Invitrogen

alpha Catenin Polyclonal Antibody

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View all (11) alpha Catenin antibodies

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Datasheet
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Datasheet
Protocols
Questions & Answers

Product Details

PA5-29247

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
-

Immunocytochemistry (ICC/IF)

1:100-1:1,000
-

Immunoprecipitation (IP)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the N-terminus region of human alpha Catenin. The exact sequence is proprietary.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol

Contains

0.01% thimerosal

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2546723

Product Specific Information

Recommended positive controls: A431, HeLa, HepG2, mouse brain, Rat2.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Alpha catenin is a member of the b-catenin family of cytosolic proteins. Alpha catenin interacts with N-cadherin and b-catenin on the cytosolic side of adherins junctions to mediate the interaction with the actin cytoskeleton. Alpha catenin is a homodimer in solution, but dissociates to form a 1:1 heterodimer with b-catenin in order to interact with cadherins. It also regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Alpha catenin also functions in the control of the startle modulation.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 102 kDa cadherin-associated protein; alpha E catenin; Alpha E-catenin; Alpha N-catenin; alpha(E)-catenin; alpha(N)-catenin; alpha-catenin; Alpha-catenin-related protein; alpha-E-catenin; alpha-N-catenin; alphaE-catenin; alphaN-catenin; cadherin associated protein; Cadherin-associated protein; cadherin-associated protein, related; cancer/testis antigen 114; CAP102; catenin; catenin (cadherin associated protein), alpha 1; catenin (cadherin-associated protein), alpha 1, 102kDa; catenin (cadherin-associated protein), alpha 2; catenin alpha 1; catenin alpha 2; Catenin alpha-1; Catenin alpha-2; Catenin alpha1; Catenin alpha2; catenin, alpha 1; Catenin-alpha1; Catenin-alpha2; cerebellar deficient folia; FLJ36832; FLJ52416; HGNC:2509; NY-REN-13 antigen; Renal carcinoma antigen NY-REN-13

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Gene Aliases: 2010010M04Rik; AA517462; AI481747; AI988031; CAP-R; CAP102; CAPR; Catna; Catna1; Catna2; cdf; chp; CT114; CTNNA1; CTNNA2; CTNR; MDPT2

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UniProt ID: (Human) P35221, (Human) P26232, (Mouse) P26231, (Mouse) Q61301

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Entrez Gene ID: (Human) 1495, (Human) 1496, (Rat) 307505, (Mouse) 12385, (Mouse) 12386, (Rat) 297357

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Function(s)
structural molecule activity protein binding beta-catenin binding vinculin binding poly(A) RNA binding gamma-catenin binding cadherin binding actin filament binding cadherin binding involved in cell-cell adhesion structural constituent of cytoskeleton
Process(es)
cytoskeleton organization axonogenesis single organismal cell-cell adhesion radial glia guided migration of Purkinje cell dendrite morphogenesis brain morphogenesis positive regulation of muscle cell differentiation regulation of synapse structural plasticity prepulse inhibition ovarian follicle development actin filament organization cell adhesion establishment or maintenance of cell polarity negative regulation of neuroblast proliferation aging male gonad development gap junction assembly axon regeneration adherens junction organization cellular protein localization odontogenesis of dentin-containing tooth apical junction assembly response to estrogen positive regulation of smoothened signaling pathway protein heterooligomerization cellular response to indole-3-methanol epithelial cell-cell adhesion negative regulation of cell motility negative regulation of integrin-mediated signaling pathway negative regulation of extrinsic apoptotic signaling pathway in absence of ligand positive regulation of extrinsic apoptotic signaling pathway in absence of ligand multicellular organism development cell differentiation response to organic cyclic compound regulation of cell proliferation negative regulation of apoptotic process
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