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Invitrogen
hnRNP A1 Monoclonal Antibody (4B10)
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FIGURE: 1 / 5
hnRNP A1 Antibody (MA5-24774) in ICC/IF
Immunofluorescence analysis of HNRNPA1 was performed using 70% confluent log phase MCF7 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with hnRNP A1 Monoclonal Antibody (4B10) (Product # MA5-24774) at 1:200 dilution in 0.1% BSA, incubated at 4 degree celsius overnight and then with Donkey anti-Mouse IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor Plus 488 (Product # A3276... View More
Product Details
MA5-24774
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Dog,
Human,
Mouse
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
4B10
Immunogen
Full length partially purified human hnRNP A1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2717249
Product Specific Information
Does not react with hnRNP A2 or B.
Target Information
HnRNP A1 belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre mRNAs in the nucleus and appear to influence pre mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. hnRNP A1 has two repeats of quasi RRM domains that bind to RNAs. It is one of the most abundant core proteins of hnRNP complexes and it is localized to the nucleoplasm. This protein, along with other hnRNP proteins, is exported from the nucleus, probably bound to mRNA, and is immediately re imported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HDP-1; Helix-destabilizing protein; Heterogeneous nuclear ribonucleoprotein A1; heterogeneous nuclear ribonucleoprotein A1B protein; heterogeneous nuclear ribonucleoprotein B2 protein; heterogeneous nuclear ribonucleoprotein core protein A1; hnRNP A1; hnRNP A1-like 3; hnRNP core protein A1; hnRNP core protein A1-like 3; hnRNP I; HNRNP-I; HNRNPI; HNRPA1MGC102835; HNRPI; MGC102835; nuclear ribonucleoprotein particle A1 protein; pPTB; PTB; PTB-1; PTB-T; PTB2; PTB3; PTB4; putative heterogeneous nuclear ribonucleoprotein A1-like 3; RP11-78J21.1; single-strand DNA-binding protein UP1; Single-strand RNA-binding protein; Single-strand-binding protein; Topoisomerase-inhibitor suppressed; Unwinding protein 1; UP1
Gene Aliases: ALS19; ALS20; BOS_4964; Fli-2; Hdp; HDP-1; hnRNP A1; hnRNP-A1; HNRNPA1; HNRPA1; HNRPA1L3; IBMPFD3; Tis; UP 1
UniProt ID: (Human) P09651, (Bovine) P09867, (Mouse) P49312
Entrez Gene ID: (Human) 3178, (Bovine) 505093, (Dog) 102152026, (Mouse) 15382
mRNA splicing, via spliceosome
mRNA processing
RNA export from nucleus
fibroblast growth factor receptor signaling pathway
gene expression
viral process
negative regulation of telomere maintenance via telomerase
positive regulation of telomere maintenance via telomerase
mRNA transport
nuclear export
nuclear import
RNA splicing
alternative mRNA splicing, via spliceosome
transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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