Proteintech

importin alpha 5 Polyclonal Antibody

importin alpha 5 Antibody in Immunocytochemistry (ICC/IF)

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importin alpha 5 Antibody (18137-1-AP) in ICC/IF

Immunofluorescent analysis of MCF-7 cells, using KPNA1 antibody 18137-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).

importin alpha 5 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

importin alpha 5 Antibody in Western Blot (WB)

importin alpha 5 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

18137-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:5,000

View 20 publications 20 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:10-1:100

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

View 3 publications 3 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

importin alpha5 Fusion Protein Ag12751 (18-272 aa encoded by BC002374)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.17 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: SLNPDEMRR RREEEGLQLR KQKREEQLFK RRNVATAEEE TEEEVMSDGG FHEAQINNME MAPGGVITSD MIEMIFSKSP EQQLSATQKF RKLLSKEPNP PIDEVISTPG VVARFVEFLK RKENCTLQFE SAWVLTNIAS GNSLQTRIVI QAGAVPIFIE LLSSEFEDVQ EQAVWALGNI AGDSTMCRDY VLDCNILPPL LQLFSKQNRL TMTRNAVWAL SNLCRGKSPP PEFAKVSPCL NVLSWLLFVS DTDVLA (18-272 aa encoded by BC002374)

Target Information

Recombination activating proteins RAG1 and RAG2 regulate and mediate VJ recombination, the process by which genes for immunoglobulins and T-cell receptors are generated. Several other ubiquitously expressed proteins are thought to be recruited in the recombination process. Among these are the genes affected in severe combined immune deficiency and genes involved in ds-DNA break repair. The protein encoded by this gene interacts with RAG1 and may play a role in VJ recombination. Two transcript variants, one protein-coding and the other not, have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

FAK-mediated phosphorylation at Y464 regulates p85β nuclear translocation to promote tumorigenesis of ccRCC by repressing RB1 expression.

Cell reports

Zhang Y,He B,Zhang D,Zhang Y,Chen C,Zhang W,Yang S,Yao M,Cui G,Gu J,Wang T,Lin Z,Fan Y,Xiong Z,Hao Y

Tue Mar 28 00:00:00 UTC 2023

FAK-mediated phosphorylation at Y464 regulates p85β nuclear translocation to promote tumorigenesis of ccRCC by repressing RB1 expression.

Cell reports

Zhang Y,He B,Zhang D,Zhang Y,Chen C,Zhang W,Yang S,Yao M,Cui G,Gu J,Wang T,Lin Z,Fan Y,Xiong Z,Hao Y

Tue Mar 28 00:00:00 UTC 2023

Dihydrotanshinone I preconditions myocardium against ischemic injury via PKM2 glutathionylation sensitive to ROS.

Acta pharmaceutica Sinica. B

Wu X,Liu L,Zheng Q,Ye H,Yang H,Hao H,Li P

Sun Jan 01 00:00:00 UTC 2023

PACS-1 contains distinct motifs for nuclear-cytoplasmic transport and interacts with the RNA-binding protein PTBP1 in the nucleus and cytosol.

FEBS letters

Trothen SM,Zang RX,Lurie A,Dikeakos JD

Sat Jan 01 00:00:00 UTC 2022

PACS-1 contains distinct motifs for nuclear-cytoplasmic transport and interacts with the RNA-binding protein PTBP1 in the nucleus and cytosol.

FEBS letters

Trothen SM,Zang RX,Lurie A,Dikeakos JD

Sat Jan 01 00:00:00 UTC 2022

METTL3 acetylation impedes cancer metastasis via fine-tuning its nuclear and cytosolic functions.

Nature communications

Li Y,He X,Lu X,Gong Z,Li Q,Zhang L,Yang R,Wu C,Huang J,Ding J,He Y,Liu W,Chen C,Cao B,Zhou D,Shi Y,Chen J,Wang C,Zhang S,Zhang J,Ye J,You H

Wed Oct 26 00:00:00 UTC 2022

Baicalin confers hepatoprotective effect against alcohol-associated liver disease by upregulating microRNA-205.

International immunopharmacology

Fang L,Wang HF,Chen YM,Bai RX,Du SY

Wed Jun 01 00:00:00 UTC 2022

Ivermectin Inhibits HBV Entry into the Nucleus by Suppressing KPNA2.

Viruses

Nakanishi A,Okumura H,Hashita T,Yamashita A,Nishimura Y,Watanabe C,Kamimura S,Hayashi S,Murakami S,Ito K,Iwao T,Ikeda A,Hirose T,Sunazuka T,Tanaka Y,Matsunaga T

Tue Nov 08 00:00:00 UTC 2022

Activated PKB/GSK-3β synergizes with PKC-δ signaling in attenuating myocardial ischemia/reperfusion injury via potentiation of NRF2 activity: Therapeutic efficacy of dihydrotanshinone-I.

Acta pharmaceutica Sinica. B

Zeng H,Wang L,Zhang J,Pan T,Yu Y,Lu J,Zhou P,Yang H,Li P

Fri Jan 01 00:00:00 UTC 2021

Activated PKB/GSK-3β synergizes with PKC-δ signaling in attenuating myocardial ischemia/reperfusion injury via potentiation of NRF2 activity: Therapeutic efficacy of dihydrotanshinone-I.

Acta pharmaceutica Sinica. B

Zeng H,Wang L,Zhang J,Pan T,Yu Y,Lu J,Zhou P,Yang H,Li P

Fri Jan 01 00:00:00 UTC 2021

Nuclear-capture of endosomes depletes nuclear G-actin to promote SRF/MRTF activation and cancer cell invasion.

Nature communications

Marco S,Neilson M,Moore M,Perez-Garcia A,Hall H,Mitchell L,Lilla S,Blanco GR,Hedley A,Zanivan S,Norman JC

Wed Nov 24 00:00:00 UTC 2021

Loss of FCHSD1 leads to amelioration of chronic obstructive pulmonary disease.

Proceedings of the National Academy of Sciences of the United States of America

Kawasaki T,Sugihara F,Fukushima K,Matsuki T,Nabeshima H,Machida T,Mitsui Y,Fujimura S,Sagawa R,Gaheun L,Kuniyoshi K,Tanaka H,Narazaki M,Kumanogoh A,Akira S,Satoh T

Tue Jun 29 00:00:00 UTC 2021

CSE1L promotes nuclear accumulation of transcriptional coactivator TAZ and enhances invasiveness of human cancer cells.

The Journal of biological chemistry

Nagashima S,Maruyama J,Honda K,Kondoh Y,Osada H,Nawa M,Nakahama KI,Ishigami-Yuasa M,Kagechika H,Sugimura H,Iwasa H,Arimoto-Matsuzaki K,Nishina H,Hata Y

Thu Jul 01 00:00:00 UTC 2021

African Swine Fever Virus MGF360-12L Inhibits Type I Interferon Production by Blocking the Interaction of Importin α and NF-κB Signaling Pathway.

Virologica Sinica

Zhuo Y,Guo Z,Ba T,Zhang C,He L,Zeng C,Dai H

Thu Apr 01 00:00:00 UTC 2021

Doublecortin undergo nucleocytoplasmic transport via the RanGTPase signaling to promote glioma progression.

Cell communication and signaling : CCS

Ayanlaja AA,Ji G,Wang J,Gao Y,Cheng B,Kanwore K,Zhang L,Xiong Y,Kambey PA,Gao D

Wed Feb 12 00:00:00 UTC 2020

Doublecortin undergo nucleocytoplasmic transport via the RanGTPase signaling to promote glioma progression.

Cell communication and signaling : CCS

Ayanlaja AA,Ji G,Wang J,Gao Y,Cheng B,Kanwore K,Zhang L,Xiong Y,Kambey PA,Gao D

Wed Feb 12 00:00:00 UTC 2020

Doublecortin undergo nucleocytoplasmic transport via the RanGTPase signaling to promote glioma progression.

Cell communication and signaling : CCS

Ayanlaja AA,Ji G,Wang J,Gao Y,Cheng B,Kanwore K,Zhang L,Xiong Y,Kambey PA,Gao D

Wed Feb 12 00:00:00 UTC 2020

Doublecortin undergo nucleocytoplasmic transport via the RanGTPase signaling to promote glioma progression.

Cell communication and signaling : CCS

Ayanlaja AA,Ji G,Wang J,Gao Y,Cheng B,Kanwore K,Zhang L,Xiong Y,Kambey PA,Gao D

Wed Feb 12 00:00:00 UTC 2020

STAT3 Regulates the Type I IFN-Mediated Antiviral Response by Interfering with the Nuclear Entry of STAT1.

International journal of molecular sciences

Wang H,Yuan M,Wang S,Zhang L,Zhang R,Zou X,Wang X,Chen D,Wu Z

Mon Sep 30 00:00:00 UTC 2019

CDK5-dependent phosphorylation and nuclear translocation of TRIM59 promotes macroH2A1 ubiquitination and tumorigenicity.

Nature communications

Sang Y,Li Y,Zhang Y,Alvarez AA,Yu B,Zhang W,Hu B,Cheng SY,Feng H

Thu Sep 05 00:00:00 UTC 2019

Tumor-derived exosomes antagonize innate antiviral immunity.

Nature immunology

Gao L,Wang L,Dai T,Jin K,Zhang Z,Wang S,Xie F,Fang P,Yang B,Huang H,van Dam H,Zhou F,Zhang L

Thu Mar 01 00:00:00 UTC 2018

Tumor-derived exosomes antagonize innate antiviral immunity.

Nature immunology

Gao L,Wang L,Dai T,Jin K,Zhang Z,Wang S,Xie F,Fang P,Yang B,Huang H,van Dam H,Zhou F,Zhang L

Thu Mar 01 00:00:00 UTC 2018

Tumor-derived exosomes antagonize innate antiviral immunity.

Nature immunology

Gao L,Wang L,Dai T,Jin K,Zhang Z,Wang S,Xie F,Fang P,Yang B,Huang H,van Dam H,Zhou F,Zhang L

Thu Mar 01 00:00:00 UTC 2018

Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2.

eLife

Kane M,Rebensburg SV,Takata MA,Zang TM,Yamashita M,Kvaratskhelia M,Bieniasz PD

Tue Aug 07 00:00:00 UTC 2018

Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2.

eLife

Kane M,Rebensburg SV,Takata MA,Zang TM,Yamashita M,Kvaratskhelia M,Bieniasz PD

Tue Aug 07 00:00:00 UTC 2018

Subcellular Distribution of HDAC1 in Neurotoxic Conditions Is Dependent on Serine Phosphorylation.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Zhu Y,Vidaurre OG,Adula KP,Kezunovic N,Wentling M,Huntley GW,Casaccia P

Wed Aug 02 00:00:00 UTC 2017

Subcellular Distribution of HDAC1 in Neurotoxic Conditions Is Dependent on Serine Phosphorylation.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Zhu Y,Vidaurre OG,Adula KP,Kezunovic N,Wentling M,Huntley GW,Casaccia P

Wed Aug 02 00:00:00 UTC 2017

Karyopherin Alpha Proteins Regulate Oligodendrocyte Differentiation.

PloS one

Laitman BM,Mariani JN,Zhang C,Sawai S,John GR

Wed Aug 23 00:00:00 UTC 2017

Karyopherin Alpha Proteins Regulate Oligodendrocyte Differentiation.

PloS one

Laitman BM,Mariani JN,Zhang C,Sawai S,John GR

Wed Aug 23 00:00:00 UTC 2017

The Transcriptional Activator Krüppel-like Factor-6 Is Required for CNS Myelination.

PLoS biology

Laitman BM,Asp L,Mariani JN,Zhang J,Liu J,Sawai S,Chapouly C,Horng S,Kramer EG,Mitiku N,Loo H,Burlant N,Pedre X,Hara Y,Nudelman G,Zaslavsky E,Lee YM,Braun DA,Lu QR,Narla G,Raine CS,Friedman SL,Casaccia P,John GR

Sun May 01 00:00:00 UTC 2016

The Transcriptional Activator Krüppel-like Factor-6 Is Required for CNS Myelination.

PLoS biology

Sun May 01 00:00:00 UTC 2016

Inhibition of Nuclear Transport of NF-ĸB p65 by the Salmonella Type III Secretion System Effector SpvD.

PLoS pathogens

Rolhion N,Furniss RC,Grabe G,Ryan A,Liu M,Matthews SA,Holden DW

Sun May 01 00:00:00 UTC 2016

Targeted disruption of one of the importin α family members leads to female functional incompetence in delivery.

The FEBS journal

Moriyama T,Nagai M,Oka M,Ikawa M,Okabe M,Yoneda Y

Sun May 01 00:00:00 UTC 2011

Targeted disruption of one of the importin α family members leads to female functional incompetence in delivery.

The FEBS journal

Moriyama T,Nagai M,Oka M,Ikawa M,Okabe M,Yoneda Y

Sun May 01 00:00:00 UTC 2011

Bioinformatics

Protein Aliases: IMA2; Importin alpha 2; importin alpha 5; Importin alpha P1; importin alpha-5; Importin alpha-S1; importin subunit alpha-1; Importin subunit alpha-5; importin-alpha-S1; IPOA 1; IPOA1; karyopherin (importin) alpha 1; Karyopherin A2; karyopherin alpha 1 (importin alpha 5); Karyopherin subunit alpha-1; karyopherin/importin alpha-1; KPNA2; m-importin-alpha-S1; NPI-1; Nucleoprotein interactor 1; RAG cohort 1; RAG cohort protein 2; RCH 1; RCH1; recombination activating gene cohort 2; SRP 1; SRP1 alpha; SRP1-beta

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Gene Aliases: AW494490; IPOA5; KPNA1; mSRP1; NPI-1; NPI1; RCH2; SRP1

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UniProt ID: (Human) P52294, (Mouse) Q60960

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Entrez Gene ID: (Human) 3836, (Mouse) 16646, (Rat) 288064

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Function(s)

protein binding nuclear localization sequence binding protein transporter activity

Process(es)

protein import into nucleus transport protein transport positive regulation of protein import into nucleus regulation of DNA recombination apoptotic DNA fragmentation NLS-bearing protein import into nucleus modulation by virus of host process intracellular transport of virus

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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importin alpha 5 Polyclonal Antibody

importin alpha 5 Antibody (18137-1-AP) in ICC/IF

Product Details

18137-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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