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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • Synuclein alpha/beta Antibodies

          Bioss

          alpha + beta Synuclein Polyclonal Antibody

          View all (5) Synuclein alpha/beta antibodies
          Datasheet
          Protocols
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          Datasheet
          Protocols
          Questions & Answers

          Cite alpha + beta Synuclein Polyclonal Antibody

          • Antibody Testing Data (1)
          alpha + beta Synuclein Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.
          alpha + beta Synuclein Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          FIGURE: 1 / 1

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          alpha + beta Synuclein Antibody (BS-11787R) in IHC (P)

          Paraformaldehyde-fixed, paraffin embedded human glioma; Antigen retrieval by boiling in sodium citrate buffer (pH6) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (normal goat serum) at 37°C for 20min; Antibody incubation with alpha + beta Synuclein Antibody, Unconjugated (bs-11787R) at 1:500 overnight at 4°C, followed by a conjugated secondary and DAB stainin... View More {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          alpha + beta Synuclein Antibody in Immunohistochemistry (Paraffin) (IHC (P))

          Product Details

          BS-11787R

          Applications
          Tested Dilution
          Publications

          Immunohistochemistry (Paraffin) (IHC (P))

          1:500
          -

          Immunohistochemistry (Frozen) (IHC (F))

          1:100-1:500
          -

          Immunocytochemistry (ICC/IF)

          1:100-1:500
          -

          ELISA (ELISA)

          1:500-1:1,000
          -
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat, Zebrafish

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          KLH conjugated synthetic peptide derived from human alpha + beta Synuclein.

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Purification

          Protein A

          Storage buffer

          0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

          Contains

          0.02% ProClin 300

          Storage conditions

          -20°C

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          Target Information

          Synuclein family of proteins is abundantly expressed in neuronal cytosol and presynaptic terminals. In vertebrates they are encoded by three different genes. Synucleins have been specifically implemented in three major diseases: Alzheimer's (AD), Parkinson's PD) and breast cancer. In AD, a peptide derived from alpha synuclein forms an intrinsic component of plaque amyloid. In PD, an alpha synuclein accumulates in Lewy bodies. An allele of alpha synuclein has been linked to many familial cases of PD. In breast cancer increased expression of gamma synuclein correlates with the disease progression. Synucleins appear to be involved in the membrane plasticity in developing song control system of songbirds.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: Alpha-synuclein; Beta-synuclein; NACP; non A-beta component of AD amyloid; Non-A beta component of AD amyloid; non-A4 component of amyloid; Non-A4 component of amyloid precursor; Phosphoneuroprotein 14; PNP 14; synuclein alpha-140; synuclein, alpha (non A4 component of amyloid precursor); zSyn-β zSynC

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          Gene Aliases: AI838531; alphaSYN; betaSYN; NACP; PARK1; PARK4; PD1; SNCA; SNCB; Syn; zgc:66343

          View more View less

          UniProt ID: (Human) P37840, (Human) Q16143, (Rat) P37377, (Mouse) O55042, (Mouse) Q91ZZ3, (Rat) Q63754

          View more View less

          Entrez Gene ID: (Human) 6622, (Human) 6620, (Rat) 29219, (Mouse) 20617, (Mouse) 104069, (Rat) 113893, (Zebrafish) 393944

          View more View less

          Function(s)
          magnesium ion binding fatty acid binding copper ion binding calcium ion binding protein binding phospholipid binding microtubule binding ferrous iron binding zinc ion binding oxidoreductase activity kinesin binding protein domain specific binding histone binding identical protein binding alpha-tubulin binding cysteine-type endopeptidase inhibitor activity involved in apoptotic process phospholipase binding transcription regulatory region DNA binding dynein binding protein N-terminus binding tau protein binding beta-tubulin binding phosphoprotein binding phospholipase D inhibitor activity phospholipase inhibitor activity enzyme binding Hsp70 protein binding arachidonic acid binding metal ion binding
          Process(es)
          larval locomotory behavior dopaminergic neuron differentiation negative regulation of transcription from RNA polymerase II promoter microglial cell activation positive regulation of receptor recycling negative regulation of protein phosphorylation positive regulation of neurotransmitter secretion fatty acid metabolic process neutral lipid metabolic process phospholipid metabolic process apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process mitochondrial membrane organization aging adult locomotory behavior response to iron(II) ion regulation of phospholipase activity negative regulation of platelet-derived growth factor receptor signaling pathway regulation of glutamate secretion regulation of dopamine secretion negative regulation of microtubule polymerization receptor internalization protein destabilization response to magnesium ion negative regulation of transporter activity response to lipopolysaccharide negative regulation of monooxygenase activity positive regulation of peptidyl-serine phosphorylation response to interferon-gamma cellular response to oxidative stress negative regulation of histone acetylation regulation of locomotion dopamine biosynthetic process response to drug mitochondrial ATP synthesis coupled electron transport regulation of macrophage activation positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process extracellular fibril organization negative regulation of neuron apoptotic process cellular protein metabolic process cellular response to fibroblast growth factor stimulus positive regulation of endocytosis negative regulation of exocytosis negative regulation of dopamine metabolic process behavioral response to cocaine regulation of long-term neuronal synaptic plasticity synaptic vesicle endocytosis synapse organization regulation of acyl-CoA biosynthetic process positive regulation of release of sequestered calcium ion into cytosol dopamine uptake involved in synaptic transmission negative regulation of dopamine uptake involved in synaptic transmission negative regulation of serotonin uptake negative regulation of norepinephrine uptake calcium ion homeostasis oxidation-reduction process excitatory postsynaptic potential long-term synaptic potentiation positive regulation of inositol phosphate biosynthetic process negative regulation of thrombin receptor signaling pathway response to interleukin-1 cellular response to copper ion cellular response to epinephrine stimulus positive regulation of protein serine/threonine kinase activity negative regulation of neuron death negative regulation of mitochondrial electron transport, NADH to ubiquinone positive regulation of glutathione peroxidase activity positive regulation of hydrogen peroxide catabolic process regulation of synaptic vesicle recycling regulation of reactive oxygen species biosynthetic process negative regulation of chaperone-mediated autophagy synaptic transmission, dopaminergic chemical synaptic transmission response to cocaine dopamine metabolic process regulation of neuron apoptotic process regulation of neurotransmitter secretion regulation of neuronal synaptic plasticity synaptic vesicle transport positive regulation of synaptic transmission membrane organization regulation of neuron death regulation of reactive oxygen species metabolic process negative regulation of catalytic activity
          It has to be done as per old AB suggested Products section.
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