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Invitrogen
p23 Recombinant Rabbit Monoclonal Antibody (JU09-31)
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Product Details
MA5-32825
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
JU09-31
Immunogen
Synthetic peptide within Human p23 aa 43-92
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2810101
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
Steroid receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. Prior to activation, steroid receptors associate with a number of different proteins in both a stable and transient fashion. Steroid receptor complex proteins include heat shock proteins (HSP70 and HSP90), immunosuppressant binding proteins called immunophilins (the FK506 binding proteins, FKBP52 & FKBP54 and the cyclosporin binding protein, CyP-40) and at least three other proteins termed p23, p60 and p48. p23 along with HSP70, HSP90 and p60, combine with progesterone receptor (PR) as members of a transient intermediate complex. Cloned human p23 encodes a protein of 160 amino acids that is highly conserved between species and shows no homology to previously identified proteins. p23 is a highly acidic phosphoprotein with an aspartic acid-rich C-terminal domain and multiple potential phosphorylation sites. In vitro studies have suggested that p23 binds to HSP90 and is necessary for the binding of HSP90 and CyP-40 to PR. While neither its exact function nor mechanism of action have been identified, p23 appears to be an important factor in PR function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Co chaperone p23; cPGES; cytosolic prostaglandin E synthase; Cytosolic prostaglandin E2 synthase; Hsp90 co chaperone; Hsp90 co-chaperone; p23 cochaperone; Progesterone receptor complex p23; Prostaglandin E synthase 3; prostaglandin E synthase 3 (cytosolic); prostaglandin-E synthase 3; ptges3 {ECO:0000250|UniProtKB:Q15185}; Sid 3177; telomerase binding protein, p23; Telomerase-binding protein p23; unactive progesterone receptor, 23 kD
Gene Aliases: 5730442A20Rik; cPGES; P23; Ptges; PTGES3; RGD1561913; Sid3177; TEBP
UniProt ID: (Human) Q15185, (Rat) P83868, (Mouse) Q9R0Q7
Entrez Gene ID: (Human) 10728, (Rat) 362809, (Mouse) 56351
prostaglandin biosynthetic process
glycogen biosynthetic process
RNA-dependent DNA biosynthetic process
prostaglandin metabolic process
cell proliferation
positive regulation of gene expression
sensory perception of pain
glucocorticoid receptor signaling pathway
skin development
lung saccule development
negative regulation of cell death
chaperone cofactor-dependent protein refolding
telomere maintenance
signal transduction
cyclooxygenase pathway
regulation of cellular response to heat
lipid metabolic process
fatty acid metabolic process
fatty acid biosynthetic process
DNA biosynthetic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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