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Fabgennix
ergo-1 Polyclonal Antibody
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Product Details
ERGO-101AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
C. elegans
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within amino acid region 190-240 on C.elegans Ergo1 protein.
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Target Information
Argonaute protein required for gene silencing in the endogenous RNA interference (RNAi) pathway (PubMed:17110334, PubMed:20133583). Involved in the 26G RNAi pathway and associates with both unmethylated and methylated 26G small interfering RNAs (26G-siRNAs), which are a class of 26 nucleotide siRNAs that possess a guanine residue at the 5'-end (PubMed:22102828, PubMed:22548001). Associated 26G-siRNAs are methylated by the methyltransferase henn-1, which stabilizes the siRNAs (PubMed:22548001). Association with 26G-siRNAs is required for the biogenesis of secondary 22G-siRNAs (a class of 22 nucleotide siRNAs that possess a triphosphorylated guanine residue at the 5'-end) (PubMed:22102828). May be involved in passenger strand cleavage of target 26G-siRNAs (PubMed:22102828).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Endogenous RNA interference deficient argonaute protein 1; ergo-1; Piwi-like protein ergo-1; R09A1.1
Gene Aliases: ergo-1; R09A1.1
UniProt ID: (C. elegans) O61931
Entrez Gene ID: (C. elegans) 178602
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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