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Nordic
beta-2 Glycoprotein 1 Polyclonal Antibody
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Product Details
RAHU-B2GP1
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Human beta-2 glycoprotein 1
Conjugate
Form
Lyophilized
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute the lyophilized antiserum by adding 1 mL sterile distilled water.
Inter-species cross-reactivity is a normal feature of antibodies to plasma proteins, since homologous proteins of different species frequently share antigenic determinants. Cross-reactivity of this antiSerum has not been tested in detail.
In immunoelectrophoresis use 2 µL human plasma or equivalent against 120 µL antiserum. In double radial immunodiffusion use a rosette arrangement with 10 µL antiserum in 3 mm diameter center well and 2 µL plasma samples (neat and serially diluted) in 2 mm diameter peripheral wells. In electroimmunodiffusion use 1 percent antiserum in the gel. Measured by quantitative precipitin analysis. The amount of beta2 glycoprotein 1 precipitated by 1 mL antiserum is approximately 0.2 mg.
Dilutions may be prepared by adding phosphate buffered saline (PBS, pH 7.2). Repeated thawing and freezing should be avoided. If a slight precipitation occurs upon storage, this should be removed by centrifugation. It will not affect the performance of the antiserum. Diluted antiserum should be stored at 4°C, not refrozen, and preferably used the same day.
Target Information
Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 2GPI; Activated protein C-binding protein; Anticardiolipin cofactor; APC inhibitor; Apo-H; Apolipoprotein H; apolipoprotein H (beta-2-glycoprotein I); B2GPI; beta(2)GPI; Beta-2-glycoprotein 1; Beta-2-glycoprotein I
Gene Aliases: APOH; B2G1; B2GP1; BG
UniProt ID: (Human) P02749
Entrez Gene ID: (Human) 350
negative regulation of endothelial cell proliferation
platelet degranulation
triglyceride metabolic process
aging
blood coagulation, intrinsic pathway
negative regulation of endothelial cell migration
positive regulation of triglyceride catabolic process
negative regulation of angiogenesis
positive regulation of blood coagulation
negative regulation of blood coagulation
organ regeneration
plasminogen activation
negative regulation of myeloid cell apoptotic process
response to triglyceride
triglyceride transport
negative regulation of smooth muscle cell apoptotic process
positive regulation of lipoprotein lipase activity
regulation of fibrinolysis
negative regulation of fibrinolysis
negative regulation of respiratory burst
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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