Invitrogen

p73 delta Monoclonal Antibody (38C674.2)

View all (2) p73 delta antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-16183

Applications
Tested Dilution
Publications

Western Blot (WB)

1-3 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

5 µg/mL
-

Immunohistochemistry (Frozen) (IHC (F))

1:20-1:1,000
-

Immunocytochemistry (ICC/IF)

1:20-1:1,000
-

Immunoprecipitation (IP)

Assay-Dependent
-

ChIP assay (ChIP)

5 µg
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

38C674.2

Immunogen

Synthetic peptide (LYVGDPARHLAT) of p73 (deltaNp73) protein.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein G

Storage buffer

PBS with 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2537702

Target Information

p73 was identified as a long-lost cousin of tumor suppressor protein, p53 (4). p73 has high homology with p53 as well as with p63, a gene implicated in the maintenance of epithelial stem cells. Significant homology between p53, p63, and p73 (approximately 63% amino acid identity in the DNA-binding domain suggest that they may have overlapping functions in the regulation of gene expression (3). The targeted disruption of p73 gene leads to defects hippocampal dysgenesis, hydrocephalus, chronic inflammation and infections (2). Recently, spilicing variant mRNAs of p73 has been identified in MCF-7, a breast carcinoma cell line. These mRNAs code for variant p73 proteins bearing distinct carboxy-terminal structures suggesting that the carboxy-terminal region of p73 may be important for the functions of this protein (1) It was found p73 to be upregulated in a significant fraction of anaplastic thyroid cancers, whereas it was not detectable in normal thyroid epithelial cells nor in papillary or follicular thyroid cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: OTTHUMP00000003479; OTTHUMP00000003480; p53-like transcription factor; p53-related protein; RP23-254N4.10; transformation related protein 73; Tumor protein p73

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Gene Aliases: deltaNp73; P73; TAp73; TP73; Trp73

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UniProt ID: (Human) O15350, (Mouse) Q9JJP2

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Entrez Gene ID: (Human) 7161, (Rat) 362675, (Mouse) 22062

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding p53 binding chromatin binding damaged DNA binding transcription factor activity, sequence-specific DNA binding protein binding transcription factor binding protein kinase binding identical protein binding transcription regulatory region DNA binding metal ion binding DNA binding double-stranded DNA binding sequence-specific DNA binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter activation of MAPK activity release of cytochrome c from mitochondria transcription, DNA-templated regulation of transcription, DNA-templated transcription from RNA polymerase II promoter apoptotic process inflammatory response cellular response to DNA damage stimulus DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator cell cycle cell cycle arrest regulation of mitotic cell cycle post-embryonic development response to X-ray response to gamma radiation regulation of gene expression hippocampus development forebrain development mitotic G1 DNA damage checkpoint cerebrospinal fluid secretion cellular response to UV intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator positive regulation of apoptotic process negative regulation of JUN kinase activity regulation of neuron apoptotic process negative regulation of neuron apoptotic process negative regulation of neuron differentiation positive regulation of cell size positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter digestive tract morphogenesis neuron development positive regulation of oligodendrocyte differentiation protein tetramerization negative regulation of cardiac muscle cell proliferation positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator positive regulation of apoptotic signaling pathway kidney development mismatch repair intrinsic apoptotic signaling pathway in response to DNA damage response to organonitrogen compound viral process response to drug regulation of apoptotic process positive regulation of cell cycle arrest positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway regulation of signal transduction by p53 class mediator
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