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Progen
p97 ATPase Monoclonal Antibody (58.13.3)
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Product Details
61078PROGEN
Product Specifications
Species Reactivity
Human,
Rabbit,
Rat,
Xenopus
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
58.13.3
Immunogen
15S Mg2+ Atpase Complex Purified From Xenopus Laevis Ovary
Conjugate
Form
Lyophilized
Storage buffer
PBS, pH 7.4, with 0.5% BSA
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute lyophilized product with 1 mL distilled water.
p97 ATPase/VCP (also described as valosin-containing protein) is implicated in homotypic membrane fusion events and is related to the N-ethyl maleimide-sensitive fusion protein NSF/Sec18p. Specificity with the p97 subunit of 15S Mg2+-ATPase. p97/VCP is involved in ubiquitin-proteasome dependent protein degradation processes and involvement was also found e.g. in the formation of neuronal inclusion bodies in neuro-degenerative diseseases (e.g. Parkinson's disease). Positive control: Immunoblots with protein extracts from all vertebrate tissues and cells.Reactivity on cultured cell lines: All vertebrate cells and tissues tested so far: e.g. Xenopus laevis; rabbit, rat, human; does not crossreact with the corresponding protein in budding yeast (Cdc48p).
Target Information
CDK5RAP2 is a regulator of CDK5 (cyclin-dependent kinase 5) activity. The protein is localized to the centrosome and Golgi complex and interacts with CDK5R1 and pericentrin (PCNT). CDK5RAP2 plays a role in centriole engagement and microtubule nucleation, and has been linked to primary microcephaly and Alzheimer's disease. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: aging-associated protein 1; DAP-5; Death-associated protein 5; eIF-4-gamma 2; eIF-4G 2; eIF4G 2; EIF4G2; Eukaryotic translation initiation factor 4 gamma 2; eukaryotic translation initiation factor 4 gamma, 2; eukaryotic translation initiation factor 4G-like 1; FLJ41344; Novel APOBEC-1 target 1; p97; Translation repressor NAT1
Gene Aliases: AAG1; DAP5; EIF4G2; eif4g2.L; NAT1; OK/SW-cl.75; P97; XELAEV_18024574mg
UniProt ID: (Rabbit) P79398, (Human) P78344
Entrez Gene ID: (Rabbit) 100009236, (Human) 1982, (Rat) 361628, (Xenopus) 100127281
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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