Invitrogen

p70 S6 Kinase Monoclonal Antibody (5G9)

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Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers

Product Details

MA5-17168

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:1,000
-

Flow Cytometry (Flow)

1:200-1:400
-

ELISA (ELISA)

1:10,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

5G9

Immunogen

Purified recombinant fragment of human RPS6KB1 expressed in E. Coli.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein G

Storage buffer

PBS

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2538639

Product Specific Information

MA5-17168 targets RPS6KB1 in FACS, IHC, indirect ELISA, and WB applications and shows reactivity with Human samples.

The MA5-17168 immunogen is purified recombinant fragment of human RPS6KB1 expressed in E. Coli.

MA5-17168 detects RPS6KB1 which has a predicted molecular weight of approximately 59kDa.

Target Information

RPS6KB1 (p70S6K) is a serine/threonine kinase with 2 non-identical kinase catalytic domains which phosphorylates several residues of the S6 ribosomal protein. p70 S6 kinase is predominantly localized in the cytoplasm, and is essential in growth factors regulated cell proliferation, pathways involving cell motility, such as metastases, the immune response, and tissue repair. p70 S6 kinase acts downstream of phosphoinositide (PI) 3-kinase, and its main physiological target is the S6 ribosomal protein, which is involved in upregulation of protein synthesis. The kinase activity of p70 S6 kinase leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding p70 S6 kinase and overexpression are seen in some breast cancer cell lines.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 70 kDa ribosomal protein S6 kinase 1; EC 2.7.11.1; kinase p70S6K; KS6B1; p70 p70-S6K; p70 ribosomal S6 kinase alpha; p70 S6 kinase alpha; p70 S6 kinase, alpha; p70S6K-alpha; P70S6K1; p80-S6K 1; p85 p85S6K; Ribosomal protein S6 kinase beta-1; Ribosomal protein S6 kinase I; ribosomal protein S6 kinase, 70kDa, polypeptide 1; S6K-beta-1; serine/threonine kinase 14 alpha; Serine/threonine-protein kinase 14A

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Gene Aliases: p70 S6KA; p70(S6K)-alpha; p70-alpha; p70-S6K; PS6K; RPS6KB1; S6K; S6K-beta-1; S6K1; STK14A

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UniProt ID: (Human) P23443

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Entrez Gene ID: (Human) 6198

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Function(s)
protein kinase activity ribosomal protein S6 kinase activity protein serine/threonine/tyrosine kinase activity protein binding ATP binding kinase activity PDZ domain binding peptide binding identical protein binding protein phosphatase 2A binding
Process(es)
G1/S transition of mitotic cell cycle behavioral fear response skeletal muscle contraction protein phosphorylation apoptotic process signal transduction germ cell development aging response to nutrient long-term memory response to heat response to wounding response to mechanical stimulus response to toxic substance response to glucose skeletal muscle atrophy response to electrical stimulus involved in regulation of muscle adaptation positive regulation of smooth muscle cell migration cell migration TOR signaling response to lipopolysaccharide response to insulin cellular response to hormone stimulus response to testosterone response to glucagon response to tumor necrosis factor response to drug negative regulation of apoptotic process response to leucine protein kinase B signaling response to ethanol positive regulation of translation positive regulation of mitotic cell cycle positive regulation of translational initiation regulation of glucose import negative regulation of insulin receptor signaling pathway phosphatidylinositol-mediated signaling positive regulation of skeletal muscle tissue growth positive regulation of smooth muscle cell proliferation response to glucocorticoid cellular response to growth factor stimulus cellular response to organic cyclic compound negative regulation of extrinsic apoptotic signaling pathway
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