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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • alpha-2b Adrenergic Receptor Antibodies

          Alomone Labs, LTD

          alpha 2B-Adrenergic Receptor (extracellular) Polyclonal Antibody

          View all (7) alpha-2b Adrenergic Receptor antibodies

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          Cite alpha 2B-Adrenergic Receptor (extracellular) Polyclonal Antibody

          • Antibody Testing Data (2)
          alpha 2B-Adrenergic Receptor (extracellular) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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          alpha 2B-Adrenergic Receptor (extracellular) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          FIGURE: 1 / 2

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          alpha 2B-Adrenergic Receptor (extracellular) Antibody (AAR-021-200UL) in IHC (P)

          Expression of alpha 2B-Adrenoreceptor in rat lung - Immunohistochemical staining of rat lung paraffin embedded sections using Anti- alpha 2B-Adrenergic Receptor (extracellular) Antibody (#AAR-021), (1:100). alpha 2B-Adrenoreceptor is expressed in the respiratory epithelium of the bronchiole (arrows). Hematoxilin is used as the counterstain. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          alpha 2B-Adrenergic Receptor (extracellular) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          alpha 2B-Adrenergic Receptor (extracellular) Antibody in Western Blot (WB)

          Product Details

          AAR-021-200UL

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:200
          -

          Immunohistochemistry (Paraffin) (IHC (P))

          1:100
          -
          Product Specifications

          Species Reactivity

          Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          (C)RPEPRGLPQ*SELNQE, corresponding to amino acid residues 160-174 of rat alpha 2B-adrenoceptor with replacement of cysteine 169 (C169) with serine (*S), 2nd extracellular loop
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Lyophilized

          Concentration

          0.8 mg/mL

          Purification

          Antigen affinity chromatography

          Storage buffer

          PBS, pH 7.4, with 1% BSA

          Contains

          0.05% sodium azide

          Storage conditions

          -20°C, Avoid Freeze/Thaw Cycles

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          Product Specific Information

          Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

          Target Information

          Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Alpha 2B adrenergic receptor subtype was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. Alpha 2B adrenergic receptor gene contains no introns in either its coding or untranslated sequences.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: ADA2B; Adrenergic alpha2B- receptor class III; adrenergic receptor, alpha 2b; adrenergic, alpha-2B-, receptor; Adrenergic, alpha2B-, receptor class III; Alpha-2B adrenergic receptor; Alpha-2B adrenoceptor; Alpha-2B adrenoreceptor; alpha-2BAR

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          Gene Aliases: Adra2b

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          UniProt ID: (Rat) P19328

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          Entrez Gene ID: (Rat) 24174

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          Function(s)
          adrenergic receptor activity alpha2-adrenergic receptor activity epinephrine binding
          Process(es)
          MAPK cascade activation of MAPK activity angiogenesis regulation of vascular smooth muscle contraction G-protein coupled receptor signaling pathway female pregnancy platelet activation activation of protein kinase B activity epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway positive regulation of neuron differentiation positive regulation of blood pressure positive regulation of uterine smooth muscle contraction adrenergic receptor signaling pathway activation of MAPK activity by adrenergic receptor signaling pathway
          It has to be done as per old AB suggested Products section.
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          Performance Guarantee

          If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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