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mPR alpha Antibody (PA5-102102) in IHC (P)
Immunohistochemistry analysis of mPR alpha in mouse testis tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with mPR alpha polyclonal antibody (Product # PA5-102102) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-102102
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human PAQR7(Accession Q86WK9), corresponding to amino acid residues H313-K346.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2851529
Product Specific Information
Antibody detects endogenous levels of total MPRA.
Target Information
The steroid progesterone induces the resumption of maturation in oocytes via a nongenomic pathway through binding to a novel, membrane progestin receptor (mPR). This pathway inhibits adenylyl cyclase and reduces intracellular cAMP, and also activates mitogen-activated protein kinase to effect signal transduction pathways. Three distinct groups, designated α, β and γ, comprise this gene family. mPRα, also designated progestin and adipoQ receptor family member VII (PAQR7), consists of an extracellular N-terminus, an intracellular C-terminus, and seven transmembrane domains. It is expressed in ovary, testis, placenta, uterus and bladder. mPRβ, also designated progestin and adipoQ receptor family member VIII (PAQR8), consists of eight putative transmembrane regions and an intracellular N-terminus that contains a leucine-rich motif. It is a 354 amino acid protein with a molecular mass of about 40 kDa and is expressed in brain and spinal cord. Both mPRα and mPRβ may be G protein-coupled receptors and may be involved in oocyte maturation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 2310021M12Rik; Membrane progesterone P4 receptor alpha; Membrane progesterone receptor alpha; Membrane progestin receptor alpha; mPR alpha; PPAR-gamma-induced liver protein; Progesterone and adipoQ receptor family member 7; Progestin and adipoQ receptor family member 7; Progestin and adipoQ receptor family member VII
Gene Aliases: 2310021M12Rik; AV001994; BB007237; mPR; MPRA; MRPA; mSR; PAQR7; PGLP
UniProt ID: (Human) Q86WK9, (Mouse) Q80ZE4
Entrez Gene ID: (Human) 164091, (Mouse) 71904
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