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Product Details
PA5-120078
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 442-721 of human eIF2B epsilon (eIF2B epsilon (EIF2B5)) (NP_0038982)
Conjugate
Form
Liquid
Concentration
1.19 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2913650
Product Specific Information
Positive test controls include: U-87MG, A-549, HL-60, HT-1080, LO2, Mouse brain.
Immunogen sequence: TLPEGSVISL HPPDAEEDED DGEFSDDSGA DQEKDKVKMK GYNPAEVGAA GKGYLWKAAG MNMEEEEELQ QNLWGLKINM EEESESESEQ SMDSEEPDSR GGSPQMDDIK VFQNEVLGTL QRGKEENISC DNLVLEINSL KYAYNISLKE VMQVLSHVVL EFPLQQMDSP LDSSRYCALL LPLLKAWSPV FRNYIKRAAD HLEALAAIED FFLEHEALGI SMAKVLMAFY QLEILAEETI LSWFSQRDTT DKGQQLRKNQ QLQRFIQWLK EAEEESSEDD
Target Information
This gene encodes one of five subunits of eukaryotic translation initiation factor 2B, a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: eIF-2B GDP-GTP exchange factor subunit epsilon; eIF2B GDP-GTP exchange factor subunit epsilon; eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa; translation initiation factor eIF-2B subunit epsilon; Translation initiation factor eIF2B subunit epsilon
Gene Aliases: C81315; CACH; CLE; EIF-2B; EIF2B5; EIF2BE; EIF2Bepsilon; LVWM
UniProt ID: (Human) Q13144, (Mouse) Q8CHW4
Entrez Gene ID: (Human) 8893, (Mouse) 224045
ovarian follicle development
translation
translational initiation
regulation of translation
response to heat
response to glucose
astrocyte development
oligodendrocyte development
negative regulation of translational initiation in response to stress
response to endoplasmic reticulum stress
cellular response to drug
myelination
response to peptide hormone
positive regulation of GTPase activity
astrocyte differentiation
aging
positive regulation of translational initiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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