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Rockland
iASSP Polyclonal Antibody
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FIGURE: 1 / 2
iASSP Antibody (600-401-926) in IHC (P)
Rocklands Affinity Purified anti-iASPP antibody shows strong cytoplasmic and membranous staining of myocytes in human heart tissue. Tissue was formalin-fixed and paraffin embedded. Brown color indicates presence of protein, blue color shows cell nuclei. Personal Communication, Kenneth Wester, www.proteinatlas.org, Uppsala, Sweden.
Product Details
600-401-926
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region near amino acids 775-800 of human iASPP (isoform 1) protein.
Conjugate
Form
Liquid
Concentration
1.1 mg/mL
Purification
Affinity chromatography
Storage buffer
0.02M potassium phosphate, pH 7.2, with 0.15M NaCl
Contains
0.01% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
This affinity-purified antibody is directed against the human iASPP protein. A BLAST analysis was used to suggest cross reactivity with iASPP proteins from human, dog and mouse sources. Expect reactivity against both isoform 1 and isoform 2. Partial reactivity may occur against iASPP from bovine. Reactivity against homologues from other sources is not known.
Target Information
IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53), whereas ASPP1. and ASPP2. are activators of p53.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: inhibitor of apoptosis stimulating protein of p53; Inhibitor of ASPP protein; NFkB interacting protein 1; NFkB-interacting protein 1; PPP1R13B-like protein; Protein iASPP; protein phosphatase 1, regulatory (inhibitor) subunit 13 like; protein phosphatase 1, regulatory subunit 13 like; RelA-associated inhibitor; retinoic acid induced 4
Gene Aliases: IASPP; NKIP1; PPP1R13BL; PPP1R13L; RAI; RAI4
UniProt ID: (Human) Q8WUF5
Entrez Gene ID: (Human) 10848
negative regulation of transcription from RNA polymerase II promoter
cardiac right ventricle morphogenesis
ventricular cardiac muscle tissue development
transcription, DNA-templated
apoptotic process
post-embryonic development
embryonic camera-type eye development
multicellular organism growth
hair cycle
positive regulation of cell differentiation
multicellular organismal homeostasis
cardiac muscle contraction
cell-cell adhesion
regulation of signal transduction by p53 class mediator
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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