p53 Tumor Suppressor Protein Monoclonal Antibody (PAb240)

transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription factor binding protease binding p53 binding DNA binding chromatin binding damaged DNA binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding copper ion binding ATP binding protein kinase binding receptor tyrosine kinase binding ubiquitin protein ligase binding histone deacetylase regulator activity histone acetyltransferase binding identical protein binding sequence-specific DNA binding transcription regulatory region DNA binding protein heterodimerization activity protein N-terminus binding chaperone binding protein phosphatase 2A binding MDM2/MDM4 family protein binding RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding protein binding transcription factor binding zinc ion binding enzyme binding protein phosphatase binding protein self-association RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding transcription cofactor binding protein C-terminus binding metal ion binding

protein import into nucleus, translocation negative regulation of transcription from RNA polymerase II promoter DNA strand renaturation in utero embryonic development somitogenesis release of cytochrome c from mitochondria T cell proliferation involved in immune response B cell lineage commitment T cell lineage commitment response to ischemia nucleotide-excision repair double-strand break repair apoptotic process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator ER overload response transforming growth factor beta receptor signaling pathway Ras protein signal transduction multicellular organism development gastrulation negative regulation of neuroblast proliferation central nervous system development cell aging negative regulation of DNA replication determination of adult lifespan rRNA transcription response to salt stress response to X-ray response to gamma radiation positive regulation of cardiac muscle cell apoptotic process negative regulation of cell growth negative regulation of transforming growth factor beta receptor signaling pathway positive regulation of histone deacetylation mitotic G1 DNA damage checkpoint positive regulation of protein oligomerization T cell differentiation in thymus regulation of tissue remodeling cellular response to UV multicellular organism growth cellular response to drug cellular response to glucose starvation intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator negative regulation of apoptotic process positive regulation of neuron apoptotic process response to antibiotic regulation of mitochondrial membrane permeability negative regulation of fibroblast proliferation positive regulation of peptidyl-tyrosine phosphorylation protein tetramerization chromosome organization neuron apoptotic process positive regulation of thymocyte apoptotic process cellular response to hypoxia cellular response to ionizing radiation mitotic cell cycle arrest positive regulation of release of cytochrome c from mitochondria positive regulation of cell aging replicative senescence oxidative stress-induced premature senescence oligodendrocyte apoptotic process negative regulation of macromitophagy negative regulation of reactive oxygen species metabolic process positive regulation of reactive oxygen species metabolic process positive regulation of intrinsic apoptotic signaling pathway positive regulation of leukocyte migration transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter protein complex assembly cellular response to DNA damage stimulus response to oxidative stress cell cycle cell cycle arrest protein localization negative regulation of cell proliferation response to UV embryo development ending in birth or egg hatching programmed cell death viral process cerebellum development DNA damage response, signal transduction by p53 class mediator chromosome breakage chromatin assembly cellular protein localization positive regulation of mitochondrial membrane permeability regulation of cell proliferation response to drug regulation of apoptotic process positive regulation of apoptotic process entrainment of circadian clock by photoperiod mitochondrial DNA repair regulation of neuron apoptotic process positive regulation of cell cycle negative regulation of proteolysis negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated negative regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter rhythmic process circadian behavior embryonic organ development negative regulation of smooth muscle cell proliferation regulation of catalytic activity regulation of intracellular pH regulation of cell cycle positive regulation of transcription from RNA polymerase II promoter in response to hypoxia intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress regulation of thymocyte apoptotic process necroptotic process positive regulation of cell cycle arrest cellular response to UV-C intrinsic apoptotic signaling pathway by p53 class mediator regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter positive regulation of execution phase of apoptosis regulation of mitochondrial membrane permeability involved in apoptotic process regulation of intrinsic apoptotic signaling pathway by p53 class mediator regulation of hydrogen peroxide-induced cell death negative regulation of glucose catabolic process to lactate via pyruvate intrinsic apoptotic signaling pathway in response to hypoxia positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress regulation of fibroblast apoptotic process negative regulation of DNA biosynthetic process regulation of cellular senescence aging response to inorganic substance response to metal ion response to UV-B response to organonitrogen compound response to organic cyclic compound response to caffeine response to retinoic acid response to vitamin B3 response to cytokine cellular response to heat wound healing response to amino acid response to hyperoxia cellular response to organonitrogen compound base-excision repair cell proliferation positive regulation of gene expression protein sumoylation cell differentiation proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of protein export from nucleus negative regulation of helicase activity negative regulation of telomerase activity intrinsic apoptotic signaling pathway positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway regulation of signal transduction by p53 class mediator regulation of cell cycle G2/M phase transition