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Product Details
60254-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
4D7E7
Immunogen
Zyxin Fusion Protein Ag0419 (278-572 aa encoded by BC008743)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: SKFSPGAPG GSGSQPNQKL GHPEALSAGT GSPQPPSFTY AQQREKPRVQ EKQHPVPPPA QNQNQVRSPG APGPLTLKEV EELEQLTQQL MQDMEHPQRQ NVAVNELCGR CHQPLARAQP AVRALGQLFH IACFTCHQCA QQLQGQQFYS LEGAPYCEGC YTDTLEKCNT CGEPITDRML RATGKAYHPH CFTCVVCARP LEGTSFIVDQ ANRPHCVPDY HKQYAPRCSV CSEPIMPEPG RDETVRVVAL DKNFHMKCYK CEDCGKPLSI EADDNGCFPL DGHVLCRKCH TARAQT (278-572 aa encoded by BC008743)
Target Information
Zyxin is involved in focal adhesions, which are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Zyxin; Zyxin-2
Gene Aliases: 9530098H06Rik; ESP-2; HED-2; R75157; ZYX
UniProt ID: (Human) Q15942, (Mouse) Q62523
Entrez Gene ID: (Human) 7791, (Mouse) 22793
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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