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beta-ENaC Polyclonal Antibody

beta-ENaC Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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beta-ENaC Antibody (14134-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded Human kidney tissue slide using (Product # 14134-1-AP) β-ENaC antibody at dilution of 1:200 (under 40x lens).

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Product Details

14134-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 10 publications 10 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Hamster, Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

beta-ENaC Fusion Protein Ag5348 (68-401 aa encoded by BC036352)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.15 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: GIFIRTYLS WEVSVSLSVG FKTMDFPAVT ICNASPFKYS KIKHLLKDLD ELMEAVLERI LAPELSHANA TRNLNFSIWN HTPLVLIDER NPHHPMVLDL FGDNHNGLTS SSASEKICNA HGCKMAMRLC SLNRTQCTFR NFTSATQALT EWYILQATNI FAQVPQQELV EMSYPGEQMI LACLFGAEPC NYRNFTSIFY PHYGNCYIFN WGMTEKALPS ANPGTEFGLK LILDIGQEDY VPFLASTAGV RLMLHEQRSY PFIRDEGIYA MSGTETSIGV LVDKLQRMGE PYSPCTVNGS EVPVQNFYSD YNTTYSIQAC LRSCFQDHMI RNCNC (68-401 aa encoded by B C036352)

Target Information

Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. Heterotetramer of two alpha, one beta and one gamma subunit. A delta subunit can replace the alpha subunit. Interacts with the WW domains of NEDD4, NEDD4L, WWP1 and WWP2. Defects in SCNN1B are a cause of autosomal recessive pseudohypoaldosteronism type 1 (PHA1) [MIM:264350]. PHA1 is a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. There are 2 forms of PHA1: the autosomal recessive form that is severe, and the dominant form which is more milder and due to defects in mineralocorticoid receptor. Autosomal recessive PHA1 is characterized by an often fulminant presentation in the neonatal period with dehydration, hyponatraemia, hyperkalaemia, metabolic acidosis, failure to thrive and weight loss. Defects in SCNN1B are a cause of Liddle syndrome. It is an autosomal dominant disorder characterized by pseudoaldosteronism and hypertension associated with hypokalemic alkalosis. The disease is caused by constitutive activation of the renal epithelial sodium channel.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Low molecular weight hyaluronan inhibits lung epithelial ion channels by activating the calcium-sensing receptor.

Matrix biology : journal of the International Society for Matrix Biology

Lazrak A,Song W,Yu Z,Zhang S,Nellore A,Hoopes CW,Woodworth BA,Matalon S

Wed Feb 01 00:00:00 UTC 2023

Inactivation of epithelial sodium ion channel molecules serves as effective diagnostic biomarkers in clear cell renal cell carcinoma.

Genes & genomics

Zheng Q,Wang Y,Zhao R,Han P,Zhao J,Li L,Zhou X,Li P,Mo Y,Pan X,Luo W,Zhou X

Sat Jul 01 00:00:00 UTC 2023

Glutamine in suppression of lipopolysaccharide-induced piglet intestinal inflammation: The crosstalk between AMPK activation and mitochondrial function.

Animal nutrition (Zhongguo xu mu shou yi xue hui)

He L,Zhou X,Wu Z,Feng Y,Liu D,Li T,Yin Y

Thu Sep 01 00:00:00 UTC 2022

Timeline of Changes in Biomarkers Associated with Spinal Cord Injury-Induced Polyuria.

Neurotrauma reports

Gumbel JH,Yang CB,Hubscher CH

Thu Apr 04 00:00:00 UTC 2024

Single-cell transcriptome analysis reveals differential nutrient absorption functions in human intestine.

The Journal of experimental medicine

Wang Y,Song W,Wang J,Wang T,Xiong X,Qi Z,Fu W,Yang X,Chen YG

Mon Feb 03 00:00:00 UTC 2020

Melatonin Attenuates Sepsis-Induced Acute Lung Injury Through Improvement of Epithelial Sodium Channel-Mediated Alveolar Fluid Clearance Via Activation of SIRT1/SGK1/Nedd4-2 Signaling Pathway.

Frontiers in pharmacology

Li J,Liu L,Zhou X,Lu X,Liu X,Li G,Long J

Mon Aug 05 00:00:00 UTC 2024

Activity-Based Training Reverses Spinal Cord Injury-Induced Changes in Kidney Receptor Densities and Membrane Proteins.

Journal of neurotrauma

Gumbel JH,Montgomery LR,Yang CB,Hubscher CH

Sat Feb 01 00:00:00 UTC 2020

Oxymatrine attenuates lipopolysaccharide-induced acute lung injury by activating the epithelial sodium channel and suppressing the JNK signaling pathway.

Experimental animals

Jin B,Jin H

Mon Jul 30 00:00:00 UTC 2018

Oxymatrine attenuates lipopolysaccharide-induced acute lung injury by activating the epithelial sodium channel and suppressing the JNK signaling pathway.

Experimental animals

Jin B,Jin H

Mon Jul 30 00:00:00 UTC 2018

Listeriolysin O Causes ENaC Dysfunction in Human Airway Epithelial Cells.

Toxins

Yang G,Pillich H,White R,Czikora I,Pochic I,Yue Q,Hudel M,Gorshkov B,Verin A,Sridhar S,Isales CM,Eaton DC,Hamacher J,Chakraborty T,Lucas R

Sun Feb 11 00:00:00 UTC 2018

Listeriolysin O Causes ENaC Dysfunction in Human Airway Epithelial Cells.

Toxins

Yang G,Pillich H,White R,Czikora I,Pochic I,Yue Q,Hudel M,Gorshkov B,Verin A,Sridhar S,Isales CM,Eaton DC,Hamacher J,Chakraborty T,Lucas R

Sun Feb 11 00:00:00 UTC 2018

AMPK/α-Ketoglutarate Axis Regulates Intestinal Water and Ion Homeostasis in Young Pigs.

Journal of agricultural and food chemistry

He L,Huang N,Li H,Tian J,Zhou X,Li T,Yao K,Wu G,Yin Y

Wed Mar 22 00:00:00 UTC 2017

High Salt Diet Affects Renal Sodium Excretion and ERRα Expression.

International journal of molecular sciences

Wang D,Wang Y,Liu FQ,Yuan ZY,Mu JJ

Fri Apr 01 00:00:00 UTC 2016

High Salt Diet Affects Renal Sodium Excretion and ERRα Expression.

International journal of molecular sciences

Wang D,Wang Y,Liu FQ,Yuan ZY,Mu JJ

Fri Apr 01 00:00:00 UTC 2016

Calreticulin positively regulates the expression and function of epithelial sodium channel.

Experimental cell research

Sugahara T,Koga T,Ueno-Shuto K,Shuto T,Watanabe E,Maekawa A,Kitamura K,Tomita K,Mizuno A,Sato T,Suico MA,Kai H

Sun Nov 15 00:00:00 UTC 2009

Calreticulin positively regulates the expression and function of epithelial sodium channel.

Experimental cell research

Sugahara T,Koga T,Ueno-Shuto K,Shuto T,Watanabe E,Maekawa A,Kitamura K,Tomita K,Mizuno A,Sato T,Suico MA,Kai H

Sun Nov 15 00:00:00 UTC 2009

Bioinformatics

Protein Aliases: Amiloride-sensitive sodium channel subunit beta; amiloride-sensitive sodium channel subunit beta 1; Beta ENaC; Beta-ENaC; Beta-NaCH; ENaC beta; Epithelial Na(+) channel subunit beta; epithelial sodium channel beta-2 subunit; epithelial sodium channel beta-3 subunit; Epithelial sodium channel subunit beta; nasal epithelial sodium channel beta subunit; Nonvoltage-gated sodium channel 1 subunit beta; SCNEB; SCNN 1B; sodium channel, non voltage gated 1 beta subunit; sodium channel, non-voltage-gated 1, beta subunit; sodium channel, nonvoltage-gated 1, beta; sodium channel, nonvoltage-gated, type I, beta

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Gene Aliases: BESC1; ENaCb; ENaCbeta; RNENACB; SCNEB; SCNN1B

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UniProt ID: (Human) P51168, (Mouse) Q9WU38, (Rat) P37090

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Entrez Gene ID: (Human) 6338, (Mouse) 20277, (Rat) 24767

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Function(s)

protein binding ligand-gated sodium channel activity WW domain binding sodium channel activity

Process(es)

response to hypoxia regulation of sodium ion transport sodium ion transport excretion ion transmembrane transport wound healing, spreading of epidermal cells sodium ion transmembrane transport multicellular organismal water homeostasis sensory perception of taste sodium ion homeostasis transport ion transport response to stimulus

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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beta-ENaC Polyclonal Antibody

beta-ENaC Antibody (14134-1-AP) in IHC (P)

Product Details

14134-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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