Invitrogen

beta Amyloid (1-40) Polyclonal Antibody

beta Amyloid (1-40) Antibody in Immunohistochemistry (IHC)

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beta Amyloid (1-40) Antibody (44-348A) in IHC

Immunofluorescent staining. Abeta (1-40) cleavage site antibody. Detection of Abeta by immunofluorescence in Alzheimer's Disease (AD) and normal brain section using (125I)-labeled Abeta (1-40) antibody. (Product # 44-348A)

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Product Details

44-348A

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

View 6 publications 6 publications

Immunohistochemistry (Paraffin) (IHC (P))

View 3 publications 3 publications

Immunohistochemistry (Frozen) (IHC (F))

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

Assay-dependent

View 1 publication 1 publication

ELISA (ELISA)

1 µg/mL

Radioimmune Assays (RIA)

Assay-dependent

Dot blot (DB)

Assay-dependent

Product Specifications

Species Reactivity

Human

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

The antibody was produced using a synthetic peptide derived from amino acids 34-40 within the C-terminal region of human beta-Amyloid protein.

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

Dulbecco's PBS, pH 7.3

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_2533639

Product Specific Information

This antibody reacts with human beta Amyloid (1-40). No significant cross-reactivity to beta Amyloid (1-42) has been observed. Previous lots have shown no cross-reactivity against beta Amyloid (1-43).

The antibody has been used in ELISA. Previous lots of this antibody have been used in dot blots, RIA, and other related assays.

Target Information

Beta-amyloid is a 40-43 amino acid peptide cleaved from amyloid precursor protein, and a putative gamma-secretase. Amyloid beta (1-40) together with Amyloid beta (1-42) are two major C-terminal variants of the amyloid beta protein, constituting the majority of amyloid beta proteins. Both the amyloid beta (40) and amyloid beta (42) alloforms are major components of the extracellular plaques found in Alzheimer's disease brain tissue.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Protective effects of 7,8-dihydroxyflavone on neuropathological and neurochemical changes in a mouse model of Alzheimer's disease.

European journal of pharmacology

Aytan N,Choi JK,Carreras I,Crabtree L,Nguyen B,Lehar M,Blusztajn JK,Jenkins BG,Dedeoglu A

44-348A was used in Immunohistochemistry on frozen tissues to study the role of 7,8 dihydroxyflavone on Alzheimer's disease related pathology, dendritic arborization, synaptic density and neurochemical changes in mouse models.

Tue Jun 05 00:00:00 UTC 2018

Comparative Analysis of Cortical Microinfarcts and Microbleeds using 3.0-Tesla Postmortem Magnetic Resonance Images and Histopathology.

Journal of Alzheimer's disease : JAD

Niwa A,Ii Y,Shindo A,Matsuo K,Ishikawa H,Taniguchi A,Takase S,Maeda M,Sakuma H,Akatsu H,Hashizume Y,Tomimoto H

44-348A was used in Immunohistochemistry to delineate the histopathological background corresponding to MRI images of cortical microinfarctions and cerebral lobar microbleeds.

Tue Apr 10 00:00:00 UTC 2018

The American journal of pathology

Nilsson P,Sekiguchi M,Akagi T,Izumi S,Komori T,Hui K,Sörgjerd K,Tanaka M,Saito T,Iwata N,Saido TC

44-348A was used in Immunohistochemistry on paraffin embedded tissues to indicate that Atg7 influences the transport of amyloid Β, possibly derived from Golgi to multivesicular bodies.

Sun Feb 01 00:00:00 UTC 2015

Combination therapy in a transgenic model of Alzheimer's disease.

Experimental neurology

Aytan N,Choi JK,Carreras I,Kowall NW,Jenkins BG,Dedeoglu A

Published figure using beta Amyloid (1-40) polyclonal antibody (Product # 44-348A) in Immunohistochemistry

Sun Dec 01 00:00:00 UTC 2013

Clinical and neuropathological findings in a patient with familial Alzheimer disease showing a mutation in the PSEN1 gene.

Neuropathology : official journal of the Japanese Society of Neuropathology

Niwa A,Matsuo K,Shindo A,Yata K,Shiraishi T,Tomimoto H

Published figure using beta Amyloid (1-40) polyclonal antibody (Product # 44-348A) in Immunohistochemistry

Mon Apr 01 00:00:00 UTC 2013

Hyperphosphorylated tau in young and middle-aged subjects.

Acta neuropathologica

Elobeid A,Soininen H,Alafuzoff I

44-348A was used in immunohistochemistry - paraffin section to examine the brains of cognitively unimpaired subjects for neurodegenerative changes

Sun Jan 01 00:00:00 UTC 2012

Amyloid-beta42 is preferentially accumulated in muscle fibers of patients with sporadic inclusion-body myositis.

Acta neuropathologica

Vattemi G,Nogalska A,King Engel W,D'Agostino C,Checler F,Askanas V

44-348A was used in immunocytochemistry and western blot to investigate intra-muscle fiber accumulation of Abeta40 and Abeta42

Fri May 01 00:00:00 UTC 2009

Intraneuronal Abeta immunoreactivity is not a predictor of brain amyloidosis-beta or neurofibrillary degeneration.

Acta neuropathologica

Wegiel J,Kuchna I,Nowicki K,Frackowiak J,Mazur-Kolecka B,Imaki H,Wegiel J,Mehta PD,Silverman WP,Reisberg B,Deleon M,Wisniewski T,Pirttilla T,Frey H,Lehtimäki T,Kivimäki T,Visser FE,Kamphorst W,Potempska A,Bolton D,Currie JR,Miller DL

44-348A was used in immunohistochemistry to test if intraneuronal Abeta immunoreactivity is an early manifestation of Alzheimer-type pathology

Sun Apr 01 00:00:00 UTC 2007

Upregulation of tPA/plasminogen proteolytic system in the periphery of amyloid deposits in the Tg2576 mouse model of Alzheimer's disease.

Neuroscience letters

Lee JY,Kweon HS,Cho E,Lee JY,Byun HR,Kim DH,Kim YH,Han PL,Koh JY

44-348A was used in immunohistochemistry to characterize a Tg2576 mouse model of Alzheimer's disease and upregulation of tPA/plasminogen proteolytic system in the periphery of amyloid deposits

Thu Aug 09 00:00:00 UTC 2007

Osteopetrotic (op/op) mice have reduced microglia, no Abeta deposition, and no changes in dopaminergic neurons.

Journal of neuroinflammation

Kondo Y,Lemere CA,Seabrook TJ

44-348A was used in immunohistochemistry to test if the lack of CSF-1 affects dopaminergic neuron development and CD200 expression

Thu Dec 20 00:00:00 UTC 2007

Brain : a journal of neurology

Scolding NJ,Joseph F,Kirby PA,Mazanti I,Gray F,Mikol J,Ellison D,Hilton DA,Williams TL,MacKenzie JM,Xuereb JH,Love S

44-348A was used in immunohistochemistry - paraffin section to describe patients with Abeta-related angiitis

Tue Mar 01 00:00:00 UTC 2005

Bioinformatics

Protein Aliases: A beta 1 40; A ß 1 40; AB40; ABPP; Alzheimer disease amyloid A4 protein homolog; Alzheimer disease amyloid protein; Amyloid; Amyloid b; Amyloid beta; amyloid beta (A4) precursor protein; Amyloid beta 1 40; Amyloid precursor protein; Amyloid β; Amyloid-beta (A4) precursor protein; Amyloid-beta A4 protein; Amyloid-beta precursor protein; APP; APPI; Aß 1 40; B APP40; BAPP40; beta-amyloid peptide; beta-amyloid peptide(1-40); beta-amyloid peptide(1-42); beta-amyloid precursor protein; BetaAPP40; Cerebral vascular amyloid peptide; CVAP; peptidase nexin-II; PN-II; PreA4; Protease nexin-II; testicular tissue protein Li 2; ß APP40; ßAPP40

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Gene Aliases: A4; AAA; ABETA; ABPP; AD1; APP; APPI; CTFgamma; CVAP; PN-II; PN2

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UniProt ID: (Human) P05067

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Entrez Gene ID: (Human) 351

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Function(s)

DNA binding serine-type endopeptidase inhibitor activity receptor binding protein binding heparin binding peptidase activator activity enzyme binding identical protein binding transition metal ion binding PTB domain binding growth factor receptor binding

Process(es)

response to yeast suckling behavior platelet degranulation mRNA polyadenylation regulation of translation protein phosphorylation cellular copper ion homeostasis endocytosis response to oxidative stress cell adhesion regulation of epidermal growth factor-activated receptor activity Notch signaling pathway axonogenesis mating behavior locomotory behavior axo-dendritic transport cholesterol metabolic process adult locomotory behavior visual learning cellular process response to lead ion negative regulation of endopeptidase activity positive regulation of peptidase activity positive regulation of G2/M transition of mitotic cell cycle axon midline choice point recognition neuron remodeling dendrite development antibacterial humoral response antifungal humoral response extracellular matrix organization forebrain development neuron projection development ionotropic glutamate receptor signaling pathway regulation of multicellular organism growth regulation of protein binding cellular protein metabolic process innate immune response negative regulation of neuron differentiation positive regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter collateral sprouting in absence of injury regulation of synapse structure or activity defense response to Gram-negative bacterium defense response to Gram-positive bacterium neuromuscular process controlling balance synaptic growth at neuromuscular junction neuron apoptotic process smooth endoplasmic reticulum calcium ion homeostasis cellular response to cAMP cellular response to norepinephrine stimulus amyloid fibril formation cellular response to nerve growth factor stimulus

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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beta Amyloid (1-40) Polyclonal Antibody

beta Amyloid (1-40) Antibody (44-348A) in IHC

Product Details

44-348A

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (Frozen) (IHC (F))

Immunocytochemistry (ICC/IF)

ELISA (ELISA)

Radioimmune Assays (RIA)

Dot blot (DB)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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