Proteintech

vwf Polyclonal Antibody

vwf Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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vwf Antibody (27186-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded Human tonsillitis tissue slide using (Product # 27186-1-AP) VWF antibody at dilution of 1:200 (under 40x lens). Proteolytic pre-treatment mediated antigen retrieval.

vwf Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

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Product Details

27186-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

View 3 publications 3 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:50-1:500

View 13 publications 13 publications

Not applicable (N/A)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

vwf Fusion Protein Ag25578

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.33 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSSPLSHRS KRSLSCRPPM VKLVCPADNL RAEGLECTKT CQNYDLECMS MGCVSGCLCP PGMVRHENRC VALERCPCFH QGKEYAPGET VKIGCNTCVC QD

Target Information

Von Willebrand factor (vWf) is a series of self-aggregated structures, all derived from common glycoprotein subunits, synthesized in endothelial cells and megakaryocytes. The molecular mass of the monomeric vWf unit is 225 kDa. vWf binds to circulating factor VIIIc (antihemophilic factor), hereby stabilizing the latter thus being an important factor in the normal primary haemostasis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Lacosamide alleviates bilateral cavernous nerve injury-induced erectile dysfunction in the rat model by ameliorating pathological changes in the corpus cavernosum.

International journal of impotence research

Yao L,Cong R,Zhou X,Zhou X,Ji C,Wei X,Meng X,Song N

Wed May 01 00:00:00 UTC 2024

Lacosamide alleviates bilateral cavernous nerve injury-induced erectile dysfunction in the rat model by ameliorating pathological changes in the corpus cavernosum.

International journal of impotence research

Yao L,Cong R,Zhou X,Zhou X,Ji C,Wei X,Meng X,Song N

Wed May 01 00:00:00 UTC 2024

The combination of machine learning and transcriptomics reveals a novel megakaryopoiesis inducer, MO-A, that promotes thrombopoiesis by activating FGF1/FGFR1/PI3K/Akt/NF-κB signaling.

European journal of pharmacology

Zhang T,Mo Q,Jiang N,Wu Y,Yang X,Chen W,Li Q,Yang S,Yang J,Zeng J,Huang F,Huang Q,Luo J,Wu J,Wang L

Wed Apr 05 00:00:00 UTC 2023

Exploring the synergic mechanism of Ligusticum striatum DC. and borneol in attenuating BMECs injury and maintaining tight junctions against cerebral ischaemia based on the HIF-1α/VEGF signalling pathway.

Journal of ethnopharmacology

Song X,Xing W,Zhang X,Wang X,Ji J,Lu J,Yu B,Ruan M

Mon Jan 30 00:00:00 UTC 2023

Journal of ethnopharmacology

Song X,Xing W,Zhang X,Wang X,Ji J,Lu J,Yu B,Ruan M

Mon Jan 30 00:00:00 UTC 2023

Curcumol suppresses endothelial-to-mesenchymal transition via inhibiting the AKT/GSK3β signaling pathway and alleviates pulmonary arterial hypertension in rats.

European journal of pharmacology

Nie X,Wu Z,Shang J,Zhu L,Liu Y,Qi Y

Wed Mar 15 00:00:00 UTC 2023

Endothelial progenitor cell-derived exosomes inhibit pulmonary artery smooth muscle cell in vitro proliferation and resistance to apoptosis by modulating the Mitofusin-2 and Ras-Raf-ERK1/2 signaling pathway.

European journal of pharmacology

Liu P,Gao S,Li Z,Pan S,Luo G,Ji Z

Thu Jun 15 00:00:00 UTC 2023

PDLIM1 inhibits cell migration and invasion in diabetic retinopathy via negatively regulating Wnt3a.

Scientific reports

Xie P,You Q,Zhu J,Xie W,Wei P,Zhu S,Du Y,Gao X

Mon Apr 10 00:00:00 UTC 2023

Platelet Membrane-Fused Circulating Extracellular Vesicles Protect the Heart from Ischemia/Reperfusion Injury.

Advanced healthcare materials

Jiang J,Ni L,Zhang X,Wang H,Liu L,Wei M,Li G,Bei Y

Tue Aug 01 00:00:00 UTC 2023

Role of hemocytin from Litopenaeus vannamei in immune response against microsporidian, Enterocytozoon hepatopenaei.

Fish & shellfish immunology

Sukonthamarn P,Nanakorn Z,Junprung W,Supungul P,Tassanakajon A

Mon May 01 00:00:00 UTC 2023

Role of Mydgf in the regulation of hypoxia/reoxygenation-induced apoptosis in cardiac microvascular endothelial cells.

In vitro cellular & developmental biology. Animal

Wang Y,Zhang Y,Li J,Zhao R,Long X,Li C,Liu W,Chen W,Shi B

Thu Sep 01 00:00:00 UTC 2022

Olmesartan Improves Hepatic Sinusoidal Remodeling in Mice with Carbon Tetrachloride-Induced Liver Fibrosis.

BioMed research international

Wu Y,Ge X,Wang SN,Zhang CQ

Wed Sep 07 00:00:00 UTC 2022

Mechanism of Endoplasmic Reticulum Stress Pathway in the Osteogenic Phenotypic Transformation of Aortic Valve Interstitial Cells.

Frontiers in endocrinology

Tao Y,Geng Y,Dang W,Xu X,Zhao H,Zou L,Li Y

Fri Apr 01 00:00:00 UTC 2022

Mechanism of Endoplasmic Reticulum Stress Pathway in the Osteogenic Phenotypic Transformation of Aortic Valve Interstitial Cells.

Frontiers in endocrinology

Tao Y,Geng Y,Dang W,Xu X,Zhao H,Zou L,Li Y

Fri Apr 01 00:00:00 UTC 2022

Oriented nanofibrous P(MMD-co-LA)/Deferoxamine nerve scaffold facilitates peripheral nerve regeneration by regulating macrophage phenotype and revascularization.

Biomaterials

Dong X,Wu P,Yan L,Liu K,Wei W,Cheng Q,Liang X,Chen Y,Dai H

Sat Jan 01 00:00:00 UTC 2022

A Novel Antithrombocytopenia Agent, Rhizoma cibotii, Promotes Megakaryopoiesis and Thrombopoiesis through the PI3K/AKT, MEK/ERK, and JAK2/STAT3 Signaling Pathways.

International journal of molecular sciences

Chen W,Zhu L,Wang L,Zeng J,Wen M,Xu X,Zou L,Huang F,Huang Q,Qin D,Mei Q,Yang J,Wang Q,Wu J

Mon Nov 14 00:00:00 UTC 2022

Extracorporeal shockwave relieves endothelial injury and dysfunction in steroid-induced osteonecrosis of the femoral head via miR-135b targeting FOXO1: in vitro and in vivo studies.

Aging

Wu X,Wang Y,Fan X,Xu X,Sun W

Fri Jan 07 00:00:00 UTC 2022

Comparative Transcriptome Analyses of Geriatric Rats Associate Age-Related Erectile Dysfunction With a lncRNA-miRNA-mRNA Regulatory Network.

Frontiers in endocrinology

Zhou X,Cong R,Yao L,Zhou X,Luan J,Zhang Q,Zhang X,Ren X,Zhang T,Meng X,Song N

Fri Jul 29 00:00:00 UTC 2022

Essential role of MALAT1 in reducing traumatic brain injury.

Neural regeneration research

Wu N,Cheng CJ,Zhong JJ,He JC,Zhang ZS,Wang ZG,Sun XC,Liu H

Mon Aug 01 00:00:00 UTC 2022

PDGF-BB/SA/Dex injectable hydrogels accelerate BMSC-mediated functional full thickness skin wound repair by promoting angiogenesis.

Journal of materials chemistry. B

Zhang Z,Li Z,Wang Y,Wang Q,Yao M,Zhao L,Shi J,Guan F,Ma S

Sat Aug 21 00:00:00 UTC 2021

Slight up-regulation of Kir2.1 channel promotes endothelial progenitor cells to transdifferentiate into a pericyte phenotype by Akt/mTOR/Snail pathway.

Journal of cellular and molecular medicine

Cui X,Li X,He Y,Yu J,Dong N,Zhao RC

Mon Nov 01 00:00:00 UTC 2021

Bioinformatics

Protein Aliases: Coagulation Factor VIII; coagulation factor VIII VWF; factor viii related antigen; von Willebrand Disease (vWD); von Willebrand factor; vWF; vwf {ECO:0000312|EMBL:CAB37852.1}

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Gene Aliases: 6820430P06Rik; AI551257; B130011O06Rik; C630030D09; F8VWF; VWD; VWF

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UniProt ID: (Human) P04275, (Mouse) Q8CIZ8

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Entrez Gene ID: (Human) 7450, (Mouse) 22371, (Rat) 116669

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Function(s)

glycoprotein binding protease binding integrin binding protein binding collagen binding immunoglobulin binding identical protein binding protein homodimerization activity protein N-terminus binding chaperone binding molecular_function

Process(es)

liver development placenta development cell adhesion blood coagulation hemostasis platelet activation cell-substrate adhesion protein homooligomerization response to immobilization stress tissue regeneration platelet degranulation blood coagulation, intrinsic pathway response to wounding extracellular matrix organization

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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vwf Polyclonal Antibody

vwf Antibody (27186-1-AP) in IHC (P)

Product Details

27186-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (PFA fixed) (IHC (PFA))

Immunocytochemistry (ICC/IF)

Not applicable (N/A)

Species Reactivity

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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