Proteintech

pan-keratin Polyclonal Antibody

pan-keratin Antibody in Immunocytochemistry (ICC/IF)

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pan-keratin Antibody (26411-1-AP) in ICC/IF

Immunofluorescent analysis of (4% PFA) fixed HeLa cells using pan-keratin antibody (Product # 26411-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).

pan-keratin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

pan-keratin Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

pan-keratin Antibody in Western Blot (WB)

pan-keratin Antibody in Flow Cytometry (Flow)

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Product Details

26411-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:50,000-1:200,000

View 3 publications 3 publications

Immunohistochemistry (IHC)

View 7 publications 7 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:1,000-1:3,200

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:50-1:500

View 7 publications 7 publications

Flow Cytometry (Flow)

Assay-dependent

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KRT5 Fusion Protein Ag24184 (316-491 aa encoded by BC024292)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is a pan-keratin antibody.

Immunogen sequence: THVSDTSVV LSMDNNRNLD LDSIIAEVKA QYEEIANRSR TEAESWYQTK YEELQQTAGR HGDDLRNTKH EISEMNRMIQ RLRAEIDNVK KQCANLQNAI ADAEQRGELA LKDARNKLAE LEEALQKAKQ DMARLLREYQ ELMNTKLALD VEIATYRKLL EGEECRLSGE GVGPVNI (316-491 aa encoded by BC024292 )

Target Information

Cytokeratin pan is part of a subfamily of intermediate filament proteins that are characterized by remarkable biochemical diversity, and represented in human epithelial tissues by at least 20 different polypeptides. Cytokeratins range in molecular weight between 40 kDa- 68 kDa, and an isoelectric pH between 4.9-7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays. The composition of cytokeratin pairs vary with the epithelial cell type, stage of differentiation, cellular growth environment, and disease state. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Mesenchymal stem cells-derived IL-6 promotes invasion and metastasis of oral squamous cell carcinoma via JAK-STAT3 signalling.

Oral diseases

Liu C,Zhou J,Zhang S,Fu J,Li Y,Hao Y,Yuan J,Tang F,Ge W,He H,Chen Q

Wed May 01 00:00:00 UTC 2024

Cancer medicine

Zhang M,Cao C,Li X,Gu Q,Xu Y,Zhu Z,Xu D,Wei S,Chen H,Yang Y,Gao H,Yu L,Li J

Sun Jan 01 00:00:00 UTC 2023

Multifunctional hydrogels for wound dressings using xanthan gum and polyacrylamide.

International journal of biological macromolecules

Tang S,Gong Z,Wang Z,Gao X,Zhang X

Fri Sep 30 00:00:00 UTC 2022

Calreticulin silencing inhibits extracellular matrix synthesis of human gingival fibroblasts cultured on three-dimensional poly(lactic-co-glycolic acid) scaffolds by inhibiting the calcineurin/nuclear factor of activated T cells 3 signalling pathway.

Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft

Wei H,Chen Z,Zheng Y,Chen Q,Min H,Ma Q,Gao B,Mo S

Sat Jan 01 00:00:00 UTC 2022

LIS1 interacts with CLIP170 to promote tumor growth and metastasis via the Cdc42 signaling pathway in salivary gland adenoid cystic carcinoma.

International journal of oncology

Li L,Wen Z,Kou N,Liu J,Jin D,Wang L,Wang F,Gao L

Sat Oct 01 00:00:00 UTC 2022

The keratin 17/YAP/IL6 axis contributes to E-cadherin loss and aggressiveness of diffuse gastric cancer.

Oncogene

Li M,Rao X,Cui Y,Zhang L,Li X,Wang B,Zheng Y,Teng L,Zhou T,Zhuo W

Tue Feb 01 00:00:00 UTC 2022

USP13 promotes development and metastasis of high-grade serous ovarian carcinoma in a novel mouse model.

Oncogene

Kwon J,Choi H,Ware AD,Morillo BC,Wang H,Bouker KB,Lu X,Waldman T,Han C

Tue Mar 01 00:00:00 UTC 2022

[Application of iodine staining technique for tumor identification in Micro-CT of mouse model with skull base-infratemporal fossa tumor].

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences

Yang R,Li QX,Wang YF,Zhou W,Wang W,Guo CB,Liu H,Guo YX

Fri Jun 18 00:00:00 UTC 2021

Preclinical Application of Conditional Reprogramming Culture System for Laryngeal and Hypopharyngeal Carcinoma.

Frontiers in cell and developmental biology

Dong Y,Wang J,Ji W,Zheng M,Wang P,Liu L,Li S

Wed Nov 17 00:00:00 UTC 2021

MEST promotes lung cancer invasion and metastasis by interacting with VCP to activate NF-κB signaling.

Journal of experimental & clinical cancer research : CR

Wang Y,Zhang J,Li YJ,Yu NN,Liu WT,Liang JZ,Xu WW,Sun ZH,Li B,He QY

Fri Sep 24 00:00:00 UTC 2021

MR imaging as a precise technique to evaluate skull-base tumor volume: Comparison of CT, MR imaging and FDG PET from murine and clinical data.

Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery

Li QX,Yang R,Wang YF,Sun HF,Wang HB,Liu H,Guo YX,Guo CB

Wed Jan 01 00:00:00 UTC 2020

Heterotypic 3D pancreatic cancer model with tunable proportion of fibrotic elements.

Biomaterials

Tanaka HY,Kurihara T,Nakazawa T,Matsusaki M,Masamune A,Kano MR

Thu Apr 30 00:00:00 UTC 2020

Microscopic distance from tumor invasion front to serosa might be a useful predictive factor for peritoneal recurrence after curative resection of T3-gastric cancer.

PloS one

Togano S,Yashiro M,Miki Y,Yamamoto Y,Sera T,Kushitani Y,Sugimoto A,Kushiyama S,Nishimura S,Kuroda K,Okuno T,Yoshii M,Tamura T,Toyokawa T,Tanaka H,Muguruma K,Tanaka S,Ohira M

Mon Apr 06 00:00:00 UTC 2020

MSC-derived exosomes protect against oxidative stress-induced skin injury via adaptive regulation of the NRF2 defense system.

Biomaterials

Wang T,Jian Z,Baskys A,Yang J,Li J,Guo H,Hei Y,Xian P,He Z,Li Z,Li N,Long Q

Thu Oct 01 00:00:00 UTC 2020

Curcumin Inhibits the Migration and Invasion of Non-Small-Cell Lung Cancer Cells Through Radiation-Induced Suppression of Epithelial-Mesenchymal Transition and Soluble E-Cadherin Expression.

Technology in cancer research & treatment

Deng X,Chen C,Wu F,Qiu L,Ke Q,Sun R,Duan Q,Luo M,Luo Z

Mon Nov 29 00:00:00 UTC 2021

Berberine inhibits proliferation and migration of colorectal cancer cells by downregulation of GRP78.

Anti-cancer drugs

Gong C,Hu X,Xu Y,Yang J,Zong L,Wang C,Zhu J,Li Z,Lu D

Sat Feb 01 00:00:00 UTC 2020

The clinicopathological significance of Thrombospondin-4 expression in the tumor microenvironment of gastric cancer.

PloS one

Kuroda K,Yashiro M,Sera T,Yamamoto Y,Kushitani Y,Sugimoto A,Kushiyama S,Nishimura S,Togano S,Okuno T,Tamura T,Toyokawa T,Tanaka H,Muguruma K,Ohira M

Wed Mar 18 00:00:00 UTC 2020

Bioinformatics

Protein Aliases: 39.1; 40-kDa keratin intermediate filament; 58 kDa cytokeratin; 65 kDa cytokeratin; 67 kDa cytokeratin; Cell proliferation-inducing gene 46 protein; CK-1; CK-10; CK-13; CK-14; CK-15; CK-16; CK-17; CK-18; CK-19; CK-1B; CK-2e; CK-2P; CK-3; CK-4; CK-5; CK-6A; CK-6D; CK-7; CK-8; cytokeratin 1; cytokeratin 10; cytokeratin 13; cytokeratin 14; cytokeratin 15; cytokeratin 16; cytokeratin 18; cytokeratin 19; cytokeratin 2; cytokeratin 3; cytokeratin 4; cytokeratin 6A; cytokeratin 6C; cytokeratin 6D; cytokeratin 7; Cytokeratin-1; Cytokeratin-10; Cytokeratin-13; Cytokeratin-14; Cytokeratin-15; Cytokeratin-16; Cytokeratin-17; Cytokeratin-18; Cytokeratin-19; Cytokeratin-1B; Cytokeratin-2e; Cytokeratin-2P; Cytokeratin-3; Cytokeratin-4; Cytokeratin-5; Cytokeratin-6A; cytokeratin-6C; Cytokeratin-6D; cytokeratin-6E; Cytokeratin-7; Cytokeratin-8; epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types; epidermolytic hyperkeratosis 1; Epithelial keratin-2e; focal non-epidermolytic palmoplantar keratoderma; Hair alpha protein; HMWCK; K1; K10; K13; K14; K15; K16; K17; K18; K19; K1B; K2e; K2P; K3; K4; K5; K6A; K7; K76; K77; K8; kamp-keratin derived antimicrobial peptide; KDAMP; keratin 1, type II; keratin 10, type I; keratin 13, type I; keratin 14, type I; keratin 15, type I; keratin 16, type I; keratin 17, type I; keratin 18, type I; keratin 19, type I; Keratin 1B; keratin 2, type II; keratin 2p; keratin 3, type II; keratin 4, type II; keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5, type II; keratin 6A, , type II; keratin 6A, type II; keratin 7, type II; keratin 76, type II; keratin 77, type II; keratin 8, type II; keratin K6h; Keratin type II cytoskeletal 5; keratin, 55K type II cytoskeletal; keratin, epidermal type II, K6A; keratin, simple epithelial type I, K7; Keratin, type I cytoskeletal 10; Keratin, type I cytoskeletal 13; Keratin, type I cytoskeletal 14; Keratin, type I cytoskeletal 15; Keratin, type I cytoskeletal 16; Keratin, type I cytoskeletal 17; Keratin, type I cytoskeletal 18; Keratin, type I cytoskeletal 19; keratin, type I, 40-kd; Keratin, type II cytoskeletal 1; Keratin, type II cytoskeletal 1b; Keratin, type II cytoskeletal 2 epidermal; Keratin, type II cytoskeletal 2 oral; Keratin, type II cytoskeletal 3; Keratin, type II cytoskeletal 4; Keratin, type II cytoskeletal 5; Keratin, type II cytoskeletal 6A; Keratin, type II cytoskeletal 7; Keratin, type II cytoskeletal 8; Keratin-1; Keratin-10; Keratin-13; Keratin-14; Keratin-15; keratin-15, basic; keratin-15, beta; Keratin-16; Keratin-17; Keratin-18; Keratin-19; Keratin-2 epidermis; Keratin-2e; Keratin-3; Keratin-4; Keratin-5; Keratin-6A; keratin-6C; Keratin-7; Keratin-76; Keratin-77; Keratin-8; KRT1B; pan Cytokeratin; pan keratin; pankeratin; Sarcolectin; type I cytoskeletal 15; type II cytoskeletal 1b; type II mesothelial keratin K7; Type-II keratin Kb1; type-II keratin Kb12; Type-II keratin Kb2; Type-II keratin Kb3; Type-II Keratin Kb39; Type-II keratin Kb4; Type-II keratin Kb5; Type-II keratin Kb6; Type-II keratin Kb7; Type-II keratin Kb8; Type-II keratin Kb9

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Gene Aliases: 39.1; BCIE; BIE; CARD2; CK-17; CK-18; CK-2e; CK-4; CK-6C; CK-6E; CK-8; CK1; CK10; CK13; CK14; CK15; CK16; CK19; CK3; CK4; CK5; CK6A; CK6C; CK6D; CK7; CK8; CYK18; CYK4; CYK8; DDD; DDD1; EBS2; EBS3; EBS4; EHK; EHK1; EPPK; FNEPPK; HUMCYT2A; K1; K10; K13; K14; K15; K16; K17; K18; K19; K1B; K1CO; K1CP; K1CS; K2C7; K2C8; K2e; K3; K4; K5; K6A; K6C; K6D; K7; K8; KO; KPP; KRT1; KRT10; KRT13; KRT14; KRT15; KRT16; KRT16A; KRT17; KRT18; KRT19; KRT1A; KRT1B; KRT2; KRT2A; KRT2B; KRT2E; KRT2P; KRT3; KRT4; KRT5; KRT5A; KRT6A; KRT6C; KRT6D; KRT7; KRT76; KRT77; KRT8; KRTA; KRTB; KRTE; NEPPK; NFJ; PC; PC1; PC2; PC3; PCHC1; PIG46; SCL; WSN1; WSN2

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Function(s)

receptor activity structural molecule activity protein binding carbohydrate binding structural constituent of epidermis structural constituent of cytoskeleton keratin filament binding scaffold protein binding MHC class II receptor activity MHC class II protein binding poly(A) RNA binding cadherin binding involved in cell-cell adhesion structural constituent of muscle protein complex binding molecular_function

Process(es)

epithelial cell differentiation intermediate filament cytoskeleton organization cytoskeleton organization negative regulation of epithelial cell proliferation complement activation, lectin pathway retina homeostasis response to oxidative stress fibrinolysis regulation of angiogenesis negative regulation of inflammatory response establishment of skin barrier Notch signaling pathway viral process response to estrogen sarcomere organization cell differentiation involved in embryonic placenta development epidermis development keratinization keratinocyte activation keratinocyte proliferation keratinocyte migration cell cycle anatomical structure morphogenesis tumor necrosis factor-mediated signaling pathway Golgi to plasma membrane CFTR protein transport negative regulation of apoptotic process extrinsic apoptotic signaling pathway hepatocyte apoptotic process cell-cell adhesion signal transduction positive regulation of cell growth hair follicle morphogenesis intermediate filament organization positive regulation of translation positive regulation of hair follicle development biological_process morphogenesis of an epithelium inflammatory response aging cell proliferation keratinocyte differentiation negative regulation of cell migration hair cycle innate immune response mitophagy in response to mitochondrial depolarization sebaceous gland development response to radiation tongue morphogenesis cellular response to retinoic acid response to zinc ion response to ionizing radiation hemidesmosome assembly intermediate filament bundle assembly response to hydrostatic pressure response to other organism

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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pan-keratin Polyclonal Antibody

pan-keratin Antibody (26411-1-AP) in ICC/IF

Product Details

26411-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (PFA fixed) (IHC (PFA))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Species Reactivity

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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