Proteintech

uPAR Polyclonal Antibody

FIGURE: 1 / 4

uPAR Antibody (10286-1-AP) in WB

RAW264.7 cells were subjected to SDS PAGE followed by western blot with 10286-1-AP (uPAR antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

uPAR Antibody in Immunoprecipitation (IP)

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Product Details

10286-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 9 publications 9 publications

Immunohistochemistry (IHC)

View 6 publications 6 publications

Immunocytochemistry (ICC/IF)

Assay-dependent

View 2 publications 2 publications

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

uPAR Fusion Protein Ag0187 (1-136 aa encoded by BC002788)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MGHPPLLPL LLLLHTCVPA SWGLRCMQCK TNGDCRVEEC ALGQDLCRTT IVRLWEEGEE LELVEKSCTH SEKTNRTLSY RTGLKITSLT EVVCGLDLCN QGNSGRAVTY SRSRYLECIS CGSSDMSCER GRHQSLQ (1-136 aa encoded by BC002788)

Target Information

The urokinase-type plasminogen activator receptor is a key molecule in the regulation of cell-surface plasminogen activation and plays an important role in many normal as well as pathologic processes. The human PLAUR cDNA encodes 335 amino acids including a predicted signal peptide of 22 residues and a hydrophobic C-terminal portion. It produces a highly glycosylated protein of about 50 kD in monocytes where it is anchored to the plasma membrane by glycosyl-phosphatidylinositol linkage. PLAUR, also known as UPAR, is directly associated with the carbohydrate-binding domain of SELL in the membrane of neutrophils, an association analogous to that between PLAUR and beta-2 integrins. PLAUR-mediated calcium mobilization is SELL dependent. UPAR mRNA levels correlate with the invasive potential of endometrial carcinomas and show a 33-fold increase in UPAR mRNA levels in advanced clinical stage endometrial tumors compared with normal endometrial tissue. Furthermore, the increase in UPAR mRNA levels correlated linearly with the progression of disease stage. UPAR protein expressioin correlated positively with rate of recurrence and mortality in patients with endometrial cancer. UPAR appears to be a useful prognostic marker for advanced endometrial cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

ICAM-1-suPAR-CD11b Axis Is a Novel Therapeutic Target for Metastatic Triple-Negative Breast Cancer.

Cancers

Li D,Hemati H,Park Y,Taftaf R,Zhang Y,Liu J,Cristofanilli M,Liu X

Fri May 12 00:00:00 UTC 2023

Bcl-xL Enforces a Slow-Cycling State Necessary for Survival in the Nutrient-Deprived Microenvironment of Pancreatic Cancer.

Cancer research

Sela Y,Li J,Maheswaran S,Norgard R,Yuan S,Hubbi M,Doepner M,Xu JP,Ho ES,Mesaros C,Sheehan C,Croley G,Muir A,Blair IA,Shalem O,Dang CV,Stanger BZ

Mon May 16 00:00:00 UTC 2022

Baohuoside I Inhibits Osteoclastogenesis and Protects Against Ovariectomy-Induced Bone Loss.

Frontiers in pharmacology

Ma M,Fan AY,Liu Z,Yang LQ,Huang JM,Pang ZY,Yin F

Sat Jul 16 00:00:00 UTC 2022

A Dual-Reporter Platform for Screening Tumor-Targeted Extracellular Vesicles.

Pharmaceutics

Kanada M,Linenfelser L,Cox E,Gilad AA

Tue Feb 22 00:00:00 UTC 2022

Endocytosis of Peptidase Inhibitor SerpinE2 promotes Myocardial Fibrosis through activating ERK1/2 and β-catenin Signaling Pathways.

International journal of biological sciences

Li C,Lv LF,Qi-Li MG,Yang R,Wang YJ,Chen SS,Zhang MX,Li TY,Yu T,Zhou YH,Liang HH,Shan HL,Li XL

Tue Nov 29 00:00:00 UTC 2022

Identification of an immune-related signature indicating the dedifferentiation of thyroid cells.

Cancer cell international

Wang X,Peng W,Li C,Qin R,Zhong Z,Sun C

Fri Apr 23 00:00:00 UTC 2021

Staphylococcus aureus on the effect of expression of MMPs/TIMPs and uPA system in bovine mammary fibroblasts.

Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi

Miao Z,Ding Y,Bi Y,Chen M,Cao X,Wang F

Tue Jun 01 00:00:00 UTC 2021

PLAUR as a Potential Biomarker Associated with Immune Infiltration in Bladder Urothelial Carcinoma.

Journal of inflammation research

Liu M,Chen S,Zhang A,Zheng Q,Fu J

Tue Apr 26 00:00:00 UTC 2022

CLEC14A protects against podocyte injury in mice with adriamycin nephropathy.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Su Z,Li Y,Lv H,Cui X,Liu M,Wang Z,Zhang Y,Zhen J,Tang W,Wang X,Yi F

Thu Jul 01 00:00:00 UTC 2021

CLEC14A protects against podocyte injury in mice with adriamycin nephropathy.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Su Z,Li Y,Lv H,Cui X,Liu M,Wang Z,Zhang Y,Zhen J,Tang W,Wang X,Yi F

Thu Jul 01 00:00:00 UTC 2021

CLEC14A protects against podocyte injury in mice with adriamycin nephropathy.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Su Z,Li Y,Lv H,Cui X,Liu M,Wang Z,Zhang Y,Zhen J,Tang W,Wang X,Yi F

Thu Jul 01 00:00:00 UTC 2021

CLEC14A protects against podocyte injury in mice with adriamycin nephropathy.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Su Z,Li Y,Lv H,Cui X,Liu M,Wang Z,Zhang Y,Zhen J,Tang W,Wang X,Yi F

Thu Jul 01 00:00:00 UTC 2021

Forkhead Box Q1 Is Critical to Angiogenesis and Macrophage Recruitment of Colorectal Cancer.

Frontiers in oncology

Tang H,Zheng J,Bai X,Yue KL,Liang JH,Li DY,Wang LP,Wang JL,Guo Q

Sat Mar 30 00:00:00 UTC 2024

The Plasma Soluble Urokinase Plasminogen Activator Receptor Is Related to Disease Activity of Patients with ANCA-Associated Vasculitis.

Mediators of inflammation

Huang F,Li Y,Xu R,Cheng A,Lv Y,Liu Q

Mon Feb 01 00:00:00 UTC 2021

Ulinastatin Inhibits Osteoclastogenesis and Suppresses Ovariectomy-Induced Bone Loss by Downregulating uPAR.

Frontiers in pharmacology

Huang JM,Ren RY,Bao Y,Guo JC,Xiang W,Jing XZ,Shi J,Zhang GX,Li L,Tian Y,Kang H,Guo FJ

Thu Oct 01 00:00:00 UTC 2020

Ulinastatin Inhibits Osteoclastogenesis and Suppresses Ovariectomy-Induced Bone Loss by Downregulating uPAR.

Frontiers in pharmacology

Huang JM,Ren RY,Bao Y,Guo JC,Xiang W,Jing XZ,Shi J,Zhang GX,Li L,Tian Y,Kang H,Guo FJ

Thu Oct 01 00:00:00 UTC 2020

High-Purity Magnesium Staples Suppress Inflammatory Response in Rectal Anastomoses.

ACS applied materials & interfaces

Xia J,Chen H,Yan J,Wu H,Wang H,Guo J,Zhang X,Zhang S,Zhao C,Chen Y

Wed Mar 22 00:00:00 UTC 2017

High-Purity Magnesium Staples Suppress Inflammatory Response in Rectal Anastomoses.

ACS applied materials & interfaces

Xia J,Chen H,Yan J,Wu H,Wang H,Guo J,Zhang X,Zhang S,Zhao C,Chen Y

Wed Mar 22 00:00:00 UTC 2017

Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling.

Nature communications

Liu M,Liang K,Zhen J,Zhou M,Wang X,Wang Z,Wei X,Zhang Y,Sun Y,Zhou Z,Su H,Zhang C,Li N,Gao C,Peng J,Yi F

Mon Sep 04 00:00:00 UTC 2017

Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling.

Nature communications

Liu M,Liang K,Zhen J,Zhou M,Wang X,Wang Z,Wei X,Zhang Y,Sun Y,Zhou Z,Su H,Zhang C,Li N,Gao C,Peng J,Yi F

Mon Sep 04 00:00:00 UTC 2017

Ligand binding alters dimerization and sequestering of urokinase receptors in raft-mimicking lipid mixtures.

Biophysical journal

Ge Y,Siegel AP,Jordan R,Naumann CA

Tue Nov 04 00:00:00 UTC 2014

Regulation of u-PAR gene expression by H2A.Z is modulated by the MEK-ERK/AP-1 pathway.

Nucleic acids research

Chauhan S,Boyd DD

Sun Jan 01 00:00:00 UTC 2012

Regulation of u-PAR gene expression by H2A.Z is modulated by the MEK-ERK/AP-1 pathway.

Nucleic acids research

Chauhan S,Boyd DD

Sun Jan 01 00:00:00 UTC 2012

Bioinformatics

Protein Aliases: CD87; Monocyte activation antigen Mo3; sCD87; soluble CD87; U-PAR; u-plasminogen activator receptor form 2; urokinase plasminogen activator receptor; Urokinase plasminogen activator surface receptor; urokinase-type plasminogen activator (uPA) receptor; urokinase-type plasminogen activator receptor

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Gene Aliases: CD87; MO3; PLAUR; U-PAR; UPAR; URKR

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UniProt ID: (Human) Q03405, (Mouse) P35456

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Entrez Gene ID: (Human) 5329, (Mouse) 18793

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Function(s)

receptor activity receptor binding protein binding enzyme binding protein domain specific binding urokinase plasminogen activator receptor activity

Process(es)

positive regulation of protein phosphorylation movement of cell or subcellular component chemotaxis signal transduction blood coagulation attachment of GPI anchor to protein regulation of proteolysis urokinase plasminogen activator signaling pathway fibrinolysis negative regulation of apoptotic process positive regulation of DNA binding positive regulation of epidermal growth factor receptor signaling pathway positive regulation of release of cytochrome c from mitochondria negative regulation of intrinsic apoptotic signaling pathway negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway positive regulation of gene expression mesenchymal cell differentiation epithelial cell differentiation involved in prostate gland development

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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uPAR Polyclonal Antibody

uPAR Antibody (10286-1-AP) in WB

Product Details

10286-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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