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Proteintech
hIST1 Polyclonal Antibody
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Product Details
19842-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
hIST1 Fusion Protein Ag13874 (1-335 aa encoded by BC000116)
Conjugate
Form
Liquid
Concentration
0.21 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MLGSGFKAE RLRVNLRLVI NRLKLLEKKK TELAQKARKE IADYLAAGKD ERARIRVEHI IREDYLVEAM EILELYCDLL LARFGLIQSM KELDSGLAES VSTLIWAAPR LQSEVAELKI VADQLCAKYS KEYGKLCRTN QIGTVNDRLM HKLSVEAPPK ILVERYLIEI AKNYNVPYEP DSVVMAEAPP GVETDLIDVG FTDDVKKGGP GRGGSGGFTA PVGGPDGTVP MPMPMPMPMP SANTPFSYPL PKGPVDDINA DKNISSAQIV GPGPKPEASA KLPSRPADNY DNFVLPELPS VPDTLPTASA GASTSASEDI DFDDLSRRFE ELKKKT (1-335 aa encoded by B C000116)
Target Information
Proposed to be involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Charged multivesicular body protein 8; CHMP8; hIST1; increased sodium tolerance 1 homolog; IST1 homolog; IST1, endosomal sorting complex required for transport-III component; MAPK activating protein PM28; MGC117220; overexpressed in lung cancer 1; pm28; Putative MAPK-activating protein PM28
Gene Aliases: 2400003C14Rik; AW536298; IST1; KIAA0174; mKIAA0174; OLC1; RGD1307799
UniProt ID: (Human) P53990, (Rat) Q568Z6, (Mouse) Q9CX00
Entrez Gene ID: (Human) 9798, (Rat) 307833, (Mouse) 71955
cytokinesis
positive regulation of defense response to virus by host
protein localization
abscission
protein transport
viral release from host cell
multivesicular body assembly
establishment of protein localization
positive regulation of proteolysis
viral capsid secondary envelopment
positive regulation of collateral sprouting
cell division
cell-cell adhesion
mitophagy in response to mitochondrial depolarization
xenophagy
ESCRT III complex disassembly
cell cycle
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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