Proteintech

alpha 1 Antichymotrypsin Polyclonal Antibody

alpha 1 Antichymotrypsin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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alpha 1 Antichymotrypsin Antibody (12192-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using 12192-1-AP ( alpha 1 Antichymotrypsin antibody at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

alpha 1 Antichymotrypsin Antibody in Western Blot (WB)

alpha 1 Antichymotrypsin Antibody in Flow Cytometry (Flow)

alpha 1 Antichymotrypsin Antibody in Immunoprecipitation (IP)

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Product Details

12192-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 4 publications 4 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Flow Cytometry (Flow)

Assay-dependent

Immunoprecipitation (IP)

0.5-4.0 µg

Miscellaneous PubMed (MISC)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

alpha 1 Antichymotrypsin Fusion Protein Ag2830 (70-423 aa encoded by BC010530)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.47 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: DKNVIFSPL SISTALAFLS LGAHNTTLTE ILKGLKFNLT ETSEAEIHQS FQHLLRTLNQ SSDELQLSMG NAMFVKEQLS LLDRFTEDAK RLYGSEAFAT DFQDSAAAKK LINDYVKNGT RGKITDLIKD LDSQTMMVLV NYIFFKAKWE MPFDPQDTHQ SRFYLSKKKW VMVPMMSLHH LTIPYFRDEE LSCTVVELKY TGNASALFIL PDQDKMEEVE AMLLPETLKR WRDSLEFREI GELYLPKFSI SRDYNLNDIL LQLGIEEAFT SKADLSGITG ARNLAVSQVV HKAVLDVFEE GTEASAATAV KITLLSALVE TRTIVRFNRP FLMIIVPTDT QNIFFMSKVT NPKQA (70-423 aa encoded by B C010530)

Target Information

SERPINA encodes Alpha 1-ACT. It is an early-stage acute-phase plasma protein and a serpin that preferentially inactivates chymotrypsin, cathepsin G, and chymase. Alpha-1-ACT, a serine protease inhibitor, is tightly associated with amyloid plaques in Alzheimer's disease (AD) and in normal aged human and monkey brain. Regulation of the serine proteases and serine protease inhibitors plays an important role in neuromuscular differentiation. Prostate specific antigen (PSA), a chymotrypsin-like serine protease, is predominantly complexed to Alpha-1-ACT.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

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Food & function

Liu Z,Liu R,Wang R,Dai J,Chen H,Wang J,Li X

Mon Oct 03 00:00:00 UTC 2022

Synaptic proteomics reveal distinct molecular signatures of cognitive change and C9ORF72 repeat expansion in the human ALS cortex.

Acta neuropathologica communications

Laszlo ZI,Hindley N,Sanchez Avila A,Kline RA,Eaton SL,Lamont DJ,Smith C,Spires-Jones TL,Wishart TM,Henstridge CM

Sat Oct 29 00:00:00 UTC 2022

Screening and identification of tissue-infiltrating immune cells and genes for patients with emphysema phenotype of COPD.

Frontiers in immunology

Wang D,Chen B,Bai S,Zhao L

Tue Oct 18 00:00:00 UTC 2022

An Integrated Proteomics and Metabolomics Strategy for the Mechanism of Calcium Oxalate Crystal-Induced Kidney Injury.

Frontiers in medicine

Gao S,Chao Y,Li N,Li H,Zhao H,Liu X,Chen W,Dong X

Tue Mar 22 00:00:00 UTC 2022

Identification of GlcNAcylated alpha-1-antichymotrypsin as an early biomarker in human non-small-cell lung cancer by quantitative proteomic analysis with two lectins.

British journal of cancer

Jin Y,Wang J,Ye X,Su Y,Yu G,Yang Q,Liu W,Yu W,Cai J,Chen X,Liang Y,Chen Y,Wong BH,Fu X,Sun H

Tue Mar 01 00:00:00 UTC 2016

Identification of GlcNAcylated alpha-1-antichymotrypsin as an early biomarker in human non-small-cell lung cancer by quantitative proteomic analysis with two lectins.

British journal of cancer

Jin Y,Wang J,Ye X,Su Y,Yu G,Yang Q,Liu W,Yu W,Cai J,Chen X,Liang Y,Chen Y,Wong BH,Fu X,Sun H

Tue Mar 01 00:00:00 UTC 2016

Identification of GlcNAcylated alpha-1-antichymotrypsin as an early biomarker in human non-small-cell lung cancer by quantitative proteomic analysis with two lectins.

British journal of cancer

Jin Y,Wang J,Ye X,Su Y,Yu G,Yang Q,Liu W,Yu W,Cai J,Chen X,Liang Y,Chen Y,Wong BH,Fu X,Sun H

Tue Mar 01 00:00:00 UTC 2016

Identification of GlcNAcylated alpha-1-antichymotrypsin as an early biomarker in human non-small-cell lung cancer by quantitative proteomic analysis with two lectins.

British journal of cancer

Jin Y,Wang J,Ye X,Su Y,Yu G,Yang Q,Liu W,Yu W,Cai J,Chen X,Liang Y,Chen Y,Wong BH,Fu X,Sun H

Tue Mar 01 00:00:00 UTC 2016

Serum protein profiling in diffuse large B-cell lymphoma.

Proteomics. Clinical applications

Riby J,Mobley J,Zhang J,Bracci PM,Skibola CF

Tue Nov 01 00:00:00 UTC 2016

Serum protein profiling in diffuse large B-cell lymphoma.

Proteomics. Clinical applications

Riby J,Mobley J,Zhang J,Bracci PM,Skibola CF

Tue Nov 01 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: ACT; Alpha-1-antichymotrypsin; Cell growth-inhibiting gene 24/25 protein; Growth inhibiting protein 24; Growth inhibiting protein 25; growth-inhibiting protein 24; growth-inhibiting protein 25; MGC88254; Serine (or cysteine) proteinase inhibitor clade A member 3; serine (or cysteine) proteinase inhibitor, clade A, member 3; Serpin A3; Serpin peptidase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 3; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3

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Gene Aliases: AACT; ACT; GIG24; GIG25; SERPINA3

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UniProt ID: (Human) P01011

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Entrez Gene ID: (Human) 12

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Function(s)

DNA binding serine-type endopeptidase inhibitor activity protein binding

Process(es)

platelet degranulation acute-phase response inflammatory response negative regulation of endopeptidase activity regulation of lipid metabolic process maintenance of gastrointestinal epithelium

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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alpha 1 Antichymotrypsin Polyclonal Antibody

alpha 1 Antichymotrypsin Antibody (12192-1-AP) in IHC (P)

Product Details

12192-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Miscellaneous PubMed (MISC)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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