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Invitrogen
alpha TTP Polyclonal Antibody
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alpha TTP Antibody (PA5-89852) in WB
Western blot analysis of alpha TTP in extracts of various cell lines. Samples were incubated with alpha TTP Polyclonal antibody (Product # PA5-89852) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.
Product Details
PA5-89852
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human TTPA (NP_0003611)
Conjugate
Form
Liquid
Concentration
0.81 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2805802
Product Specific Information
Immunogen sequence: MAEARSQPSA GPQLNALPDH SPLLQPGLAA LRRRAREAGV PLAPLPLTDS FLLRFLRARD FDLDLAWRLL KNYYKWRAEC PEISADLHPR SIIGLLKAGY HGVLRSRDPT; Positive Samples: Mouse liver, Mouse kidney, Rat liver; Cellular Location: Cytoplasm
Target Information
This gene encodes a soluble protein that binds alpha-trocopherol, a form of vitamin E, with high selectivity and affinity. This protein plays an important role in regulating vitamin E levels in the body by transporting vitamin E between membrane vesicles and facilitating the secretion of vitamin E from hepatocytes to circulating lipoproteins. Mutations in this gene cause hereditary vitamin E deficiency (ataxia with vitamin E deficiency, AVED) and retinitis pigmentosa.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha TTP; Alpha-tocopherol transfer protein; Alpha-TTP; Tocopherol transfer protein alpha
Gene Aliases: alpha-TTP; Tpp1; TTP; Ttpa
UniProt ID: (Rat) P41034, (Mouse) Q8BWP5
Entrez Gene ID: (Rat) 25571, (Mouse) 50500
placenta development
embryonic placenta development
response to nutrient
response to pH
response to toxic substance
developmental process
vitamin E metabolic process
intermembrane transport
vitamin transport
intracellular pH reduction
negative regulation of cell death
negative regulation of establishment of blood-brain barrier
transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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