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Product Details
PA5-96548
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 694-913 of human EIF3C (NP_0037431)
Conjugate
Form
Liquid
Concentration
2.23 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2808350
Product Specific Information
Immunogen sequence: EIPYMAAHES DARRRMISKQ FHHQLRVGER QPLLGPPESM REHVVAASKA MKMGDWKTCH SFIINEKMNG KVWDLFPEAD KVRTMLVRKI QEESLRTYLF TYSSVYDSIS METLSDMFEL DLPTVHSIIS KMIINEELMA SLDQPTQTVV MHRTEPTAQQ NLALQLAEKL GSLVENNERV FDHKQGTYGG YFRDQKDGYR KNEGYMRRGG YRQQQSQTAY; Positive Samples: MCF7, HL-60, HepG2, SW620, THP-1, Mouse testis; Cellular Location: Cytoplasm
Target Information
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cell migration-inducing protein 17; eIF3 p110; eIF3 p110 {ECO:0000255|HAMAP-Rule:MF_03002}; eIF3c; eIF3c {ECO:0000255|HAMAP-Rule:MF_03002}; Eukaryotic translation initiation factor 3 subunit 8; eukaryotic translation initiation factor 3 subunit 8 {ECO:0000255|HAMAP-Rule:MF_03002}; Eukaryotic translation initiation factor 3 subunit C; eukaryotic translation initiation factor 3 subunit C {ECO:0000255|HAMAP-Rule:MF_03002}; eukaryotic translation initiation factor 3, subunit 8 (110 kDa); eukaryotic translation initiation factor 3, subunit 8 (110kD); eukaryotic translation initiation factor 3, subunit 8, 110kDa; eukaryotic translation initiation factor 3, subunit C; extra-toes spotting; NIPI-like protein
Gene Aliases: 110kDa; 3230401O13Rik; eIF3-p110; EIF3C; EIF3CL; EIF3S8; NIPIL(A3); NipilA3; Xs; Xsl
UniProt ID: (Human) Q99613, (Mouse) Q8R1B4, (Rat) B5DFC8
Entrez Gene ID: (Human) 8663, (Mouse) 56347, (Rat) 293484
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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