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Invitrogen
n-Myc Recombinant Rabbit Monoclonal Antibody (1Q4E4)
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n-Myc Antibody (MA5-51313) in WB
Western blot analysis of n-Myc in Neuro-2a cells. Samples were incubated with n-Myc Recombinant monoclonal antibody (Product # MA5-51313) using a dilution of 1:3,000 followed by HRP Goat Anti-Rabbit IgG (H+L) secondary antibody at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 180s.
Product Details
MA5-51313
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
1Q4E4
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human N-Myc/MYCN (NP_005369.2).
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_3093099
Product Specific Information
Immunogen sequence: MPSCSTSTMP GMICKNPDLE FDSLQPCFYP DEDDFYFGGP DSTPPGEDIW KKFELLPTPP LSPSRGFAEH SSEPPSWVTE MLLENELWGS PAEEDAFGLG
Target Information
N-Myc protein is member of the MYC family of transcription factor proteins with a basic helix-loop-helix (bHLH) domain. N-Myc is similarly regulated and functionally complementary to C-Myc in the context of various cellular growth and differentiation processes. MYCN gene is considered the hallmark of neuroblastoma, amplification and overexpression of the MYCN proto-oncogene occurs in approximately 20% of neuroblastomas and is associated with advanced stage disease, rapid tumor progression, and poor prognosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: N-myc proto-oncogene protein; neuroblastoma myc-related oncogene 1; oncogene pp65/67
Gene Aliases: bHLHe37; c-nmyc; Mycn; N-myc; Nmyc; Nmyc-1; Nmyc1
UniProt ID: (Mouse) P03966
Entrez Gene ID: (Mouse) 18109
cartilage condensation
positive regulation of mesenchymal cell proliferation
regulation of transcription, DNA-templated
positive regulation of cell proliferation
positive regulation of cell death
lung development
embryonic digit morphogenesis
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
embryonic skeletal system morphogenesis
negative regulation of astrocyte differentiation
branching morphogenesis of an epithelial tube
negative regulation of reactive oxygen species metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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