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Invitrogen
hnRNP L Monoclonal Antibody (4D11)
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Product Details
MA5-46550
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Amphibian,
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
4D11
Immunogen
Human hnRNP proteins, from HeLa cells, purified by affinity chromatography on ssDNA agarose
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2937622
Product Specific Information
Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. Western blot detects a band of approximately 64 kDa (predicted molecular weight: 64 kDa).
Target Information
Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ35509; Heterogeneous nuclear ribonucleoprotein L; heterogenous nuclear ribonucleoprotein L; hnRNP L
Gene Aliases: C79783; D830027H13Rik; Fblim1; hnRNP-L; HNRNPL; HNRPL; P/OKcl.14
UniProt ID: (Human) P14866, (Mouse) Q8R081, (Rat) F1LQ48
Entrez Gene ID: (Human) 3191, (Mouse) 15388, (Rat) 80846
mRNA processing
cellular response to amino acid starvation
positive regulation of translation
negative regulation of mRNA splicing, via spliceosome
positive regulation of mRNA binding
regulation of alternative mRNA splicing, via spliceosome
mRNA splicing, via spliceosome
RNA processing
gene expression
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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