Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
alpha-Defensin 3 Polyclonal Antibody
Promotion
View available promotion(s)
Promo code: {{promo.promoCode}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
FIGURE: 1 / 2
alpha-Defensin 3 Antibody (PA5-103123) in ICC/IF
Immunocytochemistry analysis of alpha-Defensin 3 in HepG2 cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with alpha-Defensin 3 polyclonal antibody (Product # PA5-103123) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG (Red) and an AlexaFluor488 co... View More
Product Details
PA5-103123
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human DEFA3(Accession P59666), corresponding to amino acid residues I36-Q86.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2852493
Product Specific Information
Antibody detects endogenous levels of total Defensin alpha3.
Target Information
Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 3, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 1 by only one amino acid.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: Alpha-defensin 3; defensin 3, neutrophil-specific; Defensin, alpha 3; defensin, alpha 3, neutrophil-specific; defensin, alpha, 27; Defensin-related cryptdin-3; HNP-3; HP-3; Neutrophil defensin 3; neutrophil peptide 3
Gene Aliases: DEF3; Defa27; DEFA3; Defcr-3; Defcr3; HNP-3; HNP3; HP-3; HP3
UniProt ID: (Human) P59666, (Mouse) P28310
Entrez Gene ID: (Human) 1668, (Mouse) 13237
innate immune response in mucosa
antibacterial humoral response
intracellular estrogen receptor signaling pathway
killing of cells of other organism
innate immune response
defense response to Gram-positive bacterium
defense response to fungus
defense response to virus
response to drug
defense response to bacterium
defense response to Gram-negative bacterium
cellular response to lipopolysaccharide
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support