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Invitrogen
c-Kit (D816V Mutant) Polyclonal Antibody
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FIGURE: 1 / 1
c-Kit (D816V Mutant) Antibody (PA5-143384) in WB
Western blot analysis of c-Kit (D816V Mutant) in non-transfected (–) and transfected (+) 293T whole cell extracts (50 µg) separated by 5% SDS-PAGE. Membrane was blotted with c-Kit (D816V Mutant) Polyclonal antibody (Product # PA5-143384) using a dilution of 1:500 followed by HRP-conjugated anti-rabbit IgG secondary antibody.
Product Details
PA5-143384
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Carrier-protein conjugated synthetic peptide surrounding mutant D816V of human c-Kit. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.64 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 1% BSA, 20% glycerol
Contains
0.025% Proclin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2938379
Product Specific Information
Store as concentrated solution.
Centrifuge briefly prior to opening vial.
Target Information
This gene encodes the human homolog of the proto-oncogene c-kit|C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit|This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor)|Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism|Multiple transcript variants encoding different isoforms have been found for this gene
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C-Kit; casein kinase 1, alpha 1; casein kinase 1, alpha 1-like; casein kinase I alpha S-like; Casein kinase I isoform alpha; Casein kinase I isoform alpha-like; CASP-1; CASP1 nirs variant 1; caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase); Caspase-1; CD117; CK1; CKI-alpha; CKI-alpha-like; clock regulator kinase; down-regulated in lung cancer; epididymis secretory sperm binding protein Li 77p; ICE; IL-1 beta-converting enzyme; IL-1BC; IL1B-convertase; interleukin 1, beta, convertase; interleukin 1-B converting enzyme; Interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; KIT proto-oncogene, receptor tyrosine kinase; MASTC; p45; PBT; SCFR
Gene Aliases: CASP1; CK1; CK1a; CKIa; CSNK1A1; CSNK1A1L; HEL-S-77p; HLCDGP1; ICE; IL1BC; IL1BCE; P45; PRO2975
UniProt ID: (Human) P29466, (Human) P48729, (Human) Q8N752
Entrez Gene ID: (Human) 834, (Human) 1452, (Human) 122011
endopeptidase activity
cysteine-type endopeptidase activity
protein binding
cysteine-type endopeptidase activator activity involved in apoptotic process
cysteine-type endopeptidase activity involved in apoptotic process
protein kinase activity
protein serine/threonine kinase activity
ATP binding
kinase activity
response to hypoxia
proteolysis
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
signal transduction
regulation of autophagy
protein processing
response to lipopolysaccharide
interleukin-1 beta production
response to ATP
regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of interleukin-1 alpha secretion
positive regulation of interleukin-1 beta secretion
regulation of inflammatory response
mitochondrial depolarization
membrane hyperpolarization
pyroptosis
cellular response to mechanical stimulus
cellular response to organic substance
programmed necrotic cell death
toxin transport
cell morphogenesis
phagocytosis
regulation of cell shape
Wnt signaling pathway
peptidyl-serine phosphorylation
protein phosphorylation
Golgi organization
mitotic nuclear division
cell surface receptor signaling pathway
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
intermediate filament cytoskeleton organization
cell division
negative regulation of canonical Wnt signaling pathway
regulation of GTP binding
beta-catenin destruction complex assembly
beta-catenin destruction complex disassembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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