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Exalpha
p27 Monoclonal Antibody (DCS72)
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Product Details
C155M
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
DCS72
Immunogen
HIS-tagged recombinant full length mouse p27 protein recognizing a 27kDa protein
Conjugate
Form
Liquid
Purification
Ammonium sulfate precipitation
Storage buffer
PBS with 0.2% carrier protein
Contains
0.08% sodium azide
Storage conditions
4°C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Immunoprecipitation: co-precipitates cdk4.
Target Information
p27, also known as p27Kip1, is a crucial cyclin-dependent kinase inhibitor (CKI) involved in the regulation of the cell cycle. The p27 protein is encoded by the CDKN1B gene located on chromosome 12 and plays a vital role in controlling cell proliferation by inhibiting cyclin-CDK complexes, particularly cyclin A-CDK2 and cyclin E-CDK2. By regulating these complexes, p27 induces cell cycle arrest at the G1 phase, preventing cells from prematurely entering the S phase. This function is critical for maintaining normal cellular processes and preventing uncontrolled cell division. p27 acts as a tumor suppressor, and its expression is tightly controlled by transcriptional and post-transcriptional mechanisms, including proteasome-mediated degradation. Reduced levels of p27 have been associated with numerous cancers, highlighting its role in tumorigenesis. The regulation of p27 involves signaling pathways such as the PI3K/AKT pathway, impacting its localization and stability in response to extracellular signals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: p24 family protein gamma-3; p24gamma3; p27; Transmembrane emp24 domain-containing protein 7; transmembrane emp24 protein transport domain containing 7; UV36Sp6 ultraviolet B radiation-activated UV36
Gene Aliases: 3930401E15Rik; 5830493P14Rik; AU044611; AW545765; CGI-109; p24g3; p24gamma3; p27; TMED7; TRAM
UniProt ID: (Human) Q9Y3B3, (Rat) D3ZTX0
Entrez Gene ID: (Human) 51014, (Dog) 481436, (Mouse) 66676, (Rat) 252889
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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