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Product Details
24816-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ZRANB2 Fusion Protein Ag20487 (1-241 aa encoded by BC039814)
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
In WB, a band of ~48 kDa is detected. The immunogen of this antibody is 1-241aa. No other protein can be recognized by this antibody from the sequence BLAST results.
Immunogen sequence: MSTKNFRVS DGDWICPDKK CGNVNFARRT SCNRCGREKT TEAKMMKAGG TEIGKTLAEK SRGLFSANDW QCKTCSNVNW ARRSECNMCN TPKYAKLEER TGYGGGFNER ENVEYIEREE SDGEYDEFGR KKKKYRGKAV GPASILKEVE DKESEGEEED EDEDLSKYKL DEDEDEDDAD LSKYNLDASE EEDSNKKKSN RRSRSKSGSS HSRSSSRSSS PSSSRSRSRS RSRSSSSSQS RS (1-241 aa encoded by BC039814)
Target Information
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZNF265 (Zinc finger protein 265), also known as ZRANB2 (Zinc finger Ran-binding domain-containing protein 2), ZIS, ZIS1 or ZIS2, is a 330 amino acid protein that belongs to the ZRANB2 family. Localized to the nucleus, ZNF265 functions as a splicing factor that is responsible for alternatively splicing Tra-2 beta (transformer-2 beta) transcripts and is thought to interfere with constitutive 5'-splice selection. ZNF265 contains two RanBP2-type zinc fingers through which it conveys its RNA-binding activity. Two isoforms, designated ZIS-1 and ZIS-2, are expressed due to alternative splicing events. Upon DNA damage, ZIS-2 may be phosphorylated by ATM or ATR.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DKFZp686J1831; DKFZp686N09117; Zinc finger protein 265; Zinc finger Ran-binding domain-containing protein 2; zinc finger, RAN-binding domain containing 2; Zinc finger, splicing; zinc-finger protein 265; zinc-finger, splicing
Gene Aliases: AI227013; Zfp265; ZIS; ZIS1; ZIS2; ZNF265; ZRANB2
UniProt ID: (Human) O95218, (Mouse) Q9R020
Entrez Gene ID: (Human) 9406, (Mouse) 53861
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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