Invitrogen

pan Synuclein Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-78420

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:1,000
-

Immunocytochemistry (ICC/IF)

1:100-1:1,000
-
Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the center region of Rat pan Synuclein. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol, 1% BSA

Contains

0.025% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2736318

Product Specific Information

Positive Control: mouse brain, rat brain

Predicted Reactivity: Human (93%), Xenopus laevis (84%), Pig (92%), Chicken (87%), Sheep (91%), Chimpanzee (93%), Bovine (91%)

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Synucleins are small, soluble proteins expressed primarily in neural tissue and in certain tumors. The family includes three known proteins: alpha-synuclein, beta-synuclein, and gamma-synuclein. The alpha- and beta-synuclein proteins are found primarily in brain tissue, where they are seen mainly in presynaptic terminals. The gamma-synuclein protein is found primarily in the peripheral nervous system and retina, but its expression in breast tumors makes it a candidate as a marker for tumor progression.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Alpha-synuclein; Beta-synuclein; Gamma-synuclein; NACP; Non-A beta component of AD amyloid; non-A4 component of amyloid; Non-A4 component of amyloid precursor; Persyn; Phosphoneuroprotein 14; PNP 14; Sensory neuron synuclein; synuclein, gamma (breast cancer-specific protein 1)

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Gene Aliases: AI838531; alphaSYN; betaSYN; C79089; NACP; Persyn; Snca; Sncb; Sncg; Syn

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UniProt ID: (Rat) P37377, (Mouse) O55042, (Mouse) Q91ZZ3, (Rat) Q63754, (Rat) Q63544, (Mouse) Q9Z0F7

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Entrez Gene ID: (Rat) 29219, (Mouse) 20617, (Mouse) 104069, (Rat) 113893, (Rat) 64347, (Mouse) 20618

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Function(s)
magnesium ion binding fatty acid binding copper ion binding calcium ion binding protein binding phospholipid binding microtubule binding ferrous iron binding zinc ion binding oxidoreductase activity kinesin binding enzyme binding protein domain specific binding Hsp70 protein binding histone binding identical protein binding alpha-tubulin binding cysteine-type endopeptidase inhibitor activity involved in apoptotic process phospholipase binding dynein binding protein N-terminus binding tau protein binding beta-tubulin binding arachidonic acid binding phosphoprotein binding phospholipase D inhibitor activity metal ion binding
Process(es)
aggressive behavior chemical synaptic transmission peripheral nervous system development adult locomotory behavior protein secretion regulation of dopamine secretion response to cocaine response to drug regulation of neurotransmitter secretion synapse organization cellular response to hydrostatic pressure microglial cell activation positive regulation of receptor recycling negative regulation of protein phosphorylation positive regulation of neurotransmitter secretion synaptic transmission, dopaminergic fatty acid metabolic process neutral lipid metabolic process phospholipid metabolic process activation of cysteine-type endopeptidase activity involved in apoptotic process mitochondrial membrane organization aging response to iron(II) ion regulation of phospholipase activity negative regulation of platelet-derived growth factor receptor signaling pathway regulation of glutamate secretion negative regulation of microtubule polymerization receptor internalization protein destabilization response to magnesium ion negative regulation of transporter activity response to lipopolysaccharide negative regulation of monooxygenase activity positive regulation of peptidyl-serine phosphorylation response to interferon-gamma cellular response to oxidative stress negative regulation of histone acetylation regulation of locomotion dopamine biosynthetic process dopamine metabolic process mitochondrial ATP synthesis coupled electron transport regulation of macrophage activation negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of neuron apoptotic process negative regulation of neuron apoptotic process cellular response to fibroblast growth factor stimulus positive regulation of endocytosis negative regulation of exocytosis negative regulation of dopamine metabolic process behavioral response to cocaine regulation of neuronal synaptic plasticity regulation of long-term neuronal synaptic plasticity synaptic vesicle endocytosis synaptic vesicle transport positive regulation of synaptic transmission regulation of acyl-CoA biosynthetic process positive regulation of release of sequestered calcium ion into cytosol negative regulation of dopamine uptake involved in synaptic transmission negative regulation of serotonin uptake negative regulation of norepinephrine uptake calcium ion homeostasis oxidation-reduction process excitatory postsynaptic potential long-term synaptic potentiation positive regulation of inositol phosphate biosynthetic process membrane organization negative regulation of thrombin receptor signaling pathway response to interleukin-1 cellular response to copper ion positive regulation of protein serine/threonine kinase activity regulation of neuron death positive regulation of glutathione peroxidase activity positive regulation of hydrogen peroxide catabolic process regulation of reactive oxygen species metabolic process
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