Product References
ELF4 is a critical component of a miRNA-transcription factor network and is a bridge regulator of glioblastoma receptor signaling and lipid dynamics.
Neuro-oncology
Kosti A,Chiou J,Guardia GDA,Lei X,Balinda H,Landry T,Lu X,Qiao M,Gilbert A,Brenner A,Galante PAF,Tiziani S,Penalva LOF
62204 was used in Western Blot to suggest that targeting these two pathways simultaneously may be therapeutically beneficial to GBM patients.
Tue Mar 14 00:00:00 UTC 2023
Atypical TDP-43 protein expression in an ALS pedigree carrying a p.Y374X truncation mutation in TARDBP.
Brain pathology (Zurich, Switzerland)
Cooper-Knock J,Julian TH,Feneberg E,Highley JR,Sidra M,Turner MR,Talbot K,Ansorge O,Allen SP,Moll T,Shelkovnikova T,Castelli L,Hautbergue GM,Hewitt C,Kirby J,Wharton SB,Mead RJ,Shaw PJ
62204 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Immunomicroscopy, Immunoprecipitation, Western Blot to uncover a a monogenic, fully penetrant form of ALS whereby disease co-segregates with a heterozygous p.Y374X nonsense mutation within TDP-43.
Sun Jan 01 00:00:00 UTC 2023
Melatonin and Its Metabolites Can Serve as Agonists on the Aryl Hydrocarbon Receptor and Peroxisome Proliferator-Activated Receptor Gamma.
International journal of molecular sciences
Slominski AT,Kim TK,Slominski RM,Song Y,Qayyum S,Placha W,Janjetovic Z,Kleszczyński K,Atigadda V,Song Y,Raman C,Elferink CJ,Hobrath JV,Jetten AM,Reiter RJ
62204 was used in Western Blot to show agonistic activities of melatonin, 6-hydroxymelatonin and N-acetyl-N-formyl-5-methoxykynuramine with EC50's in the 10-4 M range showing significantly lower affinities that those of rosiglitazone, e.g., a 10-8 M range.
Mon Oct 23 00:00:00 UTC 2023
The GTPase Rab21 is required for neuronal development and migration in the cerebral cortex.
Journal of neurochemistry
Peralta Cuasolo YM,Dupraz S,Unsain N,Bisbal M,Quassollo G,Galiano MR,Grassi D,Quiroga S,Sosa LJ
62204 was used in Western Blot to demonstrate that Rab21 plays a critical role in the differentiation and migration of pyramidal neurons by regulating the levels of the amyloid precursor protein on the neuronal cell surface.
Fri Sep 01 00:00:00 UTC 2023
MAP4K3 inhibits Sirtuin-1 to repress the LKB1-AMPK pathway to promote amino acid-dependent activation of the mTORC1 complex.
Life science alliance
Branch MR,Hsu CL,Ohnishi K,Shen WC,Lee E,Meisenhelder J,Winborn B,Sopher BL,Taylor JP,Hunter T,La Spada AR
62204 was used in Western Blotting to reveal the existence of a novel signaling pathway linking amino acid satiety with MAP4K3-dependent suppression of SIRT1 to inactivate the repressive LKB1-AMPK pathway and thereby potently activate the mTORC1 complex to dictate the metabolic disposition of the cell.
Tue Aug 01 00:00:00 UTC 2023
Peptide functionalized DNA hydrogel enhances neuroblastoma cell growth and differentiation.
Nanoscale
Hivare P,Gangrade A,Swarup G,Bhavsar K,Singh A,Gupta R,Thareja P,Gupta S,Bhatia D
62204 was used in Immunocytochemistry-immunoflourescence to demonstrate strongly the ability of DNA-peptide based scaffolds as potential materials to develop nerve tissue conduits for neural tissue engineering applications in the future.
Thu Jun 23 00:00:00 UTC 2022
CYP11A1‑derived vitamin D hydroxyderivatives as candidates for therapy of basal and squamous cell carcinomas.
International journal of oncology
Slominski AT,Brożyna AA,Kim TK,Elsayed MM,Janjetovic Z,Qayyum S,Slominski RM,Oak ASW,Li C,Podgorska E,Li W,Jetten AM,Tuckey RC,Tang EKY,Elmets C,Athar M
62204 was used in Western Blotting to suggest that they might provide targets for endogenously produced or exogenously applied vitamin D hydroxyderivatives and provide excellent candidates for anti‚cancer therapy.
Mon Aug 01 00:00:00 UTC 2022
CRISPR/Cas9 genome editing system confirms centriolin's role in cytokinesis.
BMC research notes
Seronick E,Son J,Michael C,Fogg H,Gromley Z,Gromley A
62204 was used in Western Blot to investigate the role of the CRISPR/Cas9 system in reducing centriolin protein levels within cells.
Mon Jan 10 00:00:00 UTC 2022
CRISPR/Cas9 genome editing system confirms centriolin's role in cytokinesis.
BMC research notes
Seronick E,Son J,Michael C,Fogg H,Gromley Z,Gromley A
62204 was used in Western Blot to investigate the role of the CRISPR/Cas9 system in reducing centriolin protein levels within cells.
Mon Jan 10 00:00:00 UTC 2022
The Ethyl Acetate Fraction of Marine Sponge Stylissa carteri Induces Breast Cancer Cell Death via Upregulation of Mcl-1S: an In vitro Study.
Asian Pacific journal of cancer prevention : APJCP
Bashari MH,Fadhil M,Aulia Y,Sari AK,Putri T,Qomarilla N,Atmaja H,Sudji IR,Ariyanto EF,Indrati AR,Rohmawaty E
62204 was used in Western Blotting to show that the ethyl acetate fraction of Stylissa carteri induces cell death and spheroid destruction in aggressive breast cancer cells. It has a synergistic cytotoxic effect with paclitaxel on MDA MB 231 cell death and upregulates Mcl-1S protein.
Sun May 01 00:00:00 UTC 2022
Overcoming Temozolomide Resistance in Glioblastoma via Enhanced NAD+ Bioavailability and Inhibition of Poly-ADP-Ribose Glycohydrolase.
Cancers
Li J,Koczor CA,Saville KM,Hayat F,Beiser A,McClellan S,Migaud ME,Sobol RW
62204 was used in Western Blotting to discover that combining TMZ with an NAD+ precursor (dihydronicotinamide riboside) and a PARG inhibitor strongly inhibited BER and overcame TMZ resistance.
Fri Jul 22 00:00:00 UTC 2022
Involvement of a Basic Helix-Loop-Helix Gene BHLHE40 in Specification of Chicken Retinal Pigment Epithelium.
Journal of developmental biology
Kinuhata T,Sato K,Bando T,Mito T,Miyaishi S,Nohno T,Ohuchi H
62204 was used in Western Blotting to suggest that emergence of BHLHE40 expression in the OV is involved in initial RPE specification and that BHLHE40 plays a role in separation of the early OV domains by maintaining OTX2 expression and antagonizing an NR developmental program.
Sat Oct 29 00:00:00 UTC 2022
Tight junction formation by a claudin mutant lacking the COOH-terminal PDZ domain-binding motif.
Annals of the New York Academy of Sciences
Fujiwara S,Nguyen TP,Furuse K,Fukazawa Y,Otani T,Furuse M
62204 was used in Western Blotting to suggest that the interaction of claudins with ZO proteins is not a prerequisite for TJ formation at the most apical part of cell-cell contacts.
Sat Oct 01 00:00:00 UTC 2022
Chitinase 3 like 1 contributes to the development of pulmonary vascular remodeling in pulmonary hypertension.
JCI insight
Sun X,Nakajima E,Norbrun C,Sorkhdini P,Yang AX,Yang D,Ventetuolo CE,Braza J,Vang A,Aliotta J,Banerjee D,Pereira M,Baird G,Lu Q,Harrington EO,Rounds S,Lee CG,Yao H,Choudhary G,Klinger JR,Zhou Y
62204 was used in Western Blot to demonstrate that CHI3L1 and its receptors play an integral role in pulmonary vascular disease pathobiology and may offer a target for the treatment of PAH and PH associated with fibrotic lung disease.
Thu Sep 22 00:00:00 UTC 2022
Factor quinolinone inhibitors disrupt spindles and multiple LSF (TFCP2)-protein interactions in mitosis, including with microtubule-associated proteins.
PloS one
Yunes SA,Willoughby JLS,Kwan JH,Biagi JM,Pokharel N,Chin HG,York EA,Su KC,George K,Shah JV,Emili A,Schaus SE,Hansen U
62204 was used in Immunocytochemistry-immunofluorescence to show that FQI1 can rapidly and reversibly lead to mitotic arrest, even when added directly to mitotic cells, implying that FQI1-mediated mitotic defects are not transcriptionally based.
Fri Jun 17 00:00:00 UTC 2022
Repression of p53 function by SIRT5-mediated desuccinylation at Lysine 120 in response to DNA damage.
Cell death and differentiation
Liu X,Rong F,Tang J,Zhu C,Chen X,Jia S,Wang Z,Sun X,Deng H,Zha H,Ouyang G,Xiao W
62204 was used in Western Blot to identify a novel PTM of p53 that regulates its activation as well as reveals a new target of SIRT5 acting as a desuccinylase.
Fri Apr 01 00:00:00 UTC 2022
Methyltransferase SMYD3 impairs hypoxia tolerance by augmenting hypoxia signaling independent of its enzymatic activity.
The Journal of biological chemistry
Wang Z,Chen X,Fan S,Zhu C,Deng H,Tang J,Sun X,Jia S,Liao Q,Xiao W,Liu X
62204 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Immunomicroscopy, Immunoprecipitation, Western Blot to define a novel role of SMYD3 in affecting hypoxia signaling and demonstrate that SMYD3-mediated HIF1a stabilization augments hypoxia signaling, leading to the impairment of hypoxia tolerance.
Thu Dec 01 00:00:00 UTC 2022
Methyltransferase SMYD3 impairs hypoxia tolerance by augmenting hypoxia signaling independent of its enzymatic activity.
The Journal of biological chemistry
Wang Z,Chen X,Fan S,Zhu C,Deng H,Tang J,Sun X,Jia S,Liao Q,Xiao W,Liu X
62204 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Immunomicroscopy, Immunoprecipitation, Western Blot to define a novel role of SMYD3 in affecting hypoxia signaling and demonstrate that SMYD3-mediated HIF1a stabilization augments hypoxia signaling, leading to the impairment of hypoxia tolerance.
Thu Dec 01 00:00:00 UTC 2022
Colchicine-Binding Site Agent CH-2-77 as a Potent Tubulin Inhibitor Suppressing Triple-Negative Breast Cancer.
Molecular cancer therapeutics
Deng S,Krutilina RI,Hartman KL,Chen H,Parke DN,Wang R,Mahmud F,Ma D,Lukka PB,Meibohm B,Seagroves TN,Miller DD,Li W
62204 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Immunomicroscopy, Immunoprecipitation, Western Blot to demonstrate that CH-2-77 is a promising new generation of tubulin inhibitors that inhibit the growth and metastasis of TNBC, and it is worthy of further development as an anticancer agent.
Tue Jul 05 00:00:00 UTC 2022
Sec3 exocyst component knockdown inhibits axonal formation and cortical neuronal migration during brain cortex development.
Journal of neurochemistry
Bustos Plonka F,Sosa LJ,Quiroga S
62204 was used in Western Blotting to emonstrate that the exocyst complex protein Sec3 plays an important role in axon formation in neuronal differentiation and the migration of neuronal progenitors during cortex development.
Sat Jan 01 00:00:00 UTC 2022
Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes.
Cell
Scheiblich H,Dansokho C,Mercan D,Schmidt SV,Bousset L,Wischhof L,Eikens F,Odainic A,Spitzer J,Griep A,Schwartz S,Bano D,Latz E,Melki R,Heneka MT
62204 was used in Immunocytochemistry to show that microglia exposed to α-syn establish a cellular network through the formation of F-actin-dependent intercellular connections.
Thu Sep 30 00:00:00 UTC 2021
Personalized Genome-Scale Metabolic Models Identify Targets of Redox Metabolism in Radiation-Resistant Tumors.
Cell systems
Lewis JE,Forshaw TE,Boothman DA,Furdui CM,Kemp ML
62204 was used in Western Blot to represent a significant advancement in developing quantitative genome-scale models of redox metabolism and identifying personalized metabolic targets for improving radiation sensitivity in individual cancer patients.
Wed Jan 20 00:00:00 UTC 2021
SIRT2-knockdown rescues GARS-induced Charcot-Marie-Tooth neuropathy.
Aging cell
Zhao Y,Xie L,Shen C,Qi Q,Qin Y,Xing J,Zhou D,Qi Y,Yan Z,Lin X,Dai R,Lin J,Yu W
62204 was used in Western Blot to demonstrate the pathogenic role of SIRT2-dependent α-tubulin deacetylation in mutant GARS-induced neuropathies and provide new perspectives for targeting SIRT2 as a potential therapy against hereditary axonopathies.
Tue Jun 01 00:00:00 UTC 2021
Rab2 regulates presynaptic precursor vesicle biogenesis at the trans-Golgi.
The Journal of cell biology
Götz TWB,Puchkov D,Lysiuk V,Lützkendorf J,Nikonenko AG,Quentin C,Lehmann M,Sigrist SJ,Petzoldt AG
62204 was used in Western Blotting to understand the molecular mechanisms controlling the somatic assembly of presynaptic precursors.
Mon May 03 00:00:00 UTC 2021
Rab2 regulates presynaptic precursor vesicle biogenesis at the trans-Golgi.
The Journal of cell biology
Götz TWB,Puchkov D,Lysiuk V,Lützkendorf J,Nikonenko AG,Quentin C,Lehmann M,Sigrist SJ,Petzoldt AG
62204 was used in Western Blotting to understand the molecular mechanisms controlling the somatic assembly of presynaptic precursors.
Mon May 03 00:00:00 UTC 2021
Induction of osteogenic differentiation of bone marrow stromal cells on 3D polyester-based scaffolds solely by subphysiological fluidic stimulation in a laminar flow bioreactor.
Journal of tissue engineering
Yamada S,Yassin MA,Schwarz T,Hansmann J,Mustafa K
62204 was used in Immunocytochemistry to study osteogenesis initiation in synthetic environments as stimulated by a laminar flow bioreactor.
Tue Apr 02 00:00:00 UTC 2024
Zymogen-locked mutant prostasin (Prss8) leads to incomplete proteolytic activation of the epithelial sodium channel (ENaC) and severely compromises triamterene tolerance in mice.
Acta physiologica (Oxford, England)
Essigke D,Ilyaskin AV,Wörn M,Bohnert BN,Xiao M,Daniel C,Amann K,Birkenfeld AL,Szabo R,Bugge TH,Korbmacher C,Artunc F
62204 was used in Western Blotting to indicates that Prss8 plays a role in proteolytic ENaC activation and renal function independent of its proteolytic activity.
Sat May 01 00:00:00 UTC 2021
Midkine-a Regulates the Formation of a Fibrotic Scar During Zebrafish Heart Regeneration.
Frontiers in cell and developmental biology
Grivas D,González-Rajal Á,de la Pompa JL
62204 was used in Western Blot to reveal a critical role for mdka in fibrosis regulation during heart regeneration.
Wed May 26 00:00:00 UTC 2021
Cathepsins B, D, and G Are Expressed in Metastatic Head and Neck Cutaneous Squamous Cell Carcinoma.
Frontiers in oncology
Humphries F,Chang-McDonald B,Patel J,Bockett N,Paterson E,Davis PF,Tan ST
62204 was used in Western Blotting to investigate the expression and localization of cathepsins B, D, and G in relation to CSC subpopulations within mHNcSCC.
Wed Apr 27 00:00:00 UTC 2022
Three-dimensional geometry controls division symmetry in stem cell colonies.
Journal of cell science
Chaigne A,Smith MB,Lopez Cavestany R,Hannezo E,Chalut KJ,Paluch EK
62204 was used in Immunocytochemistry to the investigate if in 3D contexts, the geometry of the cell and its contacts with neighbors control division orientation and symmetry.
Thu Jul 15 00:00:00 UTC 2021
Three-dimensional geometry controls division symmetry in stem cell colonies.
Journal of cell science
Chaigne A,Smith MB,Lopez Cavestany R,Hannezo E,Chalut KJ,Paluch EK
62204 was used in Immunocytochemistry to the investigate if in 3D contexts, the geometry of the cell and its contacts with neighbors control division orientation and symmetry.
Thu Jul 15 00:00:00 UTC 2021
Label-free microscopy of mitotic chromosomes using the polarization orthogonality breaking technique.
Biomedical optics express
Desapogu R,Le Marchand G,Smith R,Ray P,Gillier É,Dutertre S,Alouini M,Tramier M,Huet S,Fade J
62204 was used in Immunocytochemistry to show how orthogonality-breaking imaging can be adapted on a classical confocal fluorescence microscope, and is able to provide informative polarization images from a single scan of the cell sample.
Sun Aug 01 00:00:00 UTC 2021
High-intensity interval training is superior to moderate intensity training on aerobic capacity in rats: Impact on hippocampal plasticity markers.
Behavioural brain research
Constans A,Pin-Barre C,Molinari F,Temprado JJ,Brioche T,Pellegrino C,Laurin J
62204 was used in Western Blot to compare work-matched high-intensity interval training (HIIT) with moderate-intensity continuous training (MICT) on aerobic performance and muscular plasticity markers in healthy rats.
Mon Feb 01 00:00:00 UTC 2021
α- Linolenic acid modulates phagocytosis and endosomal pathways of extracellular Tau in microglia.
Cell adhesion & migration
Desale SE,Chinnathambi S
62204 was used in Immunocytochemistry-immunoflourescence to suggest that microglia could be influenced to reduce extracellular Tau seed with dietary fatty acids.
Wed Dec 01 00:00:00 UTC 2021
Stemness-Associated Markers Are Expressed in Extracranial Arteriovenous Malformation.
Frontiers in surgery
Luke Krishnan CS,Brasch HD,Patel J,Bockett N,Paterson E,Davis PF,Tan ST
62204 was used in Western Blot to study the presence and expression pattern of OCT4, SOX2, NANOG, KLF4, and c-MYC in extracranial arteriovenous malformation.
Tue Apr 06 00:00:00 UTC 2021
Stemness-Associated Markers Are Expressed in Extracranial Arteriovenous Malformation.
Frontiers in surgery
Luke Krishnan CS,Brasch HD,Patel J,Bockett N,Paterson E,Davis PF,Tan ST
62204 was used in Western Blot to study the presence and expression pattern of OCT4, SOX2, NANOG, KLF4, and c-MYC in extracranial arteriovenous malformation.
Tue Apr 06 00:00:00 UTC 2021
Selective and noncovalent targeting of RAS mutants for inhibition and degradation.
Nature communications
Teng KW,Tsai ST,Hattori T,Fedele C,Koide A,Yang C,Hou X,Zhang Y,Neel BG,O'Bryan JP,Koide S
62204 was used in Western Blot to demonstrate the feasibility of selective targeting and degradation of KRAS mutants in the active state with noncovalent reagents and provide a starting point for designing noncovalent therapeutics against oncogenic RAS mutants.
Tue May 11 00:00:00 UTC 2021
Selective and noncovalent targeting of RAS mutants for inhibition and degradation.
Nature communications
Teng KW,Tsai ST,Hattori T,Fedele C,Koide A,Yang C,Hou X,Zhang Y,Neel BG,O'Bryan JP,Koide S
62204 was used in Western Blot to demonstrate the feasibility of selective targeting and degradation of KRAS mutants in the active state with noncovalent reagents and provide a starting point for designing noncovalent therapeutics against oncogenic RAS mutants.
Tue May 11 00:00:00 UTC 2021
Inhibition of HDAC6 Activity Protects Against Endothelial Dysfunction and Atherogenesis in vivo: A Role for HDAC6 Neddylation.
Frontiers in physiology
Nomura Y,Nakano M,Woo Sung H,Han M,Pandey D
62204 was used in Western Blot to determine whether HDAC6 inhibitor tubacin attenuates atherogenesis and to elucidate molecular mechanisms that regulate endothelial HDAC6 expression.
Tue Jul 06 00:00:00 UTC 2021
Inhibition of HDAC6 Activity Protects Against Endothelial Dysfunction and Atherogenesis in vivo: A Role for HDAC6 Neddylation.
Frontiers in physiology
Nomura Y,Nakano M,Woo Sung H,Han M,Pandey D
62204 was used in Western Blot to determine whether HDAC6 inhibitor tubacin attenuates atherogenesis and to elucidate molecular mechanisms that regulate endothelial HDAC6 expression.
Tue Jul 06 00:00:00 UTC 2021
Inhibition of HDAC6 Activity Protects Against Endothelial Dysfunction and Atherogenesis in vivo: A Role for HDAC6 Neddylation.
Frontiers in physiology
Nomura Y,Nakano M,Woo Sung H,Han M,Pandey D
62204 was used in Western Blot to determine whether HDAC6 inhibitor tubacin attenuates atherogenesis and to elucidate molecular mechanisms that regulate endothelial HDAC6 expression.
Tue Jul 06 00:00:00 UTC 2021
A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion.
Nature communications
Sharma J,Du M,Wong E,Mutyam V,Li Y,Chen J,Wangen J,Thrasher K,Fu L,Peng N,Tang L,Liu K,Mathew B,Bostwick RJ,Augelli-Szafran CE,Bihler H,Liang F,Mahiou J,Saltz J,Rab A,Hong J,Sorscher EJ,Mendenhall EM,Coppola CJ,Keeling KM,Green R,Mense M,Suto MJ,Rowe SM,Bedwell DM
62204 was used in Western Blot to show that combining readthrough agents that target distinct components of the translation machinery is a promising treatment strategy for diseases caused by PTCs.
Fri Jul 16 00:00:00 UTC 2021
A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion.
Nature communications
Sharma J,Du M,Wong E,Mutyam V,Li Y,Chen J,Wangen J,Thrasher K,Fu L,Peng N,Tang L,Liu K,Mathew B,Bostwick RJ,Augelli-Szafran CE,Bihler H,Liang F,Mahiou J,Saltz J,Rab A,Hong J,Sorscher EJ,Mendenhall EM,Coppola CJ,Keeling KM,Green R,Mense M,Suto MJ,Rowe SM,Bedwell DM
62204 was used in Western Blot to show that combining readthrough agents that target distinct components of the translation machinery is a promising treatment strategy for diseases caused by PTCs.
Fri Jul 16 00:00:00 UTC 2021
Expression of Components of the Renin-Angiotensin System by Cancer Stem Cells in Renal Clear Cell Carcinoma.
Biomolecules
Siljee S,Milne B,Brasch HD,Bockett N,Patel J,Davis PF,Kennedy-Smith A,Itinteang T,Tan ST
62204 was used in Western Blot to investigate the expression of components of the renin-angiotensin system (RAS) by cancer stem cells (CSCs) we have recently demonstrated in renal clear cell carcinoma (RCCC).
Wed Apr 07 00:00:00 UTC 2021
Cancer Stem Cells in Metastatic Head and Neck Cutaneous Squamous Cell Carcinoma Express Components of the Renin-Angiotensin System.
Cells
Siljee S,Buchanan O,Brasch HD,Bockett N,Patel J,Paterson E,Purdie GL,Davis PF,Itinteang T,Tan ST
62204 was used in Western Blot to investigate the expression of components of the renin-angiotensin system (RAS) by cancer stem cell (CSC) subpopulations in metastatic head and neck cutaneous squamous cell carcinoma (mHNcSCC).
Wed Jan 27 00:00:00 UTC 2021
K-fiber bundles in the mitotic spindle are mechanically reinforced by Kif15.
Molecular biology of the cell
Begley MA,Solon AL,Davis EM,Sherrill MG,Ohi R,Elting MW
62204 was used in Immunocytochemistry-immunofluorescence to suggest that forces holding k-fibers together are of similar magnitude to other spindle forces, and that Kif15, acting as a microtubule cross-linker, helps fortify and repair k-fibers.
Wed Dec 01 00:00:00 UTC 2021
Cell Populations Expressing Stemness-Associated Markers in Lung Adenocarcinoma.
Life (Basel, Switzerland)
Paterson C,Kilmister EJ,Brasch HD,Bockett N,Patel J,Paterson E,Purdie G,Galvin S,Davis PF,Itinteang T,Tan ST
62204 was used in Western Blot to suggest that the expression of the stemness-associated markers OCT4, SOX2, NANOG, KFL4 and c-MYC by LA at the mRNA and protein level, and the unique expression patterns suggest a putative presence of CSC subpopulations within LA, which may be a novel therapeutic target for this cancer.
Mon Oct 18 00:00:00 UTC 2021
A molecular trap inside microtubules probes luminal access by soluble proteins.
Nature chemical biology
Nihongaki Y,Matsubayashi HT,Inoue T
62204 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Immunomicroscopy, Immunoprecipitation, Western Blot to investigate microtubule luminal accessibility in living cells by an inducible protein trap inside microtubules.
Sun Aug 01 00:00:00 UTC 2021
Abscission Couples Cell Division to Embryonic Stem Cell Fate.
Developmental cell
Chaigne A,Labouesse C,White IJ,Agnew M,Hannezo E,Chalut KJ,Paluch EK
62204 was used in Immunocytochemistry to identify abscission as a key cellular process coupling cell division to fate transitions.
Mon Oct 26 00:00:00 UTC 2020
Abscission Couples Cell Division to Embryonic Stem Cell Fate.
Developmental cell
Chaigne A,Labouesse C,White IJ,Agnew M,Hannezo E,Chalut KJ,Paluch EK
62204 was used in Immunocytochemistry to identify abscission as a key cellular process coupling cell division to fate transitions.
Mon Oct 26 00:00:00 UTC 2020
A PI3K- and GTPase-independent Rac1-mTOR mechanism mediates MET-driven anchorage-independent cell growth but not migration.
Science signaling
Hervieu A,Heuss SF,Zhang C,Barrow-McGee R,Joffre C,Ménard L,Clarke PA,Kermorgant S
62204 was used in Western Blotting to reveal a GTPase-independent role for Rac1 in mediating a PI3K-independent MET-to-mTOR pathway and suggest alternative or combined strategies that might overcome resistance to RTK inhibitors in patients with cancer.
Tue Jun 23 00:00:00 UTC 2020
RIM-binding protein couples synaptic vesicle recruitment to release sites.
The Journal of cell biology
Petzoldt AG,Götz TWB,Driller JH,Lützkendorf J,Reddy-Alla S,Matkovic-Rachid T,Liu S,Knoche E,Mertel S,Ugorets V,Lehmann M,Ramesh N,Beuschel CB,Kuropka B,Freund C,Stelzl U,Loll B,Liu F,Wahl MC,Sigrist SJ
62204 was used in Western Blotting to show in Drosophila that RIM-binding protein (RIM-BP) connects release sites physically and functionally to the ELKS family Bruchpilot (BRP)-based scaffold engaged in SV recruitment.
Mon Jul 06 00:00:00 UTC 2020
RIM-binding protein couples synaptic vesicle recruitment to release sites.
The Journal of cell biology
Petzoldt AG,Götz TWB,Driller JH,Lützkendorf J,Reddy-Alla S,Matkovic-Rachid T,Liu S,Knoche E,Mertel S,Ugorets V,Lehmann M,Ramesh N,Beuschel CB,Kuropka B,Freund C,Stelzl U,Loll B,Liu F,Wahl MC,Sigrist SJ
62204 was used in Western Blotting to show in Drosophila that RIM-binding protein (RIM-BP) connects release sites physically and functionally to the ELKS family Bruchpilot (BRP)-based scaffold engaged in SV recruitment.
Mon Jul 06 00:00:00 UTC 2020
Maternal Vitamin D Deficiency Causes Sustained Impairment of Lung Structure and Function and Increases Susceptibility to Hyperoxia-induced Lung Injury in Infant Rats.
American journal of respiratory cell and molecular biology
Mandell EW,Ryan S,Seedorf GJ,Gonzalez T,Smith BJ,Fleet JC,Abman SH
62204 was used in Western Blot to speculate that antenatal disruption of vitamin D signaling increases the risk for late-childhood respiratory disease.
Wed Jul 01 00:00:00 UTC 2020
Mithramycin A and Mithralog EC-8042 Inhibit SETDB1 Expression and Its Oncogenic Activity in Malignant Melanoma.
Molecular therapy oncolytics
Federico A,Steinfass T,Larribère L,Novak D,Morís F,Núñez LE,Umansky V,Utikal J
Published figure using alpha Tubulin monoclonal antibody (Product # 62204) in Western Blot
Fri Sep 25 00:00:00 UTC 2020
Cancer Stem Cell Subpopulations Are Present Within Metastatic Head and Neck Cutaneous Squamous Cell Carcinoma.
Frontiers in oncology
Kilmister EJ,Patel J,van Schaijik B,Bockett N,Brasch HD,Paterson E,Sim D,Davis PF,Roth IM,Itinteang T,Tan ST
62204 was used in Western Blotting to identify and characterise CSCs in metastatic head and neck cutaneous squamous cell carcinoma.
Mon Sep 28 00:00:00 UTC 2020
Quantitative proteomics of synaptosome S-nitrosylation in Alzheimer's disease.
Journal of neurochemistry
Wijasa TS,Sylvester M,Brocke-Ahmadinejad N,Schwartz S,Santarelli F,Gieselmann V,Klockgether T,Brosseron F,Heneka MT
62204 was used in Western Blot to investigate S-nitrosylation in synaptosomal proteins isolated from APP/PS1 model mice in comparison to wild type and NOS2-/- mice, as well as human control, mild cognitive impairment and Alzheimer's disease brain tissues.
Sun Mar 01 00:00:00 UTC 2020
Zebrafish phd3 Negatively Regulates Antiviral Responses via Suppression of Irf7 Transactivity Independent of Its Prolyl Hydroxylase Activity.
Journal of immunology (Baltimore, Md. : 1950)
Yu G,Li X,Zhou Z,Tang J,Wang J,Liu X,Fan S,Ouyang G,Xiao W
62204 was used in Western Blot to demonstrate the antiviral effects of PHD-containing enzyme 3 overexpression in zebrafish.
Sat Aug 15 00:00:00 UTC 2020
Proliferating infantile hemangioma promotes α-fetoprotein production by HepG2 cells.
Pediatric research
van Schaijik B,de Jongh J,Marsh RW,Munro M,Itinteang T,Tan ST
62204 was used in Western Blotting to investigate the expression of AFP by a hepatic cell line HepG2 cells, following co-culturing with proliferating IH-derived primary cell lines.
Wed Jan 01 00:00:00 UTC 2020
Multisite phosphorylation determines the formation of Ska-Ndc80 macro-complexes that are essential for chromosome segregation during mitosis.
Molecular biology of the cell
Zhang Q,Hu L,Chen Y,Tian W,Liu H
62204 was used in Western Blotting to propose that multisite Cdk1 phosphorylation is critical for the formation of Ska-Ndc80 macro-complexes that are essential for chromosome segregation.
Sat Aug 01 00:00:00 UTC 2020
Activation of RAS Signalling is Associated with Altered Cell Adhesion in Phaeochromocytoma.
International journal of molecular sciences
Rossitti HM,Dutta RK,Larsson C,Ghayee HK,Söderkvist P,Gimm O
62204 was used in Western Blotting to conclude that NRAS activity in hPheo1 decreases adhesion to their own extracellular matrix and mirrors a transcriptomic RAS-signalling-related phenomenon in PPGLs.
Thu Oct 29 00:00:00 UTC 2020
Activation of RAS Signalling is Associated with Altered Cell Adhesion in Phaeochromocytoma.
International journal of molecular sciences
Rossitti HM,Dutta RK,Larsson C,Ghayee HK,Söderkvist P,Gimm O
62204 was used in Western Blotting to conclude that NRAS activity in hPheo1 decreases adhesion to their own extracellular matrix and mirrors a transcriptomic RAS-signalling-related phenomenon in PPGLs.
Thu Oct 29 00:00:00 UTC 2020
Up-regulation of pro-angiogenic pathways and induction of neovascularization by an acute retinal light damage.
Scientific reports
Tisi A,Parete G,Flati V,Maccarone R
62204 was used in Western Blotting to characterize the retina after an acute light damage to assess whether the vascularization was affected.
Tue Apr 14 00:00:00 UTC 2020
Up-regulation of pro-angiogenic pathways and induction of neovascularization by an acute retinal light damage.
Scientific reports
Tisi A,Parete G,Flati V,Maccarone R
62204 was used in Western Blotting to characterize the retina after an acute light damage to assess whether the vascularization was affected.
Tue Apr 14 00:00:00 UTC 2020
Genome editing enables reverse genetics of multicellular development in the choanoflagellate Salpingoeca rosetta.
eLife
Booth DS,King N
62204 was used in Immunocytochemistry-immunoflourescence to establish CRISPR/Cas9-mediated genome editing in S. rosetta by engineering a selectable marker to enrich for edited cells.
Thu Jun 04 00:00:00 UTC 2020
Genome editing enables reverse genetics of multicellular development in the choanoflagellate Salpingoeca rosetta.
eLife
Booth DS,King N
62204 was used in Immunocytochemistry-immunoflourescence to establish CRISPR/Cas9-mediated genome editing in S. rosetta by engineering a selectable marker to enrich for edited cells.
Thu Jun 04 00:00:00 UTC 2020
Controlling the Switch from Neurogenesis to Pluripotency during Marmoset Monkey Somatic Cell Reprogramming with Self-Replicating mRNAs and Small Molecules.
Cells
Petkov S,Dressel R,Rodriguez-Polo I,Behr R
62204 was used in Immunocytochemistry to enhance the role of the common marmoset as animal disease model for preclinical testing of iPSC-based therapies.
Thu Nov 05 00:00:00 UTC 2020
Loss of Caveolin-1 and caveolae leads to increased cardiac cell stiffness and functional decline of the adult zebrafish heart.
Scientific reports
Grivas D,González-Rajal Á,Guerrero Rodríguez C,Garcia R,de la Pompa JL
62204 was used in Western Blotting to generate cav1-KO zebrafish lacking Cav1 and caveolae, and investigate the impact of this loss on adult heart function and response to cryoinjury.
Thu Jul 30 00:00:00 UTC 2020
The short variant of optic atrophy 1 (OPA1) improves cell survival under oxidative stress.
The Journal of biological chemistry
Lee H,Smith SB,Sheu SS,Yoon Y
62204 was used in Immunohistochemistry to show that cells unable to generate S-OPA1 are more sensitive to this stress under obligatory respiratory conditions, leading to necrotic death.
Fri May 08 00:00:00 UTC 2020
Stop codon read-through of mammalian MTCH2 leading to an unstable isoform regulates mitochondrial membrane potential.
The Journal of biological chemistry
Manjunath LE,Singh A,Sahoo S,Mishra A,Padmarajan J,Basavaraju CG,Eswarappa SM
62204 was used in Western Blotting to demonstrate translational read-through across two evolutionarily conserved, in-frame stop codons of MTCH2 using luminescence- and fluorescence-based assays, and by analyzing ribosome-profiling and mass spectrometry (MS) data.
Fri Dec 11 00:00:00 UTC 2020
Developmental Pathogenicity of 4-Repeat Human Tau Is Lost with the P301L Mutation in Genetically Matched Tau-Transgenic Mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Gamache JE,Kemper L,Steuer E,Leinonen-Wright K,Choquette JM,Hlynialuk C,Benzow K,Vossel KA,Xia W,Koob MD,Ashe KH
62204 was used in Western Blotting to indicate that overexpression of 4-repeat human tau during postnatal development is associated with excessive microtubule binding, which may disrupt important cellular processes, such as mitochondrial dynamics, leading to elevated stability and hyperphosphorylation of tau, and eventual cognitive impairments.
Thu Jan 02 00:00:00 UTC 2020
Investigating the Vascular Toxicity Outcomes of the Irreversible Proteasome Inhibitor Carfilzomib.
International journal of molecular sciences
Efentakis P,Doerschmann H,Witzler C,Siemer S,Nikolaou PE,Kastritis E,Stauber R,Dimopoulos MA,Wenzel P,Andreadou I,Terpos E
62204 was used in Immunocytochemistry to show that carfilzomib cannot be accredited for a permanent vascular dysfunction, while Cfz+Met exert vasoprotective potency.
Wed Jul 22 00:00:00 UTC 2020
Tetranucleotide Microsatellite Mutational Behavior Assessed in Real Time: Implications for Future Microsatellite Panels.
Cellular and molecular gastroenterology and hepatology
Raeker MÖ,Pierre-Charles J,Carethers JM
62204 was used in Western Blotting to study elevated microsatellite alterations at selected tetranucleotide repeats in colorectal cancers.
Mon May 10 00:00:00 UTC 2021
Cancer Stem Cells in Head and Neck Cutaneous Squamous Cell Carcinoma Express Cathepsins.
Plastic and reconstructive surgery. Global open
Featherston T,Brasch HD,Siljee SD,van Schaijik B,Patel J,de Jongh J,Marsh RW,Itinteang T,Tan ST
62204 was used in Western Blotting to investigate the expression of cathepsins B, D, and G, which constitute bypass loops of the RAS, by CSCs in MDHNcSCC.
Sat Aug 01 00:00:00 UTC 2020
Identification of Cancer Stem Cell Subpopulations in Head and Neck Metastatic Malignant Melanoma.
Cells
Yoganandarajah V,Patel J,van Schaijik B,Bockett N,Brasch HD,Paterson E,Sim D,Davis PF,Roth IM,Itinteang T,Tan ST
62204 was used in Western Blotting to identifiy and characterize cancer stem cells in head and neck metastatic malignant melanoma to regional lymph nodes using induced pluripotent stem cell markers.
Thu Jan 30 00:00:00 UTC 2020
MYC Regulation of D2HGDH and L2HGDH Influences the Epigenome and Epitranscriptome.
Cell chemical biology
Qiu Z,Lin AP,Jiang S,Elkashef SM,Myers J,Srikantan S,Sasi B,Cao JZ,Godley LA,Rakheja D,Lyu Y,Zheng S,Madesh M,Shiio Y,Dahia PLM,Aguiar RCT
62204 was used in Western Blot to provide additional evidence for the role of mitochondria metabolism in influencing the epigenome and epitranscriptome, and imply that in specific contexts wild-type TET enzymes could demethylate and activate oncogenic enhancers.
Thu May 21 00:00:00 UTC 2020
Cancer Stem Cells in Head and Neck Metastatic Malignant Melanoma Express Components of the Renin-Angiotensin System.
Life (Basel, Switzerland)
Siljee S,Pilkington T,Brasch HD,Bockett N,Patel J,Paterson E,Davis PF,Tan ST
62204 was used in Western Blotting to investigate expression of the RAS by the CSC subpopulations in human head and neck metastatic malignant melanoma (HNmMM) tissue samples and HNmMM-derived primary cell lines.
Mon Nov 02 00:00:00 UTC 2020
New factors for protein transport identified by a genome-wide CRISPRi screen in mammalian cells.
The Journal of cell biology
Bassaganyas L,Popa SJ,Horlbeck M,Puri C,Stewart SE,Campelo F,Ashok A,Butnaru CM,Brouwers N,Heydari K,Ripoche J,Weissman J,Rubinsztein DC,Schekman R,Malhotra V,Moreau K,Villeneuve J
62204 was used in Western Blot, Immunocytochemistry to develop a genome-wide CRISPRi screen methodology that allows identification of novel biological factors involved in protein transport.
Mon Nov 04 00:00:00 UTC 2019
New factors for protein transport identified by a genome-wide CRISPRi screen in mammalian cells.
The Journal of cell biology
Bassaganyas L,Popa SJ,Horlbeck M,Puri C,Stewart SE,Campelo F,Ashok A,Butnaru CM,Brouwers N,Heydari K,Ripoche J,Weissman J,Rubinsztein DC,Schekman R,Malhotra V,Moreau K,Villeneuve J
62204 was used in Western Blot, Immunocytochemistry to develop a genome-wide CRISPRi screen methodology that allows identification of novel biological factors involved in protein transport.
Mon Nov 04 00:00:00 UTC 2019
New factors for protein transport identified by a genome-wide CRISPRi screen in mammalian cells.
The Journal of cell biology
Bassaganyas L,Popa SJ,Horlbeck M,Puri C,Stewart SE,Campelo F,Ashok A,Butnaru CM,Brouwers N,Heydari K,Ripoche J,Weissman J,Rubinsztein DC,Schekman R,Malhotra V,Moreau K,Villeneuve J
62204 was used in Western Blot, Immunocytochemistry to develop a genome-wide CRISPRi screen methodology that allows identification of novel biological factors involved in protein transport.
Mon Nov 04 00:00:00 UTC 2019
Bumetanide Prevents Brain Trauma-Induced Depressive-Like Behavior.
Frontiers in molecular neuroscience
Goubert E,Altvater M,Rovira MN,Khalilov I,Mazzarino M,Sebastiani A,Schaefer MKE,Rivera C,Pellegrino C
62204 was used in Western Blotting to study the effect of bumetanide on brain trauma induced depressive like behaviour.
Thu Oct 01 00:00:00 UTC 2020
β1 Syntrophin Supports Autophagy Initiation and Protects against Cerulein-Induced Acute Pancreatitis.
The American journal of pathology
Ye R,Onodera T,Blanchard PG,Kusminski CM,Esser V,Brekken RA,Scherer PE
62204 was used in Immunohistochemistry to reveal, for the first time, that β1 syntrophin is a critical regulator of actin cytoskeleton and autophagy in pancreatic acinar cells and is potently protective against cerulein-induced acute pancreatitis.
Mon Apr 01 00:00:00 UTC 2019
Identification of a mitofusin specificity region that confers unique activities to Mfn1 and Mfn2.
Molecular biology of the cell
Sloat SR,Whitley BN,Engelhart EA,Hoppins S
62204 was used in Western Blot to propose that MISR functions in higher order oligomerization either directly, as an interaction interface, or indirectly through conformational changes.
Thu Aug 01 00:00:00 UTC 2019
Expression of Components of the Renin-Angiotensin System by the Putative Stem Cell Population Within WHO Grade I Meningioma.
Frontiers in surgery
Shivapathasundram G,Wickremesekera AC,Brasch HD,van Schaijik B,Marsh RW,Tan ST,Itinteang T
62204 was used in Western Blotting to find that the expression of PRR, ACE, ATIIR1, and ATIIR2 on the putative stem cell population on the microvessels of WHO grade I MG may be a potential therapeutic target of Renin-Angiotensin System.
Thu Oct 01 00:00:00 UTC 2020
Transient protein accumulation at the center of the T cell antigen-presenting cell interface drives efficient IL-2 secretion.
eLife
Clark DJ,McMillan LE,Tan SL,Bellomo G,Massoue C,Thompson H,Mykhaylechko L,Alibhai D,Ruan X,Singleton KL,Du M,Hedges A,Schwartzberg PL,Verkade P,Murphy RF,Wülfing C
Published figure using alpha Tubulin monoclonal antibody (Product # 62204) in Western Blot
Wed Oct 30 00:00:00 UTC 2019
TRAF2 Controls Death Receptor-Induced Caspase-8 Processing and Facilitates Proinflammatory Signaling.
Frontiers in immunology
Kreckel J,Anany MA,Siegmund D,Wajant H
62204 was used in Western Blot to argue for (i) a non-obligate promoting function of TRAF2 in proinflammatory DR signaling and (ii) a yet unrecognized stabilizing effect of TRAF2 on caspase-8 activity.
Tue Sep 29 00:00:00 UTC 2020
Redundant and receptor-specific activities of TRADD, RIPK1 and FADD in death receptor signaling.
Cell death & disease
Füllsack S,Rosenthal A,Wajant H,Siegmund D
62204 was used in Western Blot to evaluate redundant and receptor-specific activities of TRADD, RIPK1, and FADD in RIPK3-expressing HeLa cells lacking expression of these proteins or any combination of two of these factors.
Mon Feb 11 00:00:00 UTC 2019
Interaction of Structural Glycoprotein E2 of Classical Swine Fever Virus with Protein Phosphatase 1 Catalytic Subunit Beta (PPP1CB).
Viruses
Vuono EA,Ramirez-Medina E,Holinka LG,Baker-Branstetter R,Borca MV,Gladue DP
62204 was used in Western Blotting to suggest that the CSFV E2 and PPP1CB protein interact in infected cells, and that activation of the PP1 pathway decreases virus replication.
Fri Mar 29 00:00:00 UTC 2019
Primary cilium loss in mammalian cells occurs predominantly by whole-cilium shedding.
PLoS biology
Mirvis M,Siemers KA,Nelson WJ,Stearns TP
62204 was used in Immunocytochemistry to investigate and characterise events in cilium loss in mammalian cells.
Mon Jul 01 00:00:00 UTC 2019
Primary cilium loss in mammalian cells occurs predominantly by whole-cilium shedding.
PLoS biology
Mirvis M,Siemers KA,Nelson WJ,Stearns TP
62204 was used in Immunocytochemistry to investigate and characterise events in cilium loss in mammalian cells.
Mon Jul 01 00:00:00 UTC 2019
A chromatin-associated protein required for inducing and limiting meiotic DNA double-strand break formation.
Nucleic acids research
Tian M,Loidl J
62204 was used in Western Blotting to characterize a novel gene, PARS11 (Partner of SPO11), which is required for both the DSB formation and ATR-dependent control of DSB number.
Fri Dec 14 00:00:00 UTC 2018
Herpes simplex viruses activate phospholipid scramblase to redistribute phosphatidylserines and Akt to the outer leaflet of the plasma membrane and promote viral entry.
PLoS pathogens
Cheshenko N,Pierce C,Herold BC
Published figure using alpha Tubulin monoclonal antibody (Product # 62204) in Western Blot
Mon Jan 01 00:00:00 UTC 2018
Multiple Levels of Control Determine How E4bp4/Nfil3 Regulates NK Cell Development.
Journal of immunology (Baltimore, Md. : 1950)
Kostrzewski T,Borg AJ,Meng Y,Filipovic I,Male V,Wack A,DiMaggio PA,Brady HJM
62204 was used in Western Blotting to reveal mechanisms in NK cell development and that E4bp4 is a central hub to process extrinsic stimuli.
Thu Feb 15 00:00:00 UTC 2018
Extreme nuclear branching in healthy epidermal cells of the Xenopus tail fin.
Journal of cell science
Arbach HE,Harland-Dunaway M,Chang JK,Wills AE
62204 was used in Immunohistochemistry to study the mechanisms governing nuclear shape changes in healthy cells in Xenopus.
Thu Sep 20 00:00:00 UTC 2018
Toll-like receptor signaling in macrophages is regulated by extracellular substrate stiffness and Rho-associated coiled-coil kinase (ROCK1/2).
International immunology
Gruber E,Heyward C,Cameron J,Leifer C
62204 was used in Western Blotting to investigate how physical cues affect macrophage function or TLR signalling.
Thu May 24 00:00:00 UTC 2018
Correct Laminar Positioning in the Neocortex Influences Proper Dendritic and Synaptic Development.
Cerebral cortex (New York, N.Y. : 1991)
Martineau FS,Sahu S,Plantier V,Buhler E,Schaller F,Fournier L,Chazal G,Kawasaki H,Represa A,Watrin F,Manent JB
Published figure using alpha Tubulin monoclonal antibody (Product # 62204) in Western Blot
Wed Aug 01 00:00:00 UTC 2018
Tyrosine phosphorylation of the transmembrane protein SIRPα: Sensing synaptic activity and regulating ectodomain cleavage for synapse maturation.
The Journal of biological chemistry
Nagappan-Chettiar S,Johnson-Venkatesh EM,Umemori H
Published figure using alpha Tubulin monoclonal antibody (Product # 62204) in Western Blot
Fri Aug 03 00:00:00 UTC 2018
Tyrosine phosphorylation of the transmembrane protein SIRPα: Sensing synaptic activity and regulating ectodomain cleavage for synapse maturation.
The Journal of biological chemistry
Nagappan-Chettiar S,Johnson-Venkatesh EM,Umemori H
Published figure using alpha Tubulin monoclonal antibody (Product # 62204) in Western Blot
Fri Aug 03 00:00:00 UTC 2018
Chronic vitamin D insufficiency impairs physical performance in C57BL/6J mice.
Aging
Seldeen KL,Pang M,Leiker MM,Bard JE,Rodríguez-Gonzalez M,Hernandez M,Sheridan Z,Nowak N,Troen BR
Published figure using alpha Tubulin monoclonal antibody (Product # 62204) in Western Blot
Thu Jun 14 00:00:00 UTC 2018
Immunosignature Differentiation of Non-Infectious Meningoencephalomyelitis and Intracranial Neoplasia in Dogs.
Frontiers in veterinary science
Lake BB,Rossmeisl JH,Cecere J,Stafford P,Zimmerman KL
62204 was used in Binding arrays as a control to demonstrate that immunosignature profiles may help serve as a minimally invasive tool to distinguish between meningoencephalomyelitis of unknown etiology and intracranial neoplasia in dogs.
Fri Aug 18 00:00:00 UTC 2023
Single-shot super-resolution total internal reflection fluorescence microscopy.
Nature methods
Guo M,Chandris P,Giannini JP,Trexler AJ,Fischer R,Chen J,Vishwasrao HD,Rey-Suarez I,Wu Y,Wu X,Waterman CM,Patterson GH,Upadhyaya A,Taraska JW,Shroff H
62204 was used in Immunocytochemistry to apply instant TIRF-SIM to multiple live samples and achieved rapid, high-contrast super-resolution imaging close to the coverslip surface.
Fri Jun 01 00:00:00 UTC 2018
FYCO1 and autophagy control the integrity of the haploid male germ cell-specific RNP granules.
Autophagy
Da Ros M,Lehtiniemi T,Olotu O,Fischer D,Zhang FP,Vihinen H,Jokitalo E,Sironen A,Toppari J,Kotaja N
62204 was used in immunohistochemistry to investigate how FYCO1 contributes to the integrity of the chromatoid body
Wed Feb 01 00:00:00 UTC 2017
The small molecule inhibitor YK-4-279 disrupts mitotic progression of neuroblastoma cells, overcomes drug resistance and synergizes with inhibitors of mitosis.
Cancer letters
Kollareddy M,Sherrard A,Park JH,Szemes M,Gallacher K,Melegh Z,Oltean S,Michaelis M,Cinatl J,Kaidi A,Malik K
62204 was used in Immunocytochemistry, Western Blot to conclude that YK-4-279 could potentially be used as a single-agent or in combination therapies for the treatment of high-risk and relapsing neuroblastoma, as well as other cancers.
Sun Sep 10 00:00:00 UTC 2017
The small molecule inhibitor YK-4-279 disrupts mitotic progression of neuroblastoma cells, overcomes drug resistance and synergizes with inhibitors of mitosis.
Cancer letters
Kollareddy M,Sherrard A,Park JH,Szemes M,Gallacher K,Melegh Z,Oltean S,Michaelis M,Cinatl J,Kaidi A,Malik K
62204 was used in Immunocytochemistry, Western Blot to conclude that YK-4-279 could potentially be used as a single-agent or in combination therapies for the treatment of high-risk and relapsing neuroblastoma, as well as other cancers.
Sun Sep 10 00:00:00 UTC 2017
The small molecule inhibitor YK-4-279 disrupts mitotic progression of neuroblastoma cells, overcomes drug resistance and synergizes with inhibitors of mitosis.
Cancer letters
Kollareddy M,Sherrard A,Park JH,Szemes M,Gallacher K,Melegh Z,Oltean S,Michaelis M,Cinatl J,Kaidi A,Malik K
62204 was used in Immunocytochemistry, Western Blot to conclude that YK-4-279 could potentially be used as a single-agent or in combination therapies for the treatment of high-risk and relapsing neuroblastoma, as well as other cancers.
Sun Sep 10 00:00:00 UTC 2017
The Motor KIF5C Links the Requirements of Stable Microtubules and IGF-1 Receptor Membrane Insertion for Neuronal Polarization.
Molecular neurobiology
Oksdath M,Guil AFN,Grassi D,Sosa LJ,Quiroga S
62204 was used in western blot to provide a mechanistic link between three early polarity events needed for neuronal polarity
Sun Oct 01 00:00:00 UTC 2017
Involvement of PI3K and PKA pathways in mouse tongue epithelial differentiation.
Acta histochemica
Jung JK,Jung HI,Neupane S,Kim KR,Kim JY,Yamamoto H,Cho SW,Lee Y,Shin HI,Sohn WJ,Kim JY
62204 was used in immunohistochemistry - paraffin section to clarify the impact of PI3K and PKA signaling to tongue epithelial differentiation
Sun Jan 01 00:00:00 UTC 2017
Reflective imaging improves spatiotemporal resolution and collection efficiency in light sheet microscopy.
Nature communications
Wu Y,Kumar A,Smith C,Ardiel E,Chandris P,Christensen R,Rey-Suarez I,Guo M,Vishwasrao HD,Chen J,Tang J,Upadhyaya A,La Riviere PJ,Shroff H
62204 was used in Immunocytochemistry to describe a technique that improves the spatiotemporal resolution and collection efficiency of LSFM without modifying the underlying microscope.
Mon Nov 13 00:00:00 UTC 2017
EWS-FLI-1 creates a cell surface microenvironment conducive to IGF signaling by inducing pappalysin-1.
Genes & cancer
Jayabal P,Houghton PJ,Shiio Y
62204 was used in Western Blot to suggest that EWS-FLI-1 creates a cell surface microenvironment conducive to IGF signaling by inducing pappalysin-1, which emerged as a novel target to inhibit IGF signaling in Ewing sarcoma.
Wed Nov 01 00:00:00 UTC 2017
Peroxisome proliferator-activated receptor (PPAR) α and δ activators induce ICAM-1 expression in quiescent non stimulated endothelial cells.
Journal of inflammation (London, England)
Naidenow J,Hrgovic I,Doll M,Hailemariam-Jahn T,Lang V,Kleemann J,Kippenberger S,Kaufmann R,Zöller N,Meissner M
62204 was used in western blot assess the effects of PPARalpha and delta agonists on ICAM-1 expression in primary human endothelial cells
Mon Aug 22 00:00:00 UTC 2016
Microtubules Inhibit E-Cadherin Adhesive Activity by Maintaining Phosphorylated p120-Catenin in a Colon Carcinoma Cell Model.
PloS one
Maiden SL,Petrova YI,Gumbiner BM
62204 was used in western blot to maintain phosphorylated p120-catenin in a colon carcinoma cell model by microtubules that inhibit E-cadherin adhesive activity
Tue Jul 12 00:00:00 UTC 2016
Microtubules Inhibit E-Cadherin Adhesive Activity by Maintaining Phosphorylated p120-Catenin in a Colon Carcinoma Cell Model.
PloS one
Maiden SL,Petrova YI,Gumbiner BM
62204 was used in western blot to maintain phosphorylated p120-catenin in a colon carcinoma cell model by microtubules that inhibit E-cadherin adhesive activity
Tue Jul 12 00:00:00 UTC 2016
The PTEN phosphatase functions cooperatively with the Fanconi anemia proteins in DNA crosslink repair.
Scientific reports
Vuono EA,Mukherjee A,Vierra DA,Adroved MM,Hodson C,Deans AJ,Howlett NG
62204 was used in western blot to investigate the role of the PTEN phosphatase in DNA interstrand crosslink repair
Mon Nov 07 00:00:00 UTC 2016
Leishmania infantum Asparagine Synthetase A Is Dispensable for Parasites Survival and Infectivity.
PLoS neglected tropical diseases
Faria J,Loureiro I,Santarém N,Macedo-Ribeiro S,Tavares J,Cordeiro-da-Silva A
62204 was used in western blot to learn the dispensability for parasites survival and infectivity in regards to leishmania infantum asparagine synthetase A
Fri Jan 01 00:00:00 UTC 2016
The epigenetic modifier CHD5 functions as a novel tumor suppressor for renal cell carcinoma and is predominantly inactivated by promoter CpG methylation.
Oncotarget
Du Z,Li L,Huang X,Jin J,Huang S,Zhang Q,Tao Q
62204 was used in western blot to investigate the role of CHD5 in renal cell carcinoma
Tue Apr 19 00:00:00 UTC 2016
MPT0B098, a Microtubule Inhibitor, Suppresses JAK2/STAT3 Signaling Pathway through Modulation of SOCS3 Stability in Oral Squamous Cell Carcinoma.
PloS one
Peng HY,Cheng YC,Hsu YM,Wu GH,Kuo CC,Liou JP,Chang JY,Jin SL,Shiah SG
62204 was used in immunocytochemistry and western blot to investigate the effect of a microtubule inhibitor, MPT0B098, on STAT3 signaling in oral squamous cell carcinoma
Tue Aug 08 00:00:00 UTC 2017
A Point Mutation in the Exon Junction Complex Factor Y14 Disrupts Its Function in mRNA Cap Binding and Translation Enhancement.
The Journal of biological chemistry
Chuang TW,Lee KM,Lou YC,Lu CC,Tarn WY
62204 was used in western blot to identify residues of Y14 that are needed for binding to the mRNA cap
Fri Apr 15 00:00:00 UTC 2016
Disruption of CCL20-CCR6 interaction inhibits metastasis of advanced cutaneous T-cell lymphoma.
Oncotarget
Ikeda S,Kitadate A,Ito M,Abe F,Nara M,Watanabe A,Takahashi N,Miyagaki T,Sugaya M,Tagawa H
62204 was used in western blot to test whether the CCL20-CCR6 interaction is functional in metastatic cutaneous T cell lymphoma cells
Tue Mar 22 00:00:00 UTC 2016
LRP1 Protein Deficiency Exacerbates Palmitate-induced Steatosis and Toxicity in Hepatocytes.
The Journal of biological chemistry
Hamlin AN,Basford JE,Jaeschke A,Hui DY
62204 was used in western blot to analyze exacerbation of palmitate-induced steatosis and toxicity in hepatocytes by low density lipoprotein receptor-related protein-1 deficiency
Fri Aug 05 00:00:00 UTC 2016
Mitochondrial DNA stress primes the antiviral innate immune response.
Nature
West AP,Khoury-Hanold W,Staron M,Tal MC,Pineda CM,Lang SM,Bestwick M,Duguay BA,Raimundo N,MacDuff DA,Kaech SM,Smiley JR,Means RE,Iwasaki A,Shadel GS
62204 was used in western blot to analyze the antiviral innate immune response due to mitochondrial DNA stress
Thu Apr 23 00:00:00 UTC 2015
Loss of Runx2 sensitises osteosarcoma to chemotherapy-induced apoptosis.
British journal of cancer
Roos A,Satterfield L,Zhao S,Fuja D,Shuck R,Hicks MJ,Donehower LA,Yustein JT
62204 was used in western blot to determine the sensitization of osteosarcoma to chemotherapy-induced apoptosis by a loss of Runx2
Tue Nov 03 00:00:00 UTC 2015
IFI27, a novel epidermal growth factor-stabilized protein, is functionally involved in proliferation and cell cycling of human epidermal keratinocytes.
Cell proliferation
Hsieh WL,Huang YH,Wang TM,Ming YC,Tsai CN,Pang JH
62204 was used in western blot to identify the role of IFI27 in the cell proliferation of human epidermal keratinocytes
Wed Apr 01 00:00:00 UTC 2015
S100B is required for high glucose-induced pro-fibrotic gene expression and hypertrophy in mesangial cells.
International journal of molecular medicine
Chuang CT,Guh JY,Lu CY,Chen HC,Chuang LY
62204 was used in western blot to characterize S100B reiqured for hypertrophy in mesangial cells and high glucose-induced pro-fibrotic gene expression
Sun Feb 01 00:00:00 UTC 2015
Variants in CUL4B are associated with cerebral malformations.
Human mutation
Vulto-van Silfhout AT,Nakagawa T,Bahi-Buisson N,Haas SA,Hu H,Bienek M,Vissers LE,Gilissen C,Tzschach A,Busche A,Müsebeck J,Rump P,Mathijssen IB,Avela K,Somer M,Doagu F,Philips AK,Rauch A,Baumer A,Voesenek K,Poirier K,Vigneron J,Amram D,Odent S,Nawara M,Obersztyn E,Lenart J,Charzewska A,Lebrun N,Fischer U,Nillesen WM,Yntema HG,Järvelä I,Ropers HH,de Vries BB,Brunner HG,van Bokhoven H,Raymond FL,Willemsen MA,Chelly J,Xiong Y,Barkovich AJ,Kalscheuer VM,Kleefstra T,de Brouwer AP
62204 was used in western blot to examine the relation between cullin 4B variants and intellectual disability
Thu Jan 01 00:00:00 UTC 2015
Retromer vesicles interact with RNA granules in haploid male germ cells.
Molecular and cellular endocrinology
Da Ros M,Hirvonen N,Olotu O,Toppari J,Kotaja N
62204 was used in western blot to examine the interaction of retromer vesicles with RNA granules
Thu Feb 05 00:00:00 UTC 2015
KIF1-binding protein interacts with KIF3A in haploid male germ cells.
Reproduction (Cambridge, England)
Lehti MS,Kotaja N,Sironen A
62204 was used in immunohistochemistry to investigate the interaction between KIF1-binding protein and KIF3A in haploid male germ cells
Tue Sep 01 00:00:00 UTC 2015
Allosteric Regulation of E-Cadherin Adhesion.
The Journal of biological chemistry
Shashikanth N,Petrova YI,Park S,Chekan J,Maiden S,Spano M,Ha T,Gumbiner BM,Leckband DE
Published figure using alpha Tubulin monoclonal antibody (Product # 62204) in Western Blot
Fri Aug 28 00:00:00 UTC 2015
EphrinB1: novel microtubule associated protein whose expression affects taxane sensitivity.
Oncotarget
Colbert PL,Vermeer DW,Wieking BG,Lee JH,Vermeer PD
62204 was used in western blot to test if HPV infection affects cellular proliferation by altering the localization of EphrinB1 during mitosis
Tue Jan 20 00:00:00 UTC 2015
Purifying Cytokinetic Cells from an Asynchronous Population.
Scientific reports
Panet E,Ozer E,Mashriki T,Lazar I,Itzkovich D,Tzur A
62204 was used in immunocytochemistry and western blot to assess and asynchronous population to purify cytokinetic cells
Tue Aug 11 00:00:00 UTC 2015
D-2-hydroxyglutarate is essential for maintaining oncogenic property of mutant IDH-containing cancer cells but dispensable for cell growth.
Oncotarget
Ma S,Jiang B,Deng W,Gu ZK,Wu FZ,Li T,Xia Y,Yang H,Ye D,Xiong Y,Guan KL
62204 was used in western blot to characterize D-2-hydroxyglutarate in its oncogenic property of mutant IDH-containing cancer cells but is dispensable for cell growth
Mon Apr 20 00:00:00 UTC 2015
Insulin-like growth factor-independent insulin-like growth factor binding protein 3 promotes cell migration and lymph node metastasis of oral squamous cell carcinoma cells by requirement of integrin β1.
Oncotarget
Yen YC,Hsiao JR,Jiang SS,Chang JS,Wang SH,Shen YY,Chen CH,Chang IS,Chang JY,Chen YW
62204 was used in western blot to determine promotion of cell migration and lymph node metastasis of oral squamous cell carcinoma cells by requirement of integrin beta1 and insulin-like growth factor-independent insulin-like growth factor binding protein
Tue Dec 08 00:00:00 UTC 2015
Dehydroepiandrosterone Activation of G-protein-coupled Estrogen Receptor Rapidly Stimulates MicroRNA-21 Transcription in Human Hepatocellular Carcinoma Cells.
The Journal of biological chemistry
Teng Y,Radde BN,Litchfield LM,Ivanova MM,Prough RA,Clark BJ,Doll MA,Hein DW,Klinge CM
62204 was used in western blot to study signaling events downstream to the G-protein-coupled estrogen receptor activated by dehydroepiandrosterone
Fri Jun 19 00:00:00 UTC 2015
Selected SNARE proteins are essential for the polarized membrane insertion of igf-1 receptor and the regulation of initial axonal outgrowth in neurons.
Cell discovery
Grassi D,Plonka FB,Oksdath M,Guil AN,Sosa LJ,Quiroga S
62204 was used in Immunocytochemistry to show here that five SNARE proteins (VAMP2, VAMP4, VAMP7, Syntaxin6 and SNAP23) were expressed by hippocampal pyramidal neurons before polarization.
Wed Jul 27 00:00:00 UTC 2016
Nuclear cathepsin D enhances TRPS1 transcriptional repressor function to regulate cell cycle progression and transformation in human breast cancer cells.
Oncotarget
Bach AS,Derocq D,Laurent-Matha V,Montcourrier P,Sebti S,Orsetti B,Theillet C,Gongora C,Pattingre S,Ibing E,Roger P,Linares LK,Reinheckel T,Meurice G,Kaiser FJ,Gespach C,Liaudet-Coopman E
62204 was used in western blot to determine transformation and cell cycle progression in human breast cancer cells by nuclear cathepsin D enhancing TRPS1 transcriptional repressor function
Tue Sep 29 00:00:00 UTC 2015
NF-κB signaling mediates acquired resistance after PARP inhibition.
Oncotarget
Nakagawa Y,Sedukhina AS,Okamoto N,Nagasawa S,Suzuki N,Ohta T,Hattori H,Roche-Molina M,Narváez AJ,Jeyasekharan AD,Bernal JA,Sato K
62204 was used in western blot to assess how PARP inhibition occurs after NF-kappa-B signaling mediated acquired resistance
Sat Feb 28 00:00:00 UTC 2015
TRAP150 activates splicing in composite terminal exons.
Nucleic acids research
Lee KM,Tarn WY
62204 was used in western blot to study the regulation of premature cleavage and polyadenylation by TRAP150.
Mon Nov 10 00:00:00 UTC 2014
PIP₃ induces the recycling of receptor tyrosine kinases.
Science signaling
Laketa V,Zarbakhsh S,Traynor-Kaplan A,Macnamara A,Subramanian D,Putyrski M,Mueller R,Nadler A,Mentel M,Saez-Rodriguez J,Pepperkok R,Schultz C
62204 was used in western blot to study the mechanisms underlying the recycling of receptor tyrosine kinases induced by phosphatidylinositol 3,4,5-trisphosphate
Tue Jan 14 00:00:00 UTC 2014
Rac1 as a potential therapeutic target for chemo-radioresistant head and neck squamous cell carcinomas (HNSCC).
British journal of cancer
Skvortsov S,Dudás J,Eichberger P,Witsch-Baumgartner M,Loeffler-Ragg J,Pritz C,Schartinger VH,Maier H,Hall J,Debbage P,Riechelmann H,Lukas P,Skvortsova I
62204 was used in western blot to study the expression and activity of Rac1 in chemo-radiation resistant head and neck squamous cell carcinoma and the therapeutic potential of Rac1 inhibition
Tue May 27 00:00:00 UTC 2014
Characteristics of endogenous γ-aminobutyric acid (GABA) in human platelets: functional studies of a novel collagen glycoprotein VI inhibitor.
Journal of molecular medicine (Berlin, Germany)
Lin KH,Lu WJ,Wang SH,Fong TH,Chou DS,Chang CC,Chang NC,Chiang YC,Huang SY,Sheu JR
62204 was used in western blot to study the ability of GABA to inhibit platelet activation via direct blockade of glycoprotein VI activation
Sun Jun 01 00:00:00 UTC 2014
Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover.
Journal of proteome research
Elzi DJ,Song M,Hakala K,Weintraub ST,Shiio Y
62204 was used in western blot to determine the role of the lysosome in EWS-Fli-1 turnover due to proteomic analysis of the EWS-Fli-1 interactome
Fri Aug 01 00:00:00 UTC 2014
Α-tubulin nuclear overexpression is an indicator of poor prognosis in patients with non-Hodgkin's lymphoma.
International journal of molecular medicine
Hayashi S,Mikami T,Murai Y,Takano Y,Imura J
62204 was used in Flow Cytometry to reveal that overexpression of α-tubulin is an independent prognostic factor in NHL with a relative risk of 2.786.
Fri Aug 01 00:00:00 UTC 2014
Identification of new IκBα complexes by an iterative experimental and mathematical modeling approach.
PLoS computational biology
Konrath F,Witt J,Sauter T,Kulms D
62204 was used in western blot to use experimental and mathmatical modeling techniques to identify novel IkB-alpha complexes
Sat Mar 01 00:00:00 UTC 2014
Dehydroepiandrosterone-induces miR-21 transcription in HepG2 cells through estrogen receptor β and androgen receptor.
Molecular and cellular endocrinology
Teng Y,Litchfield LM,Ivanova MM,Prough RA,Clark BJ,Klinge CM
62204 was used in western blot to study the roles of ER-beta and AR in the induction of miRNA-21 transcription by dehydroepiandrosterone in HepG2 cells
Sat Jul 05 00:00:00 UTC 2014
Hinokitiol is a novel glycoprotein VI antagonist on human platelets.
Platelets
Lu WJ,Wu MP,Lin KH,Lin YC,Chou HC,Sheu JR
62204 was used in western blot to study the role of glycoprotein VI in the ability of hinokitiol to block platelet aggregation
Wed Oct 21 00:00:00 UTC 2015
TUBB1 mutation disrupting microtubule assembly impairs proplatelet formation and results in congenital macrothrombocytopenia.
European journal of haematology
Kunishima S,Nishimura S,Suzuki H,Imaizumi M,Saito H
62204 was used in immunohistochemistry to study congenital macrothrombocytopenia caused by TUBB1 mutation affecting microtubule assembly and the formation of proplatelets
Tue Apr 01 00:00:00 UTC 2014
Α-tubulin K40 acetylation is required for contact inhibition of proliferation and cell-substrate adhesion.
Molecular biology of the cell
Aguilar A,Becker L,Tedeschi T,Heller S,Iomini C,Nachury MV
62204 was used in immunohistochemistry and western blot to study the essential role of lysine 40 acetylation of alpha-tubulin in contact inhibition of cell proliferation and cellular substrate adhesion using alpha-Tat1 (-/-) fibroblasts
Sun Jun 15 00:00:00 UTC 2014
Copy number variants are produced in response to low-dose ionizing radiation in cultured cells.
Environmental and molecular mutagenesis
Arlt MF,Rajendran S,Birkeland SR,Wilson TE,Glover TW
62204 was used in western blot to study the effect of low doses of ionizing radiation on copy number variant formation in normal human fibroblasts
Sat Mar 01 00:00:00 UTC 2014
Amarogentin, a secoiridoid glycoside, abrogates platelet activation through PLC γ 2-PKC and MAPK pathways.
BioMed research international
Yen TL,Lu WJ,Lien LM,Thomas PA,Lee TY,Chiu HC,Sheu JR,Lin KH
62204 was used in western blot to study the roles of PKC. PLC-gamma and MAPK in the mechanism by which amarogentin inhibits platelet activation
Tue Oct 06 00:00:00 UTC 2015
Myostatin knockdown and its effect on myogenic gene expression program in stably transfected goat myoblasts.
In vitro cellular & developmental biology. Animal
Patel AK,Tripathi AK,Patel UA,Shah RK,Joshi CG
62204 was used in western blot to study the effects of shRNA-mediated knockdown of myostatin on goat myoblast expression of myogenic genes
Fri Aug 01 00:00:00 UTC 2014
Hypersensitivity of mouse NEIL1-knockdown cells to hydrogen peroxide during S phase.
Journal of radiation research
Yamamoto R,Ohshiro Y,Shimotani T,Yamamoto M,Matsuyama S,Ide H,Kubo K
62204 was used in western blot to investigate hydrogen peroxide and its role in hypersensitivity of mouse NEIL1-knockdown cells during S phase
Tue Jul 01 00:00:00 UTC 2014
N1-(Quinolin-2-ylmethyl) butane-1, 4-diamine, a polyamine analog: inhibition of platelet aggregation mediated by an elevated VASP, and decreased MAPK phosphorylation.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis
Gao Y,Ji BS
62204 was used in western blot to study the roles of VASP and MAPK in the mechanism by which a polyamine analog inhibits platelet aggregation
Tue Jul 01 00:00:00 UTC 2014
Miz1 deficiency in the mammary gland causes a lactation defect by attenuated Stat5 expression and phosphorylation.
PloS one
Sanz-Moreno A,Fuhrmann D,Wolf E,von Eyss B,Eilers M,Elsässer HP
62204 was used in western blot to study the role of impaired Stat5 signaling in the mechanism by which mammary gland Miz1 deficiency leads to defective lactation
Sat Jan 10 00:00:00 UTC 2015
Circadian genes, xBmal1 and xNocturnin, modulate the timing and differentiation of somites in Xenopus laevis.
PloS one
Curran KL,Allen L,Porter BB,Dodge J,Lope C,Willadsen G,Fisher R,Johnson N,Campbell E,VonBergen B,Winfrey D,Hadley M,Kerndt T
62204 was used in western blot to analyze xNocturnin and xBmaI1, circadian genes, that regulate differentiation and timing of somites in Xenopus laevis
Mon Nov 16 00:00:00 UTC 2015
The Menin-Bach2 axis is critical for regulating CD4 T-cell senescence and cytokine homeostasis.
Nature communications
Kuwahara M,Suzuki J,Tofukuji S,Yamada T,Kanoh M,Matsumoto A,Maruyama S,Kometani K,Kurosaki T,Ohara O,Nakayama T,Yamashita M
62204 was used in western blot to study the modulation of CD4 T-cell senescence and cytokine production and the roles played by Menin and Bach2
Wed Apr 02 00:00:00 UTC 2014
The polyphenols (-)-epigallocatechin-3-gallate and luteolin synergistically inhibit TGF-β-induced myofibroblast phenotypes through RhoA and ERK inhibition.
PloS one
Gray AL,Stephens CA,Bigelow RL,Coleman DT,Cardelli JA
62204 was used in western blot to study how inhibition of TGF-beta-induced myofibroblast phenotypes occurs through polyphenols (-)-epigallocatechin-3-gallate and luteolin that inhibit through RhoA and ERK inhibition
Fri Jan 15 00:00:00 UTC 2016
The genomic landscape of the Ewing Sarcoma family of tumors reveals recurrent STAG2 mutation.
PLoS genetics
Brohl AS,Solomon DA,Chang W,Wang J,Song Y,Sindiri S,Patidar R,Hurd L,Chen L,Shern JF,Liao H,Wen X,Gerard J,Kim JS,Lopez Guerrero JA,Machado I,Wai DH,Picci P,Triche T,Horvai AE,Miettinen M,Wei JS,Catchpool D,Llombart-Bosch A,Waldman T,Khan J
62204 was used in western blot to analyze the Ewing Sarcoma family of tumors for genomics to reveal STAG2 mutations
Tue Jul 01 00:00:00 UTC 2014
Memo has a novel role in S1P signaling and is [corrected] crucial for vascular development.
PloS one
Kondo S,Bottos A,Allegood JC,Masson R,Maurer FG,Genoud C,Kaeser P,Huwiler A,Murakami M,Spiegel S,Hynes NE
62204 was used in western blot to study the role of memo in S1P signaling and embryonic vascular development
Tue Jan 06 00:00:00 UTC 2015
Reciprocal regulation of microRNA-99a and insulin-like growth factor I receptor signaling in oral squamous cell carcinoma cells.
Molecular cancer
Yen YC,Shiah SG,Chu HC,Hsu YM,Hsiao JR,Chang JY,Hung WC,Liao CT,Cheng AJ,Lu YC,Chen YW
62204 was used in immunocytochemistry and western blot to study the role of miRNA-99a as a suppressor of metastasis in oral squamous cell carcinoma and the reciprocal modulation of the expression of miRNA-99a and IGF-1R
Fri Jan 10 00:00:00 UTC 2014
Frequent truncating mutations of STAG2 in bladder cancer.
Nature genetics
Solomon DA,Kim JS,Bondaruk J,Shariat SF,Wang ZF,Elkahloun AG,Ozawa T,Gerard J,Zhuang D,Zhang S,Navai N,Siefker-Radtke A,Phillips JJ,Robinson BD,Rubin MA,Volkmer B,Hautmann R,Küfer R,Hogendoorn PC,Netto G,Theodorescu D,James CD,Czerniak B,Miettinen M,Waldman T
62204 was used in western blot to study the high rate of STAG2 truncating mutations observed in bladder cancers
Sun Dec 01 00:00:00 UTC 2013
DNA damage-activated ABL-MyoD signaling contributes to DNA repair in skeletal myoblasts.
Cell death and differentiation
Simonatto M,Marullo F,Chiacchiera F,Musaró A,Wang JY,Latella L,Puri PL
62204 was used in western blot to study the role of ABL-MyoD signalling in skeletal muscle myoblast DNA repair
Sun Dec 01 00:00:00 UTC 2013
Metabolic intervention on lipid synthesis converging pathways abrogates prostate cancer growth.
Oncogene
Fritz V,Benfodda Z,Henriquet C,Hure S,Cristol JP,Michel F,Carbonneau MA,Casas F,Fajas L
62204 was used in western blot to study the ability to block the growth of prostate cancer cells via manipulation of lipid metabolism
Thu Oct 17 00:00:00 UTC 2013
Mechanisms of andrographolide-induced platelet apoptosis in human platelets: regulatory roles of the extrinsic apoptotic pathway.
Phytotherapy research : PTR
Lien LM,Su CC,Hsu WH,Lu WJ,Chung CL,Yen TL,Chiu HC,Sheu JR,Lin KH
62204 was used in western blot to study the role of the extrinsic pathway in the induction of apoptosis in human platelets by andrographolide
Fri Nov 01 00:00:00 UTC 2013
A novel antithrombotic effect of sulforaphane via activation of platelet adenylate cyclase: ex vivo and in vivo studies.
The Journal of nutritional biochemistry
Jayakumar T,Chen WF,Lu WJ,Chou DS,Hsiao G,Hsu CY,Sheu JR,Hsieh CY
62204 was used in western blot to study the role of platelet adenylate cyclase activation in the antithrombotic actions of sulforaphane
Sat Jun 01 00:00:00 UTC 2013
Hinokitiol inhibits platelet activation ex vivo and thrombus formation in vivo.
Biochemical pharmacology
Lin KH,Kuo JR,Lu WJ,Chung CL,Chou DS,Huang SY,Lee HC,Sheu JR
62204 was used in western blot to study the molecular mechanism underlying the inhibition of collagen-induced platelet aggregation and murine thrombogenesis by hinokitiol
Wed May 15 00:00:00 UTC 2013
MicroRNA-205, a novel regulator of the anti-apoptotic protein Bcl2, is downregulated in prostate cancer.
International journal of oncology
Verdoodt B,Neid M,Vogt M,Kuhn V,Liffers ST,Palisaar RJ,Noldus J,Tannapfel A,Mirmohammadsadegh A
62204 was used in western blot to study the down-regulation of the Bcl-2 repressor miRNA-205 in prostate cancer
Mon Jul 01 00:00:00 UTC 2013
Canonical and noncanonical Wnt proteins program dendritic cell responses for tolerance.
Journal of immunology (Baltimore, Md. : 1950)
Oderup C,LaJevic M,Butcher EC
62204 was used in western blot to study the role of canonical and non-canonical Wnt proteins in stimulating the production of anti-inflammatory cytokines by murine dendritic cells
Sat Jun 15 00:00:00 UTC 2013
Unbiased transcriptome signature of in vivo cell proliferation reveals pro- and antiproliferative gene networks.
Cell cycle (Georgetown, Tex.)
Cohen M,Vecsler M,Liberzon A,Noach M,Zlotorynski E,Tzur A
62204 was used in western blot to compare the transcriptomes of resting and proliferating B-cells to identify networks of pro-inflammatory and anti-inflammatory genes
Sun Sep 15 00:00:00 UTC 2013
Tau phosphorylation affects its axonal transport and degradation.
Neurobiology of aging
Rodríguez-Martín T,Cuchillo-Ibáñez I,Noble W,Nyenya F,Anderton BH,Hanger DP
62204 was used in immunocytochemistry to study the effect of phosphorylation on the axonal transport and degradation of tau protein
Sun Sep 01 00:00:00 UTC 2013
FEZF2, a novel 3p14 tumor suppressor gene, represses oncogene EZH2 and MDM2 expression and is frequently methylated in nasopharyngeal carcinoma.
Carcinogenesis
Shu XS,Li L,Ji M,Cheng Y,Ying J,Fan Y,Zhong L,Liu X,Tsao SW,Chan AT,Tao Q
62204 was used in western blot to study the role of FEZF2 as a novel tumor suppressor and its methylation and inactivation in a substantial proportion of naspharyngeal carcinomas
Sun Sep 01 00:00:00 UTC 2013
Niclosamide suppresses Hepatoma cell proliferation via the Wnt pathway.
OncoTargets and therapy
Tomizawa M,Shinozaki F,Motoyoshi Y,Sugiyama T,Yamamoto S,Sueishi M,Yoshida T
62204 was used in western blot to study the role of Wnt in the mechanism by which niclosamide inhibits the proliferation of hepatoma cells
Mon Nov 25 00:00:00 UTC 2013
The RNA-binding protein Y14 inhibits mRNA decapping and modulates processing body formation.
Molecular biology of the cell
Chuang TW,Chang WL,Lee KM,Tarn WY
62204 was used in western blot to study the regulation of RNA-decapping and the formation of processing bodies by the Y14 RNA-binding protein
Tue Jan 01 00:00:00 UTC 2013
Novel bioactivity of ellagic Acid in inhibiting human platelet activation.
Evidence-based complementary and alternative medicine : eCAM
Chang Y,Chen WF,Lin KH,Hsieh CY,Chou DS,Lin LJ,Sheu JR,Chang CC
62204 was used in western blot to study the inhibition of human platelet activation by ellagic acid and the mechanisms involved
Thu Mar 28 00:00:00 UTC 2013
Comparative proteomic analysis of oral squamous cell carcinoma and adjacent non-tumour tissue from Thailand.
Archives of oral biology
Chanthammachat P,Promwikorn W,Pruegsanusak K,Roytrakul S,Srisomsap C,Chokchaichamnankit D,Svasti J,Boonyaphiphat P,K S,Thongsuksai P
62204 was used in immunohistochemistry to use a proteomic approach to identify those proteins differentially expressed in squamous cell carcinoma and surrounding non-cancerous tissue in a Thai population
Fri Nov 01 00:00:00 UTC 2013
Differentiated epithelial- and mesenchymal-like phenotypes in subcutaneous mouse xenografts using diffusion weighted-magnetic resonance imaging.
International journal of molecular sciences
Chen YW,Pan HB,Tseng HH,Chu HC,Hung YT,Yen YC,Chou CP
62204 was used in western blot to determine the difference in apparent diffusion coefficient values between epithelial- and mesenchymal-like subcutaneous mouse xenografted tumors using diffusion-weighted magnetic resonance imaging
Tue Nov 05 00:00:00 UTC 2013
Ran GTPase-activating protein 1 is a therapeutic target in diffuse large B-cell lymphoma.
PloS one
Chang KC,Chang WC,Chang Y,Hung LY,Lai CH,Yeh YM,Chou YW,Chen CH
62204 was used in western blot to study the therapeutic potential of RanGAP1 in diffuse large B-cell lymphoma
Fri Jun 20 00:00:00 UTC 2014
Antagonistic TNF receptor one-specific antibody (ATROSAB): receptor binding and in vitro bioactivity.
PloS one
Richter F,Liebig T,Guenzi E,Herrmann A,Scheurich P,Pfizenmaier K,Kontermann RE
62204 was used in western blot to biologically characterize a humanized antibody that acts as an antagonist of TNFR1
Thu Jan 22 00:00:00 UTC 2015
Par6b regulates the dynamics of apicobasal polarity during development of the stratified Xenopus epidermis.
PloS one
Wang S,Cha SW,Zorn AM,Wylie C
62204 was used in immunohistochemistry and western blot to study the role of Par6b in the development of the Xenopus stratified epidermis
Tue Aug 26 00:00:00 UTC 2014
A second tubulin binding site on the kinesin-13 motor head domain is important during mitosis.
PloS one
Zhang D,Asenjo AB,Greenbaum M,Xie L,Sharp DJ,Sosa H
62204 was used in immunocytochemistry to study the mitotic importance of the second tubulin binding site in the kinesin13 motor head domain
Mon Mar 31 00:00:00 UTC 2014
CD40-directed scFv-TRAIL fusion proteins induce CD40-restricted tumor cell death and activate dendritic cells.
Cell death & disease
El-Mesery M,Trebing J,Schäfer V,Weisenberger D,Siegmund D,Wajant H
62204 was used in western blot to study the activation of CD40-restricted cancer cell death and the activation of dendritic cells by CD40-targeted TRAIL fusions
Thu Nov 14 00:00:00 UTC 2013
Smooth muscle LDL receptor-related protein-1 deletion induces aortic insufficiency and promotes vascular cardiomyopathy in mice.
PloS one
Basford JE,Koch S,Anjak A,Singh VP,Krause EG,Robbins N,Weintraub NL,Hui DY,Rubinstein J
62204 was used in western blot to test if inactivation of Lrp1 in vascular smooth muscle leads to cardiomyopathy
Tue Aug 05 00:00:00 UTC 2014
Heart-specific overexpression of choline acetyltransferase gene protects murine heart against ischemia through hypoxia-inducible factor-1α-related defense mechanisms.
Journal of the American Heart Association
Kakinuma Y,Tsuda M,Okazaki K,Akiyama T,Arikawa M,Noguchi T,Sato T
62204 was used in western blot to study the role of HIF-1alpha in the mechanism by which cardiac-specific transgenic overexpression of choline acetyltransferase protects the murine heart against ischemia
Fri Jan 18 00:00:00 UTC 2013
Coordinate nuclear targeting of the FANCD2 and FANCI proteins via a FANCD2 nuclear localization signal.
PloS one
Boisvert RA,Rego MA,Azzinaro PA,Mauro M,Howlett NG
62204 was used in western blot to study the role of an amino terminal FANCD2 nuclear localization signal in the coordinated nuclear localization of both FANCD2 and FANCI
Fri Jan 02 00:00:00 UTC 2015
Regulation of the Fanconi anemia pathway by a CUE ubiquitin-binding domain in the FANCD2 protein.
Blood
Rego MA,Kolling FW,Vuono EA,Mauro M,Howlett NG
62204 was used in western blot to study the regulation of the Fanconi anemia pathway by a CUE ubiquitin-binding domain in the FANCD2 protein
Thu Sep 06 00:00:00 UTC 2012
SV40 T/t-common polypeptide enhances the sensitivity of HER2-overexpressing human cancer cells to anticancer drugs cisplatin and doxorubicin.
Cancer letters
Hsueh SP,Du JL,Hsu WB,Fang CA,Liu H,Wang WB
62204 was used in western blot to study the mechanism by which SV40 T/t-common peptide increases the sensitivity to cisplatin and doxorubicin of human cancer cells overexpressing HER2
Thu Nov 01 00:00:00 UTC 2012
Eph-A2 promotes permeability and inflammatory responses to bleomycin-induced lung injury.
American journal of respiratory cell and molecular biology
Carpenter TC,Schroeder W,Stenmark KR,Schmidt EP
62204 was used in western blot to study the role of the EphA2 receptor in the mechanism of bleomycin-induced lung injury
Sun Jan 01 00:00:00 UTC 2012
Important but differential roles for actin in trafficking of Epstein-Barr virus in B cells and epithelial cells.
Journal of virology
Valencia SM,Hutt-Fletcher LM
62204 was used in western blot to study the infection of B-cells and epithelial cells by EBV and the different roles played by actin
Sun Jan 01 00:00:00 UTC 2012
Suppression of NF-κB signaling by andrographolide with a novel mechanism in human platelets: regulatory roles of the p38 MAPK-hydroxyl radical-ERK2 cascade.
Biochemical pharmacology
Lu WJ,Lin KH,Hsu MJ,Chou DS,Hsiao G,Sheu JR
62204 was used in western blot to study the molecular mechanisms underlying the anti-platelet activity of andrographolide
Mon Oct 01 00:00:00 UTC 2012
Significant differences in incubation times in sheep infected with bovine spongiform encephalopathy result from variation at codon 141 in the PRNP gene.
The Journal of general virology
Tan BC,Blanco ARA,Houston EF,Stewart P,Goldmann W,Gill AC,de Wolf C,Manson JC,McCutcheon S
62204 was used in western blot to study the effect of a PRNP codon 141 variant on the susceptibility of sheep to BSE infection and the potential mechanism involved
Sat Dec 01 00:00:00 UTC 2012
Insulin-like growth factor I receptor involvement in proliferation of NOR-P1 cells in serum-free media.
Journal of cellular biochemistry
Tomizawa M,Shinozaki F,Sugiyama T,Yamamoto S,Sueishi M,Yoshida T
62204 was used in western blot to study the proliferation of NOR-P1 cells cultured in serum-free media and the role played by IGF-1Rbeta and the therapeutic significance for pancreatic cancer invasion
Wed Aug 01 00:00:00 UTC 2012
Xanthohumol, a Prenylated Flavonoid from Hops (Humulus lupulus), Prevents Platelet Activation in Human Platelets.
Evidence-based complementary and alternative medicine : eCAM
Lee YM,Hsieh KH,Lu WJ,Chou HC,Chou DS,Lien LM,Sheu JR,Lin KH
62204 was used in western blot to study the mechanism by which xanthohumol inhibits human platelet activation
Thu Aug 23 00:00:00 UTC 2012
Characterization of inhibitors of glucocorticoid receptor nuclear translocation: a model of cytoplasmic dynein-mediated cargo transport.
Assay and drug development technologies
Daghestani HN,Zhu G,Johnston PA,Shinde SN,Brodsky JL,Day BW
62204 was used in immunocytochemistry to study GR nuclear translocation in order to identify inhibitors of dynein-mediated cargo transport
Wed Feb 01 00:00:00 UTC 2012
Targeting the acute promyelocytic leukemia-associated fusion proteins PML/RARα and PLZF/RARα with interfering peptides.
PloS one
Beez S,Demmer P,Puccetti E
62204 was used in western blot to investigate feasibility of targeting peptides to the PML-RAR-alpha and PLF-RAR-alpha acute promyelocytic leukemia fusion proteins in order to dusrupt their protein complex formation
Wed May 01 00:00:00 UTC 2013
Foxi2 is an animally localized maternal mRNA in Xenopus, and an activator of the zygotic ectoderm activator Foxi1e.
PloS one
Cha SW,McAdams M,Kormish J,Wylie C,Kofron M
62204 was used in western blot to identify Foxi2 as a maternal activator of Foxi1e
Tue Apr 09 00:00:00 UTC 2013
Elevated cyclin G2 expression intersects with DNA damage checkpoint signaling and is required for a potent G2/M checkpoint arrest response to doxorubicin.
The Journal of biological chemistry
Zimmermann M,Arachchige-Don AS,Donaldson MS,Dallapiazza RF,Cowan CE,Horne MC
62204 was used in western blot to study the interaction of cyclin G2 with DNA damage responses and the role of cyclin G2 in robust cell cycle arrest following doxorubicin treatment
Fri Jun 29 00:00:00 UTC 2012
Krüppel-like factor 4, a tumor suppressor in hepatocellular carcinoma cells reverts epithelial mesenchymal transition by suppressing slug expression.
PloS one
Lin ZS,Chu HC,Yen YC,Lewis BC,Chen YW
62204 was used in western blot to study the role of reduced Slug expression in the mechanism by which KLF4 acts as a tumor suppressor in hepatocellular carcinoma cells
Thu Apr 25 00:00:00 UTC 2013
The Ndc80 complex uses a tripartite attachment point to couple microtubule depolymerization to chromosome movement.
Molecular biology of the cell
Tooley JG,Miller SA,Stukenberg PT
62204 was used in immunocytochemistry to study the calponin homology domain of Hec1/Ndc80
Fri Apr 15 00:00:00 UTC 2011
TNFR1 and TNFR2 regulate the extrinsic apoptotic pathway in myeloma cells by multiple mechanisms.
Cell death & disease
Rauert H,Stühmer T,Bargou R,Wajant H,Siegmund D
62204 was used in western blot to elucidate how TNF receptors regulate extrinsic apoptotic pathway in myeloma cells
Thu Aug 18 00:00:00 UTC 2011
Mitochondrial p32 is a critical mediator of ARF-induced apoptosis.
Cancer cell
Itahana K,Zhang Y
62204 was used in western blot to examine the role of mitochondrial p32 in ARF-induced apoptosis
Sun Jun 01 00:00:00 UTC 2008
Oxidative stress on the astrocytes in culture derived from a senescence accelerated mouse strain.
Neurochemistry international
Lü L,Li J,Yew DT,Rudd JA,Mak YT
62204 was used in western blot to characterize astrocytes in culture derived from a senescence accelerated mouse strain with oxidative stress
Tue Jan 01 00:00:00 UTC 2008
Activation of p53-dependent growth suppression in human cells by mutations in PTEN or PIK3CA.
Molecular and cellular biology
Kim JS,Lee C,Bonifant CL,Ressom H,Waldman T
62204 was used in western blot to study the effect of PTEN and PIK3CA mutations on the activation of p53-dependent growth suppression in human cells
Mon Jan 01 00:00:00 UTC 2007
Differentiation of rhabdomyosarcoma cell lines using retinoic acid.
Pediatric blood & cancer
Barlow JW,Wiley JC,Mous M,Narendran A,Gee MF,Goldberg M,Sexsmith E,Malkin D
62204 was used in western blot to discuss using retinoids to treat rhabdomyosarcoma
Wed Nov 01 00:00:00 UTC 2006
Taxol suppresses dynamics of individual microtubules in living human tumor cells.
Molecular biology of the cell
Yvon AM,Wadsworth P,Jordan MA
62204 was used in immunocytochemistry to test if suppression of microtubule dynamics is responsible for the ability of taxol to inhibit mitotic progression and cell proliferation
Thu Apr 01 00:00:00 UTC 1999
