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Invitrogen
alpha-2b Adrenergic Receptor Monoclonal Antibody (5G10)
Product Details
MA1-12721
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
5G10
Immunogen
Synthetic peptide corresponding to the third intracellular loop of rat alpha 2b adrenergic receptor.
Conjugate
Form
Liquid
Concentration
0.8 mg/mL
Purification
Protein A/G
Storage buffer
PBS
Contains
0.08% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2225066
Product Specific Information
A suggested positive control for this product is MDCK cells transfected with rat alpha2B adrenergic receptors.
Target Information
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Alpha 2B adrenergic receptor subtype was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. Alpha 2B adrenergic receptor gene contains no introns in either its coding or untranslated sequences.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ADA2B; Adrenergic alpha2B- receptor class III; adrenergic receptor, alpha 2b; adrenergic, alpha-2B-, receptor; Adrenergic, alpha2B-, receptor class III; Alpha-2B adrenergic receptor; Alpha-2B adrenoceptor; Alpha-2B adrenoreceptor; alpha-2BAR; subtype alpha2-C2
Gene Aliases: [a]2B; Adra-2b; Adra2b; alpha2-C2; alpha2B
UniProt ID: (Mouse) P30545, (Rat) P19328
Entrez Gene ID: (Mouse) 11552, (Rat) 24174
MAPK cascade
activation of MAPK activity
angiogenesis
regulation of vascular smooth muscle contraction
G-protein coupled receptor signaling pathway
negative regulation of adenylate cyclase activity
cell-cell signaling
female pregnancy
negative regulation of norepinephrine secretion
activation of protein kinase B activity
epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
positive regulation of neuron differentiation
positive regulation of blood pressure
negative regulation of insulin secretion involved in cellular response to glucose stimulus
positive regulation of uterine smooth muscle contraction
adrenergic receptor signaling pathway
adenylate cyclase-inhibiting adrenergic receptor signaling pathway
activation of MAPK activity by adrenergic receptor signaling pathway
platelet activation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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