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Product Details
MUB0109P
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Goat,
Human,
Pig,
Rabbit,
Rat,
Zebrafish
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
22D3
Immunogen
actin alpha-cardiac
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A/G
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Clone 22D3 is an antibody highly specific for a- cardiac actin, and does not cross react with other actin isoforms.
The epitope recognized by α-SM1 is highly conserved. The antibody therefore cross-reacts with many species including protochordates, lower craniates and mammals.
The antibody may be stored at 4°C. For prolonged storage prepare appropriate aliquots and store at or below -20°C. Prior to use, an aliquot is thawed slowly in the dark at ambient temperature, spun down again and used to prepare working dilutions by adding sterile phosphate buffered saline (PBS, pH 7.2). Repeated thawing and freezing should be avoided. Working dilutions should be stored at 4°C, not refrozen, and preferably used the same day. If a slight precipitation occurs upon storage, this should be removed by centrifugation. It will not affect the performance or the concentration of the product.
Target Information
ACTC1 are part of actins, which are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs to the actin family which is comprised of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. Defects in this gene have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: actin alpha cardiac 1; Actin, alpha cardiac muscle 1; actin, alpha, cardiac 1; actin, alpha, cardiac muscle 1; alpha-actin cardiac; Alpha-cardiac actin; cardiac muscle alpha actin 1
Gene Aliases: ACTC; ACTC1; ASD5; CMD1R; CMH11; LVNC4
UniProt ID: (Human) P68032, (Rat) P68035
Entrez Gene ID: (Human) 70, (Rabbit) 100340339, (Pig) 100152267, (Rat) 29275
apoptotic process
positive regulation of gene expression
actin filament-based movement
muscle filament sliding
skeletal muscle thin filament assembly
actomyosin structure organization
actin-myosin filament sliding
response to drug
negative regulation of apoptotic process
response to ethanol
cardiac myofibril assembly
cardiac muscle tissue morphogenesis
heart contraction
cardiac muscle contraction
mesenchyme migration
metabolic process
actin-mediated cell contraction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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