The implementation of real-time, off-gas analysis using Process Mass Spectrometry (MS) in mammalian cell culture bioprocesses can help identify process deviations during bioreactor runs and evaluate batch to batch variation, within predefined specifications, for robust biopharmaceutical manufacturing.

What you will learn from this article:

• Determination of respiratory parameters by magnetic sector MS
• Integration of magnetic sector MS analyzer with benchtop bioreactors
• Bioreactor sterility assessment
• Off-gas analysis for the determination of bacterial contamination
• Off-line measurement of cell culture parameters