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Invitrogen
sfl Polyclonal Antibody
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sfl Antibody (PA5-144403) in WB
Western blot analysis of sfl in recombinant protein using a dilution of 1:2,000. Samples were incubated with sfl polyclonal antibody (Product # PA5-144403). Secondary: Goat polyclonal to rabbit IgG at 1:50,000 dilution. Predicted band size: 33.1 kDa. Observed band size: 34 kDa.
Product Details
PA5-144403
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Fruit fly
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) NDST protein (1-172aa)
Conjugate
Form
Liquid
Concentration
2.032 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% Proclin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Wet ice
RRID
AB_3091671
Target Information
Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in diffusion of morphogen wingless (wg) via its role in heparan sulfate proteoglycans (HSPGs) biosynthesis, HSPGs being required for movement of wg morphogens. Required for wg signaling during both embryonic and imaginal disk development. Also required for FGF receptor signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase; CG8339-PA; CG8339-PB; diet-wingless; Glucosaminyl N-deacetylase/N-sulfotransferase; sfl-PA; sfl-PB; Sulfateless
Gene Aliases: CG8339; CT24567; Dmel\CG8339; Dmel_CG8339; dw; l(3)03844; lincRNA.S4253; NDST; Sfl
UniProt ID: (Fruit fly) Q9V3L1
Entrez Gene ID: (Fruit fly) 38736
glycosaminoglycan biosynthetic process
sulfur compound metabolic process
cell surface receptor signaling pathway
spermatogenesis
segment polarity determination
epithelial cell migration, open tracheal system
primary branching, open tracheal system
imaginal disc-derived wing vein specification
heart development
mesoderm migration involved in gastrulation
fibroblast growth factor receptor signaling pathway
imaginal disc-derived wing margin morphogenesis
heparan sulfate proteoglycan biosynthetic process
heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
Wnt signaling pathway
regulation of imaginal disc growth
intracellular distribution of mitochondria
synaptic vesicle endocytosis
regulation of canonical Wnt signaling pathway
regulation of decapentaplegic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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