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Invitrogen
mGluR2 Polyclonal Antibody
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Product Details
PA5-32860
Product Specifications
Species Reactivity
Human,
Non-human primate,
Rabbit
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic 19 amino acid peptide from N-terminal extracellular domain of human GRM2 / MGLUR2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2550321
Product Specific Information
Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Monkey, Marmoset, Rabbit (100%); Mouse, Rat, Bovine, Dog, Bat, Elephant, Panda (95%); Hamster, Horse, Platypus (89%); Pig (84%).
For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
Target Information
Glutamate is the main excitatory neurotransmitter in the brain. For many years it had been considered to act only on the ligand-gated receptor channels-termed NMDA, AMPA and kainite receptors that are involved in the fast excitatory synaptic transmission. Recently, glutamate has been shown to regulate enzymes producing second messengers via specific receptors coupled to G-proteins. These receptors are called metabotropic glutamate receptors. In expression systems, Group-I receptors stimulate phospholipase C as revealed by an increase in phosphoinositide turnover and calcium release from internal stores. Group-II and -III receptors are coupled to the inhibition of adenylyl cyclase. The Group-I receptors include mGluR1a and mGluR5. The Group-II receptors in include mGluR2 and mGluR3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: glutamate receptor; glutamate receptor homolog; glutamate receptor, metabotropic 2; glutamate receptor, metabotropic 7; M mGlu2; Metabotropic; Metabotropic glutamate receptor 2; mGluR2
Gene Aliases: GLUR2; GPRC1B; GRM2; mGlu2; MGLUR2
UniProt ID: (Human) Q14416
Entrez Gene ID: (Human) 2912, (Rabbit) 100343810
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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