Invitrogen

beta-2 Microglobulin Monoclonal Antibody (246-E8.E7 (HLA-ABC-m2))

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View all (92) beta-2 Microglobulin antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-13418

Applications
Tested Dilution
Publications

Immunohistochemistry (IHC)

-
View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

Assay-dependent
-

Flow Cytometry (Flow)

1 µg/test
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Mouse / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

246-E8.E7 (HLA-ABC-m2)

Immunogen

Human PBL (T-ALL patient)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4, with 0.2% BSA

Contains

0.09% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_11009491

Product Specific Information

MA5-13418 targets Microglobulin Beta-2 in FACS and IF applications and shows reactivity with Human samples.

The MA5-13418 immunogen is human PBL (T-ALL patient).

Target Information

Beta-2-microglobulin (B2M) is a 12-14 kDa protein that is a subunit of the major histocompatibility complex (MHC) class I. Human beta 2 Microglobulin associated with HLA Class I antigens are expressed on many types of cells including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells, but is absent on erythrocytes. Beta-2 microglobulin is also found in free form in the plasma. The amino acid sequence of Beta-2-microglobulin is homologous to the constant regions of immunoglobulin heavy and light chains, with a predominantly beta pleated sheet structure. The protein is ubiquitously expressed in the cytoplasm, and is involved in antigen processing and presentation. Beta-2-microglobulin also plays a role in TCR signaling, and downstream signaling in naive CD8+ cells. Beta 2-microglobulin is encoded by the B2M gene located on chromosome 15. A mutation in the Beta-2-microglobulin gene has been shown to result in hypercatabolic hypoproteinemia. Levels of beta 2 microglobulin can be used to assess renal function in kidney transplant recipients. Beta-2-microglobulin that protein can be used as a prognostic marker for HIV infection.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: B-F; B2-microglobulin; Beta 2 microglobin; Beta 2 microglobulin; beta chain of MHC class I molecules; beta-2-microglobin; Beta-2-microglobulin; Beta2 microglobulin; MHC Class I; microglobulin beta-2; Orla-B2m

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Gene Aliases: B2M; CDABP0092; HDCMA22P; IMD43

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UniProt ID: (Human) P61769

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Entrez Gene ID: (Human) 567

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Function(s)
glycoprotein binding protein binding identical protein binding
Process(es)
retina homeostasis positive regulation of T cell mediated cytotoxicity antigen processing and presentation of peptide antigen via MHC class I antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent positive regulation of T cell cytokine production regulation of membrane depolarization negative regulation of neuron projection development antibacterial humoral response antigen processing and presentation of endogenous peptide antigen via MHC class I positive regulation of protein binding T cell differentiation in thymus protein refolding response to drug cellular protein metabolic process innate immune response response to cadmium ion positive regulation of receptor-mediated endocytosis regulation of defense response to virus by virus regulation of immune response defense response to Gram-negative bacterium defense response to Gram-positive bacterium iron ion homeostasis interferon-gamma-mediated signaling pathway cellular response to lipopolysaccharide cellular response to iron ion negative regulation of receptor binding positive regulation of receptor binding positive regulation of ferrous iron import into cell positive regulation of ferrous iron binding positive regulation of transferrin receptor binding
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