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Product Details
PA5-120233
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 413-613 of human RBL2 (NP_0056023)
Conjugate
Form
Liquid
Concentration
2.345 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2913805
Product Specific Information
Positive test controls include: Neuro-2a. The target is usually found in the following locations: Nucleus.
Immunogen sequence: SPCVTPVSTA THSLSRLHTM LTGLRNAPSE KLEQILRTCS RDPTQAIANR LKEMFEIYSQ HFQPDEDFSN CAKEIASKHF RFAEMLYYKV LESVIEQEQK RLGDMDLSGI LEQDAFHRSL LACCLEVVTF SYKPPGNFPF ITEIFDVPLY HFYKVIEVFI RAEDGLCREV VKHLNQIEEQ ILDHLAWKPE SPLWEKIRDN E
Target Information
RBL2 (also known as p130) or Retinoblastoma-like protein 2 is a key regulator of entry into cell division. It is directly involved in heterochromatin formation by maintaining overall chromatin structure and (in particular) that of constitutive heterochromatin by stabilizing histone methylation. RBL2 recruits and targets histone methyltransferases KMT5B and KMT5C leading to epigenetic transcriptional repression. It controls histone H4 'Lys20' trimethylation. It probably also acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. RBL2 serves as a potent inhibitor of E2F-mediated trans-activation and associates preferentially with E2F5.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 130 kDa retinoblastoma-associated protein; FLJ26459; p130; PRB2; rb2 p130; RBR-2; retinoblastoma-like 2; Retinoblastoma-like protein 2; Retinoblastoma-related protein 2
Gene Aliases: P130; PRB2; RB2; RBL2; RBR-2
UniProt ID: (Human) Q08999, (Mouse) Q64700
Entrez Gene ID: (Human) 5934, (Mouse) 19651
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
negative regulation of gene expression
covalent chromatin modification
regulation of lipid kinase activity
regulation of transcription, DNA-templated
cell cycle
chromatin modification
regulation of cell cycle
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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