Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
PA5-50507
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to a region derived from internal residues of human glutamate receptor, metabotropic 8
Conjugate
Form
Liquid
Concentration
2.4 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2635960
Product Specific Information
The antibody detects endogenous levels of total mGluR8 protein.
Target Information
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: FLJ41058; G protein coupled receptor, family C, group 1, member H; G protein-coupled receptor family C group 1 member H; G protein-coupled receptor, family C, group 1, member H; glutamate receptor; glutamate receptor, metabotropic 8; M mGlu8; Metabotropic glutamate receptor 8; metabotropic glutamate receptor subtype 8b; MGC126724; mGluR8
Gene Aliases: A230002O04; GLUR8; GPRC1H; GRM8; mGlu8; mGlur; MGLUR8; mGluR8b
UniProt ID: (Human) O00222, (Rat) P70579, (Mouse) P47743
Entrez Gene ID: (Human) 2918, (Rat) 60590, (Mouse) 14823
adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
visual perception
sensory perception of smell
negative regulation of cAMP biosynthetic process
regulation of synaptic transmission, glutamatergic
G-protein coupled receptor signaling pathway
chemical synaptic transmission
sensory perception of pain
synaptic transmission, glutamatergic
regulation of neurotransmitter secretion
detection of mechanical stimulus involved in sensory perception of pain
regulation of neuron death
signal transduction
response to stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support