Proteintech

p19 INK4d Polyclonal Antibody

p19 INK4d Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 8

p19 INK4d Antibody (10272-2-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded mouse testis tissue slide using (Product # 10272-2-AP) (p19 INK4d antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

Product Image Gallery

Product Details

10272-2-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 10 publications 10 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

p19 INK4d Fusion Protein Ag0415 (1-166 aa encoded by BC001822)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MLLEEVRAG DRLSGAAARG DVQEVRRLLH RELVHPDALN RFGKTALQVM MFGSTAIALE LLKQGASPNV QDTSGTSPVH DAARTGFLDT LKVLVEHGAD VNVPDGTGAL PIHLAVQEGH TAVVSFLAAE SDLHRRDARG LTPLELALQR GAQDLVDILQ GHMVAPL (1-166 aa encoded by BC001822)

Target Information

p19 is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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LINC01012 upregulation promotes cervical cancer proliferation and migration via downregulation of CDKN2D.

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Cell death & disease

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Laboratory investigation; a journal of technical methods and pathology

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Possible Roles of Proinflammatory Signaling in Keratinocytes Through Aryl Hydrocarbon Receptor Ligands for the Development of Squamous Cell Carcinoma.

Frontiers in immunology

Sato Y,Fujimura T,Hidaka T,Lyu C,Tanita K,Matsushita S,Yamamoto M,Aiba S

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Resveratrol Inhibits Ischemia-Induced Myocardial Senescence Signals and NLRP3 Inflammasome Activation.

Oxidative medicine and cellular longevity

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Overexpression of ERBB4 rejuvenates aged mesenchymal stem cells and enhances angiogenesis via PI3K/AKT and MAPK/ERK pathways.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

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Fri Mar 01 00:00:00 UTC 2019

Pharmacological or transcriptional inhibition of both HDAC1 and 2 leads to cell cycle blockage and apoptosis via p21^Waf1/Cip1 and p19^INK4d upregulation in hepatocellular carcinoma.

Cell proliferation

Zhou H,Cai Y,Liu D,Li M,Sha Y,Zhang W,Wang K,Gong J,Tang N,Huang A,Xia J

Fri Jun 01 00:00:00 UTC 2018

Ginsenoside Rg1 ameliorates testicular senescence changes in D‑gal‑induced aging mice via anti‑inflammatory and antioxidative mechanisms.

Molecular medicine reports

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Interconnecting molecular pathways in the pathogenesis and drug sensitivity of T-cell acute lymphoblastic leukemia.

Blood

Sanda T,Li X,Gutierrez A,Ahn Y,Neuberg DS,O'Neil J,Strack PR,Winter CG,Winter SS,Larson RS,von Boehmer H,Look AT

Thu Mar 04 00:00:00 UTC 2010

Bioinformatics

Protein Aliases: CDK inhibitor p19INK4d; CDK4I; cell cycle inhibitor, Nur77 associating protein; Cyclin-dependent kinase 4 inhibitor D; cyclin-dependent kinase 4 inhibitor D p19; cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4); inhibitor of cyclin-dependent kinase 4d; MTS1; p16-INK4; p16-INK4a; p19-INK4d

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Gene Aliases: CDKN2D; INK4D; p19; p19-INK4D; p19INK4d

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UniProt ID: (Human) P55273, (Mouse) Q60773

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Entrez Gene ID: (Human) 1032, (Mouse) 12581

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Function(s)

cyclin-dependent protein serine/threonine kinase inhibitor activity protein binding protein kinase binding

Process(es)

regulation of cyclin-dependent protein serine/threonine kinase activity G1/S transition of mitotic cell cycle DNA synthesis involved in DNA repair cell cycle cell cycle arrest sensory perception of sound negative regulation of cell proliferation response to UV negative regulation of cell growth response to retinoic acid response to vitamin D negative regulation of phosphorylation negative regulation of cysteine-type endopeptidase activity involved in apoptotic process autophagic cell death negative regulation of protein serine/threonine kinase activity negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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p19 INK4d Polyclonal Antibody

p19 INK4d Antibody (10272-2-AP) in IHC (P)

Product Details

10272-2-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Not applicable (N/A)

Species Reactivity

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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