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Invitrogen
hnRNP C1/C2 Monoclonal Antibody (4F4)
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FIGURE: 1 / 6
hnRNP C1/C2 Antibody (MA1-24631) in ICC/IF
Immunofluorescence analysis of hnRNP C1/C2 was performed using 70% confluent log phase HeLa cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with hnRNP C1/C2 Mouse Monoclonal Antibody (Product # MA1-24631) at 5 µg/mL in 0.1% BSA, incubated at 4 degree Celsi... View More
Product Details
MA1-24631
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Chicken,
Hamster,
Human,
Non-human primate
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
4F4
Immunogen
RNPs eluted from oligo (dT) cellulose column.
Conjugate
Form
Liquid
Concentration
2.4 mg/mL
Purification
purified
Storage buffer
PBS, pH 7.4
Contains
15mM sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_794497
Product Specific Information
Recommended positive controls: HeLa nuclear extract.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. hnRNP C1 and C2 are encoded by one gene; the two alternatively spliced transcript variants have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: heterogeneous nuclear ribonucleoprotein C (C1/C2); Heterogeneous nuclear ribonucleoproteins C1/C2; hnRNP C1/C2; nuclear ribonucleoprotein particle C1 protein; nuclear ribonucleoprotein particle C2 protein
Gene Aliases: C1; C2; HNRNP; HNRNPC; HNRPC; SNRPC
UniProt ID: (Human) P07910
Entrez Gene ID: (Human) 3183, (Chinese hamster) 100751290
nucleotide binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
RNA binding
mRNA 3'-UTR binding
protein binding
poly(U) RNA binding
nucleosomal DNA binding
identical protein binding
poly(A) RNA binding
telomerase RNA binding
N6-methyladenosine-containing RNA binding
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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