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Invitrogen
hnRNP C1/C2 Polyclonal Antibody
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FIGURE: 1 / 2
hnRNP C1/C2 Antibody (PA5-75278) in IHC (P)
Immunohistochemistry analysis of hnRNP C1/C2 in paraffin-embedded human colon carcinoma tissue. Samples were incubated with hnRNP C1/C2 polyclonal antibody (Product # PA5-75278) using a dilution of 1:50 (showing nucleus staining). Secondary antibody: Goat Anti-Rabbit IgG-biotin followed by avidin-peroxidase. Negative control (the right) using PBS instead of primary antibody.
Product Details
PA5-75278
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 241-290 of Human hnRNP C1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2719006
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. hnRNP C1 and C2 are encoded by one gene; the two alternatively spliced transcript variants have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: heterogeneous nuclear ribonucleoprotein C; heterogeneous nuclear ribonucleoprotein C (C1/C2); Heterogeneous nuclear ribonucleoproteins C1/C2; hnRNP C protein C-terminal fragment (158 AA); hnRNP C1/C2; hnRNP core protein C; nuclear ribonucleoprotein particle C1 protein; nuclear ribonucleoprotein particle C2 protein
Gene Aliases: C1; C2; HNRNP; hnRNP C; HNRNPC; HNRPC; SNRPC
UniProt ID: (Human) P07910
Entrez Gene ID: (Human) 3183, (Rat) 290046
nucleotide binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
RNA binding
mRNA 3'-UTR binding
protein binding
poly(U) RNA binding
nucleosomal DNA binding
identical protein binding
poly(A) RNA binding
telomerase RNA binding
N6-methyladenosine-containing RNA binding
nucleic acid binding
mRNA binding
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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