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Invitrogen
beta-3 Adrenergic Receptor Polyclonal Antibody
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beta-3 Adrenergic Receptor Antibody (PA5-50914) in WB
Western blot was performed using Anti-beta-3 Adrenergic Receptor Polyclonal Antibody (Product # PA5-50914) and a 75 kDa band corresponding to beta-3 Adrenergic Receptor was observed in 3T3-L1 differentiated to adipocytes and Mouse Brown Adipose tissue with little or no expression in 3T3-L1, Mouse Adipose tissue, Mouse Liver, Rat Liver and Mouse Brain which are reported negative for beta-3 Adrenergic Recepto... View More
Product Details
PA5-50914
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthesized peptide derived from the Internal region of human AR-beta 3 (aa 250-299).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 0.5% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2636362
Product Specific Information
ADRB3 Polyclonal Antibody detects endogenous levels of ADRB3 protein.
Target Information
beta 3 Adrenergic Receptor is located mainly in adipose tissue and is involved in the regulation of lipolysis and thermogenesis. Beta adrenergic receptors are involved in the epinephrine and norepinephrine-induced activation of adenylate cyclase through the action of G proteins. beta 3 Adrenergic Receptor expression has been documented in adipose tissues, heart, and in smooth muscle of digestive and urinary tract organs (bladder, colon, small intestine, stomach, ureter). Utilization of alternate promoters and/or 3-prime untranslated regions may result in tissue-specific regulation of the expression of this protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: adrenergic receptor, beta 3; adrenergic, beta-3-, receptor; beta 3 adrenoceptor; beta 3-AR; Beta-3 adrenergic receptor; Beta-3 adrenoceptor; Beta-3 adrenoreceptor; Beta-3 AR; beta3-adrenergic receptor; beta3-Adrenoreceptor; Beta3-AR; FLJ99960
Gene Aliases: ADRB; Adrb-3; ADRB3; ADRB3R; B3AR; B3bar; BETA3AR
UniProt ID: (Human) P13945, (Mouse) P25962, (Rat) P26255
Entrez Gene ID: (Human) 155, (Mouse) 11556, (Rat) 25645
temperature homeostasis
diet induced thermogenesis
vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure
desensitization of G-protein coupled receptor protein signaling pathway by arrestin
carbohydrate metabolic process
generation of precursor metabolites and energy
energy reserve metabolic process
receptor-mediated endocytosis
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
activation of adenylate cyclase activity
cell-cell signaling
aging
response to cold
heat generation
negative regulation of multicellular organism growth
eating behavior
positive regulation of MAPK cascade
response to antibiotic
brown fat cell differentiation
adenylate cyclase-activating adrenergic receptor signaling pathway
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
adrenergic receptor signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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