Invitrogen

beta-Defensin 1 Polyclonal Antibody

2 Published Figures

3 References

View all (10) beta-Defensin 1 antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (1)
Published Figures (2)

beta-Defensin 1 Antibody in Western Blot (WB)

FIGURE: 1 / 3

beta-Defensin 1 Antibody (PA5-75666) in WB

Western blot analysis of beta-Defensin 1 in Lane 1: HEK293T whole cell lysate, Lane 2: mouse liver tissue lysate, Lane 3: rat heart tissue lysate. Samples were incubated with beta-Defensin 1 polyclonal antibody (Product # PA5-75666) at a dilution of 1:500.

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Product Details

PA5-75666

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to residues in Human beta-Defensin 1.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_2719394

Product Specific Information

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Target Information

Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 1, an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. This gene maps in close proximity to defensin family member, defensin, alpha 1 and has been implicated in the pathogenesis of cystic fibrosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

N-(3',4'-dimethoxycinnamonyl) anthranilic acid alleviates severe acute pancreatitis by inhibiting intestinal barrier dysfunction and NF-κB activation.

Drug development research

Zhao Z,Lu L,Li W

PA5-75666 was used in Western Blotting to investigate the role of anthranilic acid active synthetic derivative, N-(3',4'-dimethoxycinnamonyl) anthranilic acid (3,4-DAA), in intestinal barrier dysfunction of SAP.

Sat May 01 00:00:00 UTC 2021

N-(3',4'-dimethoxycinnamonyl) anthranilic acid alleviates severe acute pancreatitis by inhibiting intestinal barrier dysfunction and NF-κB activation.

Drug development research

Zhao Z,Lu L,Li W

Sat May 01 00:00:00 UTC 2021

Disruption of autophagy by increased 5-HT alters gut microbiota and enhances susceptibility to experimental colitis and Crohn's disease.

Science advances

Haq S,Wang H,Grondin J,Banskota S,Marshall JK,Khan II,Chauhan U,Cote F,Kwon YH,Philpott D,Brumell JH,Surette M,Steinberg GR,Khan WI

PA5-75666 was used in Western Blot to study the impact of the interaction between serotonin (5-hydroxytryptamine) and autophagy in colitis in mouse and human studies.

Fri Nov 05 00:00:00 UTC 2021

Disruption of autophagy by increased 5-HT alters gut microbiota and enhances susceptibility to experimental colitis and Crohn's disease.

Science advances

Haq S,Wang H,Grondin J,Banskota S,Marshall JK,Khan II,Chauhan U,Cote F,Kwon YH,Philpott D,Brumell JH,Surette M,Steinberg GR,Khan WI

PA5-75666 was used in Western Blot to study the impact of the interaction between serotonin (5-hydroxytryptamine) and autophagy in colitis in mouse and human studies.

Fri Nov 05 00:00:00 UTC 2021

Helicobacter pylori-Induced Rev-erbα Fosters Gastric Bacteria Colonization by Impairing Host Innate and Adaptive Defense.

Cellular and molecular gastroenterology and hepatology

Mao FY,Lv YP,Hao CJ,Teng YS,Liu YG,Cheng P,Yang SM,Chen W,Liu T,Zou QM,Xie R,Xu JY,Zhuang Y

PA5-75666 was used in Immunohistochemistry (Paraffin) to examine Rev-erbα in gastric samples from H pylori-infected patients and mice.

Thu Jan 27 00:00:00 UTC 2022

Bioinformatics

Protein Aliases: BD-1; beta defensin 1; Beta-defensin 1; beta-defensin-1; Defensin, beta 1; rBD-1

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Gene Aliases: AW260221; BD-1; BD1; DEFB-1; DEFB1; DEFB101; HBD1

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UniProt ID: (Human) P60022, (Rat) O89117, (Mouse) P56386

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Entrez Gene ID: (Human) 1672, (Rat) 83687, (Mouse) 13214

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Function(s)

protein binding CCR6 chemokine receptor binding molecular_function

Process(es)

innate immune response in mucosa acute inflammatory response chemotaxis immune response G-protein coupled receptor signaling pathway response to bacterium antibacterial humoral response cAMP-mediated signaling response to testosterone calcium-mediated signaling using intracellular calcium source defense response to bacterium innate immune response defense response to Gram-negative bacterium defense response to Gram-positive bacterium positive regulation of sperm motility involved in capacitation defense response

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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beta-Defensin 1 Polyclonal Antibody

beta-Defensin 1 Antibody (PA5-75666) in WB

Product Details

PA5-75666

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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