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beta-1,2 Adaptin Antibody (PA5-141069) in IHC (P)
Immunohistochemistry analysis of AP2B1 in paraffin-embedded human liver tissue. The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 20 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with AP2B1 Polyclonal antibody (Product # PA5-141069) using a dilution of 1:100 for 30 minutes at room ... View More
Product Details
PA5-141069
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein within human AP2B1 aa 400-600/937.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.4, with 0.2% BSA, 50% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2932521
Target Information
Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as one of the large subunits of this complex and is a member of the adaptin protein family. This gene is a candidate meningioma gene. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: adapter-related protein complex 1 subunit beta-1; adapter-related protein complex 2 beta subunit; adapter-related protein complex 2 subunit beta; adaptin, beta 2 (beta); Adaptor protein complex AP-1 subunit beta-1; adaptor protein complex AP-1, beta 1 subunit; Adaptor protein complex AP-2 subunit beta; adaptor related protein complex 2, beta 1 subunit; adaptor-related protein complex 1 beta 1 subunit; Adaptor-related protein complex 1 subunit beta-1; adaptor-related protein complex 1, beta 1 subunit; Adaptor-related protein complex 2 subunit beta; adaptor-related protein complex 2, beta 1 subunit; adaptor-related protein complex AP-1 beta 1 subunit; adaptor-related protein complex AP-1, beta 1 subunit; AP-1 complex subunit beta-1; AP-2 complex subunit beta; AP105B; beta adaptin; Beta-1-adaptin; Beta-2-adaptin; Beta-adaptin; Beta-adaptin 1; beta-prime adaptin; beta-prime-adaptin; beta1-adaptin; beta2-adaptin; Clathrin assembly protein complex 1 beta large chain; Clathrin assembly protein complex 2 beta large chain; clathrin-associated/assembly/adaptor protein, large, beta 1; Golgi adaptor HA1/AP1 adaptin beta subunit; Mutant line 1660; Plasma membrane adaptor HA2/AP2 adaptin beta subunit; plasma membrane adaptor HA2/AP2 adaptor beta subunit; testicular tissue protein Li 22
Gene Aliases: 1300012O03Rik; ADTB1; ADTB2; AI788979; AP105A; AP105B; AP1B1; AP2-BETA; AP2B1; b2b1660Clo; BAM22; CLAPB1; CLAPB2
UniProt ID: (Human) Q10567, (Human) P63010, (Mouse) O35643, (Rat) P62944, (Mouse) Q9DBG3
Entrez Gene ID: (Human) 162, (Human) 163, (Rat) 29663, (Mouse) 11764, (Rat) 140670, (Mouse) 71770
intracellular protein transport
vesicle-mediated transport
clathrin coat assembly
endocytosis
transport
protein transport
determination of left/right symmetry
heart development
antigen processing and presentation of exogenous peptide antigen via MHC class II
regulation of defense response to virus by virus
ventricular septum development
microtubule-based movement
aorta development
negative regulation of epidermal growth factor receptor signaling pathway
ephrin receptor signaling pathway
Wnt signaling pathway, planar cell polarity pathway
coronary vasculature development
clathrin-mediated endocytosis
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