolayer architecture.
Experimental cell research
Hernandez S,Chavez Munguia B,Gonzalez-Mariscal L
61-7300 was used in western blot to ascertain the role of ZO-2 in epithelial cells
Tue May 01 00:00:00 UTC 2007
Differences in claudin synthesis in primary cultures of acinar cells from rat salivary gland are correlated with the specific three-dimensional organization of the cells.
Cell and tissue research
Qi B,Fujita-Yoshigaki J,Michikawa H,Satoh K,Katsumata O,Sugiya H
Sun Jul 01 00:00:00 UTC 2007
Angiopoietin modulation of vascular endothelial growth factor: Effects on retinal endothelial cell permeability.
Cytokine
Peters S,Cree IA,Alexander R,Turowski P,Ockrim Z,Patel J,Boyd SR,Joussen AM,Ziemssen F,Hykin PG,Moss SE
61-7300 was used in immunocytochemistry to investigate how angiopoietin-2 and vascular endothelial growth factor contribute to vascular permeability
Thu Nov 01 00:00:00 UTC 2007
Spatial relationships of connexin36, connexin57 and zonula occludens-1 in the outer plexiform layer of mouse retina.
Neuroscience
Ciolofan C,Lynn BD,Wellershaus K,Willecke K,Nagy JI
61-7300 was used in immunohistochemistry to investigate connexin57 expression in the mouse retina
Fri Aug 24 00:00:00 UTC 2007
Foxe3 is required for morphogenesis and differentiation of the anterior segment of the eye and is sensitive to Pax6 gene dosage.
Developmental biology
Blixt A,Landgren H,Johansson BR,Carlsson P
61-7300 was used in immunohistochemistry to compare the eye defects of dyl and Foxe3 mutant mice
Thu Feb 01 00:00:00 UTC 2007
Establishment of a human in vitro model of the outer blood-retinal barrier.
Journal of anatomy
Hamilton RD,Foss AJ,Leach L
61-7300 was used in immunocytochemistry to establish a human in vitro model of the outer blood-retinal barrier
Sat Dec 01 00:00:00 UTC 2007
Immunolocalization of tight junction proteins in blood vessels in human germinal matrix and cortex.
Histochemistry and cell biology
Anstrom JA,Thore CR,Moody DM,Brown WR
61-7300 was used in immunohistochemistry to test if the expression of tight junction proteins increases in vessels of germinal matrix and cortex with gestational age
Thu Feb 01 00:00:00 UTC 2007
Pathophysiological role of the activation of p38 mitogen-activated protein kinases in poorly differentiated gastric cancer.
Pathology international
Atsumi T,Kato K,Uno K,Iijima K,Koike T,Imatani A,Ohara S,Shimosegawa T
61-7300 was used in western blot to find phospho-p38 MAPK level significantly increases in poorly differentiated gastric cancers compared to differentiated cancers and normal gastric mucosa
Mon Oct 01 00:00:00 UTC 2007
Glomerular sclerosis in kidneys with congenital nephrotic syndrome (NPHS1).
Kidney international
Kuusniemi AM,Merenmies J,Lahdenkari AT,Holmberg C,Salmela K,Karikoski R,Rapola J,Jalanko H
61-7300 was used in immunohistochemistry to study the development of glomerular sclerosis in kidneys from infants with Finnish type congenital nephrotic syndrome
Sun Oct 01 00:00:00 UTC 2006
Isolation and characterization of kidney-derived stem cells.
Journal of the American Society of Nephrology : JASN
Gupta S,Verfaillie C,Chmielewski D,Kren S,Eidman K,Connaire J,Heremans Y,Lund T,Blackstad M,Jiang Y,Luttun A,Rosenberg ME
61-7300 was used in immunohistochemistry - paraffin section to test if renal stem cells exist in the adult kidney and participate in the acute injury repair
Wed Nov 01 00:00:00 UTC 2006
Cdc42 GEF Tuba regulates the junctional configuration of simple epithelial cells.
The Journal of cell biology
Otani T,Ichii T,Aono S,Takeichi M
61-7300 was used in immunocytochemistry to report that Tuba controls the shaping of cell junctions through the local activation of Cdc42 and its effectors
Mon Oct 09 00:00:00 UTC 2006
CCL2/monocyte chemoattractant protein-1 mediates enhanced transmigration of human immunodeficiency virus (HIV)-infected leukocytes across the blood-brain barrier: a potential mechanism of HIV-CNS invasion and NeuroAIDS.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Eugenin EA,Osiecki K,Lopez L,Goldstein H,Calderon TM,Berman JW
Wed Jan 25 00:00:00 UTC 2006
Characterization of epithelial cell shedding from human small intestine.
Laboratory investigation; a journal of technical methods and pathology
Bullen TF,Forrest S,Campbell F,Dodson AR,Hershman MJ,Pritchard DM,Turner JR,Montrose MH,Watson AJ
Sun Oct 01 00:00:00 UTC 2006
Interaction of zonula occludens-1 (ZO-1) with alpha-actinin-4: application of functional proteomics for identification of PDZ domain-associated proteins.
Journal of proteome research
Chen VC,Li X,Perreault H,Nagy JI
Fri Sep 01 00:00:00 UTC 2006
Interaction of zonula occludens-1 (ZO-1) with alpha-actinin-4: application of functional proteomics for identification of PDZ domain-associated proteins.
Journal of proteome research
Chen VC,Li X,Perreault H,Nagy JI
Fri Sep 01 00:00:00 UTC 2006
Interaction of zonula occludens-1 (ZO-1) with alpha-actinin-4: application of functional proteomics for identification of PDZ domain-associated proteins.
Journal of proteome research
Chen VC,Li X,Perreault H,Nagy JI
Fri Sep 01 00:00:00 UTC 2006
Interaction of zonula occludens-1 (ZO-1) with alpha-actinin-4: application of functional proteomics for identification of PDZ domain-associated proteins.
Journal of proteome research
Chen VC,Li X,Perreault H,Nagy JI
Fri Sep 01 00:00:00 UTC 2006
Interaction of zonula occludens-1 (ZO-1) with alpha-actinin-4: application of functional proteomics for identification of PDZ domain-associated proteins.
Journal of proteome research
Chen VC,Li X,Perreault H,Nagy JI
Fri Sep 01 00:00:00 UTC 2006
Interaction of zonula occludens-1 (ZO-1) with alpha-actinin-4: application of functional proteomics for identification of PDZ domain-associated proteins.
Journal of proteome research
Chen VC,Li X,Perreault H,Nagy JI
Fri Sep 01 00:00:00 UTC 2006
Differentiation of adult rat bone marrow stem cells into epithelial progenitor cells in culture.
Cell biology international
Shu C,Li TY,Tsang LL,Fok KL,Lo PS,Zhu JX,Ho LS,Chung YW,Chan HC
61-7300 was used in western blot to differentiate adult rat bone marrow stem cells into epithelial cells
Sun Oct 01 00:00:00 UTC 2006
Adult sertoli cells are not terminally differentiated in the Djungarian hamster: effect of FSH on proliferation and junction protein organization.
Biology of reproduction
Tarulli GA,Stanton PG,Lerchl A,Meachem SJ
61-7300 was used in Immunohistochemistry to determine whether adult Sertoli cells are terminally differentiated using known characteristics of cellular differentiation, including proliferation, junction protein localisation, and expression of particular maturational markers.
Mon May 01 00:00:00 UTC 2006
Endothelia of term human placentae display diminished expression of tight junction proteins during preeclampsia.
Cell and tissue research
Liévano S,Alarcón L,Chávez-Munguía B,González-Mariscal L
61-7300 was used in immunohistochemistry - frozen section and western blot to examine the molecular composition of the tight junction present in human term placenta from normal women and from those with preeclampsia
Thu Jun 01 00:00:00 UTC 2006
Epithelial barrier characteristics and expression of cell adhesion molecules in proximal tubule-derived cell lines commonly used for in vitro toxicity studies.
Toxicology in vitro : an international journal published in association with BIBRA
Prozialeck WC,Edwards JR,Lamar PC,Smith CS
61-7300 was used in immunocytochemistry to characterize cell lines that mimic the characteristics of the proximal tubule
Fri Sep 01 00:00:00 UTC 2006
The Coxsackievirus and Adenovirus Receptor: a new adhesion protein in cochlear development.
Hearing research
Excoffon KJ,Avenarius MR,Hansen MR,Kimberling WJ,Najmabadi H,Smith RJ,Zabner J
61-7300 was used in immunohistochemistry - paraffin section to test if the coxsackievirus and adenovirus receptor is involved in cochlear development
Mon May 01 00:00:00 UTC 2006
Derivation and characterization of lentoid bodies and retinal pigment epithelial cells from monkey embryonic stem cells in vitro.
Methods in molecular biology (Clifton, N.J.)
Takahashi M,Haruta M
61-7300 was used in immunocytochemistry to describe the methods to induce retinal pigment epithelial and lens cells from monkey embryonic stem cells and characterize these cells
Tue Aug 22 00:00:00 UTC 2006
Redox regulation of 4-hydroxy-2-nonenal-mediated endothelial barrier dysfunction by focal adhesion, adherens, and tight junction proteins.
The Journal of biological chemistry
Usatyuk PV,Parinandi NL,Natarajan V
61-7300 was used in immunocytochemistry to test if 4-Hydroxy-2-nonenal-induced changes in cellular thiol redox status contribute to endothelial barrier dysfunction
Fri Nov 17 00:00:00 UTC 2006
Epithelial barrier function in vivo is sustained despite gaps in epithelial layers.
Gastroenterology
Watson AJ,Chu S,Sieck L,Gerasimenko O,Bullen T,Campbell F,McKenna M,Rose T,Montrose MH
61-7300 was used in immunohistochemistry - paraffin section to study the mechanism of epithelial shedding and the site of the permeability barrier during cell shedding
Thu Sep 01 00:00:00 UTC 2005
The Rac activator Tiam1 controls tight junction biogenesis in keratinocytes through binding to and activation of the Par polarity complex.
The Journal of cell biology
Mertens AE,Rygiel TP,Olivo C,van der Kammen R,Collard JG
Mon Sep 26 00:00:00 UTC 2005
Drebrin, an actin-binding, cell-type characteristic protein: induction and localization in epithelial skin tumors and cultured keratinocytes.
The Journal of investigative dermatology
Peitsch WK,Hofmann I,Bulkescher J,Hergt M,Spring H,Bleyl U,Goerdt S,Franke WW
Sat Oct 01 00:00:00 UTC 2005
Amphiregulin causes functional downregulation of adherens junctions in psoriasis.
The Journal of investigative dermatology
Chung E,Cook PW,Parkos CA,Park YK,Pittelkow MR,Coffey RJ
Wed Jun 01 00:00:00 UTC 2005
Amphiregulin causes functional downregulation of adherens junctions in psoriasis.
The Journal of investigative dermatology
Chung E,Cook PW,Parkos CA,Park YK,Pittelkow MR,Coffey RJ
Wed Jun 01 00:00:00 UTC 2005
Function of atypical protein kinase C lambda in differentiating photoreceptors is required for proper lamination of mouse retina.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Koike C,Nishida A,Akimoto K,Nakaya MA,Noda T,Ohno S,Furukawa T
Wed Nov 02 00:00:00 UTC 2005
Disruption of Sertoli-germ cell adhesion function in the seminiferous epithelium of the rat testis can be limited to adherens junctions without affecting the blood-testis barrier integrity: an in vivo study using an androgen suppression model.
Journal of cellular physiology
Xia W,Wong CH,Lee NP,Lee WM,Cheng CY
61-7300 was used in western blot to study regulation of the blood-testis barrier
Sat Oct 01 00:00:00 UTC 2005
Epithelial-mesenchymal transition in colonies of rhesus monkey embryonic stem cells: a model for processes involved in gastrulation.
Stem cells (Dayton, Ohio)
Behr R,Heneweer C,Viebahn C,Denker HW,Thie M
61-7300 was used in immunohistochemistry to study rhesus monkey embryonic stem cells
Fri Sep 16 00:00:00 UTC 2005
Enteropathogenic E. coli disrupts tight junction barrier function and structure in vivo.
Laboratory investigation; a journal of technical methods and pathology
Shifflett DE,Clayburgh DR,Koutsouris A,Turner JR,Hecht GA
Sat Oct 01 00:00:00 UTC 2005
Enteropathogenic E. coli disrupts tight junction barrier function and structure in vivo.
Laboratory investigation; a journal of technical methods and pathology
Shifflett DE,Clayburgh DR,Koutsouris A,Turner JR,Hecht GA
Sat Oct 01 00:00:00 UTC 2005
Polyamines are necessary for synthesis and stability of occludin protein in intestinal epithelial cells.
American journal of physiology. Gastrointestinal and liver physiology
Guo X,Rao JN,Liu L,Zou T,Keledjian KM,Boneva D,Marasa BS,Wang JY
Wed Jun 01 00:00:00 UTC 2005
Polyamines are necessary for synthesis and stability of occludin protein in intestinal epithelial cells.
American journal of physiology. Gastrointestinal and liver physiology
Guo X,Rao JN,Liu L,Zou T,Keledjian KM,Boneva D,Marasa BS,Wang JY
Wed Jun 01 00:00:00 UTC 2005
sPAR-3, a splicing variant of PAR-3, shows cellular localization and an expression pattern different from that of PAR-3 during enterocyte polarization.
American journal of physiology. Gastrointestinal and liver physiology
Yoshii T,Mizuno K,Hirose T,Nakajima A,Sekihara H,Ohno S
Tue Mar 01 00:00:00 UTC 2005
sPAR-3, a splicing variant of PAR-3, shows cellular localization and an expression pattern different from that of PAR-3 during enterocyte polarization.
American journal of physiology. Gastrointestinal and liver physiology
Yoshii T,Mizuno K,Hirose T,Nakajima A,Sekihara H,Ohno S
Tue Mar 01 00:00:00 UTC 2005
Ultrastructural and immunohistochemical characterization of the bovine epiblast.
Biology of reproduction
Vejlsted M,Avery B,Schmidt M,Greve T,Alexopoulos N,Maddox-Hyttel P
61-7300 was used in immunohistochemistry - paraffin section to characterize the bovine epiblast cell population and identify markers of pluripotency
Tue Mar 01 00:00:00 UTC 2005
Expression of zonula occludens-1 (ZO-1) and the transcription factor ZO-1-associated nucleic acid-binding protein (ZONAB)-MsY3 in glial cells and colocalization at oligodendrocyte and astrocyte gap junctions in mouse brain.
The European journal of neuroscience
Penes MC,Li X,Nagy JI
Fri Jul 01 00:00:00 UTC 2005
Establishment and characterization of primary and subsequent subcultures of normal mouse urothelial cells.
Folia biologica
Kreft ME,Hudoklin S,Sterle M
61-7300 was used in immunocytochemistry to report a reliable technique for the harvest, cultivation and expansion of monoculture of NMU and characterize the isolated cells
Fri Jan 13 00:00:00 UTC 2006
Mast cell tryptase controls paracellular permeability of the intestine. Role of protease-activated receptor 2 and beta-arrestins.
The Journal of biological chemistry
Jacob C,Yang PC,Darmoul D,Amadesi S,Saito T,Cottrell GS,Coelho AM,Singh P,Grady EF,Perdue M,Bunnett NW
Fri Sep 09 00:00:00 UTC 2005
Mast cell tryptase controls paracellular permeability of the intestine. Role of protease-activated receptor 2 and beta-arrestins.
The Journal of biological chemistry
Jacob C,Yang PC,Darmoul D,Amadesi S,Saito T,Cottrell GS,Coelho AM,Singh P,Grady EF,Perdue M,Bunnett NW
Fri Sep 09 00:00:00 UTC 2005
Connexin43 associated with an N-cadherin-containing multiprotein complex is required for gap junction formation in NIH3T3 cells.
The Journal of biological chemistry
Wei CJ,Francis R,Xu X,Lo CW
Fri May 20 00:00:00 UTC 2005
Connexin43 associated with an N-cadherin-containing multiprotein complex is required for gap junction formation in NIH3T3 cells.
The Journal of biological chemistry
Wei CJ,Francis R,Xu X,Lo CW
Fri May 20 00:00:00 UTC 2005
The short apical membrane half-life of rescued {Delta}F508-cystic fibrosis transmembrane conductance regulator (CFTR) results from accelerated endocytosis of {Delta}F508-CFTR in polarized human airway epithelial cells.
The Journal of biological chemistry
Swiatecka-Urban A,Brown A,Moreau-Marquis S,Renuka J,Coutermarsh B,Barnaby R,Karlson KH,Flotte TR,Fukuda M,Langford GM,Stanton BA
Fri Nov 04 00:00:00 UTC 2005
Connexin 43 interacts with zona occludens-1 and -2 proteins in a cell cycle stage-specific manner.
The Journal of biological chemistry
Singh D,Solan JL,Taffet SM,Javier R,Lampe PD
Fri Aug 26 00:00:00 UTC 2005
Connexin 43 interacts with zona occludens-1 and -2 proteins in a cell cycle stage-specific manner.
The Journal of biological chemistry
Singh D,Solan JL,Taffet SM,Javier R,Lampe PD
Fri Aug 26 00:00:00 UTC 2005
Connexin 43 interacts with zona occludens-1 and -2 proteins in a cell cycle stage-specific manner.
The Journal of biological chemistry
Singh D,Solan JL,Taffet SM,Javier R,Lampe PD
Fri Aug 26 00:00:00 UTC 2005
Identification of PKCzetaII: an endogenous inhibitor of cell polarity.
The EMBO journal
Parkinson SJ,Le Good JA,Whelan RD,Whitehead P,Parker PJ
Wed Jan 14 00:00:00 UTC 2004
Identification of PKCzetaII: an endogenous inhibitor of cell polarity.
The EMBO journal
Parkinson SJ,Le Good JA,Whelan RD,Whitehead P,Parker PJ
Wed Jan 14 00:00:00 UTC 2004
Induction by transforming growth factor-beta1 of epithelial to mesenchymal transition is a rare event in vitro.
Breast cancer research : BCR
Brown KA,Aakre ME,Gorska AE,Price JO,Eltom SE,Pietenpol JA,Moses HL
Tue Jul 27 00:00:00 UTC 2004
Induction by transforming growth factor-beta1 of epithelial to mesenchymal transition is a rare event in vitro.
Breast cancer research : BCR
Brown KA,Aakre ME,Gorska AE,Price JO,Eltom SE,Pietenpol JA,Moses HL
Tue Jul 27 00:00:00 UTC 2004
Induction by transforming growth factor-beta1 of epithelial to mesenchymal transition is a rare event in vitro.
Breast cancer research : BCR
Brown KA,Aakre ME,Gorska AE,Price JO,Eltom SE,Pietenpol JA,Moses HL
Tue Jul 27 00:00:00 UTC 2004
Induction by transforming growth factor-beta1 of epithelial to mesenchymal transition is a rare event in vitro.
Breast cancer research : BCR
Brown KA,Aakre ME,Gorska AE,Price JO,Eltom SE,Pietenpol JA,Moses HL
Tue Jul 27 00:00:00 UTC 2004
Histone deacetylase inhibitors up-regulate the expression of tight junction proteins.
Molecular cancer research : MCR
Bordin M,D'Atri F,Guillemot L,Citi S
61-7300 was used in immunocytochemistry and western blot to test if HDAC inhibitors affect the expression of tight junction proteins
Wed Dec 01 00:00:00 UTC 2004
Endothelia of Schlemm's canal and trabecular meshwork: distinct molecular, functional, and anatomic features.
American journal of physiology. Cell physiology
Alvarado JA,Betanzos A,Franse-Carman L,Chen J,González-Mariscal L
61-7300 was used in western blot to compare human endothelial cells from Schlemm's canal and the trabecular meshwork.
Mon Mar 01 00:00:00 UTC 2004
The specific fates of tight junction proteins in apoptotic epithelial cells.
Journal of cell science
Bojarski C,Weiske J,Schöneberg T,Schröder W,Mankertz J,Schulzke JD,Florian P,Fromm M,Tauber R,Huber O
Thu Apr 15 00:00:00 UTC 2004
The specific fates of tight junction proteins in apoptotic epithelial cells.
Journal of cell science
Bojarski C,Weiske J,Schöneberg T,Schröder W,Mankertz J,Schulzke JD,Florian P,Fromm M,Tauber R,Huber O
Thu Apr 15 00:00:00 UTC 2004
The specific fates of tight junction proteins in apoptotic epithelial cells.
Journal of cell science
Bojarski C,Weiske J,Schöneberg T,Schröder W,Mankertz J,Schulzke JD,Florian P,Fromm M,Tauber R,Huber O
Thu Apr 15 00:00:00 UTC 2004
The specific fates of tight junction proteins in apoptotic epithelial cells.
Journal of cell science
Bojarski C,Weiske J,Schöneberg T,Schröder W,Mankertz J,Schulzke JD,Florian P,Fromm M,Tauber R,Huber O
Thu Apr 15 00:00:00 UTC 2004
The rotavirus surface protein VP8 modulates the gate and fence function of tight junctions in epithelial cells.
Journal of cell science
Nava P,López S,Arias CF,Islas S,González-Mariscal L
61-7300 was used in immunocytochemistry and western blot to test if the rotavirus outer capsid proteins are capable of opening the paracellular space sealed by the tight junctions
Mon Nov 01 00:00:00 UTC 2004
Mechanism of recruiting Sec6/8 (exocyst) complex to the apical junctional complex during polarization of epithelial cells.
Journal of cell science
Yeaman C,Grindstaff KK,Nelson WJ
Sun Feb 01 00:00:00 UTC 2004
Mechanism of recruiting Sec6/8 (exocyst) complex to the apical junctional complex during polarization of epithelial cells.
Journal of cell science
Yeaman C,Grindstaff KK,Nelson WJ
Sun Feb 01 00:00:00 UTC 2004
Disruption of the cingulin gene does not prevent tight junction formation but alters gene expression.
Journal of cell science
Guillemot L,Hammar E,Kaister C,Ritz J,Caille D,Jond L,Bauer C,Meda P,Citi S
61-7300 was used in western blot to test if lack of junctional cingulin affects tight-junction organization and function
Fri Oct 15 00:00:00 UTC 2004
Oxidative stress affects the junctional integrity of retinal pigment epithelial cells.
Investigative ophthalmology & visual science
Bailey TA,Kanuga N,Romero IA,Greenwood J,Luthert PJ,Cheetham ME
61-7300 was used in immunocytochemistry to examine the effect of oxidative stress on stress protein induction and junctional integrity
Sun Feb 01 00:00:00 UTC 2004
Functional characterization of HUVEC-CS: Ca2+ signaling, ERK 1/2 activation, mitogenesis and vasodilator production.
The Journal of endocrinology
Gifford SM,Grummer MA,Pierre SA,Austin JL,Zheng J,Bird IM
61-7300 was used in ELISA, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot to conclude that HUVEC-CS are indeed endothelial cells and appear to be functionally very similar to primary HUVEC.
Wed Sep 01 00:00:00 UTC 2004
Activin A and follicle-stimulating hormone control tight junctions in avian granulosa cells by regulating occludin expression.
Biology of reproduction
Schuster MK,Schmierer B,Shkumatava A,Kuchler K
61-7300 was used in western blot to investigate the localization of occludin in granulosa cells
Sat May 01 00:00:00 UTC 2004
Characterization of the tight junction protein ZO-2 localized at the nucleus of epithelial cells.
Experimental cell research
Jaramillo BE,Ponce A,Moreno J,Betanzos A,Huerta M,Lopez-Bayghen E,Gonzalez-Mariscal L
61-7300 was used in immunoprecipitation and western blot to characterize the nuclear functions of ZO-2
Thu Jul 01 00:00:00 UTC 2004
Expression and function of tight junctions in the crypt epithelium of human palatine tonsils.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Go M,Kojima T,Takano K,Murata M,Ichimiya S,Tsubota H,Himi T,Sawada N
61-7300 was used in immunohistochemistry - frozen section to examine the expression and function of tight junctions in the epithelium of human palatine tonsils from patients with tonsillar hypertrophy or recurrent tonsillitis
Wed Dec 01 00:00:00 UTC 2004
Distribution of the tight junction proteins ZO-1, occludin, and claudin-4, -8, and -12 in bladder epithelium.
American journal of physiology. Renal physiology
Acharya P,Beckel J,Ruiz WG,Wang E,Rojas R,Birder L,Apodaca G
Sun Aug 01 00:00:00 UTC 2004
Distribution of the tight junction proteins ZO-1, occludin, and claudin-4, -8, and -12 in bladder epithelium.
American journal of physiology. Renal physiology
Acharya P,Beckel J,Ruiz WG,Wang E,Rojas R,Birder L,Apodaca G
Sun Aug 01 00:00:00 UTC 2004
Distribution of the tight junction proteins ZO-1, occludin, and claudin-4, -8, and -12 in bladder epithelium.
American journal of physiology. Renal physiology
Acharya P,Beckel J,Ruiz WG,Wang E,Rojas R,Birder L,Apodaca G
Sun Aug 01 00:00:00 UTC 2004
Neuronal connexin36 association with zonula occludens-1 protein (ZO-1) in mouse brain and interaction with the first PDZ domain of ZO-1.
The European journal of neuroscience
Li X,Olson C,Lu S,Kamasawa N,Yasumura T,Rash JE,Nagy JI
Thu Apr 01 00:00:00 UTC 2004
Lactobacillus acidophilus protects tight junctions from aspirin damage in HT-29 cells.
Digestion
Montalto M,Maggiano N,Ricci R,Curigliano V,Santoro L,Di Nicuolo F,Vecchio FM,Gasbarrini A,Gasbarrini G
61-7300 was used in immunocytochemistry and western blot to test if Lactobacillus acidophilus supernatants protect cells from aspirin-induced damage
Sat Nov 06 00:00:00 UTC 2004
Endocytosis of epithelial apical junctional proteins by a clathrin-mediated pathway into a unique storage compartment.
Molecular biology of the cell
Ivanov AI,Nusrat A,Parkos CA
Thu Jan 01 00:00:00 UTC 2004
Association of connexin36 with zonula occludens-1 in HeLa cells, betaTC-3 cells, pancreas, and adrenal gland.
Histochemistry and cell biology
Li X,Olson C,Lu S,Nagy JI
61-7300 was used in immunocytochemistry, immunohistochemistry - frozen section, and immunoprecipitation to assess the association of connexin36 with ZO-1 in various cultured cells and tissues
Mon Nov 01 00:00:00 UTC 2004
Epidermal growth factor receptor activation differentially regulates claudin expression and enhances transepithelial resistance in Madin-Darby canine kidney cells.
The Journal of biological chemistry
Singh AB,Harris RC
Fri Jan 30 00:00:00 UTC 2004
Isoforms of the polarity protein par6 have distinct functions.
The Journal of biological chemistry
Gao L,Macara IG
Fri Oct 01 00:00:00 UTC 2004
Inhibition of the Raf/MEK/ERK pathway up-regulates expression of the coxsackievirus and adenovirus receptor in cancer cells.
Cancer research
Anders M,Christian C,McMahon M,McCormick F,Korn WM
Thu May 01 00:00:00 UTC 2003
Inhibition of the Raf/MEK/ERK pathway up-regulates expression of the coxsackievirus and adenovirus receptor in cancer cells.
Cancer research
Anders M,Christian C,McMahon M,McCormick F,Korn WM
Thu May 01 00:00:00 UTC 2003
Inhibition of the Raf/MEK/ERK pathway up-regulates expression of the coxsackievirus and adenovirus receptor in cancer cells.
Cancer research
Anders M,Christian C,McMahon M,McCormick F,Korn WM
Thu May 01 00:00:00 UTC 2003
Inhibition of the Raf/MEK/ERK pathway up-regulates expression of the coxsackievirus and adenovirus receptor in cancer cells.
Cancer research
Anders M,Christian C,McMahon M,McCormick F,Korn WM
Thu May 01 00:00:00 UTC 2003
Inhibition of the Raf/MEK/ERK pathway up-regulates expression of the coxsackievirus and adenovirus receptor in cancer cells.
Cancer research
Anders M,Christian C,McMahon M,McCormick F,Korn WM
Thu May 01 00:00:00 UTC 2003
Inhibition of the Raf/MEK/ERK pathway up-regulates expression of the coxsackievirus and adenovirus receptor in cancer cells.
Cancer research
Anders M,Christian C,McMahon M,McCormick F,Korn WM
Thu May 01 00:00:00 UTC 2003
Inhibition of the Raf/MEK/ERK pathway up-regulates expression of the coxsackievirus and adenovirus receptor in cancer cells.
Cancer research
Anders M,Christian C,McMahon M,McCormick F,Korn WM
Thu May 01 00:00:00 UTC 2003
Inhibition of the Raf/MEK/ERK pathway up-regulates expression of the coxsackievirus and adenovirus receptor in cancer cells.
Cancer research
Anders M,Christian C,McMahon M,McCormick F,Korn WM
Thu May 01 00:00:00 UTC 2003
Immunohistological distribution of the tight junction components ZO-1 and occludin in regenerating human epidermis.
The British journal of dermatology
Malminen M,Koivukangas V,Peltonen J,Karvonen SL,Oikarinen A,Peltonen S
61-7300 was used in immunohistochemistry to discuss methods to study tight junctions.
Fri Aug 01 00:00:00 UTC 2003
Role of claudin interactions in airway tight junctional permeability.
American journal of physiology. Lung cellular and molecular physiology
Coyne CB,Gambling TM,Boucher RC,Carson JL,Johnson LG
Sat Nov 01 00:00:00 UTC 2003
Role of claudin interactions in airway tight junctional permeability.
American journal of physiology. Lung cellular and molecular physiology
Coyne CB,Gambling TM,Boucher RC,Carson JL,Johnson LG
Sat Nov 01 00:00:00 UTC 2003
Role of claudin interactions in airway tight junctional permeability.
American journal of physiology. Lung cellular and molecular physiology
Coyne CB,Gambling TM,Boucher RC,Carson JL,Johnson LG
Sat Nov 01 00:00:00 UTC 2003
Age-related changes in rat cerebral occludin and zonula occludens-1 (ZO-1).
Mechanisms of ageing and development
Mooradian AD,Haas MJ,Chehade JM
61-7300 was used in western blot to study tight junction proteins in the cerebrum of aging rats
Sat Feb 01 00:00:00 UTC 2003
Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms.
Journal of immunology (Baltimore, Md. : 1950)
Bruewer M,Luegering A,Kucharzik T,Parkos CA,Madara JL,Hopkins AM,Nusrat A
Mon Dec 01 00:00:00 UTC 2003
Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms.
Journal of immunology (Baltimore, Md. : 1950)
Bruewer M,Luegering A,Kucharzik T,Parkos CA,Madara JL,Hopkins AM,Nusrat A
Mon Dec 01 00:00:00 UTC 2003
Protection against hypoxia-induced increase in blood-brain barrier permeability: role of tight junction proteins and NFkappaB.
Journal of cell science
Brown RC,Mark KS,Egleton RD,Huber JD,Burroughs AR,Davis TP
Sat Feb 15 00:00:00 UTC 2003
Protection against hypoxia-induced increase in blood-brain barrier permeability: role of tight junction proteins and NFkappaB.
Journal of cell science
Brown RC,Mark KS,Egleton RD,Huber JD,Burroughs AR,Davis TP
Sat Feb 15 00:00:00 UTC 2003
Protection against hypoxia-induced increase in blood-brain barrier permeability: role of tight junction proteins and NFkappaB.
Journal of cell science
Brown RC,Mark KS,Egleton RD,Huber JD,Burroughs AR,Davis TP
Sat Feb 15 00:00:00 UTC 2003
Protection against hypoxia-induced increase in blood-brain barrier permeability: role of tight junction proteins and NFkappaB.
Journal of cell science
Brown RC,Mark KS,Egleton RD,Huber JD,Burroughs AR,Davis TP
Sat Feb 15 00:00:00 UTC 2003
Reversal of charge selectivity in cation or anion-selective epithelial lines by expression of different claudins.
American journal of physiology. Renal physiology
Van Itallie CM,Fanning AS,Anderson JM
Mon Dec 01 00:00:00 UTC 2003
The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin.
Molecular biology of the cell
Wadham C,Gamble JR,Vadas MA,Khew-Goodall Y
Sun Jun 01 00:00:00 UTC 2003
The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin.
Molecular biology of the cell
Wadham C,Gamble JR,Vadas MA,Khew-Goodall Y
Sun Jun 01 00:00:00 UTC 2003
Nectin-dependent localization of ZO-1 at puncta adhaerentia junctions between the mossy fiber terminals and the dendrites of the pyramidal cells in the CA3 area of adult mouse hippocampus.
The Journal of comparative neurology
Inagaki M,Irie K,Deguchi-Tawarada M,Ikeda W,Ohtsuka T,Takeuchi M,Takai Y
61-7300 was used in immunocytochemistry to determine the localization of ZO- in the mouse hippocampus.
Mon Jun 09 00:00:00 UTC 2003
Implications of nectin-like molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in cell-cell adhesion and transmembrane protein localization in epithelial cells.
The Journal of biological chemistry
Shingai T,Ikeda W,Kakunaga S,Morimoto K,Takekuni K,Itoh S,Satoh K,Takeuchi M,Imai T,Monden M,Takai Y
61-7300 was used in immunocytochemistry and immunohistochemistry (frozen) to characterize nectin-like molecule-2.
Fri Sep 12 00:00:00 UTC 2003
Expression of kinase-inactive c-Src delays oxidative stress-induced disassembly and accelerates calcium-mediated reassembly of tight junctions in the Caco-2 cell monolayer.
The Journal of biological chemistry
Basuroy S,Sheth P,Kuppuswamy D,Balasubramanian S,Ray RM,Rao RK
Fri Apr 04 00:00:00 UTC 2003
Expression of kinase-inactive c-Src delays oxidative stress-induced disassembly and accelerates calcium-mediated reassembly of tight junctions in the Caco-2 cell monolayer.
The Journal of biological chemistry
Basuroy S,Sheth P,Kuppuswamy D,Balasubramanian S,Ray RM,Rao RK
Fri Apr 04 00:00:00 UTC 2003
Expression of kinase-inactive c-Src delays oxidative stress-induced disassembly and accelerates calcium-mediated reassembly of tight junctions in the Caco-2 cell monolayer.
The Journal of biological chemistry
Basuroy S,Sheth P,Kuppuswamy D,Balasubramanian S,Ray RM,Rao RK
Fri Apr 04 00:00:00 UTC 2003
Distinct claudins and associated PDZ proteins form different autotypic tight junctions in myelinating Schwann cells.
The Journal of cell biology
Poliak S,Matlis S,Ullmer C,Scherer SS,Peles E
Mon Oct 28 00:00:00 UTC 2002
cAMP-dependent protein kinase and proliferation differ in normal and polycystic kidney epithelia.
American journal of physiology. Cell physiology
Marfella-Scivittaro C,Quiñones A,Orellana SA
61-7300 was used in immunocytochemistry to determine the roles of cAMP and cAMP-dependent protein kinase in control of cell proliferation in filter-grown noncystic and cystic-derived principal cell cultures.
Mon Apr 01 00:00:00 UTC 2002
E-Cadherin and tight junctions between epithelial cells of different animal species.
Pflugers Archiv : European journal of physiology
Contreras RG,Shoshani L,Flores-Maldonado C,Lázaro A,Monroy AO,Roldán ML,Fiorentino R,Cereijido M
61-7300 was used in immunocytochemistry to investigate tight junctions and E-cadherin in heterotypic borders.
Mon Jul 01 00:00:00 UTC 2002
Diabetes-related changes in rat cerebral occludin and zonula occludens-1 (ZO-1) expression.
Neurochemical research
Chehade JM,Haas MJ,Mooradian AD
61-7300 was used in western blot to test if diabetes alters tight junction proteins
Fri Mar 01 00:00:00 UTC 2002
2,3-butanedione monoxime (BDM), a potent inhibitor of actin-myosin interaction, induces ion and fluid transport in MDCK monolayers.
Journal of muscle research and cell motility
Castillo AM,Reyes JL,Sánchez E,Mondragón R,Meza I
61-7300 was used in immunocytochemistry to investigate the role of myosin in vectorial transport
Fri May 30 00:00:00 UTC 2003
Tight junctions are sensitive to peptides eliminated in the urine.
The Journal of membrane biology
Gallardo JM,Hernández JM,Contreras RG,Flores-Maldonado C,González-Mariscal L,Cereijido M
61-7300 was used in immunocytochemistry to assess the effect of adding an extract of dog urine to monolayers of MDCK cells.
Mon Jul 01 00:00:00 UTC 2002
Impaired trafficking of connexins in androgen-independent human prostate cancer cell lines and its mitigation by alpha-catenin.
The Journal of biological chemistry
Govindarajan R,Zhao S,Song XH,Guo RJ,Wheelock M,Johnson KR,Mehta PP
Fri Dec 20 00:00:00 UTC 2002
Hepatocyte polarity and the peroxisomal compartment: a comparative study.
The Histochemical journal
Depreter M,Walker T,De Smet K,Beken S,Kerckaert I,Rogiers V,Roels F
61-7300 was used in immunohistochemistry - paraffin section to compare hepatocyte polarity to peroxisome differentiation
Wed May 21 00:00:00 UTC 2003
JEAP, a novel component of tight junctions in exocrine cells.
The Journal of biological chemistry
Nishimura M,Kakizaki M,Ono Y,Morimoto K,Takeuchi M,Inoue Y,Imai T,Takai Y
Fri Feb 15 00:00:00 UTC 2002
Applications of epithelial cell culture in studies of drug transport.
Methods in molecular biology (Clifton, N.J.)
Tavelin S,Gråsjö J,Taipalensuu J,Ocklind G,Artursson P
61-7300 was used in immunocytochemistry to review applications of epithelial cell culture in studies of drug transport
Tue Nov 12 00:00:00 UTC 2002
Sec6/8 complexes on trans-Golgi network and plasma membrane regulate late stages of exocytosis in mammalian cells.
The Journal of cell biology
Yeaman C,Grindstaff KK,Wright JR,Nelson WJ
Mon Nov 12 00:00:00 UTC 2001
Epidermal tight junctions: ZO-1 and occludin are expressed in mature, developing, and affected skin and in vitro differentiating keratinocytes.
The Journal of investigative dermatology
Pummi K,Malminen M,Aho H,Karvonen SL,Peltonen J,Peltonen S
61-7300 was used in western blot to test if tight junction antigens are present in adult and developing human epidermis.
Thu Nov 01 00:00:00 UTC 2001
Inflammatory pain alters blood-brain barrier permeability and tight junctional protein expression.
American journal of physiology. Heart and circulatory physiology
Huber JD,Witt KA,Hom S,Egleton RD,Mark KS,Davis TP
Thu Mar 01 00:00:00 UTC 2001
Inflammatory pain alters blood-brain barrier permeability and tight junctional protein expression.
American journal of physiology. Heart and circulatory physiology
Huber JD,Witt KA,Hom S,Egleton RD,Mark KS,Davis TP
Thu Mar 01 00:00:00 UTC 2001
Integrity of epithelium and endothelium in organ-cultured human corneas.
Investigative ophthalmology & visual science
Crewe JM,Armitage WJ
61-7300 was used in immunohistochemistry to examine the components of the junctional complex and the actin cytoskeleton in the epithelium and endothelium of organ-cultured human corneas.
Sun Jul 01 00:00:00 UTC 2001
Long-term natural culture of cochlear sensory epithelia of guinea pigs.
Neuroscience letters
Zhao HB
61-7300 was used in immunocytochemistry to describe a method to generate non-immortalized natural cochlear cells from guinea pigs.
Fri Nov 23 00:00:00 UTC 2001
Interleukin-2 receptor beta subunit-dependent and -independent regulation of intestinal epithelial tight junctions.
The Journal of biological chemistry
Nishiyama R,Sakaguchi T,Kinugasa T,Gu X,MacDermott RP,Podolsky DK,Reinecker HC
Fri Sep 21 00:00:00 UTC 2001
Tight junction proteins ZO-1, ZO-2, and occludin along isolated renal tubules.
Kidney international
Gonzalez-Mariscal L,Namorado MC,Martin D,Luna J,Alarcon L,Islas S,Valencia L,Muriel P,Ponce L,Reyes JL
61-7300 was used in immunohistochemistry (frozen) to examine the differential expression of three tight junction proteins, ZO-1, ZO-2, and occludin, along isolated rabbit renal tubules.
Thu Jun 01 00:00:00 UTC 2000
Potential biological role of transforming growth factor-beta1 in human congenital kidney malformations.
The American journal of pathology
Yang SP,Woolf AS,Yuan HT,Scott RJ,Risdon RA,O'Hare MJ,Winyard PJ
61-7300 was used in immunocytochemistry to investigate the role of TGF-beta in the pathobiology of dysplastic kidneys.
Wed Nov 01 00:00:00 UTC 2000
Molecular physiology and pathophysiology of tight junctions III. Tight junction regulation by intracellular messengers: differences in response within and between epithelia.
American journal of physiology. Gastrointestinal and liver physiology
Karczewski J,Groot J
61-7300 was used in immunocytochemistry to discuss methods to study tight junction permeability.
Sun Oct 01 00:00:00 UTC 2000
Restoration of tight junction structure and barrier function by down-regulation of the mitogen-activated protein kinase pathway in ras-transformed Madin-Darby canine kidney cells.
Molecular biology of the cell
Chen Yh,Lu Q,Schneeberger EE,Goodenough DA
Wed Mar 01 00:00:00 UTC 2000
Restoration of tight junction structure and barrier function by down-regulation of the mitogen-activated protein kinase pathway in ras-transformed Madin-Darby canine kidney cells.
Molecular biology of the cell
Chen Yh,Lu Q,Schneeberger EE,Goodenough DA
Wed Mar 01 00:00:00 UTC 2000
Restoration of tight junction structure and barrier function by down-regulation of the mitogen-activated protein kinase pathway in ras-transformed Madin-Darby canine kidney cells.
Molecular biology of the cell
Chen Yh,Lu Q,Schneeberger EE,Goodenough DA
Wed Mar 01 00:00:00 UTC 2000
Truncation mutants of the tight junction protein ZO-1 disrupt corneal epithelial cell morphology.
Molecular biology of the cell
Ryeom SW,Paul D,Goodenough DA
Mon May 01 00:00:00 UTC 2000
Saccharomyces boulardii preserves the barrier function and modulates the signal transduction pathway induced in enteropathogenic Escherichia coli-infected T84 cells.
Infection and immunity
Czerucka D,Dahan S,Mograbi B,Rossi B,Rampal P
61-7300 was used in immunocytochemistry to show that S. boulardii exerts a protective effect on epithelial cells after EPEC adhesion by modulating the signaling pathway induced by bacterial infection.
Sun Oct 01 00:00:00 UTC 2000
The coiled-coil domain of occludin can act to organize structural and functional elements of the epithelial tight junction.
The Journal of biological chemistry
Nusrat A,Chen JA,Foley CS,Liang TW,Tom J,Cromwell M,Quan C,Mrsny RJ
Fri Sep 22 00:00:00 UTC 2000
A systematic analysis of 40 random genes in cultured vascular smooth muscle subtypes reveals a heterogeneity of gene expression and identifies the tight junction gene zonula occludens 2 as a marker of epithelioid "pup" smooth muscle cells and a participant in carotid neointimal formation.
Arteriosclerosis, thrombosis, and vascular biology
Adams LD,Lemire JM,Schwartz SM
61-7300 was used in immunocytochemistry to investigate gene expression in cell subpopulations of vascular smooth muscle.
Mon Nov 01 00:00:00 UTC 1999
Cingulin contains globular and coiled-coil domains and interacts with ZO-1, ZO-2, ZO-3, and myosin.
The Journal of cell biology
Cordenonsi M,D'Atri F,Hammar E,Parry DA,Kendrick-Jones J,Shore D,Citi S
Mon Dec 27 00:00:00 UTC 1999
Cingulin contains globular and coiled-coil domains and interacts with ZO-1, ZO-2, ZO-3, and myosin.
The Journal of cell biology
Cordenonsi M,D'Atri F,Hammar E,Parry DA,Kendrick-Jones J,Shore D,Citi S
Mon Dec 27 00:00:00 UTC 1999
Cingulin contains globular and coiled-coil domains and interacts with ZO-1, ZO-2, ZO-3, and myosin.
The Journal of cell biology
Cordenonsi M,D'Atri F,Hammar E,Parry DA,Kendrick-Jones J,Shore D,Citi S
Mon Dec 27 00:00:00 UTC 1999
Cingulin contains globular and coiled-coil domains and interacts with ZO-1, ZO-2, ZO-3, and myosin.
The Journal of cell biology
Cordenonsi M,D'Atri F,Hammar E,Parry DA,Kendrick-Jones J,Shore D,Citi S
Mon Dec 27 00:00:00 UTC 1999
Relationship between Na(+),K(+)-ATPase and cell attachment.
Journal of cell science
Contreras RG,Shoshani L,Flores-Maldonado C,Lázaro A,Cereijido M
61-7300 was used in immunocytochemistry to study the effect of ouabain treatment on cell attachment.
Wed Dec 01 00:00:00 UTC 1999
ZO-3, a novel member of the MAGUK protein family found at the tight junction, interacts with ZO-1 and occludin.
The Journal of cell biology
Haskins J,Gu L,Wittchen ES,Hibbard J,Stevenson BR
Mon Apr 06 00:00:00 UTC 1998
ZO-3, a novel member of the MAGUK protein family found at the tight junction, interacts with ZO-1 and occludin.
The Journal of cell biology
Haskins J,Gu L,Wittchen ES,Hibbard J,Stevenson BR
Mon Apr 06 00:00:00 UTC 1998
Occludin confers adhesiveness when expressed in fibroblasts.
Journal of cell science
Van Itallie CM,Anderson JM
Thu May 01 00:00:00 UTC 1997
Occludin confers adhesiveness when expressed in fibroblasts.
Journal of cell science
Van Itallie CM,Anderson JM
Thu May 01 00:00:00 UTC 1997
The junction-associated protein, zonula occludens-1, localizes to the nucleus before the maturation and during the remodeling of cell-cell contacts.
Proceedings of the National Academy of Sciences of the United States of America
Gottardi CJ,Arpin M,Fanning AS,Louvard D
61-7300 was used in immunocytochemistry and immunohistochemistry - paraffin section to show that the nuclear localization of ZO- is inversely related to the extent of cell contact.
Tue Oct 01 00:00:00 UTC 1996
Manganese and other trace elements in urban snow near an expressway.
Environmental pollution (Barking, Essex : 1987)
Loranger S,Tétrault M,Kennedy G,Zayed J
Mon Jan 24 00:00:00 UTC 2005
Manganese and other trace elements in urban snow near an expressway.
Environmental pollution (Barking, Essex : 1987)
Loranger S,Tétrault M,Kennedy G,Zayed J
Mon Jan 24 00:00:00 UTC 2005
The tight junction protein ZO-1 is homologous to the Drosophila discs-large tumor suppressor protein of septate junctions.
Proceedings of the National Academy of Sciences of the United States of America
Willott E,Balda MS,Fanning AS,Jameson B,Van Itallie C,Anderson JM
Sun Aug 15 00:00:00 UTC 1993
The tight junction protein ZO-1 is homologous to the Drosophila discs-large tumor suppressor protein of septate junctions.
Proceedings of the National Academy of Sciences of the United States of America
Willott E,Balda MS,Fanning AS,Jameson B,Van Itallie C,Anderson JM
Sun Aug 15 00:00:00 UTC 1993
The tight junction protein ZO-1 is homologous to the Drosophila discs-large tumor suppressor protein of septate junctions.
Proceedings of the National Academy of Sciences of the United States of America
Willott E,Balda MS,Fanning AS,Jameson B,Van Itallie C,Anderson JM
Sun Aug 15 00:00:00 UTC 1993
The tight junction protein ZO-1 is homologous to the Drosophila discs-large tumor suppressor protein of septate junctions.
Proceedings of the National Academy of Sciences of the United States of America
Willott E,Balda MS,Fanning AS,Jameson B,Van Itallie C,Anderson JM
Sun Aug 15 00:00:00 UTC 1993
Two classes of tight junctions are revealed by ZO-1 isoforms.
The American journal of physiology
Balda MS,Anderson JM
Thu Apr 01 00:00:00 UTC 1993
